Target RNA motif and target mRNAs of the Quaking STAR protein (original) (raw)

References

  1. Hogan, E.L. & Greenfield, S. Animal models of genetic disorders of myelin. in Myelin (ed. Morell, P.) 489–534 (Plenum Press, New York, 1984).
    Google Scholar
  2. Ebersole, T.A., Chen, Q., Justice, M.J. & Artzt, K. The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nat. Genet. 12, 260–265 (1996).
    Article CAS Google Scholar
  3. Hardy, R.J. et al. Neural cell type-specific expression of QKI proteins is altered in the quaking viable mutant mice. J. Neurosci. 16, 7941–7949 (1996).
    Article CAS Google Scholar
  4. Larocque, D. et al. Nuclear retention of MBP mRNAs in the Quaking viable mice. Neuron 36, 815–829 (2002).
    Article CAS Google Scholar
  5. Larocque, D. et al. Protection of the p27KIP1 mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation. Nat. Neurosci. 8, 27–33 (2005).
    Article CAS Google Scholar
  6. Darnell, R.B. Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. Arch. Neurol. 61, 30–32 (2004).
    Article Google Scholar
  7. Lukong, K.E. & Richard, S. Sam68, the KH domain-containing superSTAR. Biochim. Biophys. Acta 1653, 73–86 (2003).
    CAS PubMed Google Scholar
  8. Vernet, C. & Artzt, K. STAR, a gene family involved in signal transduction and activation of RNA. Trends Genet. 13, 479–484 (1997).
    Article CAS Google Scholar
  9. Wu, J.I., Reed, R.B., Grabowski, P.J. & Artzt, K. Function of quaking in myelination: regulation of alternative splicing. Proc. Natl. Acad. Sci. USA 99, 4233–4238 (2002).
    Article CAS Google Scholar
  10. Li, Z., Zhang, Y., Li, D. & Feng, Y. Destabilization and mislocalization of the myelin basic protein mRNAs in quaking dysmyelination lacking the Qk1 RNA-binding proteins. J. Neurosci. 20, 4944–4953 (2000).
    Article CAS Google Scholar
  11. Saccomanno, L. et al. The STAR protein QKI-6 is a translational repressor. Proc. Natl. Acad. Sci. USA 96, 12605–12610 (1999).
    Article CAS Google Scholar
  12. Pilotte, J., Larocque, D. & Richard, S. Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer. Genes Dev. 15, 845–858 (2001).
    Article CAS Google Scholar
  13. Li, Z. et al. Defective smooth muscle development in qkI-deficient mice. Dev. Growth Differ. 45, 449–462 (2003).
    Article CAS Google Scholar
  14. Ryder, S.P., Frater, L.A, Abramovitz, D.L., Goodwin, E.B. & Williamson, J.R. RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1. Nat. Struct. Mol. Biol. 11, 20–28 (2004).
    Article CAS Google Scholar
  15. Francis, R., Barton, M.K., Kimbel, J. & Schedl, T. Control of oogenesis, germline proliferation and sex determination by the C. elegans gene gld-1. Genetics 139, 579–606 (1995).
    CAS PubMed PubMed Central Google Scholar
  16. Ryder, S.P. & Williamson, J.R. Specificity of the STAR/GSG domain protein Qk1: implications for the regulation of myelination. RNA 10, 1449–1458 (2004).
    Article CAS Google Scholar
  17. Buckanovich, R.J. & Darnell, R.B. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. Mol. Cell. Biol. 17, 3194–3201 (1997).
    Article CAS Google Scholar
  18. Cox, R.D. et al. Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene. Genomics 57, 333–341 (1999).
    Article CAS Google Scholar
  19. Justice, M.J. & Bode, V.C. Three ENU-induced alleles of the murine quaking locus are recessive embryonic lethal mutations. Genet. Res. 51, 95–102 (1988).
    Article CAS Google Scholar
  20. Zuker, M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31, 3406–3415 (2003).
    Article CAS Google Scholar
  21. Jensen, K.B., Musunuru, K., Lewis, H.A., Burley, S.K. & Darnell, R.B. The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain. Proc. Natl. Acad. Sci. USA 97, 5740–5745 (2000).
    Article CAS Google Scholar
  22. Nabel-Rosen, H., Volohonsky, G., Reuveny, A., Zaidel-Bar, R. & Volk, T. Two isoforms of the Drosophila RNA binding protein, How, act in opposing directions to regulate tendon cell differentiation. Dev. Cell 2, 183–193 (2002).
    Article CAS Google Scholar
  23. Nagarajan, R. et al. EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression. Neuron 30, 355–368 (2001).
    Article CAS Google Scholar
  24. Dennis, G., Jr. et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 4, 3 (2003).
    Article Google Scholar
  25. Rowitch, D.H. Glial specification in the vertebrate neural tube. Nat. Rev. Neurosci. 5, 409–419 (2004).
    Article CAS Google Scholar
