Clinical and pathological features of alcohol-related brain damage (original) (raw)

References

1. Lieber, C. S. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 34, 9–19 (2004).
   CAS PubMed Google Scholar
2. Hillbom, M., Juvela, S. & Karttunen, V. Mechanisms of alcohol-related strokes. Novartis Found. Symp. 216, 193–204 (1998).
   CAS PubMed Google Scholar
3. Victor, M., Adams, R. D. & Collins, G. H. The Wernicke–Korsakoff Syndrome and Related Neurologic Disorders due to Alcoholism and Malnutrition, 2nd edn (F. A. Davis, Philadelphia, 1989).
   Google Scholar
4. Zuccoli, G. et al. Neuroimaging findings in alcohol-related encephalopathies. AJR Am. J. Roentgenol. 195, 1378–1384 (2010).
   PubMed Google Scholar
5. Sullivan, E. V. & Pfefferbaum, A. Neuroimaging of the Wernicke–Korsakoff syndrome. Alcohol Alcohol. 44, 155–165 (2009).
   PubMed Google Scholar
6. Oscar-Berman, M. & Marinkovic, K. Alcoholism and the brain: an overview. Alcohol Res. Health 27, 125–133 (2003).
   PubMed PubMed Central Google Scholar
7. Harper, C. Thiamine (vitamin B1) deficiency and associated brain damage is still common throughout the world and prevention is simple and safe! Eur. J. Neurol. 13, 1078–1082 (2006).
   CAS PubMed Google Scholar
8. Burns, E. M. et al. Introduction of laparoscopic bariatric surgery in England: observational population cohort study. BMJ 341, c4296 (2010).
   PubMed Google Scholar
9. Thomson, A. D., Cook, C. C., Touquet, R. & Henry, J. A. The Royal College of Physicians report on alcohol: guidelines for managing Wernicke's encephalopathy in the accident and emergency department. Alcohol Alcohol. 37, 513–521 (2002).
   CAS PubMed Google Scholar
10. Sechi, G. & Serra, A. Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 6, 442–455 (2007).
    CAS PubMed Google Scholar
11. Thomson, A. D., Jeyasingham, M. D., Pratt, O. E. & Shaw, G. K. Nutrition and alcoholic encephalopathies. Acta Med. Scand. 717 (Suppl.), 55–65 (1987).
    CAS Google Scholar
12. Todd, K. G. & Butterworth, R. F. Early microglial response in experimental thiamine deficiency: an immunohistochemical analysis. Glia 25, 190–198 (1999).
    CAS PubMed Google Scholar
13. Lieber, C. S. Relationships between nutrition, alcohol use, and liver disease. Alcohol Res. Health 27, 220–231 (2003).
    PubMed PubMed Central Google Scholar
14. Thomson, A. D. Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke–Korsakoff syndrome. Alcohol Alcohol. 35 (Suppl.), 2–7 (2000).
    CAS Google Scholar
15. Martin, P. R., Singleton, C. K. & Hiller-Sturmhofel, S. The role of thiamine deficiency in alcoholic brain disease. Alcohol Res. Health 27, 134–142 (2003).
    PubMed PubMed Central Google Scholar
16. Galvin, R. et al. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur. J. Neurol. 17, 1408–1418 (2010).
    CAS PubMed Google Scholar
17. Harper, C. The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J. Neuropathol. Exp. Neurol. 57, 101–110 (1998).
    CAS PubMed Google Scholar
18. Butters, N. The Wernicke–Korsakoff syndrome: a review of psychological, neuropathological and etiological factors. Curr. Alcohol. 8, 205–232 (1981).
    CAS PubMed Google Scholar
19. Feinberg, I., Fein, G., Price, L. J., Jernigan, T. L. & Floyd, T. C. in Aging in the 1980s: Psychological Issues (ed. Poon, L. W.) 71–77 (American Psychological Association, Washington D. C., 1980).
    Google Scholar
20. Butters, N. & Brandt, J. in Recent Developments in Alcoholism Vol. 3 (ed. Galanter, M.) 207–226 (Plenum Publishing, New York, 1985).
    Google Scholar
21. Harper, C. G., Giles, M. & Finlay-Jones, R. Clinical signs in the Wernicke–Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J. Neurol. Neurosurg. Psychiatry 49, 341–345 (1986).
    CAS PubMed PubMed Central Google Scholar
22. Caine, D., Halliday, G. M., Kril, J. J. & Harper, C. G. Operational criteria for the classification of chronic alcoholics: identification of Wernicke's encephalopathy. J. Neurol. Neurosurg. Psychiatry 62, 51–60 (1997).
    CAS PubMed PubMed Central Google Scholar
23. Fama, R., Marsh, L. & Sullivan, E. V. Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome. J. Int. Neuropsychol. Soc. 10, 427–441 (2004).
