In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters (original) (raw)

References

1. Sandison, J. Observations on growth of blood vessels as seen in transparent chamber introduced into rabbit's ear. Am. J. Anat. 41, 475–496 (1928).
   Article Google Scholar
2. Ide, A. & Warren, S. Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am. J. Roentgenol. 42, 891–889 (1939).
   Google Scholar
3. Algire, G. An adaptation of the transparent chamber technique to the mouse. J. Natl. Cancer Inst. 4, 1–11 (1943).
   Google Scholar
4. Huang, Q. et al. Noninvasive visualization of tumors in rodent dorsal skin window chambers. Nat. Biotechnol. 17, 1033–1035 (1999).
   Article CAS PubMed Google Scholar
5. Jain, R.K., Munn, L.L. & Fukumura, D. Dissecting tumour pathophysiology using intravital microscopy. Nat. Rev. Cancer 2, 266–276 (2002).
   Article CAS PubMed Google Scholar
6. Palmer, G.M. & Vishwanath, K. in Handbook of Physics in Medicine and Biology (ed. Robert Splinter) p. 30-31–30-11 (CRC Press/Taylor & Francis Group, 2010).
7. Vázquez, B.Y., Hightower, C.M., Sapuppo, F., Tartakovsky, D.M. & Intaglietta, M. Functional optical imaging at the microscopic level. J. Biomed. Opt. 15, 011102 doi:10.1117/1.3280270 (2010).
   Article PubMed Google Scholar
8. Cao, Y. et al. Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. Cancer Res. 65, 5498–5505 (2005).
   Article CAS PubMed Google Scholar
9. Skala, M., Fontanella, A., Hendargo, H., Dewhirst, M. & Izatt, J. Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Opt. Lett. 34, 289–291 (2009).
   Article PubMed PubMed Central Google Scholar
10. Vakoc, B.J. et al. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat. Med. 15, 1219–1223 (2009).
    Article CAS PubMed PubMed Central Google Scholar
11. Dreher, M.R. et al. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl. Cancer Inst. 98, 335–344 (2006).
    Article CAS PubMed Google Scholar
12. Moeller, B.J., Cao, Y., Li, C.Y. & Dewhirst, M.W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5, 429–441 (2004).
    Article CAS PubMed Google Scholar
13. Zhang, G., Palmer, G., Dewhirst, M. & Fraser, C. A dual-emissive-materials design concept enables tumour hypoxia imaging. Nat. Mater 8, 747–751 (2009).
    Article CAS PubMed PubMed Central Google Scholar
14. Sorg, B., Moeller, B., Donovan, O., Cao, Y. & Dewhirst, M. Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. J. Biomed. Opt. 10, 44004 doi:10.1117/1.2003369 (2005).
    Article PubMed Google Scholar
15. Shan, S., Sorg, B. & Dewhirst, M. A novel rodent mammary window of orthotopic breast cancer for intravital microscopy. Microvasc. Res. 65, 109–117 (2003).
    Article PubMed Google Scholar
16. Niedre, M. et al. Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proc. Natl. Acad. Sci. USA 105, 19126–19131 (2008).
    Article CAS PubMed PubMed Central Google Scholar
17. Sharpe, J. et al. Optical projection tomography as a tool for 3D microscopy and gene expression studies. Science 296, 541–545 (2002).
    Article CAS PubMed Google Scholar
18. Yang, G., Pan, F., Parkhurst, C., Grutzendler, J. & Gan, W. Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nat. Protoc. 5, 201–208 (2010).
    Article CAS PubMed PubMed Central Google Scholar
19. Wang, L.V. & Wu, H.-i. Biomedical Optics: Principles and Imaging (Wiley-Interscience, 2007).
20. Balas, C. Review of biomedical optical imaging—a powerful, non-invasive, non-ionizing technology for improving in vivo diagnosis. Meas. Sci. Technol. 20 doi:10.1088/0957-0233/20/10/104020 (2009).
21. Zhang, H., Maslov, K., Stoica, G. & Wang, L. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat. Biotechnol. 24, 848–851 (2006).
    Article CAS PubMed Google Scholar
22. Weissleder, R. Molecular Imaging: Principles and Practice. (People's Medical Pub. House, 2009).
23. Andersson, C. & Bro, R. The N-way Toolbox for MATLAB. Chemom. Intell. Lab. Syst. 52, 1–4 (2000).
    Article CAS Google Scholar
24. Palmer, G.M. et al. Optical imaging of tumor hypoxia dynamics. J. Biomed. Opt. 15, 066021, doi:10.1117/1.3523363 (2010).
    Article PubMed PubMed Central Google Scholar
25. Splinter, R. & Hooper, B.A. An Introduction to Biomedical Optics (Taylor & Francis, 2007).
26. Jacques, S.L. Skin optics. Oregon Medical Laser Center News, http://omlc.ogi.edu/news/jan98/skinoptics.html (1998).

Download references