Subclinical hypothyroidism in childhood — current knowledge and open issues (original) (raw)
Biondi, B. & Cooper, D. S. The clinical significance of subclinical thyroid dysfunction. Endocr. Rev.29, 76–131 (2008). ArticleCASPubMed Google Scholar
Van Vliet, G. & Deladoëy, J. Interpreting minor variations in thyroid function or echostructure: treating patients, not numbers or images. Pediatr. Clin. North Am.62, 929–942 (2015). ArticlePubMed Google Scholar
Karmisholt, J., Andersen, S. & Laurberg, P. Variation in thyroid function in subclinical hypothyroidism: importance of clinical follow-up and therapy. Eur. J. Endocrinol.164, 317–323 (2011). ArticleCASPubMed Google Scholar
Canaris, G. J., Manowitz, N. R., Mayor, G. & Ridgway, E. C. The Colorado thyroid disease prevalence study. Arch. Intern. Med.160, 526–534 (2000). ArticleCASPubMed Google Scholar
Duntas, L. H. & Wartofsky, L. Cardiovascular risk and subclinical hypothyroidism: focus on lipids and new emerging risk factors. What is the evidence? Thyroid17, 1075–1084 (2007). ArticleCASPubMed Google Scholar
Maratou, E. et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur. J. Endocrinol.160, 785–790 (2009). ArticleCASPubMed Google Scholar
Cooper, D. S. & Biondi, B. Subclinical thyroid disease. Lancet379, 1142–1154 (2012). ArticlePubMed Google Scholar
Cikim, A. S. et al. Evaluation of endothelial function in subclinical hypothyroidism and subclinical hyperthyroidism. Thyroid14, 605–609 (2004). ArticlePubMed Google Scholar
Gao, N., Zhang, W., Zhang, Y. Z., Yang, Q. & Chen, S. H. Carotid intima-media thickness in patients with subclinical hypothyroidism: a meta-analysis. Atherosclerosis227, 18–25 (2013). ArticleCASPubMed Google Scholar
Gencer, B. et al. Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation126, 1040–1049 (2012). ArticleCASPubMed Google Scholar
Razvi, S., Weaver, J. U., Vanderpump, M. P. & Pearce, S. H. The incidence of ischemic heart disease andmortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort. J. Clin. Endocrinol. Metab.95, 1734–1740 (2010). ArticleCASPubMed Google Scholar
Chaker, L. et al. Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis. J. Clin. Endocrinol. Metab.100, 2181–2191 (2015). ArticleCASPubMedPubMed Central Google Scholar
Gaber, J. R. et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid22, 1200–1235 (2012). ArticleCAS Google Scholar
Monzani, A. et al. Endocrine disorders in childhood and adolescence. Natural history of subclinical hypothyroidism in children and adolescents and potential effects of replacement therapy: a review. Eur. J. Endocrinol.168, R1–R11 (2012). ArticleCASPubMed Google Scholar
Cerbone, M. et al. Cardiovascular risk factors in children with long-standing untreated idiopathic subclinical hypothyroidism. J. Clin. Endocrinol. Metab.99, 2697–2703 (2014). ArticleCASPubMed Google Scholar
Cerbone, M. et al. Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism. Eur. J. Endocrinol.164, 591–597 (2011). ArticleCASPubMed Google Scholar
Wasniewska, M. et al. Comparative evaluation of therapy with _L_-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism. Horm. Res. Paediatr.77, 376–381 (2012). ArticleCASPubMed Google Scholar
Cerbone, M. et al. Non-autoimmune subclinical hypothyroidism due to a mutation in TSH receptor: report on two brothers. Ital. J. Pediatr.39, 5 (2013). ArticleCASPubMedPubMed Central Google Scholar
Wu, T., Flowers, J. W., Tudiver, F., Wilson, J. L. & Punyasavatsut, N. Subclinical thyroid disorders and cognitive performance among adolescents in the United States. BMC Pediatr.6, 12 (2006). ArticlePubMedPubMed Central Google Scholar
Lazar, L. et al. Natural history of thyroid function tests over 5 years in a large pediatric cohort. J. Clin. Endocrinol. Metab.94, 1678–1682 (2009). ArticleCASPubMed Google Scholar
