Blood vessels and nerves: common signals, pathways and diseases (original) (raw)

• Temple, S. The development of neural stem cells. Nature 414, 112–117 (2001). An overview of the molecular and cellular mechanisms of neural stem cells.
  Article CAS PubMed Google Scholar
• Panchision, D. M. & McKay, R. D. The control of neural stem cells by morphogenic signals. Curr. Opin. Genet. Dev. 12, 478–487 (2002).
  CAS PubMed Google Scholar
• Osterfield, M., Kirschner, M. W. & Flanagan, J. G. Graded positional information. Interpretation for both fate and guidance. Cell 113, 425–428 (2003). A recent overview that highlights how morphogens control neural development.
  CAS PubMed Google Scholar
• Hitoshi, S. et al. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev. 16, 846–858 (2002).
  CAS PubMed PubMed Central Google Scholar
• Gaiano, N. & Fishell, G. The role of notch in promoting glial and neural stem cell fates. Annu. Rev. Neurosci. 25, 471–490 (2002).
  CAS PubMed Google Scholar
• Patten, I. & Placzek, M. The role of Sonic hedgehog in neural tube patterning. Cell Mol. Life Sci. 57, 1695–1708 (2000).
  CAS PubMed Google Scholar
• Rowitch, D. H., Lu, Q. R., Kessaris, N. & Richardson, W. D. An 'oligarchy' rules neural development. Trends Neurosci. 25, 417–422 (2002).
  CAS PubMed Google Scholar
• Mehler, M. F. Mechanisms regulating lineage diversity during mammalian cerebral cortical neurogenesis and gliogenesis. Results Probl. Cell Differ. 39, 27–52 (2002).
  CAS PubMed Google Scholar
• Lyden, D. et al. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401, 670–677 (1999). This paper documents how bHLH-repressors affect both neurogenesis and angiogenesis.
  CAS PubMed Google Scholar
• Wang, S., Sdrulla, A., Johnson, J. E., Yokota, Y. & Barres, B. A. A role for the helix–loop–helix protein Id2 in the control of oligodendrocyte development. Neuron 29, 603–614 (2001).
  CAS PubMed Google Scholar
• Dupin, E., Real, C. & Ledouarin, N. The neural crest stem cells: control of neural crest cell fate and plasticity by endothelin-3. An. Acad. Bras. Cienc. 73, 533–545 (2001).
  CAS PubMed Google Scholar
• Knecht, A. K. & Bronner-Fraser, M. Induction of the neural crest: a multigene process. Nature Rev. Genet. 3, 453–461 (2002).
  CAS PubMed Google Scholar
• Etchevers, H. C., Couly, G. & Le Douarin, N. M. Morphogenesis of the branchial vascular sector. Trends Cardiovasc. Med. 12, 299–304 (2002). A recent overview that illustrates the role of neural crest cells in vascular development.
  PubMed Google Scholar
• Aybar, M. J. & Mayor, R. Early induction of neural crest cells: lessons learned from frog, fish and chick. Curr. Opin. Genet. Dev. 12, 452–458 (2002).
  CAS PubMed Google Scholar
• Soriano, P. The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites. Development 124, 2691–2700 (1997).
  CAS PubMed Google Scholar
• Maschhoff, K. L. & Baldwin, H. S. Molecular determinants of neural crest migration. Am. J. Med. Genet. 97, 280–288 (2000). Overview of the genetics of neural crest cell migration.
  CAS PubMed Google Scholar
• Kawasaki, T. et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 126, 4895–4902 (1999).
  CAS PubMed Google Scholar
• Feiner, L. et al. Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development 128, 3061–3070 (2001).
  CAS PubMed Google Scholar
• Kurihara, Y. et al. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J. Clin. Invest. 96, 293–300 (1995).
  CAS PubMed PubMed Central Google Scholar
• Williams, D. E. et al. Identification of a ligand for the c-kit proto-oncogene. Cell 63, 167–174 (1990).
  CAS PubMed Google Scholar
• Shah, N. M., Groves, A. K. & Anderson, D. J. Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members. Cell 85, 331–343 (1996).
  CAS PubMed Google Scholar
• Carmeliet, P. One cell, two fates. Nature 408, 43,45 (2000).
