Enikolopov, G. & Overstreet Wadiche, L. in Adult Neurogenesis (eds. Gage, F. H., Kempermann, G. & Song, H.) 81–100 (Cold Spring Harbor Laboratory Press, New York, 2008). Google Scholar
Kuhn, H. G. & Peterson, D. A. in Adult Neurogenesis (eds. Gage, F. H., Kempermann, G. & Song, H.) 25–47 (Cold Spring Harbor Laboratory Press, New York, 2008). Google Scholar
Zhao, C. in Adult Neurogenesis (eds. Gage, F. H., Kempermann, G. & Song, H.) 101–117 (Cold Spring Harbor Laboratory Press, New York, 2008). Google Scholar
Zhao, C., Deng, W. & Gage, F. H. Mechanisms and functional implications of adult neurogenesis. Cell132, 645–660 (2008). CASPubMed Google Scholar
Suh, H., Deng, W. & Gage, F. H. Signaling in adult neurogenesis. Annu. Rev. Cell Dev. Biol.25, 253–275 (2009). CASPubMed Google Scholar
Grubb, M. S., Nissant, A., Murray, K. & Lledo, P. M. Functional maturation of the first synapse in olfaction: development and adult neurogenesis. J. Neurosci.28, 2919–2932 (2008). CASPubMedPubMed Central Google Scholar
Nissant, A., Bardy, C., Katagiri, H., Murray, K. & Lledo, P. M. Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. Nature Neurosci.12, 728–730 (2009). CASPubMed Google Scholar
Breton-Provencher, V., Lemasson, M., Peralta, M. R. III & Saghatelyan, A. Interneurons produced in adulthood are required for the normal functioning of the olfactory bulb network and for the execution of selected olfactory behaviors. J. Neurosci.29, 15245–15257 (2009). CASPubMedPubMed Central Google Scholar
Whitman, M. C. & Greer, C. A. Adult neurogenesis and the olfactory system. Prog. Neurobiol.89, 162–175 (2009). PubMedPubMed Central Google Scholar
Squire, L. R. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol. Rev.99, 195–231 (1992). CASPubMed Google Scholar
Sahay, A. & Hen, R. Hippocampal neurogenesis and depression. Novartis Found. Symp.289, 152–160; discussion 160–164, 193–195 (2008). CASPubMed Google Scholar
David, D. J. et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron62, 479–493 (2009). CASPubMedPubMed Central Google Scholar
Cameron, H. A., Woolley, C. S., McEwen, B. S. & Gould, E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience56, 337–344 (1993). CASPubMed Google Scholar
Zhao, C., Teng, E. M., Summers, R. G. Jr, Ming, G. L. & Gage, F. H. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J. Neurosci.26, 3–11 (2006). CASPubMedPubMed Central Google Scholar
Snyder, J. S. et al. Adult-born hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice. J. Neurosci.29, 14484–14495 (2009). CASPubMedPubMed Central Google Scholar
Esposito, M. S. et al. Neuronal differentiation in the adult hippocampus recapitulates embryonic development. J. Neurosci.25, 10074–10086 (2005). The first systematic characterization of the process of adult hippocampal neurogenesis regarding the morphological and physiological maturation of adult-born DGCs. CASPubMedPubMed Central Google Scholar
Ge, S. et al. GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature439, 589–593 (2006). CASPubMed Google Scholar
Hastings, N. B., Seth, M. I., Tanapat, P., Rydel, T. A. & Gould, E. Granule neurons generated during development extend divergent axon collaterals to hippocampal area CA3. J. Comp. Neurol.452, 324–333 (2002). PubMed Google Scholar
Overstreet Wadiche, L., Bromberg, D. A., Bensen, A. L. & Westbrook, G. L. GABAergic signaling to newborn neurons in dentate gyrus. J. Neurophysiol.94, 4528–4532 (2005). PubMed Google Scholar
Markwardt, S. J., Wadiche, J. I. & Overstreet-Wadiche, L. S. Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus. J. Neurosci.29, 15063–15072 (2009). CASPubMedPubMed Central Google Scholar
Jagasia, R. et al. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J. Neurosci.29, 7966–7977 (2009). CASPubMedPubMed Central Google Scholar
Toni, N. et al. Synapse formation on neurons born in the adult hippocampus. Nature Neurosci.10, 727–734 (2007). CASPubMed Google Scholar
Toni, N. et al. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nature Neurosci.11, 901–907 (2008). CASPubMed Google Scholar
Faulkner, R. L. et al. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc. Natl Acad. Sci. USA105, 14157–14162 (2008). CASPubMedPubMed Central Google Scholar
Bliss, T. V. & Collingridge, G. L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature361, 31–39 (1993). CASPubMed Google Scholar
