- World Health Organization. Obesity and overweight fact sheet. The World Health Organization website [online], (2009).
- Cao, Y. Angiogenesis modulates adipogenesis and obesity. J. Clin. Invest. 117, 2362–2368 (2007).
CAS PubMed PubMed Central Google Scholar
- Cooke, D. & Bloom, S. The obesity pipeline: current strategies in the development of anti-obesity drugs. Nature Rev. Drug Discov. 5, 919–931 (2006).
CAS Google Scholar
- Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1, 27–31 (1995).
CAS PubMed Google Scholar
- Lijnen, H. R. Angiogenesis and obesity. Cardiovasc. Res. 78, 286–293 (2008).
CAS PubMed Google Scholar
- Cao, Y. Endogenous angiogenesis inhibitors and their therapeutic implications. Int. J. Biochem. Cell Biol. 33, 357–369 (2001).
CAS PubMed Google Scholar
- Folkman, J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N. Engl. J. Med. 333, 1757–1763 (1995).
CAS PubMed Google Scholar
- Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353–364 (1996).
CAS PubMed Google Scholar
- Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58–62 (2005).
CAS PubMed Google Scholar
- Nyberg, P., Xie, L. & Kalluri, R. Endogenous inhibitors of angiogenesis. Cancer Res. 65, 3967–3979 (2005).
CAS PubMed Google Scholar
- Escudier, B. et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356, 125–134 (2007).
CAS PubMed Google Scholar
- Hurwitz, H. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335–2342 (2004).
CAS PubMed Google Scholar
- Kerbel, R. S. Tumor angiogenesis. N. Engl. J. Med. 358, 2039–2049 (2008).
CAS PubMed PubMed Central Google Scholar
- Motzer, R. J. et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 356, 115–124 (2007).
CAS PubMed Google Scholar
- Gragoudas, E. S., Adamis, A. P., Cunningham, E. T. Jr, Feinsod, M. & Guyer, D. R. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351, 2805–2816 (2004).
CAS PubMed Google Scholar
- Steinbrook, R. The price of sight — ranibizumab, bevacizumab, and the treatment of macular degeneration. N. Engl. J. Med. 355, 1409–1412 (2006).
CAS PubMed Google Scholar
- Duh, E. & Aiello, L. P. Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes 48, 1899–1906 (1999).
CAS PubMed Google Scholar
- Gariano, R. F. & Gardner, T. W. Retinal angiogenesis in development and disease. Nature 438, 960–966 (2005).
CAS PubMed Google Scholar
- Feldmann, H. M., Golozoubova, V., Cannon, B. & Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203–209 (2009).
CAS PubMed Google Scholar
- Lodhi, I. J. & Semenkovich, C. F. Why we should put clothes on mice. Cell Metab. 9, 111–112 (2009).
CAS PubMed Google Scholar
- Xue, Y. et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 9, 99–109 (2009).
CAS PubMed Google Scholar
- Crossno, J. T. Jr, Majka, S. M., Grazia, T., Gill, R. G. & Klemm, D. J. Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells. J. Clin. Invest. 116, 3220–3228 (2006).
CAS PubMed PubMed Central Google Scholar
- Tang, W. et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583–586 (2008).
CAS PubMed PubMed Central Google Scholar
- Hotamisligil, G. S. Inflammation and metabolic disorders. Nature 444, 860–867 (2006).
CAS PubMed Google Scholar
- Powell, K. Obesity: the two faces of fat. Nature 447, 525–527 (2007).
CAS PubMed Google Scholar
- Cao, R., Brakenhielm, E., Wahlestedt, C., Thyberg, J. & Cao, Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc. Natl Acad. Sci. USA 98, 6390–6395 (2001).
CAS PubMed PubMed Central Google Scholar
- Kamba, T. et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am. J. Physiol. Heart Circ. Physiol. 290, H560–H576 (2006).
CAS PubMed Google Scholar
- Friedman, J. M. & Halaas, J. L. Leptin and the regulation of body weight in mammals. Nature 395, 763–770 (1998).
CAS PubMed Google Scholar
- Yamauchi, T. et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762–769 (2003).
CAS PubMed Google Scholar
- Jansson, P. A. Endothelial dysfunction in insulin resistance and type 2 diabetes. J. Intern. Med. 262, 173–183 (2007).
