Exercise remodels subcutaneous fat tissue and improves metabolism (original) (raw)

Metabolism

Nature Reviews Endocrinology volume 11, pages 198–200 (2015)Cite this article

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Exercise training is one of the key interventions for preventing and treating type 2 diabetes mellitus. Although the health-promoting effects of exercise are largely ascribed to improvements in skeletal muscle insulin sensitivity, new data published in Diabetes suggest 'exercise-trained' subcutaneous adipose tissue might also have an important role in enhancing glucose homeostasis.

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Figure 1: Exercise training remodels subcutaneous adipose tissue and improves glucose homeostasis.

References

  1. Egan, B. & Zierath, J. R. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 17, 162–184 (2013).
    Article CAS Google Scholar
  2. Wallberg-Henriksson, H. & Holloszy, J. O. Contractile activity increases glucose uptake by muscle in severely diabetic rats. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 57, 1045–1049 (1984).
    CAS PubMed Google Scholar
  3. Hawley, J. A., Hargreaves, M., Joyner, M. J. & Zierath, J. R. Integrative biology of exercise. Cell 159, 738–749 (2014).
    Article CAS Google Scholar
  4. Craig, B. W., Hammons, G. T., Garthwaite, S. M., Jarett, L. & Holloszy, J. O. Adaptation of fat cells to exercise: response of glucose uptake and oxidation to insulin. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 51, 1500–1506 (1981).
    CAS PubMed Google Scholar
  5. Stanford, K. I. et al. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes http://dx.doi.org/10.2337/db14–0704.
  6. Rosen, E. D. & Spiegelman, B. M. What we talk about when we talk about fat. Cell 156, 20–44 (2014).
    Article CAS Google Scholar
  7. Tran, T. T., Yamamoto, Y., Gesta, S. & Kahn, C. R. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 7, 410–420 (2008).
    Article CAS Google Scholar
  8. Enerback, S. The origins of brown adipose tissue. N. Engl. J. Med. 360, 2021–2023 (2009).
    Article Google Scholar
  9. Kharitonenkov, A. et al. FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115, 1627–1635 (2005).
    Article CAS Google Scholar
  10. Craig, B. W., Thompson, K. & Holloszy, J. O. Effects of stopping training on size and response to insulin of fat cells in female rats. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 54, 571–575 (1983).
    CAS PubMed Google Scholar

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Acknowledgements

The authors acknowledge funding from The Swedish Research Council, European Research Council, Swedish Diabetes Association, Swedish Foundation for Strategic Research, Strategic Diabetes Research Program at Karolinska Institutet, Stockholm County Council and Novo Nordisk Foundation.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institutet, von Eulers väg 4a, Stockholm, SE 171 77, Sweden
    Harriet Wallberg-Henriksson
  2. Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, von Eulers väg 4a, Stockholm, SE 171 77, Sweden
    Juleen R. Zierath

Authors

  1. Harriet Wallberg-Henriksson
  2. Juleen R. Zierath

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Correspondence toJuleen R. Zierath.

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The authors declare no competing financial interests.

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Wallberg-Henriksson, H., Zierath, J. Exercise remodels subcutaneous fat tissue and improves metabolism.Nat Rev Endocrinol 11, 198–200 (2015). https://doi.org/10.1038/nrendo.2015.24

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