Tashiro, A., Sandler, V. M., Toni, N., Zhao, C. & Gage, F. H. NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature442, 929–933 (2006). CASPubMed Google Scholar
Ge, S., Yang, C. H., Hsu, K. S., Ming, G. L. & Song, H. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron54, 559–566 (2007). This study demonstrated the enhanced plasticity of developing adult-born DGCs by a systematic characterization of retrovirus-labelled DGCs at different time points. CASPubMedPubMed Central Google Scholar
Schmidt-Hieber, C., Jonas, P. & Bischofberger, J. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature429, 184–187 (2004). CASPubMed Google Scholar
Ambrogini, P. et al. Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus. Brain Res.1017, 21–31 (2004). CASPubMed Google Scholar
Scobie, K. N. et al. Kruppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. J. Neurosci.29, 9875–9887 (2009). CASPubMedPubMed Central Google Scholar
Gould, E., Beylin, A., Tanapat, P., Reeves, A. & Shors, T. J. Learning enhances adult neurogenesis in the hippocampal formation. Nature Neurosci.2, 260–265 (1999). CASPubMed Google Scholar
Epp, J. R., Spritzer, M. D. & Galea, L. A. Hippocampus-dependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation. Neuroscience149, 273–285 (2007). CASPubMed Google Scholar
Leuner, B. et al. Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory. J. Neurosci.24, 7477–7481 (2004). CASPubMedPubMed Central Google Scholar
Leuner, B., Waddell, J., Gould, E. & Shors, T. J. Temporal discontiguity is neither necessary nor sufficient for learning-induced effects on adult neurogenesis. J. Neurosci.26, 13437–13442 (2006). CASPubMedPubMed Central Google Scholar
Dupret, D. et al. Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol.5, e214 (2007). PubMedPubMed Central Google Scholar
Dobrossy, M. D. et al. Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date. Mol. Psychiatry8, 974–982 (2003). CASPubMed Google Scholar
van Praag, H., Kempermann, G. & Gage, F. H. Neural consequences of environmental enrichment. Nature Rev. Neurosci.1, 191–198 (2000). CAS Google Scholar
Kempermann, G., Kuhn, H. G. & Gage, F. H. More hippocampal neurons in adult mice living in an enriched environment. Nature386, 493–495 (1997). The first study to show the regulation of the survival of adult-born DGCs by experience in mice. CASPubMed Google Scholar
Tashiro, A., Makino, H. & Gage, F. H. Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J. Neurosci.27, 3252–3259 (2007). The authors showed that the experiences of mice when the adult-born DGCs are in a hyper-excitable stage affect the subsequent responsiveness of these DGCs to various inputs. CASPubMedPubMed Central Google Scholar
Bruel-Jungerman, E., Laroche, S. & Rampon, C. New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur. J. Neurosci.21, 513–521 (2005). PubMed Google Scholar
Meshi, D. et al. Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nature Neurosci.9, 729–731 (2006). CASPubMed Google Scholar
Hillman, C. H., Erickson, K. I. & Kramer, A. F. Be smart, exercise your heart: exercise effects on brain and cognition. Nature Rev. Neurosci.9, 58–65 (2008). CAS Google Scholar
van Praag, H., Kempermann, G. & Gage, F. H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neurosci.2, 266–270 (1999). CASPubMed Google Scholar
van Praag, H., Shubert, T., Zhao, C. & Gage, F. H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci.25, 8680–8685 (2005). CASPubMedPubMed Central Google Scholar
Muotri, A. R., Zhao, C., Marchetto, M. C. & Gage, F. H. Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus19, 1002–1007 (2009). CASPubMedPubMed Central Google Scholar
Snyder, J. S., Glover, L. R., Sanzone, K. M., Kamhi, J. F. & Cameron, H. A. The effects of exercise and stress on the survival and maturation of adult-generated granule cells. Hippocampus19, 898–906 (2009). CASPubMedPubMed Central Google Scholar
van Praag, H., Christie, B. R., Sejnowski, T. J. & Gage, F. H. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl Acad. Sci. USA96, 13427–13431 (1999). CASPubMedPubMed Central Google Scholar
Leasure, J. L. & Decker, L. Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats. Hippocampus19, 907–912 (2009). PubMed Google Scholar
Bruel-Jungerman, E., Davis, S., Rampon, C. & Laroche, S. Long-term potentiation enhances neurogenesis in the adult dentate gyrus. J. Neurosci.26, 5888–5893 (2006). CASPubMedPubMed Central Google Scholar