    PubMed Google Scholar
24. Fama, R., Pfefferbaum, A. & Sullivan, E. V. Visuoperceptual priming in alcoholic Korsakoff syndrome. Alcohol. Clin. Exp. Res. 30, 680–687 (2006).
    PubMed Google Scholar
25. Sullivan, E. V., Deshmukh, A., Desmond, J. E., Lim, K. O. & Pfefferbaum, A. Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: relation to ataxia. Neuropsychology 14, 341–352 (2000).
    CAS PubMed Google Scholar
26. Kopelman, M. D., Thomson, A. D., Guerrini, I. & Marshall, E. J. The Korsakoff syndrome: clinical aspects, psychology and treatment. Alcohol Alcohol. 44, 148–154 (2009).
    PubMed Google Scholar
27. Oscar-Berman, M. & Ellis, R. J. Cognitive deficits related to memory impairments in alcoholism. Recent Dev. Alcohol. 5, 59–80 (1987).
    CAS PubMed Google Scholar
28. Dirksen, C. L., Howard, J. A., Cronin-Golomb, A. & Oscar-Berman, M. Patterns of prefrontal dysfunction in alcoholics with and without Korsakoff's syndrome, patients with Parkinson's disease, and patients with rupture and repair of the anterior communicating artery. Neuropsychiatr. Dis. Treat. 2, 327–339 (2006).
    PubMed PubMed Central Google Scholar
29. Oscar-Berman, M. in Review of NIAAA's Neuroscience and Behavioral Research Portfolio, NIAAA Research Monograph No. 34 (eds Noronha, A., Eckardt, M. & Warren, K.) 437–472 (NIH, Bethesda, 2000).
    Google Scholar
30. Giancola, P. R. & Moss, H. B. Executive cognitive functioning in alcohol use disorders. Recent Dev. Alcohol. 14, 227–251 (1998).
    CAS PubMed Google Scholar
31. Bates, M. E., Bowden, S. C. & Barry, D. Neurocognitive impairment associated with alcohol use disorders: implications for treatment. Exp. Clin. Psychopharmacol. 10, 193–212 (2002).
    CAS PubMed Google Scholar
32. Oscar-Berman, M. & Marinkovic, K. Alcohol: effects on neurobehavioral functions and the brain. Neuropsychol. Rev. 17, 239–257 (2007).
    PubMed PubMed Central Google Scholar
33. Sullivan, E. V., Harris, R. A. & Pfefferbaum, A. Alcohol's effects on brain and behavior. Alco. Res. Health 33, 127–143 (2010).
    Google Scholar
34. Green, A. et al. The effect of moderate to heavy alcohol consumption on neuropsychological performance as measured by the repeatable battery for the assessment of neuropsychological status. Alcohol. Clin. Exp. Res. 34, 443–450 (2010).
    PubMed Google Scholar
35. Bowden, S. C. Separating cognitive impairment in neurologically asymptomatic alcoholism from Wernicke–Korsakoff Syndrome: is the neuropsychological distinction justified? Psychol. Bull. 10 7, 355–366 (1990).
    Google Scholar
36. Squire, L. & Butters, N. (eds) Neuropsychology of Memory 2nd edn (Guilford Press, New York, 1992).
    Google Scholar
37. Pitel, A. L. et al. Episodic and working memory deficits in alcoholic Korsakoff patients: the continuity theory revisited. Alcohol. Clin. Exp. Res. 32, 1229–1241 (2008).
    PubMed Google Scholar
38. Sullivan, E. V. et al. Disruption of frontocerebellar circuitry and function in alcoholism. Alcohol. Clin. Exp. Res. 27, 301–309 (2003).
    PubMed Google Scholar
39. Pitel, A. L. et al. Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome. Neuropsychopharmacology 36, 580–588 (2011).
    PubMed Google Scholar
40. Victor, M., Adams, R. D. & Collins, G. H. The Wernicke–Korsakoff Syndrome (F. A. Davis, Philadelphia, 1971).
    Google Scholar
41. Harper, C. G. & Blumbergs, P. C. Brain weights in alcoholics. J. Neurol. Neurosurg. Psychiatry 45, 838–840 (1982).
    CAS PubMed PubMed Central Google Scholar
42. Skullerud, K. Variations in the size of the human brain. Influence of age, sex, body length, body mass index, alcoholism, Alzheimer changes, and cerebral atherosclerosis. Acta Neurol. Scand. 102, 1–94 (1985).
    CAS Google Scholar
43. Harper, C. G. & Kril, J. J. in Alcohol Induced Brain Damage: NIAAA Research Monograph No. 22 (eds Hunt, W. A. & Nixon, S. J.) 39–69 (NIH, Rockville, 1993).
    Google Scholar
44. Harper, C. G., Kril, J. J. & Holloway, R. L. Brain shrinkage in chronic alcoholics: a pathological study. Br. Med. J. 290, 501–504 (1985).
