BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery (original) (raw)

• Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM . Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 1984; 224: 1121–1124.
  Article CAS Google Scholar
• Islam A, Kageyama H, Takada N, Kawamoto T, Takayasu H, Isogai E et al. High expression of survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma. Oncogene 2000; 19: 617–623.
  Article CAS Google Scholar
• Opel D, Poremba C, Simon T, Debatin KM, Fulda S . Activation of Akt predicts poor outcome in neuroblastoma. Cancer Res 2007; 67: 735–745.
  Article CAS Google Scholar
• Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ . FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 2007; 14: 534–547.
  Article CAS Google Scholar
• Obexer P, Hagenbuchner J, Unterkircher T, Sachsenmaier N, Seifarth C, Bock G et al. Repression of BIRC5/survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA damage-induced apoptosis. Mol Biol Cell 2009; 20: 2041–2048.
  Article CAS Google Scholar
• Hagenbuchner J, Kuznetsov A, Hermann M, Hausott B, Obexer P, Ausserlechner MJ . FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. J Cell Sci 2012; 125: 1191–1203.
  Article CAS Google Scholar
• Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ . Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006; 443: 658–662.
  Article CAS Google Scholar
• Sheridan C, Delivani P, Cullen SP, Martin SJ . Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Mol Cell 2008; 31: 570–585.
  Article CAS Google Scholar
• Chen H, Chomyn A, Chan DC . Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 2005; 280: 26185–26192.
  Article CAS Google Scholar
• Kudin AP, Bimpong-Buta NY, Vielhaber S, Elger CE, Kunz WS . Characterization of superoxide-producing sites in isolated brain mitochondria. J Biol Chem 2004; 279: 4127–4135.
  Article CAS Google Scholar
• Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C et al. Electron transfer between cytochrome C and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005; 122: 221–233.
  Article CAS Google Scholar
• Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ et al. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem 2005; 280: 16916–16924.
  Article CAS Google Scholar
• Chen K, Albano A, Ho A, Keaney JF . Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. J Biol Chem 2003; 278: 39527–39533.
  Article CAS Google Scholar
• Vazquez A, Liu J, Zhou Y, Oltvai ZN . Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited. BMC Syst Biol 2010; 4: 58.
  Article Google Scholar
• Heiden MGV, Cantley LC, Thompson CB . Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029–1033.
  Article Google Scholar
• Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M . Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160: 1–40.
  Article CAS Google Scholar
• Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 2007; 109: 3812–3819.
  Article CAS Google Scholar
• Stern R, Shuster S, Neudecker BA, Formby B . Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res 2002; 276: 24–31.
  Article CAS Google Scholar
• Simonnet H, Alazard N, Pfeiffer K, Gallou C, Beroud C, Demont J et al. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis 2002; 23: 759–768.
  Article CAS Google Scholar
• Chen QR, Song YK, Yu LR, Wei JS, Chung JY, Hewitt SM et al. Global genomic and proteomic analysis identifies biological pathways related to high-risk neuroblastoma. J Proteome Res 2010; 9: 373–382.
  Article CAS Google Scholar
• Smith DJ, Cossins LR, Hatzinisiriou I, Haber M, Nagley P . Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines. BMC Cancer 2008; 8: 259.
  Article Google Scholar
• Geiger K, Hagenbuchner J, Rupp M, Fiegl H, Sergi EC, Meister B et al. FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma. Mol Biol Cell 2012; 23: 2226–2234.
  Article CAS Google Scholar
• Dohi T, Xia F, Altieri DC . Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell 2007; 27: 17–28.
  Article CAS Google Scholar
• Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 2001; 1: 515–525.
  Article CAS Google Scholar
• Ausserlechner MJ, Obexer P, Deutschmann A, Geiger K, Kofler R . A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of anti-proliferative and toxic genes. Mol Cancer Ther 2006; 5: 1927–1934.
  Article CAS Google Scholar
• Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA . Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res 2004; 64: 985–993.
  Article CAS Google Scholar
• Benard G, Bellance N, James D, Parrone P, Fernandez H, Letellier T et al. Mitochondrial bioenergetics and structural network organization. J Cell Sci 2007; 120: 838–848.
  Article CAS Google Scholar
• Guha M, Plescia J, Leav I, Li J, Languino LR, Altieri DC . Endogenous tumor suppression mediated by PTEN involves Survivin gene silencing. Cancer Res 2009; 69: 4954–4958.
  Article CAS Google Scholar
• Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K et al. An IAP-IAP complex inhibits apoptosis. J Biol Chem 2004; 279: 34087–34090.
  Article CAS Google Scholar
• Kang BH, Xia F, Pop R, Dohi T, Socolovsky M, Altieri DC . Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting Protein (AIP) involves mitochondrial import of the Survivin protein. J Biol Chem 2011; 286: 16758–16767.
  Article CAS Google Scholar
• Wu S, Zhou F, Zhang Z . Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission/fusion proteins. FEBS J 2011; 278: 941–954.
  Article CAS Google Scholar
• Herrero-Mendez A, Almeida A, Fernandez E, Maestre C, Moncada S, Bolanos JP . The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol 2009; 11: 747–U105.
  Article CAS Google Scholar
• Almeida A, Bolanos JP, Moncada S . E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Nat Acad Sci USA 2010; 107: 738–741.
  Article CAS Google Scholar
• Connell CM, Colnaghi R, Wheatley SP . Nuclear survivin has reduced stability and is not cytoprotective. J Biol Chem 2008; 283: 3289–3296.
  Article CAS Google Scholar
• De Lena M, Lorusso V, Latorre A, Fanizza G, Gargano G, Caporusso L et al. Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study. Eur J Cancer 2001; 37: 364–368.
  Article CAS Google Scholar
• Di Cosimo S, Ferretti G, Papaldo P, Carlini P, Fabi A, Cognetti F . Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors. Drugs Today 2003; 39: 157–174.
  Article CAS Google Scholar
• Singh D, Banerji AK, Dwarakanath BS, Tripathi RP, Gupta JP, Mathew TL et al. Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol 2005; 181: 507–514.
  Article Google Scholar
• Grignani F, Kinsella T, Mencarelli A, Valtieri M, Riganelli D, Grignani F et al. High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Res 1998; 58: 14–19.
  CAS Google Scholar
• Hagenbuchner J, Ausserlechner MJ, Porto V, David R, Meister B, Bodner M et al. The antiapoptotic protein BCL2L1/BCL-XL is neutralized by proapoptotic PMAIP1/Noxa in neuroblastoma thereby determining bortezomib-sensitivity independent of prosurvival MCL1 expression. J Biol Chem 2010; 285: 6904–6912.
  Article CAS Google Scholar
• Kuznetsov AV, Veksler V, Gellerich FN, Saks V, Margreiter R, Kunz WS . Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nat Protoc 2008; 3: 965–976.
  Article CAS Google Scholar