Untangling EMT's functions (original) (raw)

EMT is not required for metastasis in mouse tumour models; however, EMT can contribute to resistance to chemotherapy

Although epithelial–mesenchymal transition (EMT) is commonly believed to contribute to metastasis, definitive in vivo evidence to support this theory is lacking. Two studies in Nature report that EMT is not required for metastasis in mouse tumour models; however, EMT can contribute to resistance to chemotherapy.

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References

  1. Fischer, K. R. et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature http://dx.doi.org/10.1038/nature15748 (2015)
  2. Zheng, X., Carstens, J. L. et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature http://dx.doi.org/10.1038/nature16064 (2015)

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Authors

  1. Sarah Seton-Rogers

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Seton-Rogers, S. Untangling EMT's functions.Nat Rev Cancer 16, 1 (2016). https://doi.org/10.1038/nrc.2015.6

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