  CAS PubMed Google Scholar
• Mikkola, H. K. & Orkin, S. H. The search for the hemangioblast. J. Hematother. Stem Cell Res. 11, 9–17 (2002).
  PubMed Google Scholar
• Carmeliet, P. Angiogenesis in health and disease. Nature Med. 9, 653–660 (2003). A recent overview of the molecular and cellular mechanisms of vessel growth in health and disease.
  CAS PubMed Google Scholar
• Cleaver, O. & Melton, D. A. Endothelial signaling during development. Nature Med. 9, 661–668 (2003).
  CAS PubMed Google Scholar
• Rovainen, C. M. Labeling of developing vascular endothelium after injections of rhodamine-dextran into blastomeres of Xenopus laevis. J. Exp. Zool. 259, 209–221 (1991).
  CAS PubMed Google Scholar
• Childs, S., Chen, J. N., Garrity, D. M. & Fishman, M. C. Patterning of angiogenesis in the zebrafish embryo. Development 129, 973–982 (2002).
  CAS PubMed Google Scholar
• Liao, W., Ho, C. Y., Yan, Y. L., Postlethwait, J. & Stainier, D. Y. Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development 127, 4303–4313 (2000).
  CAS PubMed Google Scholar
• Brown, L. A. et al. Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mech. Dev. 90, 237–252 (2000).
  CAS PubMed Google Scholar
• Carmeliet, P. Controlling the cellular brakes. Nature 401, 657–658 (1999).
  CAS PubMed Google Scholar
• Yamashita, J. et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408, 92–96 (2000).
  CAS PubMed Google Scholar
• Abbot, N. J. Glial–endothelial communication in physiology and pathology. J. Neurochem. 85 (Suppl.) 2 (2003).
  Google Scholar
• LeCouter, J., Lin, R. & Ferrara, N. Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis. Nature Med. 8, 913–917 (2002).
  CAS PubMed Google Scholar
• Ruoslahti, E. Specialization of tumour vasculature. Nature Rev. Cancer 2, 83–90 (2002).
  Google Scholar
• Zhong, T. P., Childs, S., Leu, J. P. & Fishman, M. C. Gridlock signalling pathway fashions the first embryonic artery. Nature 414, 216–220 (2001).
  CAS PubMed Google Scholar
• Sumoy, L., Keasey, J. B., Dittman, T. D. & Kimelman, D. A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos. Mech. Dev. 63, 15–27 (1997).
  CAS PubMed Google Scholar
• Fouquet, B., Weinstein, B. M., Serluca, F. C. & Fishman, M. C. Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev. Biol. 183, 37–48 (1997).
  CAS PubMed Google Scholar
• Hall, C. J., Flores, M. V., Davidson, A. J., Crosier, K. E. & Crosier, P. S. Radar is required for the establishment of vascular integrity in the zebrafish. Dev. Biol. 251, 105–117 (2002).
  CAS PubMed Google Scholar
• Damert, A., Miquerol, L., Gertsenstein, M., Risau, W. & Nagy, A. Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development 129, 1881–1892 (2002).
  CAS PubMed Google Scholar
• Ferrara, N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin. Oncol. 29, 10–14 (2002).
  CAS PubMed Google Scholar
• Baron, M. Induction of embryonic hematopoietic and endothelial stem/progenitor cells by hedgehog-mediated signals. Differentiation 68, 175–185 (2001).
  CAS PubMed Google Scholar
• Dyer, M. A., Farrington, S. M., Mohn, D., Munday, J. R. & Baron, M. H. Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128, 1717–1730 (2001).
  CAS PubMed Google Scholar
• Moyon, D., Pardanaud, L., Yuan, L., Breant, C. & Eichmann, A. Plasticity of endothelial cells during arterial–venous differentiation in the avian embryo. Development 128, 3359–3370 (2001).
  CAS PubMed Google Scholar
• Othman-Hassan, K. et al. Arterial identity of endothelial cells is controlled by local cues. Dev. Biol. 237, 398–409 (2001).
  CAS PubMed Google Scholar
• Lawson, N. D., Vogel, A. M. & Weinstein, B. M. Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev. Cell 3, 127–136 (2002). This paper explains the genetic pathways that determine arterial endothelial cell fate.
  CAS PubMed Google Scholar
• Lawson, N. D. & Weinstein, B. M. Arteries and veins: making a difference with zebrafish. Nature Rev. Genet. 3, 674–682 (2002).
