Global burden of irritable bowel syndrome: trends, predictions and risk factors (original) (raw)
Lovell, R. M. & Ford, A. C. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin. Gastroenterol. Hepatol.10, 712–721.e4 (2012). PubMed Google Scholar
Canavan, C., West, J. & Card, T. Review article: the economic impact of the irritable bowel syndrome. Aliment. Pharmacol. Ther.40, 1023–1034 (2014). CASPubMed Google Scholar
Gwee, K. A. Irritable bowel syndrome in developing countries – a disorder of civilization or colonization? Neurogastroenterol. Motil.17, 317–324 (2005). PubMed Google Scholar
Danivat, D., Tankeyoon, M. & Sriratanaban, A. Prevalence of irritable bowel syndrome in a non-Western population. Br. Med. J.296, 1710 (1988). CAS Google Scholar
Gwee, K. A., Wee, S., Wong, M. L. & Png, D. J. The prevalence, symptom characteristics, and impact of irritable bowel syndrome in an asian urban community. Am. J. Gastroenterol.99, 924–931 (2004). PubMed Google Scholar
Xiong, L. S. et al. A population-based epidemiologic study of irritable bowel syndrome in South China: stratified randomized study by cluster sampling. Aliment. Pharmacol. Ther.19, 1217–1224 (2004). CASPubMed Google Scholar
Mearin, F. et al. Bowel disorders. Gastroenterology150, 1393–1407.e5 (2016). Google Scholar
Sperber, A. D. et al. Conducting multinational, cross-cultural research in the functional gastrointestinal disorders: issues and recommendations. A Rome foundation working team report. Aliment. Pharmacol. Ther.40, 1094–1102 (2014). CASPubMed Google Scholar
Schmulson, M. et al. A four-country comparison of healthcare systems, implementation of diagnostic criteria, and treatment availability for functional gastrointestinal disorders: a report of the Rome foundation working team on cross-cultural, multinational research. Neurogastroenterol. Motil.26, 1368–1385 (2014). CASPubMed Google Scholar
Drossman, D. A. Rome IV Functional Gastrointestinal Disorders: Disorders of Gut-Brain Interaction Vol. 1 Ch. 7 (Rome Foundation, 2016).
Palsson, O., Heymen, S. & Whitehead, W. Abdominal pain versus abdominal discomfort: implications for diagnostic assessment of irritable bowel syndrome (IBS) [abstract P0405]. United European Gastroenterol. J.2, A243 (2014). Google Scholar
Ghoshal, U. C. et al. Epidemiological and clinical profile of irritable bowel syndrome in India: report of the Indian Society of Gastroenterology Task Force. Indian J. Gastroenterol.27, 22–28 (2008). PubMed Google Scholar
Francisconi, C. F. et al. Multicultural aspects in functional gastrointestinal disorders (FGIDs). Gastroenterology150, 1344–1354.e2 (2016). Google Scholar
Gwee, K. A., Lu, C. L. & Ghoshal, U. C. Epidemiology of irritable bowel syndrome in Asia: something old, something new, something borrowed. J. Gastroenterol. Hepatol.24, 1601–1607 (2009). PubMed Google Scholar
Holtmann, G. J. & Talley, N. J. Inconsistent symptom clusters for functional gastrointestinal disorders in Asia: is Rome burning? Gut67, 1911–1915 (2018). PubMed Google Scholar
Longstreth, G. F. et al. Functional bowel disorders. Gastroenterology130, 1480–1491 (2006). PubMed Google Scholar
Black, C. J., Yiannakou, Y., Houghton, L. A. & Ford, A. C. Epidemiological, clinical, and psychological characteristics of individuals with self-reported irritable bowel syndrome based on the Rome IV vs Rome III criteria. Clin. Gastroenterol. Hepatol.18, 392–398.e2 (2020). PubMed Google Scholar
Sperber, A. D. et al. The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review. Gut66, 1075–1082 (2017). PubMed Google Scholar
Makharia, G. K. et al. Prevalence of irritable bowel syndrome: a community based study from northern India. J. Neurogastroenterol. Motil.17, 82–87 (2011). PubMedPubMed Central Google Scholar