Gopalakrishnan, S. et al. Goitrous autoimmune thyroiditis in a pediatric population: a longitudinal study. Pediatrics122, e670–e674 (2008). ArticlePubMed Google Scholar
Brown, R. S. Autoimmune thyroiditis in childhood. J. Clin. Res. Pediatr. Endocrinol.5 (Suppl. 1), 45–49 (2013). PubMedPubMed Central Google Scholar
Radetti, G. et al. The natural history of the normal/mild elevated TSH serum levels in children and adolescents with Hashimoto's thyroiditis and isolated hyperthyrotropinemia: a 3-year follow-up. Clin. Endocrinol.76, 394–398 (2012). ArticleCAS Google Scholar
Deladoëy, J., Ruel, J., Giguère, Y. & Van Vliet, G. Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Québec. J. Clin. Endocrinol. Metab.96, 2422–2429 (2011). ArticleCASPubMed Google Scholar
Korada, S. M. et al. Difficulties in selecting an appropriate neonatal thyroid stimulating hormone (TSH) screening threshold. Arch. Dis. Child.95, 169–173 (2010). ArticlePubMed Google Scholar
Rabbiosi, S. et al. Congenital hypothyroidism with eutopic thyroid gland: analysis of clinical and biochemical features at diagnosis and after re-evaluation. J. Clin. Endocrinol. Metab.98, 1395–1402 (2013). ArticleCASPubMed Google Scholar
Leonardi, D. et al. Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism. J. Clin. Endocrinol. Metab.93, 2679–2685 (2008). ArticleCASPubMed Google Scholar
Rapa, A. et al. Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. J. Clin. Endocrinol. Metab.94, 2414–2420 (2009). ArticleCASPubMed Google Scholar
Nicoletti, A. et al. Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. J. Clin. Endocrinol. Metab.94, 4187–4194 (2009). ArticleCASPubMed Google Scholar
Calebiro, D. et al. Frequent TSH receptor genetic alterations with variable signaling impairment in a large series of children with nonautoimmune isolated hyperthyrotropinemia. J. Clin. Endocrinol. Metab.97, E156–E160 (2012). ArticleCASPubMed Google Scholar
Tenebaum-Raskover, Y. et al. Long-term outcome of loss-of-function mutations in thyrotropin receptor gene. Thyroid25, 292–299 (2015). ArticleCAS Google Scholar
Persani, L. et al. Genetics and phenomics of hypothyroidism due to TSH resistance. Mol. Cell. Endocrinol.322, 72–82 (2010). ArticleCASPubMed Google Scholar
Cassio, A. et al. Current loss-of-function mutations in the thyrotropin receptor gene: when to investigate, clinical effects, and treatment. J. Clin. Res. Pediatr. Endocrinol.5 (Suppl. 1), 29–39 (2013). PubMedPubMed Central Google Scholar
De Marco, G. et al. Identification and functional analysis of novel dual oxidase 2 (DUOX2) mutations in children with congenital or subclinical hypothyroidism. J. Clin. Endocrinol. Metab.96, E1335–E1339 (2011). ArticleCASPubMed Google Scholar
Van Vilert, G. How often should we screen children with Down's syndrome for hypothyroidism? Arch. Dis. Child.90, 557–558 (2005). Article Google Scholar
King, K., O'Gorman, C. & Gallagher, S. Thyroid dysfunction in children with Down's syndrome: a literature review. Ir. J. Med. Sci.183, 1–6 (2014). ArticleCASPubMed Google Scholar
Gibson, P. A. et al. Longitudinal study of thyroid function in Down's syndrome in the first two decades. Arch. Dis. Child.90, 574–578 (2005). ArticleCASPubMedPubMed Central Google Scholar
Konings, C. H. et al. Plasma thyrotropin bioactivity in Down's syndrome children with subclinical hypothyroidism. Eur. J. Endocrinol.144, 1–4 (2001). ArticleCASPubMed Google Scholar
Tonacchera, M. et al. TSH receptor and Gsα genetic analysis in children with Down's syndrome and subclinical hypothyroidism. J. Endocrinol. Invest.26, 997–1000 (2003). ArticleCASPubMed Google Scholar
