IL-17 as a future therapeutic target for rheumatoid arthritis (original) (raw)

• Yao, Z. et al. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155, 5483–5486 (1995).
  CAS PubMed Google Scholar
• Rouvier, E., Luciani, M. F., Mattei, M. G., Denizot, F. & Golstein, P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpes virus saimiri gene. J. Immunol. 150, 5445–5456 (1993).
  CAS PubMed Google Scholar
• Miossec, P. Interleukin-17 in fashion, at last: ten years after its description, its cellular source has been identified. Arthritis Rheum. 56, 2111–2115 (2007).
  Article CAS Google Scholar
• Fossiez, F. et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 183, 2593–2603 (1996).
  Article CAS Google Scholar
• Kolls, J. K. & Lindén, A. Interleukin-17 family members and inflammation. Immunity 21, 467–476 (2004).
  Article CAS Google Scholar
• Iwakura, Y., Nakae, S., Saijo, S. & Ishigame, H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol. Rev. 226, 57–79 (2008).
  Article CAS Google Scholar
• Kotake, S. et al. IL-17 in synovial fluids from patients with RA is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103, 1345–1352 (1999).
  Article CAS Google Scholar
• Koenders, M. I. et al. Induction of cartilage damage by overexpression of T cell IL-17A in experimental arthritis in mice deficient in IL-1. Arthritis Rheum. 52, 975–983 (2005).
  Article CAS Google Scholar
• Gaffen, S. L. An overview of IL-17 function and signaling. Cytokine 43, 402–407 (2008).
  Article CAS Google Scholar
• Toy, D. et al. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J. Immunol. 177, 36–39 (2006).
  Article CAS Google Scholar
• Maitra, A. et al. Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc. Natl Acad. Sci. USA 104, 7507–7511 (2007).
  Article Google Scholar
• Zrioual, S. et al. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J. Immunol. 180, 655–663 (2008).
  Article CAS Google Scholar
• Aarvak, T., Chabaud, M., Miossec, P. & Natvig, J. B. IL-17 is produced by some proinflammatory TH1/TH0 cells but not by TH2 cells. J. Immunol. 162, 1246–1251 (1999).
  CAS PubMed Google Scholar
• Harrington, L. E. et al. IL-17 producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123–1132 (2005).
  Article CAS Google Scholar
• Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M. & Murphy, K. M. TH17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24, 677–688 (2006).
  Article CAS Google Scholar
• Bettelli, E., Korn, T., Oukka, M. & Kuchroo, V. K. Induction and effector functions of TH17 cells. Nature 453, 1051–1057 (2008).
  Article CAS Google Scholar
• Ivanov, B. S. et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121–1133 (2006).
  Article CAS Google Scholar
• Aggarwal, S., Ghilardi, N., Xie, M. H., de Sauvage, F. J. & Gurney, A. L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278, 1910–1914 (2003).
  Article CAS Google Scholar
• Liang, S. C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by TH17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271–2279 (2006).
  Article CAS Google Scholar
• Geboes, L. et al. Proinflammatory role of the TH17 cytokine IL-22 in collagen-induced arthritis in C57Bl/6 mice. Arthritis Rheum. 60, 390–395 (2009).
  Article CAS Google Scholar
• Lubberts, E. et al. IL-1 independent role of IL-17 in synovial inflammation and joint destruction during collagen induced arthritis. J. Immunol. 167, 1004–1013 (2001).
  Article CAS Google Scholar
• Miossec, P. Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum. 48, 594–601 (2003).
  Article CAS Google Scholar
• Sato, K. et al. TH17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203, 2673–2682 (2006).
  Article CAS Google Scholar
• Koenders, M. I., Joosten, L. A. & van den Berg, W. B. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relations to tumour necrosis factor and IL-1 in experimental arthritis. Ann. Rheum. Dis. 65 (Suppl. 3), iii29–iii33 (2006).
  PubMed PubMed Central Google Scholar
• Koenders, M. I. et al. Interleukin-17 acts independently of TNF-α under arthritic conditions. J. Immunol. 176, 6262–6269 (2006).
