Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2 (original) (raw)

• Flynn, J.L. & Chan, J. Immunology of tuberculosis. Annu. Rev. Immunol. 19, 93–129 (2001).
  Article CAS PubMed Google Scholar
• Janeway, C.A. Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).
  Article CAS PubMed Google Scholar
• Chan, J. et al. Microbial glycolipids: possible virulence factors that scavenge oxygen radicals. Proc. Natl. Acad. Sci. USA 86, 2453–2457 (1989).
  Article CAS PubMed PubMed Central Google Scholar
• Fratti, R.A., Chua, J., Vergne, I. & Deretic, V. Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest. Proc. Natl. Acad. Sci. USA 100, 5437–5442 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Vergne, I. et al. Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion. Mol. Biol. Cell 15, 751–760 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Cole, S.T. et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537–544 (1998).
  Article CAS PubMed Google Scholar
• Sutcliffe, I.C. & Harrington, D.J. Lipoproteins of Mycobacterium tuberculosis: an abundant and functionally diverse class of cell envelope components. FEMS Microbiol. Rev. 28, 645–659 (2004).
  Article CAS PubMed Google Scholar
• Bigi, F. et al. The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis . Microbes Infect. 6, 182–187 (2004).
  Article CAS PubMed Google Scholar
• Rengarajan, J., Bloom, B.R. & Rubin, E.J. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc. Natl. Acad. Sci. USA 102, 8327–8332 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Sassetti, C.M. & Rubin, E.J. Genetic requirements for mycobacterial survival during infection. Proc. Natl. Acad. Sci. USA 100, 12989–12994 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Farrow, M.F. & Rubin, E.J. Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein. J. Bacteriol. 190, 1783–1791 (2008).
  Article CAS PubMed Google Scholar
• Sulzenbacher, G. et al. LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis . EMBO J. 25, 1436–1444 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Jones, B.W. et al. Different Toll-like receptor agonists induce distinct macrophage responses. J. Leukoc. Biol. 69, 1036–1044 (2001).
  CAS PubMed Google Scholar
• Gilleron, M., Quesniaux, V.F. & Puzo, G. Acylation state of the phosphatidyl inositol hexamannosides from Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv and its implication in TLR response. J. Biol. Chem. 278, 29880–29889 (2003).
  Article CAS PubMed Google Scholar
• Elass, E. et al. Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism. Infect. Immun. 73, 7064–7068 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Tapping, R.I. & Tobias, P.S. Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling. J. Endotoxin Res. 9, 264–268 (2003).
  Article CAS PubMed Google Scholar
• Bhatt, K. & Salgame, P. Host innate immune response to Mycobacterium tuberculosis . J. Clin. Immunol. 27, 347–362 (2007).
  Article CAS PubMed Google Scholar
• Pai, R.K., Convery, M., Hamilton, T.A., Boom, W.H. & Harding, C.V. Inhibition of IFN-γ-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion. J. Immunol. 171, 175–184 (2003).
  Article CAS PubMed Google Scholar
• Noss, E.H. et al. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19 kD lipoprotein of Mycobacterium tuberculosis . J. Immunol. 167, 910–918 (2001).
  Article CAS PubMed Google Scholar
• Brightbill, H.D. et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285, 732–736 (1999).
  Article CAS PubMed Google Scholar
• Takeuchi, O. et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10–14 (2002).
  Article CAS PubMed Google Scholar
• Nigou, J. et al. Mannan chain length controls lipoglycans signaling via and binding to TLR2. J. Immunol. 180, 6696–6702 (2008).
  Article CAS PubMed Google Scholar
• Pecora, N.D., Gehring, A.J., Canaday, D.H., Boom, W.H. & Harding, C.V. Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function. J. Immunol. 177, 422–429 (2006).
  Article CAS PubMed Google Scholar
• Gehring, A.J., Dobos, K.M., Belisle, J.T., Harding, C.V. & Boom, W.H. Mycobacterium tuberculosis LprG (Rv1411c): A novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing. J. Immunol. 173, 2660–2668 (2004).
  Article CAS PubMed Google Scholar
• Jung, S.B. et al. The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes. Infect. Immun. 74, 2686–2696 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Jin, M.S. et al. Crystal structure of the TLR1–TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071–1082 (2007).
  Article CAS PubMed Google Scholar
• Rezwan, M., Grau, T., Tschumi, A. & Sander, P. Lipoprotein synthesis in mycobacteria. Microbiology 153, 652–658 (2007).
  Article CAS PubMed Google Scholar
• Nigou, J., Gilleron, M. & Puzo, G. Lipoarabinomannans: characterization of the multiacylated forms of the phosphatidyl-myo-inositol anchor by NMR spectroscopy. Biochem. J. 337, 453–460 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Bigi, F. et al. The gene encoding P27 lipoprotein and a putative antibiotic-resistance gene form an operon in Mycobacterium tuberculosis and Mycobacterium bovis . Microbiology 146, 1011–1018 (2000).
  Article CAS PubMed Google Scholar
• Gilleron, M., Nigou, J., Nicolle, D., Quesniaux, V. & Puzo, G. The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2. Chem. Biol. 13, 39–47 (2006).
  Article CAS PubMed Google Scholar
• Kang, J.Y. et al. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31, 873–884 (2009).
  Article CAS PubMed Google Scholar
• Berg, S., Kaur, D., Jackson, M. & Brennan, P.J. The glycosyltransferases of _Mycobacterium tuberculosis_—roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 17, 35R–56R (2007).
  Article CAS Google Scholar
• Finberg, R.W., Re, F., Popova, L., Golenbock, D.T. & Kurt-Jones, E.A. Cell activation by Toll-like receptors: role of LBP and CD14. J. Endotoxin Res. 10, 413–418 (2004).
  Article CAS PubMed Google Scholar
• Jiang, Z. et al. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol. 6, 565–570 (2005).
  Article CAS PubMed Google Scholar
• Sklar, M.D., Tereba, A., Chen, B.D. & Walker, W.S. Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1. J. Cell. Physiol. 125, 403–412 (1985).
  Article CAS PubMed Google Scholar
• Flo, T.H. et al. Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. J. Biol. Chem. 277, 35489–35495 (2002).
  Article CAS PubMed Google Scholar
• Latz, E. et al. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2–CD14 complex in a process that is distinct from the initiation of signal transduction. J. Biol. Chem. 277, 47834–47843 (2002).
  Article CAS PubMed Google Scholar
• Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307–326 (1997).
  Article CAS PubMed Google Scholar
• Vonrhein, C., Blanc, E., Roversi, P. & Bricogne, G. Automated structure solution with autoSHARP. Methods Mol. Biol. 364, 215–230 (2007).
  CAS PubMed Google Scholar
• Murshudov, G.N., Vagin, A.A. & Dodson, E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53, 240–255 (1997).
  Article CAS PubMed Google Scholar
• Adams, P.D. et al. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D Biol. Crystallogr. 58, 1948–1954 (2002).
  Article PubMed Google Scholar
• Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126–2132 (2004).
  Article PubMed Google Scholar
• Pettersen, E.F. et al. UCSF Chimera–a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605–1612 (2004).
  Article CAS PubMed Google Scholar
• Dundas, J. et al. CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res. 34, W116–8 (2006).
  Article CAS PubMed PubMed Central Google Scholar