Mantovani, G., Spada, A. & Elli, F. M. Pseudohypoparathyroidism and Gsα-cAMP-linked disorders: current view and open issues. Nat. Rev. Endocrinol.12, 347–356 (2016). ArticleCASPubMed Google Scholar
Rosene, M. L. et al. Inihibition of type 2 iodothyronine diodinase underlies the elevated plasma TSH associated with amiodarone treatment. Endocrinology151, 5961–5970 (2010). ArticleCASPubMedPubMed Central Google Scholar
Strolin Benedetti, M., Whomsley, R., Baltes, E. & Tonner, F. Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction. Eur. J. Clin. Phamacol.61, 863–872 (2005). ArticleCAS Google Scholar
Verrotti, A., Scardapane, A., Manco, R. & Chiarelli, F. Antiepileptic drugs and thyroid function. J. Pediatr. Endocrinol. Metab.21, 401–408 (2008). ArticleCASPubMed Google Scholar
Ishiguro, H. et al. Long-term follow-up of thyroid function in patients who received bone marrow transplantation during childhood and adolescence. J. Clin. Endocrinol. Metab.89, 5981–5986 (2004). ArticleCASPubMed Google Scholar
Ostroumova, E. et al. Subclinical hypothyroidism after radioiodine exposure: Ukrainian-American cohort study of thyroid cancer and other thyroid diseases after the Chernobyl accident (1998–2000). Environ. Health Perspect.117, 745–750 (2009). ArticleCASPubMed Google Scholar
Ostroumova, E. et al. Measures of thyroid function among Belarusian children and adolescents exposed to Iodine-131 from the accident at Chernobyl nuclear plant. Environ. Health Perspect.121, 865–871 (2013). ArticleCASPubMedPubMed Central Google Scholar
Reinher, T. et al. Thyroid function in the nutritionally obese child and adolescent. Curr. Opin. Pediatr.23, 415–420 (2011). ArticleCAS Google Scholar
Reinehr, T., de Sousa, G. & Andler, W. Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J. Clin. Endocrinol. Metab.91, 3088–3091 (2006). ArticleCASPubMed Google Scholar
Reinehr, T., Isa, A., de Sousa, G., Dieffenbach, R. & Andler, W. Thyroid hormones and their relation to weight status. Horm. Res.70, 51–57 (2008). ArticleCASPubMed Google Scholar
Wolters, B., Lass, N. & Reinehr, T. TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children. Eur. J. Endocrinol.168, 323–329 (2013). ArticleCASPubMed Google Scholar
Pacifico, A., Anania, C., Ferraro, F., Andreoli, G. M. & Chiesa, C. Thyroid function in childhood obesity and metabolic comorbidity. Clin. Chim. Acta.413, 396–405 (2012). ArticleCASPubMed Google Scholar
Wasniewska, M. et al. Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence. Eur. J. Endocrinol.160, 417–421 (2009). ArticleCASPubMed Google Scholar
Lazarus, J. et al. 2014 European Thyroid Association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur. Thyroid J.3, 76–94 (2014). ArticleCASPubMedPubMed Central Google Scholar
Aversa, T. et al. Underlying Hashimoto's thyroiditis negatively affects the evolution of subclinical hypothyroidism in children irrespective of other concomitant risk factors. Thyroid25, 183–187 (2015). ArticleCASPubMed Google Scholar
Wasniewska, M. et al. Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology. Eur. J. Endocrinol.173, 801–808 (2015). ArticleCASPubMed Google Scholar
Claret, C. et al. Subclinical hypothyroidism in the first years of life in patients with Down's syndrome. Pediatr. Res.73, 674–678 (2013). ArticleCASPubMed Google Scholar
Chase, H. P., Garg, S. K., Cockerham, R. S., Wilcox, W. D. & Walravens, P. A. Thyroid hormone replacement and growth of children with subclinical hypothyroidism and diabetes. Diabet. Med.7, 299–303 (1990). ArticleCASPubMed Google Scholar
Radetti, G. et al. The natural history of euthyroid Hashimoto's thyroiditis in children. J. Pediatr.149, 827–832 (2006). ArticlePubMed Google Scholar
