Chan, S.W-L. & Blackburn, E. H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene21, 553–563 (2002). ArticleCASPubMed Google Scholar
Griffith, J. D. et al. Mammalian telomeres end in a large duplex loop. Cell97, 503–514 (1999). ArticleCASPubMed Google Scholar
Ancelin, K. et al. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol. Cell. Biol.22, 3474–3487 (2002). ArticleCASPubMed Google Scholar
Karlseder, J., Smogorzewska, A. and de Lange, T. Senescence induced by altered telomere state, not telomere loss. Science295, 2446–2449 (2002). ArticleCASPubMed Google Scholar
Goytisolo, F. A. & Blasco, M. A. Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene21, 584–591 (2002). ArticleCASPubMed Google Scholar
Blasco, M. A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell91, 25–34 (1997). ArticleCAS Google Scholar
Espejel, S. et al. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J.21, 2207–2219 (2002). ArticleCASPubMed Google Scholar
Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature345, 458–460 (1990). ArticleCAS Google Scholar
Collins, K. & Mitchell, J. R. Telomerase in the human organism. Oncogene21, 564–579 (2002). ArticleCAS Google Scholar
Lee, H-W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature392, 569–574 (1998). ArticleCAS Google Scholar
Samper, E., Flores, J. M. & Blasco, M. A. Restoration of telomerase activity rescues chromosomal instability and premature aging in _Terc_−/− mice with short telomeres. EMBO Rep.2, 800–807 (2001). ArticleCASPubMed Google Scholar
Hemann, M. T., Strong, M. A., Hao, L. Y. and Greider, C. W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell107, 67–77 (2001). ArticleCAS Google Scholar
Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science279, 349–352 (1998). ArticleCAS Google Scholar
Hiyama, E. & Hiyama, K. Clinical utility of telomerase in cancer. Oncogene21, 643–649 (2002). ArticleCASPubMed Google Scholar
Mattson, M. P., Fu, W. & Zhang, P. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech. Aging Dev.122, 659–671 (2001). ArticleCASPubMed Google Scholar
González-Suárez, E. et al. Increased epidermal tumors and increased wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J.20, 2619–2630 (2001). ArticlePubMed Google Scholar
Reyes, M. et al. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood98, 2615–2625 (2001). ArticleCASPubMed Google Scholar
McEachern, M. J. & Blackburn, E. H. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature376, 403–409 (1995). ArticleCAS Google Scholar
Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol.20, 1659–1668 (2000). ArticleCASPubMed Google Scholar
Prescott, J. C. & Blackburn, E. H. Telomerase RNA template mutations reveal sequence-specific requirements for activation and repression of telomerase action at telomeres. Mol. Cell. Biol.20, 2941–2948 (2000). ArticleCASPubMed Google Scholar
Herrera, E. et al. Disease states associated to telomerase deficiency appear earlier in mice with short telomeres. EMBO J.18, 2950–2960 (1999). ArticleCASPubMed Google Scholar
Hastie, N. D. et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature346, 866–868 (1990). ArticleCASPubMed Google Scholar
de Lange, T. et al. Structure and variability of human chromosome ends. Mol. Cell. Biol.10, 518–527 (1990). ArticleCASPubMed Google Scholar
Zhu, J., Wang, H., Bishop, M. and Blackburn, E. H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl Acad. Sci. USA96, 3723–3728 (1999). ArticleCAS Google Scholar
Chin, L. et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell97, 527–538 (1999). ArticleCASPubMed Google Scholar
González-Suárez, E., Samper, E., Flores, J. M. & Blasco, M. A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nature Genet.26, 114–117 (2000). ArticlePubMed Google Scholar
Corey, D. R. Telomerase inhibition, oligonucleotides, and clinical trials. Oncogene21, 631–727 (2002). ArticleCASPubMed Google Scholar
Neidle, S. & Read, M. A. G-quadruplexes as therapeutic targets. Biopolymers56, 195–208 (2000). ArticleCASPubMed Google Scholar
Damm, K. et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J.20, 6958–6968 (2001). ArticleCASPubMed Google Scholar
Blasco, M. A., Rizen, M., Greider, C. W. and Hanahan, D. Differential regulation of telomerase activity and its RNA component during multistage tumorigenesis. Nature Genet.12, 200–204 (1996). ArticleCAS Google Scholar
Broccoli, D., Godley, L. A., Donehower, L. A., Varmus, H. E. & de Lange, T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol. Cell. Biol.16, 3765–3772 (1996). ArticleCASPubMed Google Scholar
González–Suárez, E., Flores, J. M. & Blasco, M. A. Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol. Cell. Biol. (in the press).
Artandi, S. E. et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl Acad. Sci. USA99, 8191–8196 (2002). ArticleCAS Google Scholar
Thomas, M. et al. Cooperation between hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: a cell transplantation model using bovine adrenocortical cells. Neoplasia (in the press).
Oh, H. et al. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc. Natl Acad. Sci. USA98, 10308–11033 (2001). ArticleCAS Google Scholar
Stampfer, M. R. et al. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor-β growth inhibition in p16INK4A(−) human mammary epithelial cells. Proc. Natl Acad. Sci. USA98, 4498–4503 (2001). ArticleCAS Google Scholar
Lu, C. L., Fu, W. & Mattson, M. P. Telomerase protects developing neurons against DNA damage-induced cell death. Brain Res Dev Brain Res131, 167–171 (2001). ArticleCASPubMed Google Scholar
Zhu, H., Fu, W. & Mattson, M. P. The catalytic subunit of telomerase protects neurones against amyloid β-peptide induced apoptosis. J. Neurochem.75, 117–124 (2000). ArticleCAS Google Scholar
Xiang, H. et al. Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating Rb/E2F pathway. Oncogene21, 3784–3791 (2002). ArticleCASPubMed Google Scholar
Liu, Y. et al. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr. Biol.10, 1459–1462 (2000). ArticleCASPubMed Google Scholar
Nikaido, R. et al. Presence of telomeric G-strand tails in the telomerase catalytic subunit Tert knockout mice. Genes Cells4, 563–572 (1999). ArticlePubMed Google Scholar
Bailey, S. M., Conforth, M. N., Kurimasa, A., Chen, D. J. and Goodwin, E. H. Strand-specific postreplicative processing of mammalian telomeres. Science293, 2462–2465 (2001). ArticleCASPubMed Google Scholar
Goytisolo, F. A. et al. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J. Exp. Med.192, 1625–1636 (2000). ArticleCASPubMed Google Scholar