    CAS Google Scholar
45. De la Monte, S. M. Disproportionate atrophy of cerebral white matter in chronic alcoholics. Arch. Neurol. 45, 990–992 (1988).
    CAS PubMed Google Scholar
46. Harper, C. & Kril, J. J. Brain atrophy in chronic alcoholic patients: a quantitative pathological study. J. Neurol. Neurosurg. Psychiatry 48, 211–217 (1985).
    CAS PubMed PubMed Central Google Scholar
47. Kril, J. J. & Butterworth, R. F. Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease. Hepatology 26, 837–841 (1997).
    CAS PubMed Google Scholar
48. Phillips, S. C., Harper, C. G. & Kril, J. A quantitative histological study of the cerebellar vermis in alcoholic patients. Brain 110, 301–314 (1987).
    PubMed Google Scholar
49. Harper, C. G. & Kril, J. J. Corpus callosal thickness in alcoholics. Br. J. Addict. 83, 577–580 (1988).
    CAS PubMed Google Scholar
50. Tarnowska-Dziduszko, E., Bertrand, E. & Szpak, G. Morphological changes in the corpus callosum in chronic alcoholism. Folia Neuropathol. 33, 25–29 (1995).
    CAS PubMed Google Scholar
51. Lee, S. T., Jung, Y. M., Na, D. L., Park, S. H. & Kim, M. Corpus callosum atrophy in Wernicke's encephalopathy. J. Neuroimaging 15, 367–372 (2005).
    PubMed Google Scholar
52. Harper, C. et al. The pathophysiology of 'brain shrinkage' in alcoholics structural and molecular changes and clinical implications. Alcohol. Clin. Exp. Res. 29, 1106–1115 (2005).
    Google Scholar
53. Harding, A., Halliday, G., Caine, D. & Kril, J. Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia. Brain 12 3, 141–154 (2000).
    Google Scholar
54. Cullen, K. M., Halliday, G. M., Caine, D. & Kril, J. J. The nucleus basalis (Ch4) in the alcoholic Wernicke–Korsakoff syndrome: reduced cell number in both amnesic and non-amnesic patients. J. Neurol. Neurosurg. Psychiatry 63, 315–320 (1997).
    CAS PubMed PubMed Central Google Scholar
55. Baker, K., Harding, A., Halliday, G., Kril, J. & Harper, C. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy. Neuroscience 91, 429–438 (1999).
    CAS PubMed Google Scholar
56. Harper, C. & Kril, J. An introduction to alcohol-induced brain damage and its causes. Alcohol Alcohol. 2 (Suppl.), 237–243 (1994).
    CAS Google Scholar
57. Kril, J. J., Halliday, G. M., Svoboda, M. D. & Cartwright, H. The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79, 983–998 (1997).
    CAS PubMed Google Scholar
58. Harper, C. & Corbett, D. Changes in the basal dendrites of cortical pyramidal cells from alcoholic patients—a quantitative Golgi study. J. Neurol. Neurosurg. Psychiatry 53, 856–861 (1990).
    CAS PubMed PubMed Central Google Scholar
59. McMullen, P. A., Saint-Cyr, J. A. & Carlen, P. L. Morphological alterations in the rat CA1 hippocampal pyramidal cell dendrites resulting from chronic ethanol consumption and withdrawal. J. Comp. Neurol. 225, 111–118 (1984).
    CAS PubMed Google Scholar
60. Harding, A. J., Halliday, G. M., Ng, J. L., Harper, C. G. & Kril, J. J. Loss of vasopressin-immunoreactive neurons in alcoholics is dose-related and time-dependent. Neuroscience 72, 699–708 (1996).
    CAS PubMed Google Scholar
61. Harper, C., Dixon, G., Sheedy, D. & Garrick, T. Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 951–961 (2003).
    CAS PubMed Google Scholar
62. Harding, A. J., Wong, A., Svoboda, M., Kril, J. J. & Halliday, G. M. Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus 7, 78–87 (1997).
    CAS PubMed Google Scholar
63. Baker, K. G., Halliday, G. M., Kril, J. J. & Harper, C. G. Chronic alcoholics without Wernicke–Korsakoff syndrome or cirrhosis do not lose serotonergic neurons in the dorsal raphe nucleus. Alcohol. Clin. Exp. Res. 20, 61–66 (1996).
    CAS PubMed Google Scholar
64. Jernigan, T. L. et al. Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. Alcohol. Clin. Exp. Res. 15, 418–427 (1991).
    CAS PubMed Google Scholar
65. Sullivan, E. V. et al. In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics. Alcohol. Clin. Exp. Res. 23, 1629–1636 (1999).
    CAS PubMed Google Scholar
66. Sheedy, D., Lara, A., Garrick, T. & Harper, C. Size of mamillary bodies in health and disease: useful measurements in neuroradiological diagnosis of Wernicke's encephalopathy. Alcohol. Clin. Exp. Res. 23, 1624–1628 (1999).
