- Ni M, Lee AS . ER chaperones in mammalian development and human diseases. FEBS Lett 2007; 581: 3641–3651.
Article CAS Google Scholar
- Pfaffenbach KT, Lee AS . The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol 2011; 23: 150–156.
Article CAS Google Scholar
- Ron D, Walter P . Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8: 519–529.
Article CAS Google Scholar
- Lee AS . GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 2007; 67: 3496–3499.
Article CAS Google Scholar
- Gonzalez-Gronow M, Selim MA, Papalas J, Pizzo SV . GRP78: a multifunctional receptor on the cell surface. Antioxid Redox Signal 2009; 11: 2299–2306.
Article CAS Google Scholar
- Ni M, Zhang Y, Lee AS . Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J 2011; 434: 181–188.
Article CAS Google Scholar
- Sansal I, Sellers WR . The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004; 22: 2954–2963.
Article CAS Google Scholar
- Whittaker S, Marais R, Zhu AX . The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010; 29: 4989–5005.
Article CAS Google Scholar
- Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ et al. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci USA 2004; 101: 2082–2087.
Article CAS Google Scholar
- Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA et al. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology 2010; 139: 2170–2182.
Article CAS Google Scholar
- Roskams T . Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 2006; 25: 3818–3822.
Article CAS Google Scholar
- Hendershot LM . The ER function BiP is a master regulator of ER function. Mt Sinai J Med 2004; 71: 289–297.
PubMed Google Scholar
- Luo B, Lee AS . The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 2013; 32: 805–818.
Article CAS Google Scholar
- Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P et al. Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci USA 2008; 105: 19444–19449.
Article CAS Google Scholar
- Wey S, Luo B, Tseng CC, Ni M, Zhou H, Fu Y et al. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood 2012; 119: 817–825.
Article CAS Google Scholar
- Ye R, Jung DY, Jun JY, Li J, Luo S, Ko HJ et al. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes 2010; 59: 6–16.
Article CAS Google Scholar
- Ye R, Mareninova OA, Barron E, Wang M, Hinton DR, Pandol SJ et al. Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. Am J Pathol 2010; 177: 2827–2836.
Article CAS Google Scholar
- Zhu G, Ye R, Jung DY, Barron E, Friedline RH, Benoit VM et al. GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J 2013; 27: 955–964.
Article CAS Google Scholar
- Luo S, Mao C, Lee B, Lee AS . GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol 2006; 26: 5688–5697.
Article CAS Google Scholar
- Ji C, Kaplowitz N, Lau MY, Kao E, Petrovic LM, Lee AS . Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology 2011; 54: 229–239.
Article CAS Google Scholar
- Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999; 274: 305–315.
Article CAS Google Scholar
- Tanaka M, Itoh T, Tanimizu N, Miyajima A . Liver stem/progenitor cells: their characteristics and regulatory mechanisms. J Biochem 2011; 149: 231–239.
Article CAS Google Scholar
- Lee AH, Scapa EF, Cohen DE, Glimcher LH . Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008; 320: 1492–1496.
Article CAS Google Scholar
- Wang C, Huang Z, Du Y, Cheng Y, Chen S, Guo F . ATF4 regulates lipid metabolism and thermogenesis. Cell Res 2010; 20: 174–184.
Article CAS Google Scholar
- Zeng N, Li Y, He L, Xu X, Galicia V, Deng C et al. Adaptive basal phosphorylation of eIF2alpha is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res 2011; 9: 1708–1717.
Article CAS Google Scholar
- Zhang XF, Tan X, Zeng G, Misse A, Singh S, Kim Y et al. Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology 2010; 52: 954–965.
Article CAS Google Scholar
- Stock P, Monga D, Tan X, Micsenyi A, Loizos N, Monga SP . Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer. Mol Cancer Ther 2007; 6: 1932–1941.
Article CAS Google Scholar
- Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S et al. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ 2010; 17: 488–498.
Article CAS Google Scholar
- Wey S, Luo B, Lee AS . Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling. PLoS One 2012; 7: e39047.
Article CAS Google Scholar
- Nikolaou K, Sarris M, Talianidis I . Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer. Clin Cancer Res 2013; 19: 2810–2816.
Article CAS Google Scholar
- Nejak-Bowen KN, Monga SP . Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol 2011; 21: 44–58.
Article CAS Google Scholar
- Thompson MD, Wickline ED, Bowen WB, Lu A, Singh S, Misse A et al. Spontaneous repopulation of beta-catenin null livers with beta-catenin-positive hepatocytes after chronic murine liver injury. Hepatology 2011; 54: 1333–1343.
Article CAS Google Scholar
- Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep 2013; 3: 1128–1139.
Article CAS Google Scholar
- Michalopoulos GK, Barua L, Bowen WC . Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005; 41: 535–544.
Article CAS Google Scholar
- Desmet V, Roskams T, Van Eyken P . Ductular reaction in the liver. Pathol Res Pract 1995; 191: 513–524.
Article CAS Google Scholar
- Luk JM, Lam CT, Siu AF, Lam BY, Ng IO, Hu MY et al. Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values. Proteomics 2006; 6: 1049–1057.
Article CAS Google Scholar
- Su R, Li Z, Li H, Song H, Bao C, Wei J et al. Grp78 promotes the invasion of hepatocellular carcinoma. BMC Cancer 2010; 10: 20.
Article Google Scholar
- Wang C, Jiang K, Gao D, Kang X, Sun C, Zhang Q et al. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PLoS One 2013; 8: e55981.
Article CAS Google Scholar
- Hensel F, Eckstein M, Rosenwald A, Brandlein S . Early development of PAT-SM6 for the treatment of melanoma. Melanoma Res 2013; 23: 264–75s.
CAS PubMed Google Scholar
- Liu R, Li X, Gao W, Zhou Y, Wey S, Mitra S et al. Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth and metastasis. Clin Cancer Res (e-pub ahead of print 18 September 2013).
- Nakagawa H, Maeda S . Molecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPK. Patholog Res Int 2012; 2012: 172894.
PubMed PubMed Central Google Scholar
- Behari J, Yeh TH, Krauland L, Otruba W, Cieply B, Hauth B et al. Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis. Am J Pathol 2010; 176: 744–753.
Article CAS Google Scholar
- Ding WX . Role of autophagy in liver physiology and pathophysiology. World J Biol Chem 2010; 1: 3–12.
Article Google Scholar
- Ni M, Zhou H, Wey S, Baumeister P, Lee AS . Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One 2009; 4: e6868.
Article Google Scholar
- Luo B, Lam BS, Lee SH, Wey S, Zhou H, Wang M et al. The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One 2011; 6: e20364.
Article CAS Google Scholar