CAS PubMed Google Scholar
- Bakker, W., Eringa, E. C., Sipkema, P. & van Hinsbergh, V. W. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity. Cell Tissue Res. 335, 165–189 (2009).
CAS PubMed Google Scholar
- Goldberg, R. B. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J. Clin. Endocrinol. Metab. 94, 3171–3182 (2009).
CAS PubMed Google Scholar
- Rutkowski, J. M., Davis, K. E. & Scherer, P. E. Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue. FEBS J. 276, 5738–5746 (2009).
CAS PubMed PubMed Central Google Scholar
- Sierra-Honigmann, M. R. et al. Biological action of leptin as an angiogenic factor. Science 281, 1683–1686 (1998).
CAS PubMed Google Scholar
- Aleffi, S. et al. Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 42, 1339–1348 (2005).
CAS PubMed Google Scholar
- Dobson, D. E. et al. 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Cell 61, 223–230 (1990).
CAS PubMed Google Scholar
- Brakenhielm, E. et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc. Natl Acad. Sci. USA 101, 2476–2481 (2004).
CAS PubMed PubMed Central Google Scholar
- Mahadev, K. et al. Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells. Cardiovasc. Res. 78, 376–384 (2008).
CAS PubMed Google Scholar
- Scroyen, I., Jacobs, F., Cosemans, L., De Geest, B. & Lijnen, H. R. Effect of plasminogen activator inhibitor-1 on adipogenesis in vivo. Thromb. Haemost. 101, 388–393 (2009).
CAS PubMed Google Scholar
- Wang, Y. et al. Adiponectin modulates the glycogen synthase kinase-3β/β-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res. 66, 11462–11470 (2006).
CAS PubMed Google Scholar
- Voros, G. et al. Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 146, 4545–4554 (2005).
CAS PubMed Google Scholar
- Landskroner-Eiger, S. et al. Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin. Cancer Res. 15, 3265–3276 (2009).
CAS PubMed PubMed Central Google Scholar
- Ouchi, N. et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 279, 1304–1309 (2004).
CAS PubMed Google Scholar
- de Fraipont, F., Nicholson, A. C., Feige, J. J. & Van Meir, E. G., Thrombospondins and tumor angiogenesis. Trends Mol. Med. 7, 401–407 (2001).
CAS PubMed Google Scholar
- Hosogai, N. et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56, 901–911 (2007).
CAS PubMed Google Scholar
- Trayhurn, P., Wang, B. & Wood, I. S. Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br. J. Nutr. 100, 227–235 (2008).
CAS PubMed Google Scholar
- Bertolini, F., Shaked, Y., Mancuso, P. & Kerbel, R. S. The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nature Rev. Cancer 6, 835–845 (2006).
CAS Google Scholar
- Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Med. 7, 1194–1201 (2001).
CAS PubMed Google Scholar
- Shaked, Y. et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313, 1785–1787 (2006).
CAS PubMed Google Scholar
- Takahashi, T. et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nature Med. 5, 434–438 (1999).
CAS PubMed Google Scholar
- Pittenger, M. F. & Martin, B. J. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ. Res. 95, 9–20 (2004).
CAS PubMed Google Scholar
- Prockop, D. J. et al. Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochem. Soc. Trans. 28, 341–345 (2000).
CAS PubMed Google Scholar
- Wu, Y., Chen, L., Scott, P. G. & Tredget, E. E. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 25, 2648–2659 (2007).
CAS PubMed Google Scholar
- Meliga, E., Strem, B. M., Duckers, H. J. & Serruys, P. W. Adipose-derived cells. Cell Transplant 16, 963–970 (2007).
PubMed Google Scholar
- Valina, C. et al. Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction. Eur. Heart J. 28, 2667–2677 (2007).
PubMed Google Scholar
- Grenier, G. et al. Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis. Stem Cells 25, 3101–3110 (2007).
CAS PubMed Google Scholar
- Kahn, C. R. Medicine. Can we nip obesity in its vascular bud? Science 322, 542–543 (2008).
CAS PubMed PubMed Central Google Scholar
- Timmons, J. A. et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc. Natl Acad. Sci. USA 104, 4401–4406 (2007).
CAS PubMed PubMed Central Google Scholar
- Tong, Q. et al. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290, 134–138 (2000).
CAS PubMed Google Scholar
- Seale, P. et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961–967 (2008).
