Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells (original) (raw)

• Stathis A, Moore MJ . Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev 2010; 7: 163–172.
  CAS Google Scholar
• Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM . Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 2014; 74: 2913–2921.
  Article CAS PubMed Google Scholar
• Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 2007; 297: 267–277.
  Article CAS PubMed Google Scholar
• Kleeff J, Beckhove P, Esposito I, Herzig S, Huber PE, Lohr JM et al. Pancreatic cancer microenvironment. Int J Cancer 2007; 121: 699–705.
  Article CAS PubMed Google Scholar
• Chu GC, Kimmelman AC, Hezel AF, DePinho RA . Stromal biology of pancreatic cancer. J Cell Biochem 2007; 101: 887–907.
  Article CAS PubMed Google Scholar
• Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, Rivera A et al. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res 2008; 68: 918–926.
  Article CAS PubMed PubMed Central Google Scholar
• Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009; 324: 1457–1461.
  Article CAS PubMed PubMed Central Google Scholar
• Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013; 369: 1691–1703.
  Article CAS PubMed PubMed Central Google Scholar
• Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 2014; 25: 735–747.
  Article CAS PubMed PubMed Central Google Scholar
• Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654–659.
  Article CAS PubMed Google Scholar
• Mathivanan S, Ji H, Simpson RJ . Exosomes: extracellular organelles important in intercellular communication. J Proteomics 2010; 73: 1907–1920.
  Article CAS PubMed Google Scholar
• Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E et al. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 2012; 151: 1542–1556.
  Article CAS PubMed Google Scholar
• Boelens Mirjam C, Wu Tony J, Nabet Barzin Y, Xu B, Qiu Y, Yoon T et al. Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell 159: 499–513.
  Article CAS PubMed PubMed Central Google Scholar
• Cheng L, Sharples RA, Scicluna BJ, Hill AF . Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood. J Extracell Vesicles 2014; 3: 10.3402/jev.v3.23743.
  Article Google Scholar
• Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer cell 2014; 25: 501–515.
  Article CAS PubMed PubMed Central Google Scholar
• Umezu T, Ohyashiki K, Kuroda M, Ohyashiki JH . Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 2013; 32: 2747–2755.
  Article CAS PubMed Google Scholar
• Kadera BE, Li L, Toste PA, Wu N, Adams C, Dawson DW et al. MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. PLoS ONE 2013; 8: e71978.
  Article CAS PubMed PubMed Central Google Scholar
• Braicu C, Tomuleasa C, Monroig P, Cucuianu A, Berindan-Neagoe I, Calin GA . Exosomes as divine messengers: are they the Hermes of modern molecular oncology? Cell Death Differ 2015; 22: 34–45.
  Article CAS PubMed Google Scholar
• Chernyshev VS, Rachamadugu R, Tseng YH, Belnap DM, Jia Y, Branch KJ et al. Size and shape characterization of hydrated and desiccated exosomes. Anal Bioanal Chem 2015; 407: 3285–3301.
  Article CAS PubMed Google Scholar
• Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C . Exosomal-like vesicles are present in human blood plasma. Int Immunol 2005; 17: 879–887.
  Article CAS PubMed Google Scholar
• Svensson KJ, Christianson HC, Wittrup A, Bourseau-Guilmain E, Lindqvist E, Svensson LM et al. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem 2013; 288: 17713–17724.
  Article CAS PubMed PubMed Central Google Scholar
• Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol 2014; 16: 268–280.
  Article CAS PubMed Google Scholar
• Essandoh K, Yang L, Wang X, Huang W, Qin D, Hao J et al. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochim Biophys Acta 2015; 1852: 2362–2371.
  Article CAS PubMed PubMed Central Google Scholar
• Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS et al. An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor kappaB- and hypoxia-inducible factor 1alpha-mediated up-regulation of CXCR4. J Biol Chem 2013; 288: 21197–21207.
  Article CAS PubMed PubMed Central Google Scholar
• Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, Padhye S et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res. 2009; 69: 5575–5583.
  Article CAS PubMed Google Scholar
• Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR et al. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003; 22: 3243–3251.
  Article CAS PubMed Google Scholar
• Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ et al. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res. 2005; 65: 9064–9072.
  Article CAS PubMed Google Scholar
• Quint K, Tonigold M, Di Fazio P, Montalbano R, Lingelbach S, Rückert F et al. Pancreatic cancer cells surviving gemcitabine treatment express markers of stem cell differentiation and epithelial-mesenchymal transition. Int J Oncol 2012; 41: 2093–2102.
  Article CAS PubMed Google Scholar
• Namba T, Kodama R, Moritomo S, Hoshino T, Mizushima T . Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3beta-Snail pathway. Cell Death Dis 2015; 6: e1795.
  Article CAS PubMed PubMed Central Google Scholar
• Kaufhold S, Bonavida B . Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. J Exp Clin Cancer Res 2014; 33: 62.
  Article PubMed PubMed Central Google Scholar
• Lee TH, Chennakrishnaiah S, Audemard E, Montermini L, Meehan B, Rak J . Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells. Biochem Biophys Res Commun 2014; 451: 295–301.
  Article CAS PubMed Google Scholar
• Hu Y, Yan C, Mu L, Huang K, Li X, Tao D et al. Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer. PLoS One 2015; 10: e0125625.
  Article PubMed PubMed Central Google Scholar
• Boelens MC, Wu Tony, J, Nabet BY, Xu B, Qiu Y, Yoon T et al. Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell 2014; 159: 499–513.
  Article CAS PubMed PubMed Central Google Scholar
• Ray K . Pancreatic cancer: Pancreatic cancer exosomes prime the liver for metastasis. Nat Rev 2015; 12: 371.
  Google Scholar
• Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 2015; 527: 100–104.
  Article CAS PubMed PubMed Central Google Scholar
• Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M et al. Tumour exosome integrins determine organotropic metastasis. Nature 2015; 527: 329–335.
  Article CAS PubMed PubMed Central Google Scholar
• Arensman MD, Kovochich AN, Kulikauskas RM, Lay AR, Yang PT, Li X et al. WNT7B mediates autocrine Wnt/beta-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma. Oncogene 2014; 33: 899–908.
  Article CAS PubMed Google Scholar
• Sun N, Johnson J, Stack MS, Szajko J, Sander C, Rebuyon R et al. Nanoparticle analysis of cancer cells by light transmission spectroscopy. Anal Biochem 2015; 484: 58–65.
  Article CAS PubMed Google Scholar
• Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, Abbruzzese JL et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res. 2009; 69: 5820–5828.
  Article CAS PubMed PubMed Central Google Scholar
• Gifford JB, Huang W, Zeleniak AE, Hindoyan A, Wu H, Donahue TR et al. Expression Of GRP78, master regulator of the unfolded protein response, increases chemoresistance in pancreatic ductal adenocarcinoma. Mol Cancer Ther 2016; 15: 1043–1052.
  Article CAS PubMed Google Scholar