The early history of B cells (original) (raw)

• von Behring, E. & Kitasato, S. Ueber das zutandekommen der diphtherie-immunitat und der tetanus-immunitat bei thieren. Deutsche Medizinsche Wochenschrift 16, 1113–1114 (1890).
  Article Google Scholar
• Ehrlich, P. Nobel Lecture, December 11, 1908. Nobel lectures, Physiology or Medicine, 1901–1921 (Elsevier, 1967).
  Google Scholar
• Haurowitz, F. Immunochemistry. Annu. Rev. Biochem. 29, 609–634 (1960).
  Article CAS PubMed Google Scholar
• Tiselius, A. & Kabat, E. A. An electrophoretic study of immune sera and purified antibody preparations. J. Exp. Med. 69, 119–131 (1939).
  Article CAS PubMed PubMed Central Google Scholar
• Fagraeus, A. The plasma cellular reaction and its relation to the formation of antibodies in vitro. J. Immunol. 58, 1–13 (1948).
  CAS PubMed Google Scholar
• Coons, A. H., Leduc, E. H. & Connolly, J. M. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J. Exp. Med. 102, 49–60 (1955).
  Article CAS PubMed PubMed Central Google Scholar
• Cooper, M. D., Peterson, R. D. & Good, R. A. Delineation of the thymic and bursal lymphoid systems in the chicken. Nature 205, 143–146 (1965).
  Article CAS PubMed Google Scholar
• Landsteiner, K. & Chase, M. W. Experiments on transfer of cutaneous sensitivity to simple compounds. P. Soc. Exp. Biol. Med. 49, 688–690 (1942).
  Article CAS Google Scholar
• Chase, M. W. The cellular transfer of cutaneous hypersensitivity to tuberculin. P. Soc. Exp. Biol. Med. 59, 134–135 (1945).
  Article Google Scholar
• Mechnikov, I. Nobel lecture, December 11, 1908. Nobel lectures, Physiology or Medicine, 1901–1921 (Elsevier, 1967).
  Google Scholar
• Bruton, O. C. Agammaglobulinemia. Pediatrics. 6, 722–728 (1952).
  Google Scholar
• Good, R. A. & Varco, R. L. A clinical and experimental study of agammaglobulinemia. Lancet 75, 245–271 (1955).
  CAS Google Scholar
• Glick, B., Chang, T. S. & Jaap, R. G. The bursa of fabricius and antibody production. Poultry Science 35, 224–225 (1956).
  Article Google Scholar
• Edelman, G. M. Dissociation of gamma-globulin. J. Am. Chem. Soc. 81, 3155–3156 (1959).
  Article CAS Google Scholar
• Porter, R. R. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem. J. 73, 119–126 (1959).
  Article CAS PubMed PubMed Central Google Scholar
• Burnet, F. M. The Clonal Selection Theory of Acquired Immunity. (Vanderbilt Univ. Press, 1959).
  Book Google Scholar
• Hilschmann, N. & Craig, L. C. Amino acid sequence studies with Bence-Jones proteins. Proc. Natl Acad. Sci. USA 53, 1403–1409 (1965).
  Article CAS PubMed PubMed Central Google Scholar
• Dreyer, W. J. & Bennett, J. C. The molecular basis of antibody formation: a paradox. Proc. Natl Acad. Sci. USA 54, 864–869 (1965).
  Article CAS PubMed PubMed Central Google Scholar
• Eisen, H. N. & Siskind, G. W. Variations in affinities of antibodies during the immune Response. Biochemistry 3, 996–1008 (1964).
  Article CAS PubMed Google Scholar
• Weigert, M. G., Cesari, I. M., Yonkovich, S. J. & Cohn, M. Variability in the lambda light chain sequences of mouse antibody. Nature 228, 1045–1047 (1970).
  Article CAS PubMed Google Scholar
• Miller, J. F. Immunological function of the thymus. Lancet 2, 748–749 (1961).
  Article CAS PubMed Google Scholar
• Good, R. A. et al. The role of the thymus in development of immunologic capacity in rabbits and mice. J. Exp. Med. 116, 773–796 (1962).
