NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos (original) (raw)

References

  1. Ullrich, A. & Schlessinger, J. Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203–212 (1990).
    Article CAS Google Scholar
  2. Cantley, L.C. et al. Oncogenes and signal transduction. Cell 64, 281–302 (1991).
    Article CAS Google Scholar
  3. Fry, M.J., Panayotou, G., Booker, G.W. & Waterfield, M.D. New insights into protein-tyrosine kinase receptor signaling complexes. Prot. Sci. 2, 1785–1797 (1993).
    Article CAS Google Scholar
  4. Pawson, T. & Gish, G.D. SH2 and SH3 domains: from structure to function. Cell 71, 359–362 (1992).
    Article CAS Google Scholar
  5. Pawson, T. & Schlessinger, J. SH2 and SH3 domains. Curr. Biol. 3, 434–442 (1993).
    Article CAS Google Scholar
  6. Koch, C.A., Anderson, D., Moran, M.F., Ellis, C. & Pawson, T. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252, 668–674 (1991).
    Article CAS Google Scholar
  7. Musacchio, A., Gibson, T., Lehto, V.P. & Saraste, M. SH3 - an abundant protein domain in search of a function. FEBS Letts. 307, 55–61 (1992).
    Article CAS Google Scholar
  8. Lowenstein, E.J. et al. The SH2 and SH3 domain-containing protein Grb2 links receptor tyrosine kinases to ras signaling. Cell 70, 431–442 (1992).
    Article CAS Google Scholar
  9. Matuoka, K., Shibasaki, F., Shibata, M. & Takenawa, T. Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF AND PDGF EMBO J. 12, 3467–3473 (1993).
    Article CAS Google Scholar
  10. Skolnik, E.Y. et al. The SH2/SH3 domain-containing protein Grb2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signaling. EMBO J. 12, 1929–1936 (1993).
    Article CAS Google Scholar
  11. Egan, S.E. et al. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase sinal transduction and transformation. Nature 363, 45–51 (1993).
    Article CAS Google Scholar
  12. Chardin, P. et al. Human Sos 1: A guanine nucleotide exchange factor for Ras that binds Grb2. Science 260, 1338–1343 (1993).
    Article CAS Google Scholar
  13. Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T. & Bowtell, D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to Ras activator mSos1. Nature 363, 83–85 (1993).
    Article CAS Google Scholar
  14. Li, N. et al. Guanine-nucleotide releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling. Nature 363, 85–88 (1993).
    Article CAS Google Scholar
  15. Yu, H. et al. Solution structure of the SH3 domain of src and identification of its ligand-binding site. Science 258, 1665–1668 (1992).
    Article CAS Google Scholar
  16. Koyama, S. et al. Structure of the PI3K SH3 domain and analysis of the SH3 family. Cell 72, 945–952 (1993).
    Article CAS Google Scholar
  17. Booker, G.W. et al. Solution structure and ligand-binding site of the SH3 domain of the p85a subunit of phosphatidylinositol 3-kinase. Cell 73, 813–822 (1993).
    Article CAS Google Scholar
  18. Kohda, D. et al. Solution structure of the SH3 domain of phospholipase C-γ. Cell 72, 953–960 (1993).
    Article CAS Google Scholar
  19. Yang, Y.S. et al. Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence. EMBO J. 13, 1270–1279 (1994).
    Article CAS Google Scholar
  20. Musacchio, A., Noble, M., Pauptit, R., Wierenga, R. & Saraste, M. Crystal structure of a Src-homology 3 (SH3) domain. Nature 359, 851–855 (1992).
    Article CAS Google Scholar
  21. Noble, M., Musacchio, A., Saraste, M., Courtneidge, S.A. & Wierenga, R. Crystal structure of the SH3 domain in human Fyn:comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin. EMBO J. 12, 2617–2624 (1993).
    Article CAS Google Scholar
  22. Borchert, T.V., Mathieu, M., Zeelen, J.P., Courtneidge, S.A. & Wierenga, R.K. The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop. FEBS letts 341, 79–85 (1994).
    Article CAS Google Scholar
  23. Eck, M.J., Atwell, S.K., Shoelson, S.E. & Harrison, S.C. Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature 368, 764–769 (1994).
    Article CAS Google Scholar
  24. Yu, H. et al. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 76, 933–945 (1994).
    CAS Google Scholar
  25. Musacchio, A., Saraste, M. & Wilmanns, M. High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. Nature struct. Biol. 1, 546–551 (1994).
    Article CAS Google Scholar
  26. Nilges, M., Clore, G.M. & Gronenborn, A.M. Determination of three-dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array or atoms. FEBS Letts 239, 129–134 (1988).
    Article CAS Google Scholar
  27. Olivier, J.P. et al. A drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. 73, 179–191 (1993).
    Article CAS Google Scholar
  28. Lim, W.A. & Richards, F.M. Critical residues in an SH3 domain from Sem-5 suggest a machanism for praline-rich peptide recognition. Nature struct. Biol. 1, 221–225 (1994).
    Article CAS Google Scholar
  29. Trahey, M. et al. Molecular cloning of two types of GAP complementary DNA from human placenta. Science 242, 1697–1700 (1988).
    Article CAS Google Scholar
  30. Chen, J.K., Lane, W.S., Brauer, A.W., Tanaka, A. & Schreiber, S.L. Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase. J. Am. chem. Soc. 115, 12591–12592 (1993).
    Article CAS Google Scholar
  31. Cussac, D., Frech, M., & Chardin, P. Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs. EMBO J. 13, 4011–4021 (1994).
    Article CAS Google Scholar
  32. Wüthrich, K. NMR of proteins and nucleic acids. (Wileq, NewYork, N.Y.; 1986).
    Book Google Scholar
  33. Rance, M. et al. Improved spectral resolution in COSY 1H NMR spectra of proteins via double quantum filtering. Biochem. biophys. Res. Commun. 117, 479–485 (1983).
    Article CAS Google Scholar
  34. Griesinger, C., Otting, G., Wuthrich, K. & Ernst, R.R. Clean TOCSY for 1H spin system identification in macromolecules. J. Am. chem. Soc. 110, 7870–7872 (1988).
    Article CAS Google Scholar
  35. Jeener, J., Meier, B.H., Bachmann, P. & Ernst, R.R. Investigation of exchange processes by two-dimensional NMR spectroscopy. J. chem. Phys. 71, 4546–4553 (1979).
    Article CAS Google Scholar
  36. Macura, S., Huang, Y., Suter, D. & Ernst, R.R. Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear-spins. J. magn. Reson. 43, 259–281 (1981).
    CAS Google Scholar
  37. Bax, A. & Davis, D.G. Pratical aspects of two-dimensional transverse NOE spectroscopy. J. magn. Reson. 63, 207–213 (1985).
    CAS Google Scholar
  38. Marion, D. & Wüthrich, K. Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. Biochem. biophys. Res. Commun. 113, 967–974 (1983).
    Article CAS Google Scholar
  39. Clore, G.M., Brünger, A.T., Karplus, M. & Gronenborn, A.M. Application of molecular dynamics with interproton distance restraints to three-dimensional protein structure determination. J. molec. Biol. 191, 523–551 (1986).
    Article CAS Google Scholar

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