  CAS PubMed Google Scholar
• Chen, J. N. et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123, 293–302 (1996).
  CAS PubMed Google Scholar
• Mukouyama, Y. S., Shin, D., Britsch, S., Taniguchi, M. & Anderson, D. J. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 109, 693–705 (2002). This study provides genetic insights into how arteries are guided by nerves.
  CAS PubMed Google Scholar
• Stalmans, I. et al. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J. Clin. Invest. 109, 327–336 (2002).
  CAS PubMed PubMed Central Google Scholar
• Visconti, R. P., Richardson, C. D. & Sato, T. N. Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc. Natl Acad. Sci. USA 99, 8219–8224 (2002).
  CAS PubMed PubMed Central Google Scholar
• Itoh, M. et al. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 4, 67–82 (2003).
  CAS PubMed Google Scholar
• Lawson, N. D. et al. Notch signaling is required for arterial–venous differentiation during embryonic vascular development. Development 128, 3675–3683 (2001).
  CAS PubMed Google Scholar
• Zhong, T. P., Rosenberg, M., Mohideen, M. A., Weinstein, B. & Fishman, M. C. gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science 287, 1820–1824 (2000). This paper reports how bHLH proteins determine arterial cell fate.
  CAS PubMed Google Scholar
• Lawson, N. D., Mugford, J. W., Diamond, B. A. & Weinstein, B. M. Phospholipase C γ-1 is required downstream of vascular endothelial growth factor during arterial development. Genes Dev. 17, 1346–1351 (2003).
  CAS PubMed PubMed Central Google Scholar
• Kalimo, H., Ruchoux, M. M., Viitanen, M. & Kalaria, R. N. CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia. Brain Pathol. 12, 371–384 (2002).
  CAS PubMed Google Scholar
• Iso, T., Hamamori, Y. & Kedes, L. Notch signaling in vascular development. Arterioscler. Thromb. Vasc. Biol. 23, 543–553 (2003).
  CAS PubMed Google Scholar
• Taylor, K. L., Henderson, A. M. & Hughes, C. C. Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc. Res. 64, 372–383 (2002).
  CAS PubMed Google Scholar
• Compernolle, V. et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nature Med. 8, 702–710 (2002).
  CAS PubMed Google Scholar
• Gerber, H. P. et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nature Med. 5, 623–628 (1999).
  CAS PubMed Google Scholar
• Eremina, V. et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J. Clin. Invest. 111, 707–716 (2003).
  CAS PubMed PubMed Central Google Scholar
• LeCouter, J. et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299, 890–893 (2003).
  CAS PubMed Google Scholar
• Bahary, N. & Zon, L. I. Endothelium — chicken soup for the endoderm. Science 294, 530–531 (2001).
  CAS PubMed Google Scholar
• Stainier, D. Y. et al. Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development 123, 285–292 (1996).
  CAS PubMed Google Scholar
• Zerlin, M. & Goldman, J. E. Interactions between glial progenitors and blood vessels during early postnatal corticogenesis: blood vessel contact represents an early stage of astrocyte differentiation. J. Comp. Neurol. 387, 537–546 (1997).
  CAS PubMed Google Scholar
• Huxlin, K. R., Sefton, A. J. & Furby, J. H. The origin and development of retinal astrocytes in the mouse. J. Neurocytol. 21, 530–544 (1992).
  CAS PubMed Google Scholar
• Louissaint, A., Rao, S., Leventhal, C. & Goldman, S. A. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34, 945–960 (2002). This report documents how VEGF-driven angiogenesis stimulates BDNF-driven neurogenesis.
  CAS PubMed Google Scholar
• Palmer, T. D., Willhoite, A. R. & Gage, F. H. Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425, 479–494 (2000). This study highlights the link between angiogenesis and neurogenesis.
  CAS PubMed Google Scholar
• Mi, H., Haeberle, H. & Barres, B. A. Induction of astrocyte differentiation by endothelial cells. J. Neurosci. 21, 1538–1547 (2001).
  CAS PubMed PubMed Central Google Scholar
• Yang, K. & Cepko, C. L. Flk-1, a receptor for vascular endothelial growth factor (VEGF) is expressed by retinal progenitor cells. J. Neurosci. 16, 6089–6099 (1996).