    CAS PubMed PubMed Central Google Scholar
67. Shear, P. K., Sullivan, E. V., Lane, B. & Pfefferbaum, A. Mammillary body and cerebellar shrinkage in chronic alcoholics with and without amnesia. Alcohol. Clin. Exp. Res. 20, 1489–1495 (1996).
    CAS PubMed Google Scholar
68. Jernigan, T. L., Schafer, K., Butters, N. & Cermak, L. S. Magnetic resonance imaging of alcoholic Korsakoff patients. Neuropsychopharmacology 4, 175–186 (1991).
    CAS PubMed Google Scholar
69. Lenz, V. et al. Value of MRI findings in Gayet–Wernicke encephalopathy [French]. J. Neuroradiol. 29, 153–160 (2002).
    CAS PubMed Google Scholar
70. Pfefferbaum, A. et al. Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol. Clin. Exp. Res. 16, 1078–1089 (1992).
    CAS PubMed Google Scholar
71. Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H. & Lim, K. O. Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol. Clin. Exp. Res. 21, 521–529 (1997).
    CAS PubMed Google Scholar
72. Cardenas, V. A., Studholme, C., Gazdzinski, S., Durazzo, T. C. & Meyerhoff, D. J. Deformation-based morphometry of brain changes in alcohol dependence and abstinence. Neuroimage 34, 879–887 (2007).
    PubMed Google Scholar
73. Pfefferbaum, A. et al. Increase in brain cerebrospinal fluid volume is greater in older than in younger alcoholic patients: a replication study and CT/MRI comparison. Psychiatry Res. 50, 257–274 (1993).
    CAS PubMed Google Scholar
74. Pfefferbaum, A., Lim, K. O., Desmond, J. E. & Sullivan, E. V. Thinning of the corpus callosum in older alcoholic men: a magnetic resonance imaging study. Alcohol. Clin. Exp. Res. 20, 752–757 (1996).
    CAS PubMed Google Scholar
75. Estruch, R. et al. Atrophy of the corpus callosum in chronic alcoholism. J. Neurol. Sci. 146, 145–151 (1997).
    CAS PubMed Google Scholar
76. Sullivan, E. V. et al. Cerebellar volume deficits and neuropsychological function in alcoholics [abstract]. Alcohol. Clin. Exp. Res. 22, 63A (1998).
77. Agartz, I., Momenan, R., Rawlings, R. R., Kerich, M. J. & Hommer, D. W. Hippocampal volume in patients with alcohol dependence. Arch. Gen. Psychiatry 56, 356–363 (1999).
    CAS PubMed Google Scholar
78. Sullivan, E. V., Marsh, L., Mathalon, D. H., Lim, K. O. & Pfefferbaum, A. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics. Alcohol. Clin. Exp. Res. 19, 110–122 (1995).
    CAS PubMed Google Scholar
79. Blansjaar, B., Vielvoye, G., van Dijk, J. & Rijnders, R. Similar brain lesions in alcoholics and Korsakoff patients: MRI, psychometric and clinical findings. Clin. Neurol. Neurosurg. 93, 197–203 (1992).
    Google Scholar
80. O'Neill, J., Cardenas, V. A. & Meyerhoff, D. J. Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse. Alcohol. Clin. Exp. Res. 25, 1673–1682 (2001).
    CAS PubMed Google Scholar
81. Pfefferbaum, A., Adalsteinsson, E. & Sullivan, E. V. Dysmorphology and microstructural degradation of the corpus callosum: interaction of age and alcoholism. Neurobiol. Aging 27, 994–1009 (2006).
    CAS PubMed Google Scholar
82. Schroth, G., Naegele, T., Klose, U., Mann, K. & Petersen, D. Reversible brain shrinkage in abstinent alcoholics, measured by MRI. Neuroradiology 30, 385–389 (1988).
    CAS PubMed Google Scholar
83. Carlen, P. L., Wilkinson, D. A., Wortzman, G. & Holgate, R. Partially reversible cerebral atrophy and functional improvement in recently abstinent alcoholics. Can. J. Neurol. Sci. 11, 441–446 (1984).
    CAS PubMed Google Scholar
84. Schweinsburg, B. C. et al. Chemical pathology in brain white matter of recently detoxified alcoholics: a 1H magnetic resonance spectroscopy investigation of alcohol-associated frontal lobe injury. Alcohol. Clin. Exp. Res. 25, 924–934 (2001).
    CAS PubMed Google Scholar
85. Fein, G., Meyerhoff, D. J. & Weiner, M. W. Magnetic resonance spectroscopy of the brain in alcohol abuse. Alcohol Health Res. World 19, 3056–3314 (1995).
    Google Scholar
86. Jagannathan, N. R., Desai, N. G. & Raghunathan, P. Brain metabolite changes in alcoholism: An in vivo proton magnetic resonance spectroscopy (MRS) study. Magn. Reson. Imaging 14, 553–557 (1996).
