Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors (original) (raw)

• Baba, M. et al. Highly specific inhibition of human immunodeficiency virus type-1 by a novel 6-substituted acyclouridine derivative. Biochem. biophys. Res. Commun. 165, 1375–1381 (1989).
  Article CAS Google Scholar
• Pauwels, R. et al. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature 343, 470–474 (1990).
  Article CAS Google Scholar
• Merluzzi, V.J. et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science 250, 1411–1413 (1990).
  Article CAS Google Scholar
• De Clercq, E. HIV-1-specific RT inhibitors: highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase. Med. Res. Rev. 13, 229–258 (1993).
  Article CAS Google Scholar
• Wu, J.C. et al. A novel dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a non-substrate binding site. Biochemistry 30, 2022–2026 (1991).
  Article CAS Google Scholar
• Debyser, Z. et al. An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5 1-jk][1,4] benzodiazepin-2(1H)-oneand -thione derivatives. Proc. natn. Acad. Sci. U.S.A. 88, 1451–1455 (1991).
  Article CAS Google Scholar
• Kohlstaedt, L.A., Wang, J., Friedman, J.M., Rice, P.A. & Steitz, T.A. Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256, 1783–1790 (1992).
  Article CAS Google Scholar
• Smerdon, S.J. et al. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficency virus type 1. Proc. natn. Acad. Sci. U.S.A. 91, 3911–3915 (1994).
  Article CAS Google Scholar
• Ren, J.S. et al. High resolution structure of HIV-1 RT: insights from four RT-inhibitor complexes. Nature struct. Biol. 2, 293–302 (1995).
  Article CAS Google Scholar
• Tantillo, C. et al. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. J. molec. Biol. 243, 369–387 (1994).
  Article CAS Google Scholar
• Stammers, O.K. et al. Crystals of HIV-1 reverse transcriptase diffracting to 2.2 Å resolution. J. molec. Biol. 242, 586–588 (1994).
  Article CAS Google Scholar
• Debyser, Z. et al. Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds. Molec. Pharmacol. 41, 203–208 (1992).
  CAS Google Scholar
• Bakhanashvili, M. & Hizi, A. Interaction of the reverse transcriptase of human immunodeficiency virus type 1 with DNA. Biochemistry 33, 12222–12228 (1994).
  Article CAS Google Scholar
• Divita, G. etal. Kinetics of interaction of HIV reverse transcriptase with primer/template. Biochemistry 32, 7966–7971 (1993).
  Article CAS Google Scholar
• Sakabe, N. X-ray diffraction data collection system for modern protein crystallography with a Weissenberg camera and an imaging plate using synchrotron radiation. Nucl. Instr. Meths phys. Res. 303, 448–463 (1991).
  Article Google Scholar
• Stuart, D.I. & Jones, E.Y. Weissenberg data collection for macromolecular crystallography. Curr. Opin. struct. Biol. 3, 737–740 (1993).
  Article CAS Google Scholar
• Otwinowski, Z., Oscillation data reduction program, in Data collection and Processing (L. Sawyer, N. Isaacs, S. Bailey, Eds.) pp. 56–62 (SERC Daresbury Laboratory, Warrington, England, 1993).
  Google Scholar
• Brünger, A.T., X-PLOR Manual V. 3.1. (Yale University, New Haven, CT; 1992).
  Google Scholar
• Jones, T.A. Interactive computer graphics: FRODO. Meths. Enzymol. 115 157–171 (1985).
  Article CAS Google Scholar
• Brünger, A.T., Krukowski, A. & Erickson, J. Slow-cooling protocols for crystallographic refinement by simulated annealing. Acta crystallogr. A46, 585–593 (1990).
  Article Google Scholar
• Brünger, A.T. Extension of molecular replacement: a new search strategy based on Patterson correlation coefficient refinement. Acta crystallogr. 46, A46–57 (1990).
  Article Google Scholar
• Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta. crystallogr. A47, 110–119 (1991).
  Article CAS Google Scholar
• Kraulis, P.J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. appl. Crystallogr. 24, 946–950 (1991).
  Article Google Scholar
• Merritt, E.A. & Murphy, M.E.P. Raster3D version 2.0 Å program for photorealistic molecular graphics. Acta crystallogr. D50, 869–873 (1994).
  CAS Google Scholar
• Spence, R.A. Kati, W.M. Anderson, K.S. & Johnson, K.A. Science 267, 988–993 (1995).
  Article CAS Google Scholar