Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J15: 6541–6551. ArticleCAS Google Scholar
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr Biol7: 261–269. ArticleCAS Google Scholar
Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M et al. (1997). Role of translocation in the activation and function of protein kinase B. J Biol Chem272: 31515–31524. ArticleCAS Google Scholar
Brownawell AM, Kops GJ, Macara IG, Burgering BM . (2001). Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. Mol Cell Biol21: 3534–3546. ArticleCAS Google Scholar
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell96: 857–868. ArticleCAS Google Scholar
Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME . (2001). Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol21: 952–965. ArticleCAS Google Scholar
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y et al. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science303: 2011–2015. ArticleCAS Google Scholar
Burgering BM, Coffer PJ . (1995). Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature376: 599–602. ArticleCAS Google Scholar
Carlsson P, Mahlapuu M . (2002). Forkhead transcription factors: key players in development and metabolism. Dev Biol250: 1–23. ArticleCAS Google Scholar
Cassada RC, Russell RL . (1975). The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans. Dev Biol46: 326–342. ArticleCAS Google Scholar
Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J . (1994). PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature370: 71–75. ArticleCAS Google Scholar
Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E et al. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science292: 104–106. ArticleCAS Google Scholar
Davis RJ, D'Cruz CM, Lovell MA, Biegel JA, Barr FG . (1994). Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res54: 2869–2872. CASPubMed Google Scholar
Dorman JB, Albinder B, Shroyer T, Kenyon C . (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics141: 1399–1406. CASPubMedPubMed Central Google Scholar
Downward J . (1994). The GRB2/Sem-5 adaptor protein. FEBS Lett338: 113–117. ArticleCAS Google Scholar
Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC . (2005). Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science308: 1181–1184. ArticleCAS Google Scholar
Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL et al. (2004). FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J23: 4802–4812. ArticleCAS Google Scholar
Franke TF, Kaplan DR, Cantley LC, Toker A . (1997). Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science275: 665–668. ArticleCAS Google Scholar
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK et al. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell81: 727–736. ArticleCAS Google Scholar
Furuyama T, Nakazawa T, Nakano I, Mori N . (2000). Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J349: 629–634. ArticleCAS Google Scholar
Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher III FJ, Emanuel BS et al. (1993). Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet5: 230–235. ArticleCAS Google Scholar
Hafen E, Dickson B, Brunner T, Raabe T . (1993). Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila. Philos Trans R Soc Lond B Biol Sci340: 273–278. ArticleCAS Google Scholar
Harlan JE, Hajduk PJ, Yoon HS, Fesik SW . (1994). Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature371: 168–170. ArticleCAS Google Scholar
Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP . (2003). FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem278: 35959–35967. ArticleCAS Google Scholar
Kaestner KH, Knochel W, Martinez DE . (2000). Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev14: 142–146. CASPubMed Google Scholar
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R . (1993). A C. elegans mutant that lives twice as long as wild type. Nature366: 461–464. ArticleCAS Google Scholar
Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G . (1997). daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science277: 942–946. ArticleCAS Google Scholar
Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM . (1999). Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature398: 630–634. ArticleCAS Google Scholar
Mayer BJ, Ren R, Clark KL, Baltimore D . (1993). A putative modular domain present in diverse signaling proteins. Cell73: 629–630. ArticleCAS Google Scholar
Ming XF, Burgering BM, Wennstrom S, Claesson-Welsh L, Heldin CH, Bos JL et al. (1994). Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature371: 426–429. ArticleCAS Google Scholar
Mora A, Komander D, van Aalten DM, Alessi DR . (2004). PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol15: 161–170. ArticleCAS Google Scholar
Morris JZ, Tissenbaum HA, Ruvkun G . (1996). A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature382: 536–539. ArticleCAS Google Scholar
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W et al. (2004). Mammalian SIRT1 represses forkhead transcription factors. Cell116: 551–563. ArticleCAS Google Scholar
Musacchio A, Gibson T, Rice P, Thompson J, Saraste M . (1993). The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci18: 343–348. ArticleCAS Google Scholar
Nakae J, Park BC, Accili D . (1999). Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem274: 15982–15985. ArticleCAS Google Scholar
Ogg S, Ruvkun G . (1998). The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell2: 887–893. ArticleCAS Google Scholar
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA et al. (1997). The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature389: 994–999. ArticleCAS Google Scholar
Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA . (2005). JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA102: 4494–4499. ArticleCAS Google Scholar
Paradis S, Ruvkun G . (1998). Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev12: 2488–2498. ArticleCAS Google Scholar
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G . (1999). A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev13: 1438–1452. ArticleCAS Google Scholar
Plas DR, Thompson CB . (2002). Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab13: 75–78. Article Google Scholar
Rena G, Guo S, Cichy SC, Unterman TG, Cohen P . (1999). Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem274: 17179–17183. ArticleCAS Google Scholar
Riddle DL, Swanson MM, Albert PS . (1981). Interacting genes in nematode dauer larva formation. Nature290: 668–671. ArticleCAS Google Scholar
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB et al. (1998). Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science279: 710–714. ArticleCAS Google Scholar
Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF et al. (1997). Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science277: 567–570. ArticleCAS Google Scholar
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA et al. (1991). Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature352: 73–77. ArticleCAS Google Scholar
Teleman AA, Chen YW, Cohen SM . (2005). Drosophila Melted modulates FOXO and TOR activity. Dev Cell9: 271–281. ArticleCAS Google Scholar
Tissenbaum HA, Guarente L . (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature410: 227–230. ArticleCAS Google Scholar
van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM . (2004). FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem279: 28873–28879. ArticleCAS Google Scholar
Wang MC, Bohmann D, Jasper H . (2005). JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell121: 115–125. ArticleCAS Google Scholar
Weigel D, Jackle H . (1990). The fork head domain: a novel DNA binding motif of eukaryotic transcription factors? Cell63: 455–456. ArticleCAS Google Scholar
White MF, Maron R, Kahn CR . (1985). Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185 000 protein in intact cells. Nature318: 183–186. ArticleCAS Google Scholar
Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A . (2006). SMK-1, an essential regulator of DAF-16-mediated longevity. Cell124: 1039–1053. ArticleCAS Google Scholar
Wolkow CA, Munoz MJ, Riddle DL, Ruvkun G . (2002). Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem277: 49591–49597. ArticleCAS Google Scholar
Yang Z, Whelan J, Babb R, Bowen BR . (2002). An mRNA splice variant of the AFX gene with altered transcriptional activity. J Biol Chem277: 8068–8075. ArticleCAS Google Scholar