Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor (original) (raw)

References

  1. Hardingham, T.E., Fosang, A.J. & Dudhia, J. Aggrecan — the chondroitin sulfate keratin sulfate proteoglycan from cartilage. in Articular Cartilage and Osteoarthritis (Eds Kuettner, K. et al. 5–20 (Raven, N.Y., 1992).
    Google Scholar
  2. Murphy, G.J.P., Murphy, G. & Reynolds, J.J. The origin of matrix metalloproteinases and their familail relationships. FEES Lett. 289, 4–7 (1991).
    Article CAS Google Scholar
  3. Docherty, A.J.P., OConnell, J., Crabbe, T., Angal, S. & Murphy, G. The matrix metalloproteinases and their natural inhibitors—prospects for treating degenerative tissue diseases.. Trends Biotech. 10, 200–207 (1992).
    Article CAS Google Scholar
  4. Johnson, W.H., Roberts, N.A. & Borkakoti, N. Collagenase inhibitors : their design and potential therapeutic use J. Enzyme Inhib. 2, 1–22 (1987).
    Article CAS Google Scholar
  5. Murphy, G., Docherty, A.J.P., Hembry, R.M. & Reynolds, J.J. Metalloproteinases and tissue damage. British J. Rheum. 30(Suppl 1), 25–31 (1991).
    Article Google Scholar
  6. Murphy, G., Hembry, R.M., Hughes, C.E., Fosang, A.J. & Hardingham, T.E. Role and regulation of metalloproteinases in connective tissue turnover. Biochem. Soc. Trans. 18, 812–815 (1990).
    Article CAS Google Scholar
  7. Bode, W., Gomis-Ruth, F.X., Huber, R., Zwilling, R. & Stacker, W. Structure of asatcin and implications for activation of astacins and zinc-ligation of collagenase. Nature 358, 164–167 (1992).
    Article CAS Google Scholar
  8. Hunt-Lois, T., Barker, W.C. & Chen, H.R. A domain structure common to hemopexin, vitronectin, interstitial collagenase and a collagenase homolog. Prot. Seq. Data Anal. 1, 21–26 (1987).
    Google Scholar
  9. Sanchez-Lopez, R., Alexander, C.M., Behrendtsen, O., Behrendtsen, R. & Werb, Z. Role of zinc-binding-encoded and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins. J. biol. Chem. 268, 7238–7247 (1993).
    CAS PubMed Google Scholar
  10. Clark, I.N. & Cawston, T.E. Fragments of human fibroblast collagenase-purification and characterisation. Biochem. J. 263, 201–206 (1989).
    Article CAS Google Scholar
  11. Windsor, L.J., Birkedal-Hansen, H., Birkedal-Hansen, B. & Engler, J.A. An internal cysteine plays a role in maintenance of the latency of human fibroblast collagenase. Biochemistry 30, 641–647 (1991).
    Article CAS Google Scholar
  12. Lowry, C.L., McGeehan, G. & LeVine, H. Metal ion stabilisation of the conformation of a recombinant 19-kDa catalytic fragment of fibroblast collagenase. Proteins 12, 42–48 (1992).
    Article CAS Google Scholar
  13. Schnierer, S., Kleine, T., Gote, T., Hillemann, A., Knauper, V. & Tschesche, H. The recombinant catalytic domain of human neutrophil collaganase lacks type -I collagen substrate specificity. Biochem. biophy. Res. Comm. 191, 319–326 (1993).
    Article CAS Google Scholar
  14. Gomis-Ruth, F.X., Stacker, W., Huber, R., Zwilling, R. & Bode, W. Refined 1.8 angstrøm x-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish astacus-astacus—structure determination, refinement, molecular-structure and comparison with thermolysin. J. molec. Biol. 229, 945–968 (1993).
    Article CAS Google Scholar
  15. Matthews, B.W., Jansonious, J.N., Colman, P.M., Schoenborn, B.P. & Dupourque, D. Three dimensional structure of thermolysin. Nature 238, 37–41 (1972).
    Article CAS Google Scholar
  16. Thayer, M.M., Flaherty, K.M. & McKay, D.B. Three dimensional structure of pseudomonas-aeruginosa at 1.5 angstrøm resolution. J. molec. Biol. 266, 2864–2871 (1991).
    CAS Google Scholar
  17. Vallee, B.L. & Auld, D.S. Zinc coordination function and structure of zinc enzymes and proteins. Biochemistry 29, 5647–5659 (1990).
    Article CAS Google Scholar
  18. Jiang, W. & Bond, J.S. Families of metallopeptidases and their relationships. FEBS Lett. 312, 110–114 (1992).
    Article CAS Google Scholar
  19. Vallee, B.L. & Auld, D.S. Active site zinc ligands and activated waters of zinc enzymes. Proc. natn. Acad. Sci. U.S.A. 87, 220–224 (1990).
    Article CAS Google Scholar
  20. Springman, E.B., Angelton, E.L., Birkedal-Hansen, H. & Van Wart, H. Multiple modes of activation of latent human fibroblast collagenase-evidence for the role of a cys-73 active site zinc complex in latency and a cysteine switch mechanism. Proc. natn. Acad. Sci. U.S.A. 87, 364–368 (1990).
    Article CAS Google Scholar
  21. Monzingo, A.F. & Matthews, B.W. Structure of a mercaptan thermolysin complex illustrates mode of inhibition of zinc proteases by substrate analog mercaptans. Biochemistry 21, 33–90 (1982).
    Article Google Scholar
  22. Holden, H.M., Tronrud, D.S., Monzingo, A.F., Weaver, L.H. & Matthews, B.W. Slow-binding and fast-binding inhibitors of thermolysin display different modes of binding—crystallographic analysis of extended phosphonamidate transition state analogs. Biochemistry 26, 8524–8553 (1987).
    Article Google Scholar
  23. Kabsch, W. Evaluation of single-crystal X-ray diffraction data from a position sensitive detector. J. appl. Crystallogr. 21, 916–924 (1988).
    Article CAS Google Scholar
  24. Jones, T.A. A graphics model building and refinement system for macromolecules. J. appl. Crystallogr. 11, 268–272 (1978).
    Article CAS Google Scholar
  25. Brunger, A.T., Karplus, M. & Petsko, G.A. Crystallographic refinement by simulated annealing-application to crambin. Acta Crystallogr. 45, 50–61 (1989).
    Article Google Scholar
  26. Gerber, P.R. Peptide mechanics-a force field for peptides and proteins working with entire residues as the smallest units. Biopolymers 32, 1003–1017 (1992).
    Article CAS Google Scholar
  27. Collier, I.E. et al. H-ras oncogene-transformed human bronchial epitheliail-cells (tbe-l)secrete a single metalloprotease capable of degrading basement-membrane collagen. J. biol. Chem. 263, 6579–6587 (1988).
    CAS Google Scholar
  28. Carson, M. Ribbon models of macromolecules J. molec. Graphics 5, 103–106 (1987).
    Article CAS Google Scholar
  29. Kabsh, W. A solution for the best rotation to relate two sets of vectors. Acta Crystallogr. A32, 922–923 (1976).
    Article Google Scholar

Download references