Chang, F. Y. et al. Prevalence of functional gastrointestinal disorders in Taiwan: questionnaire-based survey for adults based on the Rome III criteria. Asia Pac. J. Clin. Nutr.21, 594–600 (2012). PubMed Google Scholar
Krogsgaard, L. R., Engsbro, A. L. & Bytzer, P. The epidemiology of irritable bowel syndrome in Denmark. A population-based survey in adults ≤50 years of age. Scand. J. Gastroenterol.48, 523–529 (2013). PubMed Google Scholar
Matsumoto, S. et al. Relationship between overactive bladder and irritable bowel syndrome: a large-scale internet survey in Japan using the overactive bladder symptom score and Rome III criteria. BJU Int.111, 647–652 (2013). PubMed Google Scholar
Perveen, I., Rahman, M. M., Saha, M., Rahman, M. M. & Hasan, M. Q. Prevalence of irritable bowel syndrome and functional dyspepsia, overlapping symptoms, and associated factors in a general population of Bangladesh. Indian J. Gastroenterol.33, 265–273 (2014). PubMed Google Scholar
Cai, S. T. et al. Overlap of gastroesophageal reflux disease and functional bowel disorders in the general Chinese rural population. J. Dig. Dis.16, 395–399 (2015). PubMed Google Scholar
Le Pluart, D. et al. Functional gastrointestinal disorders in 35,447 adults and their association with body mass index. Aliment. Pharmacol. Ther.41, 758–767 (2015). PubMed Google Scholar
Rasmussen, S. et al. Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population. Scand. J. Gastroenterol.50, 162–169 (2015). CASPubMed Google Scholar
Kanazawa, M. et al. Abdominal bloating is the most bothersome symptom in irritable bowel syndrome with constipation (IBS-C): a large population-based Internet survey in Japan. Biopsychosoc. Med.10, 19 (2016). PubMedPubMed Central Google Scholar
Althaus, A. et al. Determinants and frequency of irritable bowel syndrome in a German sample. Z. Gastroenterol.54, 217–225 (2016). CASPubMed Google Scholar
Siah, K. T., Wong, R. K., Chan, Y. H., Ho, K. Y. & Gwee, K. A. Prevalence of irritable bowel syndrome in Singapore and its association with dietary, lifestyle, and environmental factors. J. Neurogastroenterol. Motil.22, 670–676 (2016). PubMedPubMed Central Google Scholar
Long, Y. et al. Prevalence and risk factors for functional bowel disorders in South China: a population based study using the Rome III criteria. Neurogastroenterol. Motil.29, e12897 (2017).
Ghoshal, U. C. & Singh, R. Frequency and risk factors of functional gastro-intestinal disorders in a rural Indian population. J. Gastroenterol. Hepatol.32, 378–387 (2017). PubMed Google Scholar
Saha, M. et al. Irritable bowel syndrome: prevalence and dietary factors in the sylhet district of Bangladesh. Mymensingh Med. J.27, 82–88 (2018). CASPubMed Google Scholar
Torres, M. J. et al. Food consumption and dietary intakes in 36,448 adults and their association with irritable bowel syndrome: Nutrinet-Sante study. Therap. Adv. Gastroenterol.11, 1756283x17746625 (2018). PubMedPubMed Central Google Scholar
Schauer, B. et al. Irritable bowel syndrome, mental health, and quality of life: data from a population-based survey in Germany (SHIP-Trend-0). Neurogastroenterol. Motil.31, e13511 (2019). PubMed Google Scholar
Iri, R. et al. Epidemiological study of irritable bowel syndrome and its related factors in Sanandaj from 2013 to 2014: a population-based study. Sci. J. Kurd. Univ. Med. Sci.22, 61–71 (2017). Google Scholar
Keshteli, A. H., Dehestani, B., Daghaghzadeh, H. & Adibi, P. Epidemiological features of irritable bowel syndrome and its subtypes among Iranian adults. Ann. Gastroenterol.28, 253–258 (2015). PubMedPubMed Central Google Scholar