Chun, S. K., Sun, W., Park, J. J. & Jung, M. W. Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus. Neurobiol. Learn. Mem.86, 322–329 (2006). PubMed Google Scholar
Madsen, T. M., Greisen, M. H., Nielsen, S. M., Bolwig, T. G. & Mikkelsen, J. D. Electroconvulsive stimuli enhance both neuropeptide Y receptor Y1 and Y2 messenger RNA expression and levels of binding in the rat hippocampus. Neuroscience98, 33–39 (2000). CASPubMed Google Scholar
Malberg, J. E., Eisch, A. J., Nestler, E. J. & Duman, R. S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci.20, 9104–9110 (2000). CASPubMedPubMed Central Google Scholar
Parent, J. M. et al. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci.17, 3727–3738 (1997). CASPubMedPubMed Central Google Scholar
Jessberger, S. et al. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J. Neurosci.27, 9400–9407 (2007). CASPubMedPubMed Central Google Scholar
Parent, J. M., Elliott, R. C., Pleasure, S. J., Barbaro, N. M. & Lowenstein, D. H. Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Ann. Neurol.59, 81–91 (2006). PubMed Google Scholar
Overstreet-Wadiche, L. S., Bromberg, D. A., Bensen, A. L. & Westbrook, G. L. Seizures accelerate functional integration of adult-generated granule cells. J. Neurosci.26, 4095–4103 (2006). CASPubMedPubMed Central Google Scholar
Guzowski, J. F. et al. Mapping behaviorally relevant neural circuits with immediate-early gene expression. Curr. Opin. Neurobiol.15, 599–606 (2005). CASPubMed Google Scholar
Jessberger, S. & Kempermann, G. Adult-born hippocampal neurons mature into activity-dependent responsiveness. Eur. J. Neurosci.18, 2707–2712 (2003). PubMed Google Scholar
Ramirez-Amaya, V., Marrone, D. F., Gage, F. H., Worley, P. F. & Barnes, C. A. Integration of new neurons into functional neural networks. J. Neurosci.26, 12237–12241 (2006). CASPubMedPubMed Central Google Scholar
Kee, N., Teixeira, C. M., Wang, A. H. & Frankland, P. W. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nature Neurosci.10, 355–362 (2007). CASPubMed Google Scholar
Trouche, S., Bontempi, B., Roullet, P. & Rampon, C. Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. Proc. Natl Acad. Sci. USA106, 5919–5924 (2009). CASPubMedPubMed Central Google Scholar
Gould, E., Tanapat, P., Hastings, N. B. & Shors, T. J. Neurogenesis in adulthood: a possible role in learning. Trends Cogn. Sci.3, 186–192 (1999). CASPubMed Google Scholar
Kempermann, G., Wiskott, L. & Gage, F. H. Functional significance of adult neurogenesis. Curr. Opin. Neurobiol.14, 186–191 (2004). CASPubMed Google Scholar
Schinder, A. F. & Gage, F. H. A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology (Bethesda)19, 253–261 (2004). Google Scholar
Marr, D. Simple memory: a theory for archicortex. Philos. Trans. R. Soc. Lond. B Biol. Sci.262, 23–81 (1971). CASPubMed Google Scholar
McNaughton, B. L. & Morris, R. G. M. Hippocampal synaptic enhancement and information storage within a distributed memory system. Trends Neurosci.10, 408–415 (1987). Google Scholar
O'Reilly, R. C. & McClelland, J. L. Hippocampal conjunctive encoding, storage, and recall: avoiding a trade-off. Hippocampus4, 661–682 (1994). CASPubMed Google Scholar
Rolls, E. T. A theory of hippocampal function in memory. Hippocampus6, 601–620 (1996). CASPubMed Google Scholar
Treves, A. & Rolls, E. T. Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network. Hippocampus2, 189–199 (1992). CASPubMed Google Scholar
Bakker, A., Kirwan, C. B., Miller, M. & Stark, C. E. Pattern separation in the human hippocampal CA3 and dentate gyrus. Science319, 1640–1642 (2008). CASPubMedPubMed Central Google Scholar
Leutgeb, J. K., Leutgeb, S., Moser, M. B. & Moser, E. I. Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science315, 961–966 (2007). CASPubMed Google Scholar
McHugh, T. J. et al. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science317, 94–99 (2007). CASPubMed Google Scholar
Aimone, J. B. & Wiskott, L. in Adult Neurogenesis (eds. Gage, F. H., Kempermann, G. & Song, H.) 101–117 (Cold Spring Harbor Laboratory Press, New York, 2008). Google Scholar
Chambers, R. A., Potenza, M. N., Hoffman, R. E. & Miranker, W. Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks. Neuropsychopharmacology29, 747–758 (2004). PubMed Google Scholar
Deisseroth, K. et al. Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron42, 535–552 (2004). CASPubMed Google Scholar