    CAS PubMed Google Scholar
87. Seitz, D. et al. Localized proton magnetic resonance spectroscopy of the cerebellum in detoxifying alcoholics. Alcohol. Clin. Exp. Res. 2 3, 158–163 (1999).
    Google Scholar
88. Durazzo, T. C., Gazdzinski, S., Rothlind, J. C., Banys, P. & Meyerhoff, D. J. Brain metabolite concentrations and neurocognition during short-term recovery from alcohol dependence: preliminary evidence of the effects of concurrent chronic cigarette smoking. Alcohol. Clin. Exp. Res. 30, 539–551 (2006).
    CAS PubMed Google Scholar
89. Martin, P. R. et al. Brain proton magnetic resonance spectroscopy studies in recently abstinent alcoholics. Alcohol. Clin. Exp. Res. 19, 1078–1082 (1995).
    CAS PubMed Google Scholar
90. Bartsch, A. J. et al. Manifestations of early brain recovery associated with abstinence from alcoholism. Brain 130, 36–47 (2007).
    PubMed Google Scholar
91. Shear, P. K., Jernigan, T. L. & Butters, N. Volumetric magnetic resonance imaging quantification of longitudinal brain changes in abstinent alcoholics. Alcohol. Clin. Exp. Res. 18, 172–176 (1994).
    CAS PubMed Google Scholar
92. Pfefferbaum, A. et al. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol. Clin. Exp. Res. 19, 1177–1191 (1995).
    CAS PubMed Google Scholar
93. Gazdzinski, S., Durazzo, T. C. & Meyerhoff, D. J. Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence. Drug Alcohol Depend. 78, 263–273 (2005).
    CAS PubMed Google Scholar
94. Sullivan, E. V. & Marsh, L. Hippocampal volume deficits in alcoholic Korsakoff's syndrome. Neurology 61, 1716–1719 (2003).
    PubMed Google Scholar
95. Kim, E. et al. Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy. Brain 132, 369–376 (2009).
    PubMed Google Scholar
96. Schulte, T., Sullivan, E. V., Muller-Oehring, E. M., Adalsteinsson, E. & Pfefferbaum, A. Corpus callosal microstructural integrity influences interhemispheric processing: a diffusion tensor imaging study. Cereb. Cortex 15, 1384–1392 (2005).
    CAS PubMed Google Scholar
97. Pfefferbaum, A., Adalsteinsson, E. & Sullivan, E. V. Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women. Biol. Psychiatry 59, 364–372 (2006).
    PubMed Google Scholar
98. Pfefferbaum, A., Adalsteinsson, E. & Sullivan, E. V. Dysmorphology and microstructural degradation of the corpus callosum: interaction of age and alcoholism. Neurobiol. Aging 27, 994–1009 (2006).
    CAS PubMed Google Scholar
99. Sullivan, E. V. Compromised pontocerebellar and cerebellothalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism. Alcohol. Clin. Exp. Res. 27, 1409–1419 (2003).
    PubMed Google Scholar
100. Leiner, H. C., Leiner, A. L. & Dow, R. S. Cognitive and language functions of the human cerebellum. Trends Neurosci. 16, 444–447 (1993).
     CAS PubMed Google Scholar
101. Chanraud, S. et al. Diffusion tensor tractography in mesencephalic bundles: relation to mental flexibility in detoxified alcohol-dependent subjects. Neuropsychopharmacology 34, 1223–1232 (2009).
     PubMed Google Scholar
102. Zahr, N. M., Pitel, A. L., Chanraud, S. & Sullivan, E. V. Contributions of studies on alcohol use disorders to undrestanding cerebellar function. Neuropsychol. Rev. 20, 280–289 (2010).
     PubMed PubMed Central Google Scholar
103. Parks, M. H. et al. Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy. Alcohol. Clin. Exp. Res. 26, 1368–1380 (2002).
     CAS PubMed Google Scholar
104. Schmahmann, J. & Sherman, J. The cerebellar cognitive affective syndrome. Brain 121, 561–579 (1998).
     PubMed Google Scholar
105. Meyerhoff, D. J. Brain spectroscopic imaging, morphometry, and cognition in social drinkers and recovering alcoholics. Alcohol. Clin. Exp. Res. 29, 153–154 (2005).
     Google Scholar
106. Sullivan, E. V., Rosenbloom, M. J., Lim, K. O. & Pfefferbaum, A. Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: relationships to changes in brain structure. Neuropsychology 14, 178–188 (2000).
     CAS PubMed Google Scholar
107. Rosenbloom, M. J., Pfefferbaum, A. & Sullivan, E. V. Recovery of short-term memory and psychomotor speed but not postural stability with long-term sobriety in alcoholic women. Neuropsychology 1 8, 589–597 (2004).