  Article CAS PubMed PubMed Central Google Scholar
• Jankovic, B. D., Waksman, B. H. & Arnason, B. G. Role of the thymus in immune reactions in rats. I. The immunologic response to bovine serum albumin (antibody formation, arthus reactivity, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth. J. Exp. Med. 116, 159–176 (1962).
  Article CAS PubMed PubMed Central Google Scholar
• Hilgard, H. R., Yunis, E. J., Sjodin, K., Martinez, C. & Good, R. A. Reversal of wasting in thymectomized mice by the injection of syngeneic spleen or thymus cell suspensions. Nature 202, 668–670 (1964).
  Article CAS PubMed Google Scholar
• Gowans, J. L. & Knight, E. J. The route of re-circulation of lymphocytes in the rat. Proc. R. Soc. B. Biol. Sci. 159, 257–282 (1964).
  Article CAS Google Scholar
• Gowans, J. L. & McGregor, D. D. The Origins of Antibody-Forming Cells. Immunopathology: IIIrd International Symposium (eds Grabar, P. & Miescher, P. A.) 89 (Schwabe, 1963).
  Google Scholar
• Auerbach, R. Experimental analysis of the origin of cell types in the development of the mouse thymus. Dev. Biol. 3, 336–354 (1961).
  Article CAS PubMed Google Scholar
• Szenberg, A. & Warner, N. L. Dissociation of immunological responsiveness in fowls with a hormonally arrested development of lymphoid tissues. Nature 194, 146–147 (1962).
  Article Google Scholar
• Warner, N. L., Szenberg, A. & Burnet, F. M. The immunological role of different lymphoid organs in the chicken. I. Dissociation of immunological responsiveness. Austral. J. Exp. Biol. Med. Sci. 40, 373–387 (1962).
  Article CAS Google Scholar
• Peterson, R. D., Burmester, B. R., Frederick, T. N., Purchase, H. G. & Good, R. A. Effect of bursectomy and thymectomy on development of visceral lymphomatosis in chicken. J. Natl Cancer Inst. 32, 1343–1353 (1964).
  Article CAS PubMed Google Scholar
• Cooper, M. D., Chae, H. P., Lowman, J. T., Krivit, W. & Good, R. A. Wiskott–Aldrich syndrome. An immunologic deficiency disease involving the afferent limb of immunity. Am. J. Med. 44, 499–513 (1968).
  Article CAS PubMed Google Scholar
• Cooper, M. D., Raymond, D. A., Peterson, R. D., South, M. A. & Good, R. A. The functions of the thymus system and the bursa system in the chicken. J. Exp. Med. 123, 75–102 (1966).
  Article CAS PubMed PubMed Central Google Scholar
• Cooper, M. D., Schwartz, M. M. & Good, R. A. Restoration of γ-globulin production in agammaglobulinemic chickens. Science 151, 471–473 (1966).
  Article CAS PubMed Google Scholar
• Glanzmann, E. Die essentielle erythroblastopenie mit anamie vom typus Diamond-Blackfan. Experientia 1, 118 (1945).
  Article Google Scholar
• Hitzig, W. H., Biro, Z., Bosch, H. & Huser, H. J. Agammaglobulinemia and alymphocytosis with atrophy of lymphatic tissue. Helvet. Paediatr. Acta 13, 551–585 (1958).
  CAS Google Scholar
• DiGeorge, A. M. Congenital absence of the thymus and its immunologic consequences: Concurrence with congenital hypoparathyroidism. Birth Defects Original Article Series 4, 116–121 (1968).
  Google Scholar
• Becker, A. J., Mc, C. E. & Till, J. E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197, 452–454 (1963).
  Article CAS PubMed Google Scholar
• Ford, C. E. & Micklem, H. S. The thymus and lymph-nodes in radiation chimaeras. Lancet 1, 359–362 (1963).
  Article CAS PubMed Google Scholar
• Moore, M. A. S. & Owen, J. J. T. Stem-cell migration in developing myeloid and lymphoid systems. Lancet 2, 658–659 (1967).
  Article Google Scholar
• Roitt, I. M., Greaves, M. F., Torrigiani, G., Brostoff, J. & Playfair, J. H. The cellular basis of immunological responses. A synthesis of some current views. Lancet 2, 367–371 (1969).