Crick, C. & Miranker, W. Apoptosis, neurogenesis, and information content in Hebbian networks. Biol. Cybern.94, 9–19 (2006). PubMed Google Scholar
Becker, S. A computational principle for hippocampal learning and neurogenesis. Hippocampus15, 722–738 (2005). PubMed Google Scholar
Wiskott, L., Rasch, M. J. & Kempermann, G. A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus. Hippocampus16, 329–343 (2006). PubMed Google Scholar
Weisz, V. I. & Argibay, P. F. A putative role for neurogenesis in neuro-computational terms: inferences from a hippocampal model. Cognition112, 229–240 (2009). PubMed Google Scholar
Aimone, J. B., Wiles, J. & Gage, F. H. Computational influence of adult neurogenesis on memory encoding. Neuron61, 187–202 (2009). A bottom-up computational model of adult hippocampal neurogenesis. The authors proposed a role for adult-born DGCs with enhanced excitability in pattern integration through their broad tuning properties. CASPubMedPubMed Central Google Scholar
Aimone, J. B., Wiles, J. & Gage, F. H. Potential role for adult neurogenesis in the encoding of time in new memories. Nature Neurosci.9, 723–727 (2006). CASPubMed Google Scholar
Friedman, W. J. Comment on “Potential role for adult neurogenesis in the encoding of time in new memories”. Hippocampus17, 503–504 (2007). PubMed Google Scholar
Becker, S. & Wojtowicz, J. M. A model of hippocampal neurogenesis in memory and mood disorders. Trends Cogn. Sci.11, 70–76 (2007). PubMed Google Scholar
Dupret, D. et al. Spatial relational memory requires hippocampal adult neurogenesis. PLoS One3, e1959 (2008). PubMedPubMed Central Google Scholar
Saxe, M. D. et al. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc. Natl Acad. Sci. USA103, 17501–17506 (2006). CASPubMedPubMed Central Google Scholar
Shors, T. J. et al. Neurogenesis in the adult is involved in the formation of trace memories. Nature410, 372–376 (2001). The first study to show the functional importance of adult neurogenesis. The authors discovered that rats with reduced adult neurogenesis were impaired in learning conditioned response in an eye blink trace conditioning paradigm. CASPubMed Google Scholar
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y. & Gould, E. Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus12, 578–584 (2002). PubMedPubMed Central Google Scholar
Clelland, C. D. et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science325, 210–213 (2009). The first study to suggest an involvement of adult hippocampal neurogenesis in pattern separation, a proposed function for the dentate gyrus. CASPubMedPubMed Central Google Scholar
Deng, W., Saxe, M. D., Gallina, I. S. & Gage, F. H. Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J. Neurosci.29, 13532–13542 (2009). This study showed that adult-born DGCs contribute to learning and memory before their full maturation, at a stage when they have enhanced excitability. CASPubMedPubMed Central Google Scholar
Zhang, C. L., Zou, Y., He, W., Gage, F. H. & Evans, R. M. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature451, 1004–1007 (2008). CASPubMed Google Scholar
Jessberger, S. et al. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn. Mem.16, 147–154 (2009). PubMedPubMed Central Google Scholar
Madsen, T. M., Kristjansen, P. E., Bolwig, T. G. & Wortwein, G. Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience119, 635–642 (2003). CASPubMed Google Scholar
Snyder, J. S., Hong, N. S., McDonald, R. J. & Wojtowicz, J. M. A role for adult neurogenesis in spatial long-term memory. Neuroscience130, 843–852 (2005). CASPubMed Google Scholar
Imayoshi, I. et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neurosci.11, 1153–1161 (2008). CASPubMed Google Scholar
Warner-Schmidt, J. L., Madsen, T. M. & Duman, R. S. Electroconvulsive seizure restores neurogenesis and hippocampus-dependent fear memory after disruption by irradiation. Eur. J. Neurosci.27, 1485–1493 (2008). PubMed Google Scholar
Winocur, G., Wojtowicz, J. M., Sekeres, M., Snyder, J. S. & Wang, S. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus16, 296–304 (2006). PubMed Google Scholar
Ko, H. G. et al. Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory. Mol. Brain2, 1 (2009). PubMedPubMed Central Google Scholar
Ben Abdallah, N. M., Slomianka, L., Vyssotski, A. L. & Lipp, H. P. Early age-related changes in adult hippocampal neurogenesis in C57 mice. Neurobiol. Aging31, 151–161.