Liu, C. et al. Prevalence of and risk factors for irritable bowel syndrome in community residents in Nanning. World Chin. J. Digestol.22, 5365–5370 (2014). Google Scholar
Miwa, H. Life style in persons with functional gastrointestinal disorders-large-scale internet survey of lifestyle in Japan. Neurogastroenterol. Motil.24, 464–471, e217 (2012). CASPubMed Google Scholar
Gomez Alvarez, D. F. et al. Prevalence of irritable bowel syndrome and associated factors according to the Rome III diagnostic criteria in a general population in Colombia [Spanish]. Gastroenterol. Hepatol.32, 395–400 (2009). PubMed Google Scholar
Khoshkrood-Mansoori, B. et al. Irritable bowel syndrome: a population based study. J. Gastrointestin. Liver Dis.18, 413–418 (2009). PubMed Google Scholar
Lee, S. et al. Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study. Aliment. Pharmacol. Ther.30, 643–651 (2009). CASPubMed Google Scholar
Grubic, P. et al. Irritable bowel syndrome in Croatia. Coll. Antropol.38, 565–570 (2014). PubMed Google Scholar
Sperber, A. D., Shvartzman, P., Friger, M. & Fich, A. A comparative reappraisal of the Rome II and Rome III diagnostic criteria: are we getting closer to the ‘true’ prevalence of irritable bowel syndrome? Eur. J. Gastroenterol. Hepatol.19, 441–447 (2007). PubMed Google Scholar
Palsson, O. S., Whitehead, W., Tornblom, H., Sperber, A. D. & Simren, M. Prevalence of Rome IV functional bowel disorders among adults in the United States, Canada, and the United Kingdom. Gastroenterology158, 1262–1273.e3 (2020). PubMed Google Scholar
Lovell, R. M. & Ford, A. C. Effect of gender on prevalence of irritable bowel syndrome in the community: systematic review and meta-analysis. Am. J. Gastroenterol.107, 991–1000 (2012). PubMed Google Scholar
Gwee, K. A., Ghoshal, U. C. & Chen, M. Irritable bowel syndrome in Asia: pathogenesis, natural history, epidemiology, and management. J. Gastroenterol. Hepatol.33, 99–110 (2018). PubMed Google Scholar
Wigington, W. C., Johnson, W. D. & Minocha, A. Epidemiology of irritable bowel syndrome among African Americans as compared with whites: a population-based study. Clin. Gastroenterol. Hepatol.3, 647–653 (2005). PubMed Google Scholar
Kang, J. Y. Systematic review: the influence of geography and ethnicity in irritable bowel syndrome. Aliment. Pharmacol. Ther.21, 663–676 (2005). CASPubMed Google Scholar
Ho, K. Y., Kang, J. Y. & Seow, A. Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms. Am. J. Gastroenterol.93, 1816–1822 (1998). CASPubMed Google Scholar
Rajendra, S. & Alahuddin, S. Prevalence of irritable bowel syndrome in a multi-ethnic Asian population. Aliment. Pharmacol. Ther.19, 704–706 (2004). CASPubMed Google Scholar
Qumseya, B. J. et al. Irritable bowel syndrome in middle-aged and elderly Palestinians: its prevalence and effect of location of residence. Am. J. Gastroenterol.109, 723–739 (2014). PubMed Google Scholar
Sperber, A. D. et al. Rates of functional bowel disorders among Israeli Bedouins in rural areas compared with those who moved to permanent towns. Clin. Gastroenterol. Hepatol.3, 342–348 (2005). PubMed Google Scholar
Klooker, T. K. et al. Exposure to severe wartime conditions in early life is associated with an increased risk of irritable bowel syndrome: a population-based cohort study. Am. J. Gastroenterol.104, 2250–2256 (2009). PubMed Google Scholar
Gralnek, I. M., Hays, R. D., Kilbourne, A., Naliboff, B. & Mayer, E. A. The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology119, 654–660 (2000). CASPubMed Google Scholar
Frank, L. et al. Health-related quality of life associated with irritable bowel syndrome: comparison with other chronic diseases. Clin. Ther.24, 675–689 (2002). PubMed Google Scholar