  Article CAS Google Scholar
• Nakae, S., Nambu, A., Sudo, K. & Iwakura, Y. Suppression of immune induction of collagen-induced arthritis in Il-17 deficient mice. J. Immunol. 171, 6173–6177 (2003).
  Article CAS Google Scholar
• Bush, K. A., Farmer, K. M., Walker, J. S. & Kirkham, B. W. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with IL-17 receptor IgG1 Fc fusion protein. Arthritis Rheum. 46, 802–805 (2002).
  Article CAS Google Scholar
• Lubberts, E. et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen induced arthritis reduces joint inflammation, cartilage destruction and bone erosion. Arthritis Rheum. 50, 650–659 (2004).
  Article CAS Google Scholar
• Koenders, M. I. et al. Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1. Am. J. Pathol. 167, 141–149 (2005).
  Article CAS Google Scholar
• Abdollahi-Roodsaz, S. et al. Shift from Toll-like receptor 2 (TLR2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production. Arthritis Rheum. 58, 3753–3764 (2008).
  Article CAS Google Scholar
• Ogura, H. et al. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29, 628–636 (2008).
  Article CAS Google Scholar
• Iwakura, Y. & Ishigame, H. The IL-23/IL-17 axis in inflammation. J. Clin. Invest. 116, 1218–1222 (2006).
  Article CAS Google Scholar
• Hirota, K. et al. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ TH cells that cause autoimmune arthritis. J. Exp. Med. 204, 41–47 (2007).
  Article CAS Google Scholar
• Nakae, S. et al. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc. Natl Acad. Sci. USA 100, 5986–5990 (2003).
  Article CAS Google Scholar
• Koenders, M. I. et al. IL-1 drives pathogenic TH17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum. 58, 3461–3470 (2008).
  Article CAS Google Scholar
• Abdollahi-Roodsaz, S. et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J. Clin. Invest. 118, 205–216 (2008).
  Article CAS Google Scholar
• Abdollahi-Roodsaz, S. et al. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum. 56, 2957–2967 (2007).
  Article CAS Google Scholar
• Chabaud, M. et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 42, 963–970 (1999).
  Article CAS Google Scholar
• Chabaud, M. & Miossec, P. The combination of tumor necrosis factor-α blockade with interleukin-1 and interleukin-17 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo model. Arthritis Rheum. 44, 1293–1303 (2001).
  Article CAS Google Scholar
• Chabaud, M., Lubberts, E., Joosten, L., van den Berg, W. B. & Miossec, P. IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res. 3, 168–177 (2001).
  Article CAS Google Scholar
• Andersson, M. K. et al. Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prothesis and from osteoarthritis patients. Arthritis Res. Ther. 9, R18 (2007).
  Article Google Scholar
• Annunziato, F. et al. Phenotypic and functional features of human TH17 cells. J. Exp. Med. 204, 1849–1861 (2007).
  Article CAS Google Scholar
• Wei, G. et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155–167 (2009).
  Article Google Scholar
• Lee, Y. K. et al. Late developmental plasticity in the T helper 17 lineage. Immunity 30, 92–107 (2009).
  Article CAS Google Scholar
• Martin-Orozco, N., Chung, Y., Chang, S. H., Wang, Y. H. & Dong, C. TH17 cells promote pancreatic inflammation but only induces diabetes efficiently in lymphopenic hosts after conversion into TH1 cells. Eur. J. Immunol. 39, 216–224 (2009).
  Article CAS Google Scholar
• Bending, D. et al. Highly purified TH17 cells from BDC2.5NOD mice convert into TH1-like cells in NOD/SCID recipient mice. J. Clin. Invest. 119, 565–572 (2009).
  Article CAS Google Scholar
• Kirkham, B. W. et al. Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort). Arthritis Rheum. 54, 1122–1131 (2006).
  Article CAS Google Scholar
• Raza, K. et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal origin. Arthritis Res. Ther. 7, R784–R795 (2005).
  Article CAS Google Scholar
• Yamada, H. et al. TH1 but not TH17 cells predominate in the joints of patients with rheumatoid arthritis. Ann. Rheum. Dis. 67, 1299–1304 (2008).
