Hereditary disorders of renal phosphate wasting (original) (raw)

• Reilly, R. F. & Perazella, M. A. Nephrology in 30 Days (McGraw-Hill Medical Pub. Division, New York, 2005).
  Google Scholar
• Amanzadeh, J. & Reilly, R. F. Jr. Hypophosphatemia: an evidence-based approach to its clinical consequences and management. Nat. Clin. Pract. Nephrol. 2, 136–148 (2006).
  Article CAS PubMed Google Scholar
• Hilfiker, H. et al. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc. Natl Acad. Sci. USA 95, 14564–14569 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Giral, H. et al. Regulation of rat intestinal Na-dependent phosphate transporters by dietary phosphate. Am. J. Physiol. Renal Physiol. 297, F1466–F1475 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Danisi, G., Bonjour, J. P. & Straub, R. W. Regulation of Na-dependent phosphate influx across the mucosal border of duodenum by 1,25-dihydroxycholecalciferol. Pflugers Arch. 388, 227–232 (1980).
  Article CAS PubMed Google Scholar
• Danisi, G., Caverzasio, J., Trechsel, U., Bonjour, J. P. & Straub, R. W. Phosphate transport adaptation in rat jejunum and plasma level of 1,25-dihydroxyvitamin D3. Scand. J. Gastroenterol. 25, 210–215 (1990).
  CAS PubMed Google Scholar
• Hildmann, B., Storelli, C., Danisi, G. & Murer, H. Regulation of Na+-Pi cotransport by 1,25-dihydroxyvitamin D3 in rabbit duodenal brush-border membrane. Am. J. Physiol. 242, G533–G539 (1982).
  CAS PubMed Google Scholar
• Radanovic, T., Wagner, C. A., Murer, H. & Biber, J. Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G496–G500 (2005).
  Article CAS PubMed Google Scholar
• Xu, H., Bai, L., Collins, J. F. & Ghishan, F. K. Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)2 vitamin D3 . Am. J. Physiol. Cell Physiol. 282, C487–C493 (2002).
  Article CAS PubMed Google Scholar
• Coe, F. L. & Favus, M. J. Disorders of Bone and Mineral Metabolism, 2nd edn (Lippincott Williams & Wilkins, Philadelphia, 2002).
  Google Scholar
• Lang, F., Greger, R., Marchand, G. R. & Knox, F. G. Stationary microperfusion study of phosphate reabsorption in proximal and distal nephron segments. Pflugers Arch. 368, 45–48 (1977).
  Article CAS PubMed Google Scholar
• Villa-Bellosta, R. et al. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am. J. Physiol. Renal Physiol. 296, F691–F699 (2009).
  Article CAS PubMed Google Scholar
• Segawa, H. et al. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am. J. Physiol. Renal Physiol. 297, F671–F678 (2009).
  Article CAS PubMed Google Scholar
• Murer, H., Forster, I. & Biber, J. The sodium phosphate cotransporter family SLC34. Pflugers Arch. 447, 763–767 (2004).
  Article CAS PubMed Google Scholar
• Werner, A. et al. Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex. Proc. Natl Acad. Sci. USA 88, 9608–9612 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Busch, A. E. et al. Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. Proc. Natl Acad. Sci. USA 93, 5347–5351 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Virkki, L. V., Biber, J., Murer, H. & Forster, I. C. Phosphate transporters: a tale of two solute carrier families. Am. J. Physiol. Renal Physiol. 293, F643–F654 (2007).
  Article CAS PubMed Google Scholar
• Reimer, R. J. & Edwards, R. H. Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. Pflugers Arch. 447, 629–635 (2004).
  Article CAS PubMed Google Scholar
• Beck, L. et al. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc. Natl Acad. Sci. USA 95, 5372–5377 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Prie, D. et al. Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter. N. Engl. J. Med. 347, 983–991 (2002).
  Article CAS PubMed Google Scholar
• Virkki, L. V., Forster, I. C., Hernando, N., Biber, J. & Murer, H. Functional characterization of two naturally occurring mutations in the human sodium-phosphate cotransporter type IIa. J. Bone Miner. Res. 18, 2135–2141 (2003).
  Article CAS PubMed Google Scholar
• Lapointe, J. Y. et al. NPT2a gene variation in calcium nephrolithiasis with renal phosphate leak. Kidney Int. 69, 2261–2267 (2006).
  Article CAS PubMed Google Scholar
• Magen, D. et al. A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome. N. Engl. J. Med. 362, 1102–1109 (2010).
  Article CAS PubMed Google Scholar
• Kavanaugh, M. P. et al. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc. Natl Acad. Sci. USA 91, 7071–-7075 (1994).
• Miller, D. G. & Miller, A. D. A family of retroviruses that utilize related phosphate transporters for cell entry. J. Virol. 68, 8270–8276 (1994).