Singh, P. et al. Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation. World J. Gastroenterol.21, 8103–8109 (2015). PubMedPubMed Central Google Scholar
Buono, J. L., Carson, R. T. & Flores, N. M. Health-related quality of life, work productivity, and indirect costs among patients with irritable bowel syndrome with diarrhea. Health Qual. Life Outcomes15, 35 (2017). PubMedPubMed Central Google Scholar
Ballou, S. et al. Effects of irritable bowel syndrome on daily activities vary among subtypes based on results from the IBS in America survey. Clin. Gastroenterol. Hepatol.17, 2471–2478.e36 (2019). PubMedPubMed Central Google Scholar
Bushnell, D. M., Martin, M. L., Ricci, J. F. & Bracco, A. Performance of the EQ-5D in patients with irritable bowel syndrome. Value Health9, 90–97 (2006). PubMed Google Scholar
Drossman, D. A. et al. A focus group assessment of patient perspectives on irritable bowel syndrome and illness severity. Dig. Dis. Sci.54, 1532–1541 (2009). PubMed Google Scholar
Lacy, B. E. et al. IBS patients’ willingness to take risks with medications. Am. J. Gastroenterol.107, 804–809 (2012). PubMed Google Scholar
Drossman, D. A. et al. International survey of patients with IBS: symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefit. J. Clin. Gastroenterol.43, 541–550 (2009). PubMedPubMed Central Google Scholar
Canavan, C., West, J. & Card, T. Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study. PLoS One10, e0139389 (2015). PubMedPubMed Central Google Scholar
Weerts, Z. Z. R. M. et al. Reduction in IBS symptom severity is not paralleled by improvement in quality of life in patients with irritable bowel syndrome. Neurogastroenterol. Motil.31, e13629 (2019). PubMedPubMed Central Google Scholar
Spiegel, B. M. et al. Clinical determinants of health-related quality of life in patients with irritable bowel syndrome. Arch. Intern. Med.164, 1773–1780 (2004). PubMed Google Scholar
World Health Organization. WHOQOL: measuring quality of life (WHO, 2019).
Kanazawa, M. et al. Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress. Dig. Dis. Sci.49, 1046–1053 (2004). PubMed Google Scholar
Kanazawa, M. et al. Translation and validation of a Japanese version of the irritable bowel syndrome-quality of life measure (IBS-QOL-J). Biopsychosoc. Med.1, 6 (2007). PubMedPubMed Central Google Scholar
Park, J. M. et al. Cross-cultural validation of irritable bowel syndrome quality of life in Korea. Dig. Dis. Sci.51, 1478–1484 (2006). PubMed Google Scholar
Schmulson, M. et al. Further validation of the IBS-QOL: female Mexican IBS patients have poorer quality of life than females from North Carolina. Dig. Dis. Sci.52, 2950–2955 (2007). PubMed Google Scholar
Zhang, F., Xiang, W., Li, C. Y. & Li, S. C. Economic burden of irritable bowel syndrome in China. World J. Gastroenterol.22, 10450–10460 (2016). PubMedPubMed Central Google Scholar
Muller-Lissner, S. A. & Pirk, O. Irritable bowel syndrome in Germany. A cost of illness study. Eur. J. Gastroenterol. Hepatol.14, 1325–1329 (2002). PubMed Google Scholar
Nellesen, D., Yee, K., Chawla, A., Lewis, B. E. & Carson, R. T. A systematic review of the economic and humanistic burden of illness in irritable bowel syndrome and chronic constipation. J. Manag. Care Pharm.19, 755–764 (2013). PubMed Google Scholar
Flacco, M. E. et al. Costs of irritable bowel syndrome in European countries with universal healthcare coverage: a meta-analysis. Eur. Rev. Med. Pharmacol. Sci.23, 2986–3000 (2019). CASPubMed Google Scholar
Tack, J. et al. Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries. BMC Gastroenterol.19, 69 (2019). PubMedPubMed Central Google Scholar