     Google Scholar
108. Shatz, C. J. MHC class I: an unexpected role in neuronal plasticity. Neuron 64, 40–45 (2009).
     CAS PubMed PubMed Central Google Scholar
109. Luna-Medina, R. et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J. Neurosci. 27, 5766–5776 (2007).
     CAS PubMed PubMed Central Google Scholar
110. He, J. & Crews, F. T. Increased MCP-1 and microglia in various regions of the human alcoholic brain. Exp. Neurol. 210, 349–358 (2008).
     CAS PubMed Google Scholar
111. Barres, B. A. The mystery and magic of glia: a perspective on their roles in health and disease. Neuron 60, 430–440 (2008).
     CAS PubMed Google Scholar
112. Cook, C. C., Hallwood, P. M. & Thomson, A. D. B vitamin deficiency and neuropsychiatric syndromes in alcohol misuse. Alcohol Alcohol. 33, 317–336 (1998).
     CAS PubMed Google Scholar
113. Butterworth, R. F., Kril, J. J. & Harper, C. G. Thiamine-dependent enzyme changes in the brains of alcoholics—relationship to the Wernicke–Korsakoff syndrome. Alcohol. Clin. Exp. Res. 17, 1084–1088 (1993).
     CAS PubMed Google Scholar
114. Morgan, M. Y. Alcohol and nutrition. Br. Med. Bull. 38, 21–29 (1982).
     CAS PubMed Google Scholar
115. Tallaksen, C. M., Bøhmer, T. & Bell, H. Blood and serum thiamin and thiamin phosphate esters concentrations in patients with alcohol dependence syndrome before and after thiamin treatment. Alcohol. Clin. Exp. Res. 16, 320–325 (1992).
     CAS PubMed Google Scholar
116. Harper, C., Rodriguez, M., Gold, J. & Perdices, M. The Wernicke–Korsakoff syndrome in Sydney—a prospective necropsy study. Med. J. Aust. 149, 718 (1988).
     CAS PubMed Google Scholar
117. Blass, J. P. & Gibson, G. E. Abnormality of a thiamine-requiring enzyme in patients with Wernicke–Korsakoff syndrome. N. Engl. J. Med. 297, 1367–1370 (1977).
     CAS PubMed Google Scholar
118. Mukherjee, A. B. et al. Transketolase abnormality in cultured fibroblasts from familial chronic alcoholic men and their male offspring. J. Clin. Invest. 79, 1039–1043 (1987).
     CAS PubMed PubMed Central Google Scholar
119. Nixon, P. F., Kaczmarek, M. J., Tate, J., Kerr, R. A. & Price, J. An erythrocyte transketolase isoenzyme pattern associated with the Wernicke–Korsakoff syndrome. Eur. J. Clin. Invest. 14, 278–281 (1984).
     CAS PubMed Google Scholar
120. Coy, J. F. et al. Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes. Genomics 32, 309–316 (1996).
     CAS PubMed Google Scholar
121. Guerrini, I. et al. Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). Am. J. Med. Genet. B Neuropsychiatr. Genet. 137B, 17–19 (2005).
     PubMed Google Scholar
122. Loh, E. W. et al. Association between variants at the GABAAβ2, GABAAα6 and GABAAγ2 gene cluster and alcohol dependence in a Scottish population. Mol. Psychiatry 4, 539–544 (1999).
     CAS PubMed Google Scholar
123. Singleton, C. K. & Martin, P. R. Molecular mechanisms of thiamine utilization. Curr. Mol. Med. 1, 197–207 (2001).
     CAS PubMed Google Scholar
124. Liu, J. et al. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31, 1574–1582 (2006).
     CAS PubMed Google Scholar
125. Mayfield, R. D. et al. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J. Neurochem. 81, 802–813 (2002).
     CAS PubMed Google Scholar
126. Iwamoto, K. et al. Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. Neurosci. Res. 49, 379–385 (2004).
     CAS PubMed Google Scholar
127. Etheridge, N., Lewohl, J. M., Mayfield, R. D., Harris, R. A. & Dodd, P. R. Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain. Proteomics Clin. Appl. 3, 730–742 (2009).
     CAS PubMed PubMed Central Google Scholar
128. Sokolov, B. P., Jiang, L., Trivedi, N. S. & Aston, C. Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. J. Neurosci. Res. 72, 756–767 (2003).
     CAS PubMed Google Scholar
129. Weimbs, T. & Stoffel, W. Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP. Biochemistry 31, 12289–12296 (1992).
     CAS PubMed Google Scholar
130. Boison, D. & Stoffel, W. Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc. Natl Acad. Sci. USA 91, 11709–11713 (1994).
     CAS PubMed PubMed Central Google Scholar
131. Lewohl, J. M., Dodd, P. R., Mayfield, R. D. & Harris, R. A. Application of DNA microarrays to study human alcoholism. J. Biomed. Sci. 8, 28–36 (2001).
     CAS PubMed Google Scholar
132. Matsuda-Matsumoto, H., Iwazaki, T., Kashem, M. A., Harper, C. & Matsumoto, I. Differential protein expression profiles in the hippocampus of human alcoholics. Neurochem. Int. 51, 370–376 (2007).