  CAS PubMed PubMed Central Google Scholar
• Yourey, P. A., Gohari, S., Su, J. L. & Alderson, R. F. Vascular endothelial cell growth factors promote the in vitro development of rat photoreceptor cells. J. Neurosci. 20, 6781–6788 (2000).
  CAS PubMed PubMed Central Google Scholar
• Jin, K. et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl Acad. Sci. USA 99, 11946–11950 (2002). This study documents how the prototype angiogenic factor VEGF affects neurogenesis.
  CAS PubMed PubMed Central Google Scholar
• Zhu, Y., Jin, K., Mao, X. O. & Greenberg, D. A. Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. FASEB J. 17, 186–193 (2003).
  CAS PubMed Google Scholar
• Bagnard, D. et al. Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J. Neurosci. 21, 3332–3341 (2001).
  CAS PubMed PubMed Central Google Scholar
• Miao, H. Q. et al. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J. Cell Biol. 146, 233–242 (1999). This paper illustrates how the neurorepellent Sema3A and VEGF antagonistically affect endothelial cells through binding neuropilin-1.
  CAS PubMed PubMed Central Google Scholar
• Leventhal, C., Rafii, S., Rafii, D., Shahar, A. & Goldman, S. A. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol. Cell Neurosci. 13, 450–464 (1999).
  CAS PubMed Google Scholar
• Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A. & Greenough, W. T. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc. Natl Acad. Sci. USA 87, 5568–5572 (1990).
  CAS PubMed PubMed Central Google Scholar
• Kokaia, Z. & Lindvall, O. Neurogenesis after ischaemic brain insults. Curr. Opin Neurobiol. 13, 127–132 (2003).
  CAS PubMed Google Scholar
• Monje, M. L., Mizumatsu, S., Fike, J. R. & Palmer, T. D. Irradiation induces neural precursor-cell dysfunction. Nature Med. 8, 955–962 (2002).
  CAS PubMed Google Scholar
• Cooke, J. E. & Moens, C. B. Boundary formation in the hindbrain: Eph only it were simple. Trends Neurosci. 25, 260–267 (2002). A review of the role of ephrins in boundary formation in the brain.
  CAS PubMed Google Scholar
• Tepass, U., Godt, D. & Winklbauer, R. Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries. Curr. Opin. Genet. Dev. 12, 572–582 (2002).
  CAS PubMed Google Scholar
• Krull, C. E. Segmental organization of neural crest migration. Mech. Dev. 105, 37–45 (2001).
  CAS PubMed Google Scholar
• Mellitzer, G., Xu, Q. & Wilkinson, D. G. Eph receptors and ephrins restrict cell intermingling and communication. Nature 400, 77–81 (1999).
  CAS PubMed Google Scholar
• Coulthard, M. G. et al. The role of the Eph–ephrin signalling system in the regulation of developmental patterning. Int. J. Dev. Biol. 46, 375–384 (2002).
  CAS PubMed Google Scholar
• Cooke, J. et al. Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain. Development 128, 571–580 (2001).
  CAS PubMed Google Scholar
• Xu, Q., Alldus, G., Holder, N. & Wilkinson, D. G. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development 121, 4005–4016 (1995).
  CAS PubMed Google Scholar
• Holmberg, J. & Frisen, J. Ephrins are not only unattractive. Trends Neurosci. 25, 239–243 (2002).
  CAS PubMed Google Scholar
• Adams, R. H. & Klein, R. Eph receptors and ephrin ligands: essential mediators of vascular development. Trends Cardiovasc. Med. 10, 183–188 (2000). An overview of the role of ephrins in vascular development.
  CAS PubMed Google Scholar
• Cheng, N., Brantley, D. M. & Chen, J. The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 13, 75–85 (2002).
  CAS PubMed Google Scholar
• Gale, N. W. et al. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev. Biol. 230, 151–160 (2001).
  CAS PubMed Google Scholar
• Shin, D. et al. Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev. Biol. 230, 139–150 (2001).
  CAS PubMed Google Scholar
• Adams, R. H. et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13, 295–306 (1999).
  CAS PubMed PubMed Central Google Scholar
• Wang, H. U., Chen, Z. F. & Anderson, D. J. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93, 741–753 (1998). A seminal study that documents the role of ephrins in vascular development.