Horn, S. & Heuer, H. Thyroid hormone action during brain development: more questions than answers. Mol. Cell. Endocrinol.315, 19–26 (2010). ArticleCASPubMed Google Scholar
Pérez-Lobato, R. et al. Thyroid status and its association with cognitive functioning in healthy boys at 10 years of age. Eur. J. Endocrinol.172, 129–139 (2015). ArticleCASPubMed Google Scholar
Ergür, A. T. et al. Neurocognitive functions in children and adolescents with subclinical hypothyroidism. J. Clin. Res. Pediatr. Endocrinol.4, 21–24 (2012). ArticlePubMed Google Scholar
Aijaz, N. J. et al. Neurocognitive function in children with compensated hypothyroidism: lack of short term effects on or off thyroxin. BMC Endocr. Disord.6, 2 (2006). ArticleCASPubMedPubMed Central Google Scholar
Gogakos, A. I., Duncan Bassett, J. H. & Williams, G. R. Thyroid and bone. Arch. Biochem. Biophys.503, 129–136 (2010). ArticleCASPubMed Google Scholar
Saggese, G., Bertelloni, S., Baroncelli, G. I., Costa, S. & Ceccarelli, C. Bone mineral density in adolescent females treated with L-thyroxine: a longitudinal study. Eur. J. Pediatr.155, 452–457 (1996). ArticleCASPubMed Google Scholar
Di Mase, R. et al. Bone health in children with long-term idiopathic subclinical hypothyroidism. Ital. J. Pediatr.38, 56 (2012). ArticlePubMedPubMed Central Google Scholar
Kahaly, G. J. & Dillmann, W. H. Thyroid hormone action in the heart. Endocr. Rev.26, 704–728 (2005). ArticleCASPubMed Google Scholar
Danzi, S. & Klein, I. Thyroid disease and the cardiovascular system. Endocrinol. Metab. Clin. North Am.43, 517–528 (2014). ArticlePubMed Google Scholar
Cappola, A. R. & Ladenson, P. W. Hypothyroidism and atherosclerosis. J. Clin. Endocrinol. Metab.88, 2438–2444 (2003). ArticleCASPubMed Google Scholar
Biondi, B., Palmieri, E. A., Lombardi, G. & Fazio, S. Subclinical hypothyroidism and cardiac function. Thyroid12, 505–510 (2002). ArticlePubMed Google Scholar
Taddei, S. et al. Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J. Clin. Endocrinol. Metab.88, 3731–3737 (2003). ArticleCASPubMed Google Scholar
Stary, H. C. et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation92, 1355–1374 (1995). ArticleCASPubMed Google Scholar
Berenson, G. S., Srinivasan, S. R. & Nicklas, T. A. Atherosclerosis: a nutritional disease of childhood. Am. J. Cardiol.82, 22T–29T (1998). ArticleCASPubMed Google Scholar
Paoli-Valeri, M. et al. Atherogenic lipid profile in children with subclinical hypothyroidism. An. Pediatr. (Barc.)62, 128–134 (in Spanish) (2005). ArticleCAS Google Scholar
Marwaha, R. K. et al. Dyslipidemia in subclinical hypothyroidism in an Indian population. Clin. Biochem.4, 1214–1217 (2011). ArticleCAS Google Scholar
Nader, N. S. et al. Relationships between thyroid function and lipid status or insulin resistance in a pediatric population. Thyroid20, 1333–1339 (2010). ArticleCASPubMed Google Scholar
Zhang, J. et al. Serum thyrotropin is positively correlated with the metabolic syndrome components of obesity and dyslipidemia in Chinese adolescents. Int. J. Endocrinol.2014, 289503 (2014). PubMedPubMed Central Google Scholar
Witte, T., Ittermann, T., Thamm, M., Riblet, N. B. & Völzke, H. Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth. J. Clin. Endocrinol. Metab.100, 2090–2097 (2015). ArticleCASPubMed Google Scholar
Ittermann, T., Thamm, M., Wallaschofski, H., Rettig, R. & Völzke, H. Serum thyroid-stimulating hormone levels are associated with blood pressure in children and adolescents. J. Clin. Endocrinol. Metab.97, 828–834 (2012). ArticleCASPubMed Google Scholar
Chen, H. et al. Investigation of thyroid function and blood pressure in school-aged subjects without overt thyroid disease. Endocrine41, 122–129 (2012). ArticleCASPubMed Google Scholar