  Article CAS Google Scholar
• Pène, J. et al. Chronically inflamed human tissues are infiltrated by highly differentiated TH17 lymphocytes. J. Immunol. 180, 7423–7430 (2008).
  Article Google Scholar
• Nishala, K. et al. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 58, 875–887 (2008).
  Article Google Scholar
• Shahrara, S., Huang, Q. Q., Mandelin, A. M. & Pope, R. M. TH17 cells in rheumatoid arthritis. Arthritis Res. Ther. 10, R93 (2008).
  Article Google Scholar
• Evans, H. G. et al. In vivo activated monocytes from the site of inflammation in humans specifically promote TH17 responses. Proc. Natl Acad. Sci. USA 106, 6232–6237 (2009).
  Article CAS Google Scholar
• Egan, P. J., van Nieuwenhuijzen, A., Campbell, I. K. & Wicks, I. P. Promotion of the local differentiation of murine TH17 cells by synovial macrophages during acute inflammatory arthritis. Arthritis Rheum. 58, 3720–3729 (2008).
  Article CAS Google Scholar
• Peng, M. Y. et al. Interleukin-17 producing γδ T cells increased in patients with active pulmonary tuberculosis. Cell. Mol. Immunol. 5, 203–208 (2008).
  Article Google Scholar
• Roark, C. L., Simonian, P. L., Fontenot, A. P., Born, W. K. & O'Brien, R. L. γδ T cells: an important source of IL-17. Curr. Opin. Immunol. 20, 353–357 (2008).
  Article CAS Google Scholar
• Michel, M. L. et al. Critical role of ROR-γt in a new thymic pathway leading to IL-17 producing invariant NKT cell differentiation. Proc. Natl Acad. Sci. USA 105, 19845–19850 (2008).
  Article CAS Google Scholar
• Takahashi, N. et al. IL-17 produced by Paneth cells drives TNF-induced shock. J. Exp. Med. 8, 1755–1761 (2008).
  Article Google Scholar
• Ishigame, H. et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30, 108–119 (2009).
  Article CAS Google Scholar
• Milner, J. D. et al. Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452, 773–776 (2008).
  Article CAS Google Scholar
• Luger, D. et al. Either a TH17 or a TH1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 205, 1517–1522 (2008).
  Article Google Scholar
• Doodes, P. D. et al. Development of proteoglycan-induced arthritis is independent of IL-17. J. Immunol. 181, 329–337 (2008).
  Article CAS Google Scholar
• Van den Berg, W. B., van Lent, P. L., Joosten, L. A., Abdollahi-Roodsaz, S. & Koenders, M. I. Amplifying elements of arthritis and joint destruction. Ann. Rheum. Dis. 66 (Suppl. 3), iii45–iii48 (2007).
  CAS PubMed PubMed Central Google Scholar
• Ivanov, S. & Linden, A. Interleukin-17 as drug target in human disease. Trends Pharmacol. Sci. 30, 95–103 (2009).
  Article CAS Google Scholar
• Miossec, P. Diseases that may benefit from manipulating the TH17 pathway. Eur. J. Immunol. 39, 667–669 (2009).
  Article CAS Google Scholar
• Durez, P. et al. AIN457, an anti-IL-17 antibody, shows good safety and induces clinical responses in patients with active rheumatoid arthritis (RA) despite methotrexate therapy in a randomized, double-blind, proof-of-concept trial [abstract LB0002]. Ann. Rheum. Dis. 68 (Suppl. 3), 125 (2009).
  Google Scholar
• Sloan-Lancaster, J., Genovese, M. C., Roberson, S. A. & van den Bosch, F. Safety, tolerability and evidence of efficacy of intravenous LY2439821 in patients with rheumatoid arthritis receiving background oral DMARDs [abstract OP-0160]. Ann. Rheum. Dis. 68 (Suppl. 3), 123 (2009).
  Google Scholar
• Firestein, G. S. Evolving concepts of rheumatoid arthritis. Nature 423, 356–361 (2003).
  Article CAS Google Scholar