  Article CAS PubMed Google Scholar
• Crotty, S. A brief history of T cell help to B cells. Nature Rev. Immunol.(in the press).
• Cooper, M. D., Cain, W. A., Van Alten, P. J. & Good, R. A. Development and function of the immunoglobulin producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins and antibody production. Int. Arch. Allergy Appl. Immunol. 35, 242–252 (1969).
  Article CAS PubMed Google Scholar
• Kincade, P. W., Lawton, A. R., Bockman, D. E. & Cooper, M. D. Suppression of immunoglobulin G synthesis as a result of antibody-mediated suppression of immunoglobulin M synthesis in chickens. Proc. Natl Acad. Sci. USA 67, 1918–1925 (1970).
  Article CAS PubMed PubMed Central Google Scholar
• Lawton, A. R., Asofsky, R., Hylton, M. B. & Cooper, M. D. Suppression of immunoglobulin class synthesis in mice. I. Effects of treatment with antibody to μ-chain. J. Exp. Med. 135, 277–297 (1972).
  Article PubMed PubMed Central Google Scholar
• Moller, G. Demonstration of mouse isoantigens at the cellular-level by the fluorescent-antibody technique. J. Exp. Med. 114, 415–434 (1961).
  Article CAS PubMed PubMed Central Google Scholar
• Raff, M. C., Sternber, M. & Taylor, R. B. Immunoglobulin determinants on surface of mouse lymphoid cells. Nature 225, 553–554 (1970).
  Article CAS PubMed Google Scholar
• Rabellino, E. & Grey, H. M. Immunoglobulins on the surface of lymphocytes. 3. Bursal origin of surface immunoglobulins on chicken lymphocytes. J. Immunol. 106, 1418–1420 (1971).
  CAS PubMed Google Scholar
• Kincade, P. W., Lawton, A. R. & Cooper, M. D. Restriction of surface immunoglobulin determinants to lymphocytes of the plasma cell line. J. Immunol. 106, 1421–1423 (1971).
  CAS PubMed Google Scholar
• Cooper, M. D., Lawton, A. R. & Bockman, D. E. Agammaglobulinaemia with B lymphocytes: A specific defect of plasma cell differentiation. Lancet 2, 791–795 (1971).
  Article CAS PubMed Google Scholar
• Cooper, M. D. et al. A mammalian equivalent of the avian bursa of Fabricius. Lancet 1, 1388–1391 (1966).
  Article CAS PubMed Google Scholar
• Owen, J. J., Cooper, M. D. & Raff, M. C. In vitro generation of B lymphocytes in mouse foetal liver, a mammalian 'bursa equivalent'. Nature 249, 361–363 (1974).
  Article CAS PubMed Google Scholar
• Osmond, D. G. & Nossal, G. J. Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling. Cellular Immunology 13, 132–145 (1974).
  Article CAS PubMed Google Scholar
• Ryser, J. E. & Vassalli, P. Mouse bone marrow lymphocytes and their differentiation. J. Immunol. 113, 719–728 (1974).
  CAS PubMed Google Scholar
• Owen, J. J., Raff, M. C. & Cooper, M. D. Studies on the generation of B lymphocytes in the mouse embryo. Eur. J. Immunol. 3, 468–473 (1975).
  Article Google Scholar
• Raff, M. C., Megson, M., Owen, J. J. & Cooper, M. D. Early production of intracellular IgM by B-lymphocyte precursors in mouse. Nature 259, 224–226 (1976).
  Article CAS PubMed Google Scholar
• Kohler, G. & Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495–497 (1975).
  Article CAS PubMed Google Scholar
• Burrows, P., LeJeune, M. & Kearney, J. F. Evidence that murine pre-B cells synthesise μ-heavy chains but no light chains. Nature 280, 838–840 (1979).
  Article CAS PubMed Google Scholar
• Alt, F. W. et al. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 3, 1209–1219 (1984).
  Article CAS PubMed PubMed Central Google Scholar
• Hozumi, N. & Tonegawa, S. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc. Natl Acad. Sci. USA 73, 3628–3632 (1976).
  Article CAS PubMed PubMed Central Google Scholar
• Bernard, O., Hozumi, N. & Tonegawa, S. Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell 15, 1133–1144 (1978).
