The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks (original) (raw)

• Saintigny, Y. et al. Characterization of homologous recombination induced by replication inhibition in mammalian cells. EMBO J. 20, 3861–3870 (2001).
  Article CAS Google Scholar
• Higuchi, K. et al. Fate of DNA replication fork encountering a single DNA lesion during oriC plasmid DNA replication in vitro. Genes Cells 8, 437–449 (2003).
  Article CAS Google Scholar
• Saleh-Gohari, N. et al. Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol. Cell. Biol. 25, 7158–7169 (2005).
  Article CAS Google Scholar
• Wyman, C. & Kanaar, R. DNA double-strand break repair: All's well that ends well. Annu. Rev. Genet. 40, 363–383 (2006).
  Article CAS Google Scholar
• Hanada, K. et al. RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli. Proc. Natl. Acad. Sci. USA 94, 3860–3865 (1997).
  Article CAS Google Scholar
• Sonoda, E. et al. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J. 17, 598–608 (1998).
  Article CAS Google Scholar
• Lundin, C. et al. Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol. Cell. Biol. 22, 5869–5878 (2002).
  Article CAS Google Scholar
• Seigneur, M., Bidnenko, V., Ehrlich, S.D. & Michel, B. RuvAB acts at arrested replication forks. Cell 95, 419–430 (1998).
  Article CAS Google Scholar
• West, S.C. Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell Biol. 4, 435–445 (2003).
  Article CAS Google Scholar
• Baharoglu, Z., Petranovic, M., Flores, M.J. & Michel, B. RuvAB is essential for replication forks reversal in certain replication mutants. EMBO J. 25, 596–604 (2006).
  Article CAS Google Scholar
• Kogoma, T. Stable DNA replication: interplay between DNA replication, homologous recombination, and transcription. Microbiol. Mol. Biol. Rev. 61, 212–238 (1997).
  CAS PubMed PubMed Central Google Scholar
• McGlynn, P., Al-Deib, A.A., Liu, J., Marians, K.J. & Lloyd, R.G. The DNA replication protein PriA and the recombination protein RecG bind D-loops. J. Mol. Biol. 270, 212–221 (1997).
  Article CAS Google Scholar
• Xu, L. & Marians, K.J. PriA mediates DNA replication pathway choice at recombination intermediates. Mol. Cell 11, 817–826 (2003).
  Article CAS Google Scholar
• Sonoda, E., Hochegger, H., Saberi, A., Taniguchi, Y. & Takeda, S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst.) 5, 1021–1029 (2006).
  Article CAS Google Scholar
• Kraus, E., Leung, W.Y. & Haber, J.E. Break-induced replication: a review and an example in budding yeast. Proc. Natl. Acad. Sci. USA 98, 8255–8262 (2001).
  Article CAS Google Scholar
• Davis, A.P. & Symington, L.S. RAD51-dependent break-induced replication in yeast. Mol. Cell. Biol. 24, 2344–2351 (2004).
  Article CAS Google Scholar
• Branzei, D. & Foiani, M. The DNA damage response during DNA replication. Curr. Opin. Cell Biol. 17, 568–575 (2005).
  Article CAS Google Scholar
• Heyer, W.D., Ehmsen, K.T. & Solinger, J.A. Holliday junctions in the eukaryotic nucleus: resolution in sight? Trends Biochem. Sci. 28, 548–557 (2003).
  Article CAS Google Scholar
• Boddy, M.N. et al. Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell 107, 537–548 (2001).
  Article CAS Google Scholar
• Chen, X.B. et al. Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Mol. Cell 8, 1117–1127 (2001).
  Article CAS Google Scholar
• Kaliraman, V., Mullen, J.R., Fricke, W.M., Bastin-Shanower, S.A. & Brill, S.J. Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev. 15, 2730–2740 (2001).
  Article CAS Google Scholar
• Whitby, M.C., Osman, F. & Dixon, J. Cleavage of model replication forks by fission yeast Mus81-Eme1 and budding yeast Mus81-Mms4. J. Biol. Chem. 278, 6928–6935 (2003).
  Article CAS Google Scholar
• Osman, F., Dixon, J., Doe, C.L. & Whitby, M.C. Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis. Mol. Cell 12, 761–774 (2003).
  Article CAS Google Scholar
• Doe, C.L., Osman, F., Dixon, J. & Whitby, M.C. DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51. Nucleic Acids Res. 32, 5570–5581 (2004).