Javed, A. et al. Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents. Thyroid25, 478–484 (2015). ArticleCASPubMedPubMed Central Google Scholar
Sawicka, B. et al. Relationship between metabolic parameters and thyroid hormones and the level of gastric peptides in children with autoimmune thyroid diseases. J. Pediatr. Endocrinol. Metab.23, 345–354 (2010). ArticleCASPubMed Google Scholar
Mokha, J. S. et al. Utility of waist-to-height ratio in assessing the status of central obesity and related cardiometabolic risk profile among normal weight and overweight/obese children: the Bogalusa Heart Study. BMC Pediatr.10, 73 (2010). ArticlePubMedPubMed Central Google Scholar
Canas, J. A., Sweeten, S. & Balagopal, P. B. Biomarkers for cardiovascular risk in children. Curr. Opin. Cardiol.28, 103–114 (2013). ArticlePubMed Google Scholar
Bossowski, A. et al. Analysis of serum adiponectin, resistin and leptin levels in children and adolescents with autoimmune thyroid disorders. J. Pediatr. Endocrinol. Metab.23, 369–377 (2010). ArticleCASPubMed Google Scholar
Fonseca, V., Guba, S. C. & Fink, L. M. Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis. Endocr. Rev.20, 738–759 (1999). ArticleCASPubMed Google Scholar
Atabek, M. E., Pirgon, O. & Erkul, I. Plasma homocysteine concentrations in adolescents with subclinical hypothyroidism. J. Pediatr. Endocrinol. Metab.16, 1245–1248 (2003). ArticleCASPubMed Google Scholar
Lekakis, J. et al. Flow-mediated, endothelium-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin (TSH) values. Thyroid7, 411–414 (1997). ArticleCASPubMed Google Scholar
Cerbone, M. et al. Effects of L-thyroxine treatment on early markers of atherosclerotic disease in children with subclinical hypothyroidism. Eur. J. Endocrinol.175, 11–19 (2016). ArticleCASPubMed Google Scholar
Boger, R. H. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the 'L-arginine paradox' and acts as a novel cardiovascular risk factor. J. Nutr.134, 2842S–2847S (2004). ArticlePubMed Google Scholar
Çatli, G. et al. The effect of L-thyroxine treatment on left ventricular functions in children with subclinical hypothyroidism. Arch. Dis. Child.100, 130–137 (2015). ArticlePubMed Google Scholar
Toscano, E. et al. Subclinical hypothyroidism and Down's syndrome; studies on myocardial structure and function. Arch. Dis. Child.88, 1005–1008 (2003). ArticleCASPubMedPubMed Central Google Scholar
Dörr, H. G. et al. Levothyroxine treatment of euthyroid children with autoimmune Hashimoto thyroiditis: results of a multicenter, randomized, controlled trial. Horm. Res. Paediatr.84, 266–274 (2015). ArticleCASPubMed Google Scholar
Özen, S., Berk, Ö., S¸ims¸ek, D. G. & Darcan, S. Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. J. Clin. Res. Pediatr. Endocrinol.3, 192–197 (2011). ArticlePubMedPubMed Central Google Scholar
Scarpa, V. et al. Treatment with thyroxine reduces thyroid volume in euthyroid children and adolescents with chronic autoimmune thyroiditis. Horm. Res. Paediatr.73, 61–67 (2010). ArticleCASPubMed Google Scholar
Svensson, J. et al. Levothyroxine treatment reduces thyroid size in children and adolescents with chronic autoimmune thyroiditis. J. Clin. Endocrinol. Metab.91, 1729–1734 (2006). ArticleCASPubMed Google Scholar
Cetinkaya, E., Aslan, A., Vidinlisan, S. & Ocal, G. Height improvement by L-thyroxine treatment in subclinical hypothyroidism. Pediatr. Int.45, 534–537 (2003). ArticleCASPubMed Google Scholar
Çatlı, G., Anık, A., Ünver Tuhan, H., Böber, E., & Abacı, A. The effect of L-thyroxine treatment on hypothyroid symptom scores and lipid profile in children with subclinical hypothyroidism. J. Clin. Res. Pediatr. Endocrinol.6, 238–244 (2014). ArticlePubMedPubMed Central Google Scholar