  CAS PubMed PubMed Central Google Scholar
• Tenenhouse, H. S., Roy, S., Martel, J. & Gauthier, C. Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney. Am. J. Physiol. 275, F527–F534 (1998).
  Article CAS PubMed Google Scholar
• Leung, J. C., Barac-Nieto, M., Hering-Smith, K. & Silverstein, D. M. Expression of the rat renal PiT-2 phosphate transporter. Horm. Metab. Res. 37, 265–269 (2005).
  Article CAS PubMed Google Scholar
• Nowik, M. et al. Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption. Pflugers Arch. 457, 539–549 (2008).
  Article CAS PubMed Google Scholar
• Breusegem, S. Y. et al. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency. Am. J. Physiol. Renal Physiol. 297, F350–F361 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Villa-Bellosta, R. & Sorribas, V. Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis. Pflugers Arch. 459, 499–508 (2010).
  Article CAS PubMed Google Scholar
• Moe, O. W. PiT-2 coming out of the pits. Am. J. Physiol. Renal Physiol. 296, F689–F690 (2009).
  Article CAS PubMed Google Scholar
• Forster, I. C., Loo, D. D. & Eskandari, S. Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters. Am. J. Physiol. 276, F644–F649 (1999).
  CAS PubMed Google Scholar
• Segawa, H. et al. Growth-related renal type II Na/Pi cotransporter. J. Biol. Chem. 277, 19665–19672 (2002).
  Article CAS PubMed Google Scholar
• Ravera, S., Virkki, L. V., Murer, H. & Forster, I. C. Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements. Am. J. Physiol. Cell Physiol. 293, C606–C620 (2007).
  Article CAS PubMed Google Scholar
• Berndt, T. & Kumar, R. Phosphatonins and the regulation of phosphate homeostasis. Annu. Rev. Physiol. 69, 341–359 (2007).
  Article CAS PubMed Google Scholar
• Miyamoto, K., Ito, M., Tatsumi, S., Kuwahata, M. & Segawa, H. New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter. Am. J. Nephrol. 27, 503–515 (2007).
  Article CAS PubMed Google Scholar
• Murer, H., Hernando, N., Forster, I. & Biber, J. Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol. Rev. 80, 1373–1409 (2000).
  Article CAS PubMed Google Scholar
• Cai, Q. et al. Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. N. Engl. J. Med. 330, 1645–1649 (1994).
  Article CAS PubMed Google Scholar
• Econs, M. J. & Drezner, M. K. Tumor-induced osteomalacia—unveiling a new hormone. N. Engl. J. Med. 330, 1679–1681 (1994).
  Article CAS PubMed Google Scholar
• Weidner, N. & Santa Cruz, D. Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer 59, 1442–1454 (1987).
  Article CAS PubMed Google Scholar
• ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat. Genet. 26, 345–348 (2000).
• Carpenter, T. O. et al. Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. J. Clin. Endocrinol. Metab. 90, 1012–1020 (2005).
  Article CAS PubMed Google Scholar
• Dobbie, H., Unwin, R. J., Faria, N. J. & Shirley, D. G. Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Nephrol. Dial. Transplant. 23, 730–733 (2008).
  Article CAS PubMed Google Scholar
• Berndt, T. et al. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J. Clin. Invest. 112, 785–794 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Shaikh, A., Berndt, T. & Kumar, R. Regulation of phosphate homeostasis by the phosphatonins and other novel mediators. Pediatr. Nephrol. 23, 1203–1210 (2008).
  Article PubMed PubMed Central Google Scholar
• Shimada, T. et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J. Bone Miner. Res. 19, 429–435 (2004).
  Article CAS PubMed Google Scholar
• Perwad, F., Zhang, M. Y., Tenenhouse, H. S. & Portale, A. A. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1-alpha-hydroxylase expression in vitro. Am. J. Physiol. Renal Physiol. 293, F1577–F1583 (2007).
  Article CAS PubMed Google Scholar
• Perwad, F. et al. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 146, 5358–5364 (2005).
  Article CAS PubMed Google Scholar
• Antoniucci, D. M., Yamashita, T. & Portale, A. A. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J. Clin. Endocrinol. Metab. 91, 3144–3149 (2006).
  Article CAS PubMed Google Scholar
• Nishida, Y. et al. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int. 70, 2141–2147 (2006).
  Article CAS PubMed Google Scholar
• Shimada, T. et al. FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem. Biophys. Res. Commun. 314, 409–414 (2004).
  Article CAS PubMed Google Scholar
• Shimada, T. et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl Acad. Sci. USA 98, 6500–6505 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Urakawa, I. et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770–774 (2006).