CAS PubMed PubMed Central Google Scholar
- Brakenhielm, E. et al. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ. Res. 94, 1579–1588 (2004).
CAS PubMed Google Scholar
- Rupnick, M. A. et al. Adipose tissue mass can be regulated through the vasculature. Proc. Natl Acad. Sci. USA 99, 10730–10735 (2002).
CAS PubMed PubMed Central Google Scholar
- O'Reilly, M. S. et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315–328 (1994).
CAS PubMed Google Scholar
- O'Reilly, M. S. et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88, 277–285 (1997).
CAS PubMed Google Scholar
- Tam, J. et al. Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells. PLoS ONE 4, e4974 (2009).
PubMed PubMed Central Google Scholar
- Fukumura, D. et al. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ. Res. 93, e88–97 (2003).
CAS PubMed PubMed Central Google Scholar
- Kim, Y. M. et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J. Mol. Endocrinol. 38, 455–465 (2007).
CAS PubMed Google Scholar
- Satchi-Fainaro, R. et al. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nature Med. 10, 255–261 (2004).
CAS PubMed Google Scholar
- Cao, Y. Molecular mechanisms and therapeutic development of angiogenesis inhibitors. Adv. Cancer Res. 100, 113–131 (2008).
CAS PubMed Google Scholar
- Cao, Y., Zhong, W. & Sun, Y. Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance. Semin. Cancer Biol. 19, 338–343 (2009).
CAS PubMed Google Scholar
- Kolonin, M. G., Saha, P. K., Chan, L., Pasqualini, R. & Arap, W. Reversal of obesity by targeted ablation of adipose tissue. Nature Med. 10, 625–632 (2004).
CAS PubMed Google Scholar
- Piqueras, L. et al. Activation of PPARβ/δ induces endothelial cell proliferation and angiogenesis. Arterioscler. Thromb. Vasc. Biol. 27, 63–69 (2007).
CAS PubMed Google Scholar
- Gealekman, O. et al. Enhanced angiogenesis in obesity and in response to PPARg activators through adipocyte VEGF and ANGPTL4 production. Am. J. Physiol. Endocrinol. Metab. 295, E1056–E1064 (2008).
CAS PubMed PubMed Central Google Scholar
- Demeulemeester, D., Collen, D. & Lijnen, H. R. Effect of matrix metalloproteinase inhibition on adipose tissue development. Biochem. Biophys. Res. Commun. 329, 105–110 (2005).
CAS PubMed Google Scholar
- Chavey, C. et al. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J. Biol. Chem. 278, 11888–11896 (2003).
CAS PubMed Google Scholar
- Lijnen, H. R. et al. Matrix metalloproteinase inhibition impairs adipose tissue development in mice. Arterioscler Thromb. Vasc. Biol. 22, 374–379 (2002).
CAS PubMed Google Scholar
- Christiaens, V., Voros, G., Scroyen, I. & Lijnen, H. R. On the role of placental growth factor in murine adipogenesis. Thromb. Res. 120, 399–405 (2007).
CAS PubMed Google Scholar
- Lijnen, H. R. et al. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 55, 2698–2704 (2006).
CAS PubMed Google Scholar
- Ejaz, A., Wu, D., Kwan, P. & Meydani, M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J. Nutr. 139, 919–25 (2009).
CAS PubMed Google Scholar
- Shin, J. H., Shin, D. W. & Noh, M. Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes. Biochem. Pharmacol. 77, 1835–44 (2009).
CAS PubMed Google Scholar
- Hill, A. M. et al. Can EGCG reduce abdominal fat in obese subjects? J. Am. Coll. Nutr. 26, 396S–402S (2007).
CAS PubMed Google Scholar
- Kao, Y. H., Chang, H. H., Lee, M. J. & Chen, C. L. Tea, obesity, and diabetes. Mol. Nutr. Food Res. 50, 188–210 (2006).
CAS PubMed Google Scholar
- Lin, J., Della-Fera, M. A. & Baile, C. A. Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obes. Res. 13, 982–990 (2005).
CAS PubMed Google Scholar
- Klaus, S., Pultz, S., Thone-Reineke, C. & Wolfram, S. Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. Int. J. Obes. (Lond.) 29, 615–623 (2005).
CAS Google Scholar
- Cao, Y. & Cao, R. Angiogenesis inhibited by drinking tea. Nature 398, 381 (1999).