     CAS PubMed Google Scholar
133. Alexander-Kaufman, K., Harper, C., Wilce, P. & Matsumoto, I. Cerebellar vermis proteome of chronic alcoholic individuals. Alcohol. Clin. Exp. Res. 31, 1286–1296 (2007).
     CAS PubMed Google Scholar
134. Alexander-Kaufman, K., Dedova, I., Harper, C. & Matsumoto, I. Proteome analysis of the dorsolateral prefrontal region from healthy individuals. Neurochem. Int. 51, 433–439 (2007).
     CAS PubMed Google Scholar
135. Alexander-Kaufman, K., James, G., Sheedy, D., Harper, C. & Matsumoto, I. Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Mol. Psychiatry 11, 56–65 (2006).
     CAS PubMed Google Scholar
136. Kashem, M. A., James, G., Harper, C., Wilce, P. & Matsumoto, I. Differential protein expression in the corpus callosum (splenium) of human alcoholics: a proteomics study. Neurochem. Int. 50, 450–459 (2007).
     CAS PubMed Google Scholar
137. Kashem, M. A., Harper, C. & Matsumoto, I. Differential protein expression in the corpus callosum (genu) of human alcoholics. Neurochem. Int. 53, 1–11 (2008).
     CAS PubMed Google Scholar
138. Lishman, W. A. Cerebral disorder in alcoholism: syndromes of impairment. Brain 1 04, 1–20 (1981).
     Google Scholar
139. Crabbe, J. C. Alcohol and genetics: new models. Am. J. Med. Genet. 114, 969–974 (2002).
     PubMed Google Scholar
140. Chen, Y. C. et al. Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet. Genomics 19, 588–599 (2009).
     CAS PubMed Google Scholar
141. Enoch, M. A. Genetic and environmental influences on the development of alcoholism: resilience vs. risk. Ann. NY Acad. Sci. 1094, 193–201 (2006).
     PubMed Google Scholar
142. Caspi, A. et al. Role of genotype in the cycle of violence in maltreated children. Science 297, 851–854 (2002).
     CAS PubMed Google Scholar
143. Foley, D. L. et al. Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder. Arch. Gen. Psychiatry 61, 738–744 (2004).
     CAS PubMed Google Scholar
144. Rangaswamy, M. et al. A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism. Neuroimage 21, 329–339 (2004).
     PubMed Google Scholar
145. Wiers, R. W., Sergeant, J. A. & Gunning, W. B. Psychological mechanisms of enhanced risk of addiction in children of alcoholics: a dual pathway? Acta Paediatr. Suppl. 40 4, 9–13 (1994).
     Google Scholar
146. Whipple, S. C. & Noble, E. P. Personality characteristics of alcoholic fathers and their sons. J. Stud. Alcohol 52, 331–337 (1991).
     CAS PubMed Google Scholar
147. Blum, K. et al. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J. Psychoactive Drugs 32 (Suppl. i–iv), 1–112 (2000).
     Google Scholar
148. Mathalon, D. H., Pfefferbaum, A., Lim, K. O., Rosenbloom, M. J. & Sullivan, E. V. Compounded brain volume deficits in schizophrenia–alcoholism comorbidity. Arch. Gen. Psychiatry 60, 245–252 (2003).
     PubMed Google Scholar
149. Sullivan, E. V. et al. Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. Arch. Gen. Psychiatry 57, 894–902 (2000).
     CAS PubMed Google Scholar
150. Krystal, J. H. et al. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. Neurotox. Res. 10, 235–252 (2006).
     CAS PubMed Google Scholar
151. Cargiulo, T. Understanding the health impact of alcohol dependence. Am. J. Health Syst. Pharm. 64, S5–S11 (2007).
     PubMed Google Scholar
152. Ceballos, N. A., Nixon, S. J., Phillips, J. A. & Tivis, R. Semantic processing in alcoholics with and without antisocial symptomatology. J. Stud. Alcohol 64, 286–291 (2003).
     PubMed Google Scholar
153. Grant, B. F. et al. Co-occurrence of 12-month alcohol and drug use disorders and personality disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch. Gen. Psychiatry 61, 361–368 (2004).
     PubMed Google Scholar
154. Kessler, R. C., Chiu, W. T., Demler, O., Merikangas, K. R. & Walters, E. E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch. Gen. Psychiatry 62, 617–627 (2005).
     PubMed PubMed Central Google Scholar
155. New South Wales Tissue Resource Centre. 'Brain Bank' [online], (2010).
156. Harper, C. et al. How important are brain banks for alcohol research? Alcohol. Clin. Exp. Res. 27, 310–323 (2003).
     PubMed Google Scholar
157. Pfefferbaum, A., Sullivan, E. V., Adalsteinsson, E., Garrick, T. & Harper, C. Postmortem MR imaging of formalin-fixed human brain. Neuroimage 21, 1585–1595 (2004).