  CAS PubMed Google Scholar
• Hirano, S., Suzuki, S. T. & Redies, C. M. The cadherin superfamily in neural development: diversity, function and interaction with other molecules. Front. Biosci. 8, 306–355 (2003).
  Google Scholar
• Dejana, E., Spagnuolo, R. & Bazzoni, G. Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration. Thromb. Haemost. 86, 308–315 (2001).
  CAS PubMed Google Scholar
• Inoue, T. et al. Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development. Development 128, 561–569 (2001).
  CAS PubMed Google Scholar
• Guthrie, S. Neuronal development: sorting out motor neurons. Curr. Biol. 12, 488–490 (2002). This overview highlights how cadherins are involved in sorting neurons.
  Google Scholar
• Carmeliet, P. et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98, 147–157 (1999).
  CAS PubMed Google Scholar
• Wolburg, H. & Lippoldt, A. Tight junctions of the blood–brain barrier: development, composition and regulation. Vascul. Pharmacol. 38, 323–337 (2002).
  CAS PubMed Google Scholar
• Gerhardt, H., Wolburg, H. & Redies, C. N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken. Dev. Dyn. 218, 472–479 (2000).
  CAS PubMed Google Scholar
• Lawson, N. D. & Weinstein, B. M. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev. Biol. 248, 307–318 (2002).
  CAS PubMed Google Scholar
• Gerhardt, H. et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell. Biol. 161, 1163–1177 (2003).
  CAS PubMed PubMed Central Google Scholar
• Dickson, B. J. Molecular mechanisms of axon guidance. Science 298, 1959–1964 (2002). A recent overview of the cellular and molecular mechanisms of axon guidance.
  CAS PubMed Google Scholar
• Yamamoto, N., Tamada, A. & Murakami, F. Wiring of the brain by a range of guidance cues. Prog. Neurobiol. 68, 393–407 (2002).
  PubMed Google Scholar
• Cooper, H. M. Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge. Int. J. Dev. Biol. 46, 621–631 (2002).
  CAS PubMed Google Scholar
• McFarlane, S. Attraction vs. repulsion: the growth cone decides. Biochem. Cell Biol. 78, 563–568 (2000).
  CAS PubMed Google Scholar
• Nguyen-Ba-Charvet, K. T. & Chedotal, A. Role of Slit proteins in the vertebrate brain. J. Physiol. Paris 96, 91–98 (2002).
  CAS PubMed Google Scholar
• Guthrie, S. Axon guidance: Robos make the rules. Curr. Biol. 11, 300–303 (2001). A review of the genetic pathways, in particular of the Robo receptors, which determine neuronal route finding.
  Google Scholar
• Wong, K., Park, H. T., Wu, J. Y. & Rao, Y. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr. Opin. Genet. Dev. 12, 583–591 (2002).
  CAS PubMed Google Scholar
• Kidd, T., Bland, K. S. & Goodman, C. S. Slit is the midline repellent for the robo receptor in Drosophila. Cell 96, 785–794 (1999).
  CAS PubMed Google Scholar
• Fricke, C., Lee, J. S., Geiger-Rudolph, S., Bonhoeffer, F. & Chien, C. B. astray, a zebrafish roundabout homolog required for retinal axon guidance. Science 292, 507–510 (2001).
  CAS PubMed Google Scholar
• Plump, A. S. et al. Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron 33, 219–232 (2002).
  CAS PubMed Google Scholar
• Manitt, C. & Kennedy, T. E. Where the rubber meets the road: netrin expression and function in developing and adult nervous systems. Prog. Brain Res. 137, 425–442 (2002).
  CAS PubMed Google Scholar
• Giger, R. J. & Kolodkin, A. L. Silencing the siren: guidance cue hierarchies at the CNS midline. Cell 105, 1–4 (2001).
  CAS PubMed Google Scholar
• Knoll, B. & Drescher, U. Ephrin-As as receptors in topographic projections. Trends Neurosci. 25, 145–149 (2002).
  CAS PubMed Google Scholar
• Feldheim, D. A. et al. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron 25, 563–574 (2000).
  CAS PubMed Google Scholar
• McLaughlin, T., Hindges, R. & O'Leary, D. D. Regulation of axial patterning of the retina and its topographic mapping in the brain. Curr. Opin. Neurobiol. 13, 57–69 (2003).