  Article CAS PubMed Google Scholar
• Farrow, E. G. & White, K. E. Recent advances in renal phosphate handling. Nat. Rev. Nephrol. 6, 207–217 (2010).
  Article PubMed PubMed Central Google Scholar
• Prie, D., Urena Torres, P. & Friedlander, G. Latest findings in phosphate homeostasis. Kidney Int. 75, 882–889 (2009).
  Article CAS PubMed Google Scholar
• Gaasbeek, A. & Meinders, A. E. Hypophosphatemia: an update on its etiology and treatment. Am. J. Med. 118, 1094–1101 (2005).
  Article CAS PubMed Google Scholar
• Young, J. A., Lichtman, M. A. & Cohen, J. Reduced red cell 2,3-diphosphoglycerate and adenosine triphosphate, hypophosphatemia, and increased hemoglobin-oxygen affinity after cardiac surgery. Circulation 47, 1313–1318 (1973).
  Article CAS PubMed Google Scholar
• Hettleman, B. D., Sabina, R. L., Drezner, M. K., Holmes, E. W. & Swain, J. L. Defective adenosine triphosphate synthesis. An explanation for skeletal muscle dysfunction in phosphate-deficient mice. J. Clin. Invest. 72, 582–589 (1983).
  Article CAS PubMed PubMed Central Google Scholar
• de Menezes Filho, H., de Castro, L. C. & Damiani, D. Hypophosphatemic rickets and osteomalacia. Arq. Bras. Endocrinol. Metabol. 50, 802–813 (2006).
  Article PubMed Google Scholar
• Hypophosphatemic rickets, X-linked dominant Online Mendelian Inheritance in Man [online].
• Winters, R. W., Graham, J. B., Williams, T. F., McFalls, V. W. & Burnett, C. H. A genetic study of familial hypophosphatemia and vitamin D resistant rickets with a review of the literature. Medicine (Baltimore) 37, 97–142 (1958).
  Article CAS Google Scholar
• Morgan, J. M., Hawley, W. L, Chenoweth, A. I., Retan, W. J. & Diethelm, A. G. Renal transplantation in hypophosphatemia with vitamin D-resistant rickets. Arch. Intern. Med. 134, 549–552 (1974).
  Article CAS PubMed Google Scholar
• Phosphate-regulating endopeptidase homolog, X-linked; PHEX Online Mendelian Inheritance in Man [online].
• HYP Consortium. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium. Nat. Genet. 11, 130–136 (1995).
• Guo, R. & Quarles, L. D. Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts. J. Bone Miner. Res. 12, 1009–1017 (1997).
  Article CAS PubMed Google Scholar
• Holm, I. A., Huang, X. & Kunkel, L. M. Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets. Am. J. Hum. Genet. 60, 790–797 (1997).
  CAS PubMed PubMed Central Google Scholar
• Dixon, P. H. et al. Mutational analysis of PHEX gene in X-linked hypophosphatemia. J. Clin. Endocrinol. Metab. 83, 3615–3623 (1998).
  CAS PubMed Google Scholar
• Filisetti, D. et al. Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues. Eur. J. Hum. Genet. 7, 615–619 (1999).
  Article CAS PubMed Google Scholar
• Bowe, A. E. et al. FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem. Biophys. Res. Commun. 284, 977–981 (2001).
  Article CAS PubMed Google Scholar
• Benet-Pages, A. et al. FGF23 is processed by proprotein convertases but not by PHEX. Bone 35, 455–462 (2004).
  Article CAS PubMed Google Scholar
• Liu, S. et al. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J. Biol. Chem. 278, 37419–37426 (2003).
  Article CAS PubMed Google Scholar
• Strom, T. M. & Juppner, H. PHEX, FGF23, DMP1 and beyond. Curr. Opin. Nephrol. Hypertens. 17, 357–362 (2008).
  Article CAS PubMed Google Scholar
• Hypophosphatemic rickets, Autosomal dominant; ADHR Online Mendelian Inheritance in Man [online].
• Bianchine, J. W., Stambler, A. A. & Harrison, H. E. Familial hypophosphatemic rickets showing autosomal dominant inheritance. Birth Defects Orig. Artic. Ser. 7, 287–295 (1971).
  CAS PubMed Google Scholar
• Riminucci, M. et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J. Clin. Invest. 112, 683–692 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Mirams, M., Robinson, B. G., Mason, R. S. & Nelson, A. E. Bone as a source of FGF23: regulation by phosphate? Bone 35, 1192–1199 (2004).
  Article CAS PubMed Google Scholar
• Shimada, T. et al. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am. J. Physiol. Renal Physiol. 289, F1088–F1095 (2005).
  Article CAS PubMed Google Scholar
• Larsson, T. et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145, 3087–3094 (2004).
  Article CAS PubMed Google Scholar
• Fibroblast growth factor 23; FGF23 Online Mendelian Inheritance in Man, [online].