     PubMed Google Scholar
158. Dedova, I. et al. The importance of brain banks for molecular neuropathological research: the New South Wales Tissue Resource Centre experience. Int. J. Mol. Sci. 10, 366–384 (2009).
     CAS PubMed PubMed Central Google Scholar
159. Garrick, T., Azizi, L., Merrick, J. & Harper, C. Brain donation for research, what do people say? Intern. Med. J. 33, 475 (2003).
     CAS PubMed Google Scholar
160. Glaw, X. M. et al. Brain donation: who and why? Cell Tissue Bank 10, 241–246 (2009).
     PubMed Google Scholar
161. Fein, G. & Landman, B. Treated and treatment-naive alcoholics come from different populations. Alcohol 35, 19–26 (2005).
     PubMed Google Scholar
162. Nakamura, K. et al. Acetaldehyde adducts in the brain of alcoholics. Arch. Toxicol. 77, 591–593 (2003).
     CAS PubMed Google Scholar
163. Bora, P. S. & Lange, L. G. Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esters. Alcohol. Clin. Exp. Res. 1 7, 28–30 (1993).
     Google Scholar
164. Coyle, J. T. & Puttfarcken, P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689–695 (1993).
     CAS PubMed Google Scholar
165. Tsai, G. E. et al. Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal. Am. J. Psychiatry 155, 726–732 (1998).
     CAS PubMed Google Scholar
166. Ikegami, Y. et al. Increased TUNEL positive cells in human alcoholic brains. Neurosci. Lett. 349, 201–205 (2003).
     CAS PubMed Google Scholar
167. Brooks, P. J. Brain atrophy and neuronal loss in alcoholism: a role for DNA damage? Neurochem. Int. 37, 403–412 (2000).
     CAS PubMed Google Scholar
168. Climent, E., Pascual, M., Renau-Piqueras, J. & Guerri, C. Ethanol exposure enhances cell death in the developing cerebral cortex: role of brain-derived neurotrophic factor and its signaling pathways. J. Neurosci. Res. 68, 213–225 (2002).
     CAS PubMed Google Scholar
169. Fadda, F. & Rossetti, Z. L. Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Prog. Neurobiol. 56, 385–431 (1998).
     CAS PubMed Google Scholar
170. Butterworth, R. F. Hepatic encephalopathy—a serious complication of alcoholic liver disease. Alcohol Res. Health 27, 143–145 (2003).
     PubMed PubMed Central Google Scholar
171. Felipo, V. & Butterworth, R. F. Neurobiology of ammonia. Prog. Neurobiol. 67, 259–279 (2002).
     CAS PubMed Google Scholar
172. Zahr, N. M. et al. Glutamate and glutamine changes induced by ethanol treatment in the rat brain detectable at 3T. In Proc. ISMRM 18 th Annual Meeting 917 (Stockholm, Sweden, 2010).
     Google Scholar
173. Mousseau, D. D., Perney, P., Layrargues, G. P. & Butterworth, R. F. Selective loss of pallidal dopamine D2 receptor density in hepatic encephalopathy. Neurosci. Lett. 162, 192–196 (1993).
     CAS PubMed Google Scholar
174. Donaldson, J., LaBella, F. S. & Gesser, D. Enhanced autoxidation of dopamine as a possible basis of manganese neurotoxicity. Neurotoxicology 2, 53–64 (1981).
     CAS PubMed Google Scholar
175. Niemela, O. et al. Antibodies against acetaldehyde-modified protein epitopes in human alcoholics. Hepatology 7, 1210–1214 (1987).
     CAS PubMed Google Scholar
176. Albano, E. Alcohol, oxidative stress and free radical damage. Proc. Nutr. Soc. 65, 278–290 (2006).
     CAS PubMed Google Scholar
177. Yokoyama, H. et al. Experimental hepatitis induced by ethanol after immunization with acetaldehyde adducts. Hepatology 1 7, 14–19 (1993).
     Google Scholar
178. Horner, M., Behrens, U. J., Worner, T. & Lieber, C. S. Humoral immune response to acetaldehyde adducts in alcoholic patients. Res. Comm. Chem. Pathol. Pharmacol. 54, 3–12 (1996).
     Google Scholar
179. Qin, L. et al. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J. Neuroinflammation 5, 10 (2008).
     PubMed PubMed Central Google Scholar
180. Crews, F. T. & Nixon, K. Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol Alcohol. 44, 115–127 (2009).
181. Phillips, S. C. Cytoprotective value of lysine, penicillamine, and pyridoxal phosphate against the neurotoxicity of acetaldehyde. Toxicol. Appl. Pharmacol. 98, 553–560 (1989).
     CAS PubMed Google Scholar
182. Butterworth, R. F. Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. Metab. Brain Dis. 10, 1–8 (1995).
     CAS PubMed Google Scholar

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