  CAS PubMed Google Scholar
• Murai, K. K., Nguyen, L. N., Irie, F., Yamaguchi, Y. & Pasquale, E. B. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nature Neurosci. 6, 153–160 (2003).
  CAS PubMed Google Scholar
• Adams, R. H. et al. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 104, 57–69 (2001).
  CAS PubMed Google Scholar
• Bagri, A. & Tessier-Lavigne, M. Neuropilins as semaphorin receptors: in vivo functions in neuronal cell migration and axon guidance. Adv. Exp. Med. Biol. 515, 13–31 (2002). An overview of the role of semaphorins and their neuropilin receptors in neurobiology.
  CAS PubMed Google Scholar
• Pasterkamp, R. J. & Kolodkin, A. L. Semaphorin junction: making tracks toward neural connectivity. Curr. Opin. Neurobiol. 13, 79–89 (2003).
  CAS PubMed Google Scholar
• Puschel, A. W. The function of neuropilin/plexin complexes. Adv. Exp. Med. Biol. 515, 71–80 (2002).
  PubMed Google Scholar
• Song, H. et al. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science 281, 1515–1518 (1998).
  CAS PubMed Google Scholar
• Neufeld, G. et al. The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc. Med. 12, 13–19 (2002).
  CAS PubMed Google Scholar
• Isogai, S., Horiguchi, M. & Weinstein, B. M. The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development. Dev. Biol. 230, 278–301 (2001).
  CAS PubMed Google Scholar
• Pugh, C. W. & Ratcliffe, P. J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Med. 9, 677–684 (2003).
  CAS PubMed Google Scholar
• Carmeliet, P. et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nature Med. 5, 495–502 (1999).
  CAS PubMed Google Scholar
• Mattot, V. et al. Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice. J. Am. Soc. Nephrol. 13, 1548–1560 (2002).
  CAS PubMed Google Scholar
• Oosthuyse, B. et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nature Genet. 28, 131–138 (2001). A study that reports a neurotrophic and vascular role for the prototype angiogenic factor VEGF in motor neuron degeneration.
  CAS PubMed Google Scholar
• Gerber, H. P. et al. VEGF is required for growth and survival in neonatal mice. Development 126, 1149–1159 (1999).
  CAS PubMed Google Scholar
• Egginton, S., Zhou, A. L., Brown, M. D. & Hudlicka, O. Unorthodox angiogenesis in skeletal muscle. Cardiovasc. Res. 49, 634–646 (2001).
  CAS PubMed Google Scholar
• Djonov, V. G., Kurz, H. & Burri, P. H. Optimality in the developing vascular system: branching remodeling by means of intussusception as an efficient adaptation mechanism. Dev. Dyn. 224, 391–402 (2002).
  PubMed Google Scholar
• Helbling, P. M., Saulnier, D. M. & Brandli, A. W. The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis. Development 127, 269–278 (2000).
  CAS PubMed Google Scholar
• Gerety, S. S. & Anderson, D. J. Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development 129, 1397–1410 (2002).
  CAS PubMed Google Scholar
• Ruhrberg, C. et al. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16, 2684–2698 (2002). A genetic study that documents the role of VEGF isoforms in vessel patterning and branching.
  CAS PubMed PubMed Central Google Scholar
• van der Zwaag, B. et al. PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. Dev. Dyn. 225, 336–343 (2002).
  CAS PubMed Google Scholar
• Shoji, W., Isogai, S., Sato-Maeda, M., Obinata, M. & Kuwada, J. Y. Semaphorin3a1 regulates angioblast migration and vascular development in zebrafish embryos. Development 130, 3227–3236 (2003).
  CAS PubMed Google Scholar
• Huminiecki, L., Gorn, M., Suchting, S., Poulsom, R. & Bicknell, R. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics 79, 547–552 (2002).
  CAS PubMed Google Scholar
• Stalmans, I. et al. VEGF: a modifier of the del22q11 (DiGeorge) syndrome? Nature Med. 9, 173–182 (2003). A study that uses genetics in mice, zebrafish and humans to document a role of VEGF-isoforms in the patterning of the great thoracic arteries.
