Enterotypes in the landscape of gut microbial community composition (original) (raw)

Change history

• 13 February 2018

In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective.

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Acknowledgements

The authors are grateful to the members of the Bork group at EMBL for discussions and assistance. The research leading to these results has received funding from EMBL, the VIB, the Rega institute for Medical Research, the European Research Council via the CancerBiome project (project reference 268985), MicrobesInside (250172) and the European Community’s Seventh Framework Programme via the MetaHIT (HEALTH-F4-2007-201052), the METACARDIS project (FP7-HEALTH-2012-INNOVATION-I-305312), the European Union’s Horizon 2020 research and innovation programme (Marie Sklodowska-Curie grant 600375), Metagenopolis grant ANR-11-DPBS-0001 and the IHMS project (FP7-HEALTH-2010-single-stage-261376).

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Author notes

1. Paul I. Costea and Falk Hildebrand contributed equally to this work.

Authors and Affiliations

1. European Molecular Biology Laboratory, Heidelberg, Germany
   Paul I. Costea, Falk Hildebrand, Shinichi Sunagawa, Georg Zeller & Peer Bork
2. VIB Center for Microbiology, VIB, Belgium
   Falk Hildebrand & Jeroen Raes
3. Laboratory of Microbiology, Vrije Universiteit Brussel, Brussels, Belgium
   Falk Hildebrand & Jeroen Raes
4. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
   Manimozhiyan Arumugam
5. Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
   Fredrik Bäckhed & Jun Wang
6. Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
   Fredrik Bäckhed
7. New York University Langone Medical Center, New York, NY, USA
   Martin J. Blaser
8. Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
   Frederic D. Bushman
9. RPU Immunobiology, Department of Bacteriology & Immunology, University of Helsinki, Helsinki, Finland
   Willem M. de Vos
10. Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
    Willem M. de Vos
11. Metagenopolis, Institut National de la Recherche Agronomique, Jouy en Josas, France
    S. Dusko Ehrlich
12. King’s College London, Centre for Host-Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital, London, UK
    S. Dusko Ehrlich
13. Institute for Genome Sciences at the University of Maryland School of Medicine, Baltimore, MD, USA
    Claire M. Fraser
14. Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    Masahira Hattori
15. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Curtis Huttenhower
16. APC Microbiome Institute, University College Cork, Cork, Ireland
    Ian B. Jeffery, Paul W. O’Toole & Fergus Shanahan
17. Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA
    Dan Knights
18. Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA
    Dan Knights
19. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    James D. Lewis
20. MPI Department of Microbiome Science, Tübingen, Germany
    Ruth E. Ley
21. Department of Integrative Biology, University of Texas, Austin, TX, USA
    Howard Ochman
22. Warwick Medical School, University of Warwick, Coventry, UK
    Christopher Quince
23. Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA
    David A. Relman
24. Department of Medicine, Stanford University, Stanford, CA, USA
    David A. Relman
25. Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    David A. Relman
26. Department of Biology, Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Shinichi Sunagawa
27. Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Jun Wang
28. Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia
    Jun Wang
29. Macau University of Science and Technology, Avenida Wai long, Taipa, Macau, China
    Jun Wang
30. Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Pokfulam, Hong Kong
    Jun Wang
31. The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
    George M. Weinstock
32. Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Gary D. Wu
33. Ministry of Education Key Laboratory for Systems Biomedicine, Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
    Liping Zhao
34. Department of Microbiology and Immunology, Rega Institute KU Leuven, Leuven, Belgium
    Jeroen Raes
35. Department of Computer Science, University of Colorado, Boulder, CO, USA
    Rob Knight
36. Biofrontiers Institute, University of Colorado, Boulder, CO, USA
    Rob Knight
37. Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA
    Rob Knight
38. Howard Hughes Medical Institute, University of Colorado, Boulder, CO, USA
    Rob Knight
39. Max-Delbrück-Centre for Molecular Medicine, Berlin, Germany
    Peer Bork
40. Molecular Medicine Partnership Unit, Heidelberg, Germany
    Peer Bork

Authors

1. Paul I. Costea
2. Falk Hildebrand
3. Manimozhiyan Arumugam
4. Fredrik Bäckhed
5. Martin J. Blaser
6. Frederic D. Bushman
7. Willem M. de Vos
8. S. Dusko Ehrlich
9. Claire M. Fraser
10. Masahira Hattori
11. Curtis Huttenhower
12. Ian B. Jeffery
13. Dan Knights
14. James D. Lewis
15. Ruth E. Ley
16. Howard Ochman
17. Paul W. O’Toole
18. Christopher Quince
19. David A. Relman
20. Fergus Shanahan
21. Shinichi Sunagawa
22. Jun Wang
23. George M. Weinstock
24. Gary D. Wu
25. Georg Zeller
26. Liping Zhao
27. Jeroen Raes
28. Rob Knight
29. Peer Bork

Contributions

P.B., R.K. and J.R. conceived the review. P.I.C., F.H. and G.Z. performed data analysis. F.H., P.I.C., J.R. and P.B. performed the literature research, with input from all co-authors. P.I.C., F.H., S.S., R.K., J.R. and P.B. wrote the manuscript with contributions from M.A., F.B., M.J.B., F.D.B., W.M.d.V., S.D.E., C.m.F., M.H., C.H., I.B.J., D.K., J.D.L., R.E.L., H.O., P.W.O., C.Q., D.A.R., F.S., J.W., G.M.W., G.D.W., G.Z. and L.Z.

Corresponding authors

Correspondence toJeroen Raes, Rob Knight or Peer Bork.

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The authors declare no competing financial interests.

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Costea, P.I., Hildebrand, F., Arumugam, M. et al. Enterotypes in the landscape of gut microbial community composition.Nat Microbiol 3, 8–16 (2018). https://doi.org/10.1038/s41564-017-0072-8

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• Received: 15 August 2017
• Accepted: 27 October 2017
• Published: 18 December 2017
• Issue date: January 2018
• DOI: https://doi.org/10.1038/s41564-017-0072-8