CAS PubMed Google Scholar
- Yamauchi, T. et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Med. 13, 332–339 (2007).
CAS PubMed Google Scholar
- Seeley, R. J., D'Alessio, D. A. & Woods, S. C. Fat hormones pull their weight in the CNS. Nature Med. 10, 454–455 (2004).
CAS PubMed Google Scholar
- Saltiel, A. R. You are what you secrete. Nature Med. 7, 887–888 (2001).
CAS PubMed Google Scholar
- O'Rahilly, S. Life without leptin. Nature 392, 330–331 (1998).
CAS PubMed Google Scholar
- Friedman, J. M. Obesity in the new millennium. Nature 404, 632–634 (2000).
CAS PubMed Google Scholar
- Frederich, R. C. et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med. 1, 1311–1314 (1995).
CAS PubMed Google Scholar
- Licinio, J. et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nature Med. 3, 575–579 (1997).
CAS PubMed Google Scholar
- Miller, K. et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 357, 2666–2676 (2007).
CAS PubMed Google Scholar
- Caputo, G. M., Cavanagh, P. R., Ulbrecht, J. S., Gibbons, G. W. & Karchmer, A. W. Assessment and management of foot disease in patients with diabetes. N. Engl. J. Med. 331, 854–860 (1994).
CAS PubMed Google Scholar
- Cao, Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci. Signal. 2, re1 (2009).
PubMed Google Scholar
- Carmeliet, P. Angiogenesis in life, disease and medicine. Nature 438, 932–936 (2005).
CAS PubMed Google Scholar
- Ferrara, N. & Kerbel, R. S. Angiogenesis as a therapeutic target. Nature 438, 967–974 (2005).
CAS PubMed Google Scholar
- Carmeliet, P. & Tessier-Lavigne, M. Common mechanisms of nerve and blood vessel wiring. Nature 436, 193–200 (2005).
CAS PubMed Google Scholar
- Carmeliet, P. VEGF gene therapy: stimulating angiogenesis or angioma-genesis? Nature Med. 6, 1102–1103 (2000).
CAS PubMed Google Scholar
- Celletti, F. L. et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nature Med. 7, 425–429 (2001).
CAS PubMed Google Scholar
- Jinnin, M. et al. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nature Med. 14, 1236–1246 (2008).
CAS PubMed Google Scholar
- Ware, J. A. Too many vessels? Not enough? The wrong kind? The VEGF debate continues. Nature Med. 7, 403–404 (2001).
CAS PubMed Google Scholar
- Kopelman, P. G. Obesity as a medical problem. Nature 404, 635–643 (2000).
CAS PubMed Google Scholar
- Couzin, J. Medicine. Bypassing medicine to treat diabetes. Science 320, 438–440 (2008).
CAS PubMed Google Scholar
- Cappuzzo, F., Bartolini, S. & Crino, L. Emerging drugs for non-small cell lung cancer. Expert Opin. Emerg. Drugs 8, 179–192 (2003).
CAS PubMed Google Scholar
- Mistry, T., Digby, J. E., Desai, K. M. & Randeva, H. S. Obesity and prostate cancer: a role for adipokines. Eur. Urol. 52, 46–53 (2007).
CAS PubMed Google Scholar
- Rakic, J. M., Blaise, P. & Foidart, J. M. Pegaptanib and age-related macular degeneration. N. Engl. J. Med. 352, 1720–1721 (2005); author reply 352, 1720–1721 (2005).
CAS PubMed Google Scholar
- Brown, D. M. et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1432–1444 (2006).
CAS PubMed Google Scholar
- Rosenfeld, P. J. et al. Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1419–1431 (2006).
CAS PubMed Google Scholar
- Margolis, D. J., Crombleholme, T. & Herlyn, M. Clinical protocol: Phase I trial to evaluate the safety of H5.020CMV.PDGF-B for the treatment of a diabetic insensate foot ulcer. Wound Repair Regen. 8, 480–493 (2000).
CAS PubMed Google Scholar
- Josifova, T., Schneider, U., Henrich, P. B. & Schrader, W. Eye disorders in diabetes: potential drug targets. Infect. Disord. Drug Targets. 8, 70–75 (2008).
CAS PubMed Google Scholar
- Rodriguez-Fontal, M., Alfaro, V., Kerrison, J. B. & Jablon, E. P. Ranibizumab for diabetic retinopathy. Curr. Diabetes Rev. 5, 47–51 (2009).