Seki, T. & Arai, Y. Age-related production of new granule cells in the adult dentate gyrus. Neuroreport6, 2479–2482 (1995). CASPubMed Google Scholar
Raber, J. et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat. Res.162, 39–47 (2004). CASPubMed Google Scholar
Rola, R. et al. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp. Neurol.188, 316–330 (2004). CASPubMed Google Scholar
Garthe, A., Behr, J. & Kempermann, G. Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies. PLoS One4, e5464 (2009). PubMedPubMed Central Google Scholar
Nakashiba, T., Young, J. Z., McHugh, T. J., Buhl, D. L. & Tonegawa, S. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science319, 1260–1264 (2008). CASPubMed Google Scholar
Brun, V. H. et al. Impaired spatial representation in CA1 after lesion of direct input from entorhinal cortex. Neuron57, 290–302 (2008). CASPubMed Google Scholar
Gilbert, P. E., Kesner, R. P. & Lee, I. Dissociating hippocampal subregions: double dissociation between dentate gyrus and CA1. Hippocampus11, 626–636 (2001). CASPubMed Google Scholar
Saxe, M. D. et al. Paradoxical influence of hippocampal neurogenesis on working memory. Proc. Natl Acad. Sci. USA104, 4642–4646 (2007). CASPubMedPubMed Central Google Scholar
Zhang, F., Aravanis, A. M., Adamantidis, A., de Lecea, L. & Deisseroth, K. Circuit-breakers: optical technologies for probing neural signals and systems. Nature Rev. Neurosci.8, 577–581 (2007). CAS Google Scholar
Kitamura, T. et al. Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell139, 814–827 (2009). The first study to show a role for adult hippocampal neurogenesis in system consolidation. CASPubMed Google Scholar
Kesner, R. P. A behavioral analysis of dentate gyrus function. Prog. Brain Res.163, 567–576 (2007). PubMed Google Scholar
Manganas, L. N. et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science318, 980–985 (2007). CASPubMedPubMed Central Google Scholar
Pereira, A. C. et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc. Natl Acad. Sci. USA104, 5638–5643 (2007). CASPubMedPubMed Central Google Scholar
Amaral, D. G., Scharfman, H. E. & Lavenex, P. The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies). Prog. Brain Res.163, 3–22 (2007). PubMedPubMed Central Google Scholar
Baker, J. L. Is there a support vector machine hiding in the dentate gyrus? Neurocomputing52–54, 199–207 (2003). Google Scholar
Houser, C. R. Interneurons of the dentate gyrus: an overview of cell types, terminal fields and neurochemical identity. Prog. Brain Res.163, 217–232 (2007). CASPubMed Google Scholar
Jung, M. W. & McNaughton, B. L. Spatial selectivity of unit activity in the hippocampal granular layer. Hippocampus3, 165–182 (1993). CASPubMed Google Scholar
Myers, C. E. & Scharfman, H. E. A role for hilar cells in pattern separation in the dentate gyrus: a computational approach. Hippocampus19, 321–337 (2009). PubMedPubMed Central Google Scholar
Henze, D. A., Wittner, L. & Buzsaki, G. Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo. Nature Neurosci.5, 790–795 (2002). CASPubMed Google Scholar
Rolls, E. T. & Kesner, R. P. A computational theory of hippocampal function, and empirical tests of the theory. Prog. Neurobiol.79, 1–48 (2006). CASPubMed Google Scholar
Hopfield, J. J. Neural networks and physical systems with emergent collective computational abilities. Proc. Natl Acad. Sci. USA79, 2554–2558 (1982). CASPubMedPubMed Central Google Scholar
Dupret, D. et al. Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus. Eur. J. Neurosci.22, 778–783 (2005). PubMed Google Scholar
Monje, M. L., Toda, H. & Palmer, T. D. Inflammatory blockade restores adult hippocampal neurogenesis. Science302, 1760–1765 (2003). CASPubMed Google Scholar
Garcia, A. D., Doan, N. B., Imura, T., Bush, T. G. & Sofroniew, M. V. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nature Neurosci.7, 1233–1241 (2004). CASPubMed Google Scholar
Farioli-Vecchioli, S. et al. The timing of differentiation of adult hippocampal neurons is crucial for spatial memory. PLoS Biol.6, e246 (2008). PubMedPubMed Central Google Scholar