  Article CAS PubMed Google Scholar
• Early, P., Huang, H., Davis, M., Calame, K. & Hood, L. An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell 19, 981–992 (1980).
  Article CAS PubMed Google Scholar
• Rogers, J. et al. Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ-chain. Cell 20, 303–312 (1980).
  Article CAS PubMed Google Scholar
• Davis, M. M. et al. An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature 283, 733–739 (1980).
  Article CAS PubMed Google Scholar
• Sakano, H., Maki, R., Kurosawa, Y., Roeder, W. & Tonegawa, S. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature 286, 676–683 (1980).
  Article CAS PubMed Google Scholar
• Yaoita, Y. & Honjo, T. Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome. Nature 286, 850–853 (1980).
  Article CAS PubMed Google Scholar
• McKean, D. et al. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl Acad. Sci. USA 81, 3180–3184 (1984).
  Article CAS PubMed PubMed Central Google Scholar
• Jacob, J., Kelsoe, G., Rajewsky, K. & Weiss, U. Intraclonal generation of antibody mutants in germinal centres. Nature 354, 389–392 (1991).
  Article CAS PubMed Google Scholar
• Kocks, C. & Rajewsky, K. Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. Annu. Rev. Immunol. 7, 537–559 (1989).
  Article CAS PubMed Google Scholar
• Schatz, D. G., Oettinger, M. A. & Baltimore, D. The V(D)J recombination activating gene, RAG-1. Cell 59, 1035–1048 (1989).
  Article CAS PubMed Google Scholar
• Oettinger, M. A., Schatz, D. G., Gorka, C. & Baltimore, D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517–1523 (1990).
  Article CAS PubMed Google Scholar
• Muramatsu, M., et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553–563 (2000).
  Article CAS PubMed Google Scholar
• Reynaud, C. A., Anquez, V., Grimal, H. & Weill, J. C. A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 48, 379–388 (1987).
  Article CAS PubMed Google Scholar
• Thompson, C. B. & Neiman, P. E. Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment. Cell 48, 369–378 (1987).
  Article CAS PubMed Google Scholar
• Di Noia, J. M. & Neuberger, M. S. Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. Eur. J. Immunol. 34, 504–508 (2004).
  Article CAS PubMed Google Scholar
• Zinkernagel, R. M. & Doherty, P. C. Cytotoxic thymus-derived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis. J. Exp. Med. 138, 1266–1269 (1973).
  Article CAS PubMed PubMed Central Google Scholar
• Yanagi, Y. et al. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 308, 145–149 (1984).
  Article CAS PubMed Google Scholar
• Hedrick, S. M., Cohen, D. I., Nielsen, E. A. & Davis, M. M. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308, 149–153 (1984).
  Article CAS PubMed Google Scholar
• Pancer, Z. et al. Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature 430, 174–180 (2004).
  Article CAS PubMed Google Scholar
• Litman, G. W., Rast, J. P. & Fugmann, S. D. The origins of vertebrate adaptive immunity. Nature Rev. Immunol. 10, 543–553 (2010).
  Article CAS Google Scholar
• Herrin, B. R. & Cooper, M. D. Alternative adaptive immunity in jawless vertebrates. J. Immunol. 185, 1367–1374 (2010).
  Article CAS PubMed Google Scholar
• Hirano, M. et al. Evolutionary implications of a third lymphocyte lineage in lampreys. Nature 501, 435–438 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Reth, M. et al. The B-cell antigen receptor complex. Immunol. Today 12, 196–201 (1991).
  Article CAS PubMed Google Scholar
• Karasuyama, H., Rolink, A. & Melchers, F. Surrogate light chain in B cell development. Adv. Immunol. 63, 1–41 (1996).
  Article CAS PubMed Google Scholar
• Reth, M. & Nielsen, P. Signaling circuits in early B-cell development. Adv. Immunol. 122, 129–175 (2014).
  Article CAS PubMed Google Scholar
• Avalos, A. M., Meyer-Wentrup, F. & Ploegh, H. L. B-cell receptor signaling in lymphoid malignancies and autoimmunity. Adv. Immunol. 123, 1–49 (2014).
  Article CAS PubMed Google Scholar