DNA damage: ubiquitin marks the spot (original) (raw)
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- Published: January 2008
Nature Structural & Molecular Biology volume 15, pages 20–22 (2008)Cite this article
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DNA damage activates signaling cascades driven by the ATM–ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.
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Figure 1: The hierarchical signaling network within the DDR.
Kim Caesar
Figure 2: Modification of the ubiquitin signal.
Kim Caesar
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Authors and Affiliations
- Eric J. Bennett and J. Wade Harper are at the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. wade_harper@hms.harvard.edu,
Eric J Bennett & J Wade Harper
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Bennett, E., Harper, J. DNA damage: ubiquitin marks the spot.Nat Struct Mol Biol 15, 20–22 (2008). https://doi.org/10.1038/nsmb0108-20
- Issue Date: January 2008
- DOI: https://doi.org/10.1038/nsmb0108-20
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