CAS PubMed Google Scholar
- Simo, R. & Hernandez, C. Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy. Diabetologia 51, 1574–1580 (2008).
CAS PubMed Google Scholar
- Balfour, J. A. B. & Noble, S. Becaplermin. BioDrugs 11, 359–364 (1999).
CAS PubMed Google Scholar
- Ladin, D. Becaplermin gel (PDGF-BB) as topical wound therapy. Plastic Surgery Educational Foundation DATA Committee. Plast. Reconstr. Surg. 105, 1230–1231 (2000).
CAS PubMed Google Scholar
- Steed, D. L. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast. Reconstr. Surg. 117, 143S–149S; discussion 150S–151S (2006).
CAS PubMed Google Scholar
- Lazar, M. A. How obesity causes diabetes: not a tall tale. Science 307, 373–375 (2005).
CAS PubMed Google Scholar
- Lehrke, M. & Lazar, M. A. The many faces of PPARg. Cell 123, 993–999 (2005).
CAS PubMed Google Scholar
- Menghini, R. et al. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 136, 663–672 e4 (2009).
CAS PubMed Google Scholar
- Fantuzzi, G. & Faggioni, R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J. Leukoc. Biol. 68, 437–446 (2000).
CAS PubMed Google Scholar
- Cho, C. H. et al. Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ. Res. 100, e47–57 (2007).
CAS PubMed Google Scholar
- Kaipainen, A. et al. PPARa deficiency in inflammatory cells suppresses tumor growth. PLoS ONE 2, e260 (2007).
PubMed PubMed Central Google Scholar
- Arany, Z. et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α. Nature 451, 1008–1012 (2008).
CAS PubMed Google Scholar
- Rophael, J. A. et al. Angiogenic growth factor synergism in a murine tissue engineering model of angiogenesis and adipogenesis. Am. J. Pathol. 171, 2048–2057 (2007).
CAS PubMed PubMed Central Google Scholar
- Moon, M. H. et al. Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia. Cell Physiol. Biochem. 17, 279–290 (2006).
CAS PubMed Google Scholar
- Nakagami, H. et al. Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. J. Atheroscler Thromb. 13, 77–81 (2006).
PubMed Google Scholar
- Fraser, J. K., Wulur, I., Alfonso, Z. & Hedrick, M. H. Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol. 24, 150–154 (2006).
CAS PubMed Google Scholar
- Kubis, N. et al. Vascular fate of adipose tissue-derived adult stromal cells in the ischemic murine brain: a combined imaging-histological study. Neuroimage 34, 1–11 (2007).
PubMed Google Scholar
- Lin, J., Lindsey, M. L., Zhu, B., Agrawal, C. M. & Bailey, S. R. Effects of surface-modified scaffolds on the growth and differentiation of mouse adipose-derived stromal cells. J. Tissue Eng. Regen. Med. 1, 211–217 (2007).
CAS PubMed Google Scholar
- Lovren, F. et al. Visfatin (nicotinomide phosphoribosyltransferase/pre-B cell colony-enhancing factor) activates eNOS via Akt and MAP kinases and improves endothelial function. Am. J. Physiol. Endocrinol. Metab. 7 Apr 2009 (doi:10.1152/ajpendo.90780.2008).
CAS PubMed Google Scholar
- Marcus, A. J., Coyne, T. M., Black, I. B. & Woodbury, D. Fate of amnion-derived stem cells transplanted to the fetal rat brain: migration, survival and differentiation. J. Cell. Mol. Med. 12, 1256–1264 (2008).
CAS PubMed PubMed Central Google Scholar
- Suga, H. et al. Functional implications of CD34 expression in human adipose-derived stem/progenitor cells. Stem Cells Dev. 18, 1201–1210 (2009).
CAS PubMed Google Scholar
- Traktuev, D. O. et al. A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ. Res. 102, 77–85 (2008).
CAS PubMed Google Scholar
- Enerback, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90–94 (1997).
CAS PubMed Google Scholar
- Wallberg-Henriksson, H. & Zierath, J. R. A new twist on brown fat metabolism. Cell 137, 22–24 (2009).
CAS PubMed Google Scholar
- Kuo, L. E. et al. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nature Med. 13, 803–811 (2007).
CAS PubMed Google Scholar