On a knife-edge—weight-loss surgery for NAFLD in adolescents (original) (raw)

Paediatric gastroenterology

Nature Reviews Gastroenterology & Hepatology volume 12, pages 316–318 (2015)Cite this article

Subjects

A new position statement from Europe endorses expert-based recommendations to consider bariatric surgery as a treatment for severe NAFLD in severely obese adolescents. This article discusses the problem of severe paediatric obesity, its relationship with NAFLD, and the knowledge and needs regarding bariatric surgery in adolescents.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$189.00 per year

only $15.75 per issue

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

References

  1. Nobili, V. et al. Indications and limitations of bariatric intervention in severely obese children and adolescents with and without non-alcoholic steatohepatitis: the ESPGHAN Hepatology Committee Position Statement. J. Pediatr. Gastroenterol. Nutr. 60, 550–561 (2015).
    Article Google Scholar
  2. Chalasani, N. et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 55, 2005–2023 (2012).
    Google Scholar
  3. Kelly, A. S. et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation 128, 1689–1712 (2013).
    Article Google Scholar
  4. Schwimmer, J. B. et al. Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation 118, 277–283 (2008).
    Article CAS Google Scholar
  5. Whitlock, E. P. et al. Effectiveness of weight management interventions in children: a targeted systematic review for the USPSTF. Pediatrics 125, 396–418 (2010).
    Article Google Scholar
  6. Savoye, M. et al. Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial. JAMA 297, 2697–2704 (2007).
    Article CAS Google Scholar
  7. Inge, T. H. et al. Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics 114, 217–223 (2004).
    Article Google Scholar
  8. Michalsky, M. et al. ASMBS pediatric committee best practice guidelines. Surg. Obes. Relat. Dis. 8, 1–7 (2012).
    Article Google Scholar
  9. Pratt, J. S. et al. Best practice updates for pediatric/adolescent weight loss surgery. Obesity (Silver Spring) 17, 901–910 (2009).
    Article Google Scholar
  10. Chavez- Tapia, N. C. et al. Bariatric surgery for non-alcoholic steatohepatitis in obese patients. Cochrane Database of Systematic Reviews, Issue 1 Art. No.: CD007340. http://dx.doi.org/10.1002/14651858.CD007340.pub2.

Download references

Acknowledgements

The work of the authors is supported in part by DK088925, DK090350, DK088831 and DK100429. The funders did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

Author information

Authors and Affiliations

  1. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2010, Cincinnati, 45229, OH, USA
    Stavra A. Xanthakos
  2. Division of Gastroenterology, Department of Pediatrics, Department of Gastroenterology, Hepatology, and Nutrition, University of California, San Diego, Rady Children's Hospital–San Diego, 3020 Children's Way, MC 5030, San Diego, 92123, CA, USA
    Jeffrey B. Schwimmer

Authors

  1. Stavra A. Xanthakos
  2. Jeffrey B. Schwimmer

Corresponding author

Correspondence toJeffrey B. Schwimmer.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

PowerPoint slides

Rights and permissions

About this article

Cite this article

Xanthakos, S., Schwimmer, J. On a knife-edge—weight-loss surgery for NAFLD in adolescents.Nat Rev Gastroenterol Hepatol 12, 316–318 (2015). https://doi.org/10.1038/nrgastro.2015.59

Download citation