  26. Hardy, R.J. QKI expression is regulated during neuron-glial cell fate decisions. J. Neurosci. Res. 54, 46–57 (1998).
    Article CAS Google Scholar
  27. Chen, T., Boisvert, F.M., Bazett-Jones, D.P. & Richard, S. A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines. Mol. Biol. Cell 10, 3015–3033 (1999).
    Article CAS Google Scholar
  28. Itoh, M., Haga, I., Li, Q.-H. & Fujisawa, J.-I. Identification of cellular mRNA targets for RNA-binding protein Sam68. Nucleic Acids Res. 30, 5452–5464 (2002).
    Article CAS Google Scholar
  29. Keene, J.D. Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome. Proc. Natl. Acad. Sci. USA 98, 7018–7024 (2001).
    Article CAS Google Scholar
  30. Liu, Z. et al. Structural basis for recognition of the intron branch site RNA by splicing factor 1. Science 294, 1098–1102 (2001).
    Article CAS Google Scholar
  31. Jan, E., Motzny, C.K., Graves, L.E. & Goodwin, E.B. The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans. EMBO J. 18, 258–269 (1999).
    Article CAS Google Scholar
  32. Chen, T., Côté, J., Carvajal, H.V. & Richard, S. Identification of Sam68 arginine glycine-rich sequences capable of conferring non-specific RNA binding to the GSG domain. J. Biol. Chem. 276, 30803–30811 (2001).
    Article CAS Google Scholar
  33. Lee, M.-H. & Schedl, T. Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Genes Dev. 15, 2408–2420 (2001).
    Article CAS Google Scholar
  34. Schumacher, B. et al. Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell 120, 357–368 (2005).
    Article CAS Google Scholar
  35. Min, H., Turck, C.W., Nikolic, J.M. & Black, D.L. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev. 11, 1023–1036 (1997).
    Article CAS Google Scholar
  36. Stoss, O. et al. The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. J. Biol. Chem. 276, 8665–8673 (2001).
    Article CAS Google Scholar
  37. Arning, S., Gruter, P., Bilbe, G. & Kramer, A. Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA. RNA 2, 794–810 (1996).
    CAS PubMed PubMed Central Google Scholar
  38. Berglund, J.A., Chua, K., Abovich, N., Reed, R. & Rosbash, M. The splicing factor BBP interacts specifically with the pre-mRNA branch-point sequence UACUAAC. Cell 89, 781–787 (1997).
    Article CAS Google Scholar
  39. Matter, N., Herrlich, P. & Konig, H. Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature 420, 691–695 (2002).
    Article CAS Google Scholar
  40. Butcher, S.E. & Wickens, M. STAR-studded circuitry. Nat. Struct. Mol. Biol. 11, 2–3 (2004).
    Article CAS Google Scholar
  41. Hardy, R.J., Lazzarini, R.A., Colman, D.R. & Friedrich, V.L., Jr. Cytoplasmic and nuclear localization of myelin basic proteins reveals heterogeneity among oligodendrocytes. J. Neurosci. Res. 46, 246–257 (1996).
    Article CAS Google Scholar
  42. Wu, H.Y., Dawson, M.R.L., Reynolds, R. & Hardy, R.J. Expression of QKI proteins and MAP1B identifies actively myelinating oligodendrocytes in adult rat brain. Mol. Cell. Neurosci. 17, 292–302 (2001).
    Article CAS Google Scholar
  43. Baehrecke, E.H. who encodes a KH RNA binding protein that functions in muscle development. Development 124, 1323–1332 (1997).
    CAS PubMed Google Scholar
  44. Zorn, A.M. & Krieg, P.A. The KH domain protein encoded by quaking functions as a dimer and is essential for notochord development in Xenopus embryos. Genes Dev. 11, 2176–2190 (1997).
    Article CAS Google Scholar
  45. Zaffran, S., Astier, M., Gratecos, D. & Semeriva, M. The held out wings (how) Drosophila gene encodes a putative RNA binding protein involved in the control of muscular and cardiac activity. Development 124, 2087–2098 (1997).
    CAS PubMed Google Scholar
  46. Jones, A.R., Francis, R. & Schedl, T. GLD-1, a cytoplasmic protein essential for oocyte differentiation, shows stage- and sex-specific expression during Caenorhabditis elegans germline development. Dev. Biol. 180, 165–183 (1996).
    Article CAS Google Scholar
  47. Li, Z.Z. et al. Expression of Hqk encoding a KH RNA binding protein is altered in human glioma. Jpn. J. Cancer Res. 93, 167–177 (2002).
    Article CAS Google Scholar
  48. Francis, R., Barton, M.K., Kimble, J. & Schedl, T. gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics 139, 579–606 (1995).
    CAS PubMed PubMed Central Google Scholar
  49. Galarneau, A., Primeau, M., Trudeau, L.E. & Michnick, S.W. Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions. Nat. Biotechnol. 20, 619–622 (2002).
    Article CAS Google Scholar

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