  CAS PubMed Google Scholar
• Carmeliet, P. Fibroblast growth factor-1 stimulates branching and survival of myocardial arteries: a goal for therapeutic angiogenesis? Circ. Res. 87, 176–178 (2000).
  CAS PubMed Google Scholar
• Hilgers, K. F., Norwood, V. F. & Gomez, R. A. Angiotensin's role in renal development. Semin. Nephrol. 17, 492–501 (1997).
  CAS PubMed Google Scholar
• Lee, S. H., Schloss, D. J., Jarvis, L., Krasnow, M. A. & Swain, J. L. Inhibition of angiogenesis by a mouse sprouty protein. J. Biol. Chem. 276, 4128–4133 (2001).
  CAS PubMed Google Scholar
• Honma, Y. et al. Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron 35, 267–282 (2002). This study provides genetic evidence for how vessel-produced artemin directs nerve patterning.
  CAS PubMed Google Scholar
• Bates, D. et al. Neurovascular congruence results from a shared patterning mechanism that utilizes semaphorin3A and neuropilin-1. Dev. Biol. 255, 77–98 (2003).
  CAS PubMed Google Scholar
• Borisov, A. B., Huang, S. K. & Carlson, B. M. Remodeling of the vascular bed and progressive loss of capillaries in denervated skeletal muscle. Anat. Rec. 258, 292–304 (2000).
  CAS PubMed Google Scholar
• Zukowska, Z., Grant, D. S. & Lee, E. W. Neuropeptide Y: a novel mechanism for ischemic angiogenesis. Trends Cardiovasc. Med. 13, 86–92 (2003).
  CAS PubMed Google Scholar
• Teunis, M. A. et al. Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system. FASEB J. 16, 1465–1467 (2002).
  CAS PubMed Google Scholar
• Basu, S. et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nature Med. 7, 569–574 (2001).
  CAS PubMed Google Scholar
• Heeschen, C. et al. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nature Med. 7, 833–839 (2001).
  CAS PubMed Google Scholar
• Donovan, M. J. et al. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 127, 4531–4540 (2000).
  CAS PubMed Google Scholar
• Calza, L., Giardino, L., Giuliani, A., Aloe, L. & Levi-Montalcini, R. Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors. Proc. Natl Acad. Sci. USA 98, 4160–4165 (2001).
  CAS PubMed PubMed Central Google Scholar
• Carmichael, S. T. Plasticity of cortical projections after stroke. Neuroscientist 9, 64–75 (2003).
  PubMed Google Scholar
• Carmeliet, P. Creating unique blood vessels. Nature 412, 868–869 (2001).
  CAS PubMed Google Scholar
• Cleveland, D. W. & Rothstein, J. D. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nature Rev. Neurosci. 2, 806–819 (2001).
  CAS Google Scholar
• Lambrechts, D. et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nature Genet. 34, 383–394 (2003).
  CAS PubMed Google Scholar
• Poltorak, Z., Cohen, T. & Neufeld, G. The VEGF splice variants: properties, receptors, and usage for the treatment of ischemic diseases. Herz 25, 126–129 (2000).
  CAS PubMed Google Scholar
• Kalaria, R. N. Small vessel disease and Alzheimer's dementia: pathological considerations. Cerebrovasc. Disc. 13 (Suppl.), 48–52 (2002). An overview that highlights the role of blood vessels in neurodegenerative Alzheimer Disease.
  CAS Google Scholar
• Wick, A. et al. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J. Neurosci. 22, 6401–6407 (2002).
  CAS PubMed PubMed Central Google Scholar
• Isner, J. M., Ropper, A. & Hirst, K. VEGF gene transfer for diabetic neuropathy. Hum. Gene Ther. 12, 1593–1594 (2001).
  CAS PubMed Google Scholar
• Schratzberger, P. et al. Reversal of experimental diabetic neuropathy by VEGF gene transfer. J. Clin. Invest. 107, 1083–1092 (2001).
  CAS PubMed PubMed Central Google Scholar
• Sondell, M., Sundler, F. & Kanje, M. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. Eur. J. Neurosci. 12, 4243–4254 (2000).
  CAS PubMed Google Scholar
• Hobson, M. I., Green, C. J. & Terenghi, G. VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy. J. Anat. 197, 591–605 (2000).
  CAS PubMed PubMed Central Google Scholar