• Gribaa, M. et al. An autosomal dominant hypophosphatemic rickets phenotype in a Tunisian family caused by a new FGF23 missense mutation. J. Bone Miner. Metab. 28, 111–115 (2009).
  Article PubMed Google Scholar
• Econs, M. J. & McEnery, P. T. Autosomal dominant hypophosphatemic rickets/osteomalacia: clinical characterization of a novel renal phosphate-wasting disorder. J. Clin. Endocrinol. Metab. 82, 674–681 (1997).
  Article CAS PubMed Google Scholar
• Hypophosphatemic rickets, autosomal recessive, 1; ARHR1 Online Mendelian Inheritance in Man, [online].
• Feng, J. Q. et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat. Genet. 38, 1310–1315 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Lorenz-Depiereux, B. et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat. Genet. 38, 1248–1250 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Dentin matrix acidic phosphoprotein 1; DMP1 Online Mendelian Inheritance in Man, [online].
• George, A., Sabsay, B., Simonian, P. A. & Veis, A. Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization. J. Biol. Chem. 268, 12624–12630 (1993).
  CAS PubMed Google Scholar
• George, A., Ramachandran, A., Albazzaz, M. & Ravindran, S. _DMP1_-a key regulator in mineralized matrix formation. J. Musculoskelet. Neuronal Interact. 7, 308 (2007).
  CAS PubMed Google Scholar
• Narayanan, K. et al. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J. Biol. Chem. 278, 17500–17508 (2003).
  Article CAS PubMed Google Scholar
• Levy-Litan, V. et al. Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene. Am. J. Hum. Genet. 86, 273–278 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Rutsch, F. et al. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat. Genet. 34, 379–381 (2003).
  Article CAS PubMed Google Scholar
• Hypophosphatemic rickets with hypercalciuria, hereditary; HHRH Online Mendelian Inheritance in Man, [online].
• Lorenz-Depiereux, B. et al. Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. Am. J. Hum. Genet. 78, 193–201 (2006).
  Article CAS PubMed Google Scholar
• Bergwitz, C. et al. SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. Am. J. Hum. Genet. 78, 179–192 (2006).
  Article CAS PubMed Google Scholar
• Solute carrier family 34 (sodium/phosphate cotransporter), member 3; SLC34A3 Online Mendelian Inheritance in Man, [online].
• Tieder, M. et al. Hereditary hypophosphatemic rickets with hypercalciuria. N. Engl. J. Med. 312, 611–617 (1985).
  Article CAS PubMed Google Scholar
• Tencza, A. L. et al. Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/type IIc sodium-phosphate cotransporter: presentation as hypercalciuria and nephrolithiasis. J. Clin. Endocrinol. Metab. 94, 4433–4438 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Kremke, B. et al. Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/NaPi-IIc can be masked by vitamin D deficiency and can be associated with renal calcifications. Exp. Clin. Endocrinol. Diabetes 117, 49–56 (2009).
  Article CAS PubMed Google Scholar
• Page, K., Bergwitz, C., Jaureguiberry, G., Harinarayan, C. V. & Insogna, K. A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3. Endocr. Pract. 14, 869–874 (2008).
  Article PubMed PubMed Central Google Scholar
• Tieder, M. et al. Elevated serum 1,25-dihydroxyvitamin D concentrations in siblings with primary Fanconi's syndrome. N. Engl. J. Med. 319, 845–849 (1988).
  Article CAS PubMed Google Scholar
• McCune-albright syndrome; MAS Online Mendelian Inheritance in Man, [online].
• Weinstein, L. S. et al. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N. Engl. J. Med. 325, 1688–1695 (1991).
  Article CAS PubMed Google Scholar
• Chapurlat, R. D. & Orcel, P. Fibrous dysplasia of bone and McCune-Albright syndrome. Best Pract. Res. Clin. Rheumatol. 22, 55–69 (2008).
  Article CAS PubMed Google Scholar
• Yamamoto, T. et al. The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome. J. Bone Miner. Metab. 23, 231–237 (2005).
  Article CAS PubMed Google Scholar
• Collins, M. T. et al. Renal phosphate wasting in fibrous dysplasia of bone is part of a generalized renal tubular dysfunction similar to that seen in tumor-induced osteomalacia. J. Bone Miner. Res. 16, 806–813 (2001).
  Article CAS PubMed Google Scholar
• Kobayashi, K. et al. Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. Life Sci. 78, 2295–2301 (2006).
  Article CAS PubMed Google Scholar
• Faroqui, S., Levi, M., Soleimani, M. & Amlal, H. Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. Kidney Int. 73, 1141–1150 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Ishiguro, M. et al. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene. Biochem. J. 427, 161–169 (2010).
  Article CAS PubMed Google Scholar