  Article CAS Google Scholar
• Fricke, W.M., Bastin-Shanower, S.A. & Brill, S.J. Substrate specificity of the Saccharomyces cerevisiae Mus81-Mms4 endonuclease. DNA Repair (Amst.) 4, 243–251 (2005).
  Article CAS Google Scholar
• Constantinou, A., Chen, X.B., McGowan, C.H. & West, S.C. Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J. 21, 5577–5585 (2002).
  Article CAS Google Scholar
• Ciccia, A., Constantinou, A. & West, S.C. Identification and characterization of the human MUS81-EME1 endonuclease. J. Biol. Chem. 278, 25172–25178 (2003).
  Article CAS Google Scholar
• Ogrunc, M. & Sancar, A. Identification and characterization of human MUS81–MMS4 structure-specific endonuclease. J. Biol. Chem. 278, 21715–21720 (2003).
  Article Google Scholar
• Abraham, J. et al. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J. 22, 6137–6147 (2003).
  Article CAS Google Scholar
• Interthal, H. & Heyer, W.D. MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae. Mol. Gen. Genet. 263, 812–827 (2000).
  Article CAS Google Scholar
• Odagiri, N. et al. Budding yeast mms4 is epistatic with rad52 and the function of Mms4 can be replaced by a bacterial Holliday junction resolvase. DNA Repair (Amst.) 2, 347–358 (2003).
  Article CAS Google Scholar
• Boddy, M.N. et al. Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1. Mol. Cell. Biol. 20, 8758–8766 (2000).
  Article CAS Google Scholar
• Doe, C.L., Ahn, J.S., Dixon, J. & Whitby, M.C. Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks. J. Biol. Chem. 277, 32753–32759 (2002).
  Article CAS Google Scholar
• Fabre, F., Chan, A., Heyer, W.D. & Gangloff, S. Alternate pathways involving Sgs1/Top3, Mus81/Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc. Natl. Acad. Sci. USA 99, 16887–16892 (2002).
  Article CAS Google Scholar
• McPherson, J.P. et al. Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science 304, 1822–1826 (2004).
  Article CAS Google Scholar
• Dendouga, N. et al. Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol. Cell. Biol. 25, 7569–7579 (2005).
  Article CAS Google Scholar
• Hiyama, T. et al. Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res. 34, 880–892 (2006).
  Article CAS Google Scholar
• Hanada, K. et al. The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J. 25, 4921–4932 (2006).
  Article CAS Google Scholar
• Arnaudeau, C., Tenorio Miranda, E., Jenssen, D. & Helleday, T. Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells. Mutat. Res. 461, 221–228 (2000).
  Article CAS Google Scholar
• Merrick, C.J., Jackson, D. & Diffley, J.F. Visualization of altered replication dynamics after DNA damage in human cells. J. Biol. Chem. 279, 20067–20075 (2004).
  Article CAS Google Scholar
• Courcelle, J., Donaldson, J.R., Chow, K.H. & Courcelle, C.T. DNA damage-induced replication fork regression and processing in Escherichia coli. Science 299, 1064–1067 (2003).
  Article CAS Google Scholar
• Magee, T.R. & Kogoma, T. Requirement of RecBC enzyme and an elevated level of activated RecA for induced stable DNA replication in Escherichia coli. J. Bacteriol. 172, 1834–1839 (1990).
  Article CAS Google Scholar
• Grompone, G., Ehrlich, D. & Michel, B. Cells defective for replication restart undergo replication fork reversal. EMBO Rep. 5, 607–612 (2004).
  Article CAS Google Scholar
• Masai, H., Asai, T., Kubota, Y., Arai, K. & Kogoma, T. Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication. EMBO J. 13, 5338–5345 (1994).
  Article CAS Google Scholar
• Kai, M., Boddy, M.N., Russell, P. & Wang, T.S. Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev. 19, 919–932 (2005).
  Article CAS Google Scholar
• Davies, S.L., North, P.S. & Hickson, I.D. Role for BLM in replication-fork restart and suppression of origin firing after replicative stress. Nat. Struct. Mol. Biol. 14, 677–679 (2007).
  Article CAS Google Scholar
• Essers, J. et al. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell 89, 195–204 (1997).
  Article CAS Google Scholar
• Van Veelen, L.R. et al. Analysis of ionizing radiation-induced foci of DNA damage repair proteins. Mutat. Res. 574, 22–33 (2005).
  Article CAS Google Scholar
• Niedernhofer, L.J. et al. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol. Cell. Biol. 24, 5776–5787 (2004).
  Article CAS Google Scholar