Akehurst, R. L. et al. Health-related quality of life and cost impact of irritable bowel syndrome in a UK primary care setting. Pharmacoeconomics20, 455–462 (2002). PubMed Google Scholar
Hungin, A. P., Whorwell, P. J., Tack, J. & Mearin, F. The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects. Aliment. Pharmacol. Ther.17, 643–650 (2003). CASPubMed Google Scholar
Frandemark, A., Tornblom, H., Jakobsson, S. & Simren, M. Work productivity and activity impairment in irritable bowel syndrome (IBS): a multifaceted problem. Am. J. Gastroenterol.113, 1540–1549 (2018). PubMed Google Scholar
Cash, B., Sullivan, S. & Barghout, V. Total costs of IBS: employer and managed care perspective. Am. J. Manag. Care11 (Suppl. 1), S7–S16 (2005). PubMed Google Scholar
Leong, S. A. et al. The economic consequences of irritable bowel syndrome: a US employer perspective. Arch. Intern. Med.163, 929–935 (2003). PubMed Google Scholar
Poulsen, C. H. et al. Irritable bowel symptoms, use of healthcare, costs, sickness and disability pension benefits: a long-term population-based study. Scand. J. Public. Health47, 867–875 (2019). PubMed Google Scholar
Wong, R. K. et al. Partner burden in irritable bowel syndrome. Clin. Gastroenterol. Hepatol.11, 151–155 (2013). PubMed Google Scholar
Saito, Y. A. et al. Familial aggregation of irritable bowel syndrome: a family case-control study. Am. J. Gastroenterol.105, 833–841 (2010). PubMedPubMed Central Google Scholar
Waehrens, R., Ohlsson, H., Sundquist, J., Sundquist, K. & Zoller, B. Risk of irritable bowel syndrome in first-degree, second-degree and third-degree relatives of affected individuals: a nationwide family study in Sweden. Gut64, 215–221 (2015). PubMed Google Scholar
Levy, R. L. et al. Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterology121, 799–804 (2001). CASPubMed Google Scholar
Bengtson, M. B., Ronning, T., Vatn, M. H. & Harris, J. R. Irritable bowel syndrome in twins: genes and environment. Gut55, 1754–1759 (2006). PubMedPubMed Central Google Scholar
Mohammed, I., Cherkas, L. F., Riley, S. A., Spector, T. D. & Trudgill, N. J. Genetic influences in irritable bowel syndrome: a twin study. Am. J. Gastroenterol.100, 1340–1344 (2005). PubMed Google Scholar
Jin, D. C. et al. Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome. World J. Gastroenterol.22, 8137–8148 (2016). CASPubMedPubMed Central Google Scholar
Zhu, Y., Zheng, G. & Hu, Z. Association between SERT insertion/deletion polymorphism and the risk of irritable bowel syndrome: a meta-analysis based on 7039 subjects. Gene679, 133–137 (2018). CASPubMed Google Scholar
Garcia-Etxebarria, K. et al. Increased prevalence of rare sucrase-isomaltase pathogenic variants in irritable bowel syndrome patients. Clin. Gastroenterol. Hepatol.16, 1673–1676 (2018). CASPubMedPubMed Central Google Scholar
Verstraelen, T. E., Ter Bekke, R. M., Volders, P. G., Masclee, A. A. & Kruimel, J. W. The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders. Neurogastroenterol. Motil.27, 906–913 (2015). CASPubMed Google Scholar
Bonfiglio, F. et al. A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome. Neurogastroenterol. Motil.30, e13358 (2018). CASPubMed Google Scholar
Bonfiglio, F. et al. Female-specific association between variants on chromosome 9 and self-reported diagnosis of irritable bowel syndrome. Gastroenterology155, 168–179 (2018). CASPubMed Google Scholar
Norcliffe-Kaufmann, L., Slaugenhaupt, S. A. & Kaufmann, H. Familial dysautonomia: History, genotype, phenotype and translational research. Prog. Neurobiol.152, 131–148 (2017). PubMed Google Scholar
Komuro, H. et al. Corticotropin-releasing hormone receptor 2 gene variants in irritable bowel syndrome. PLoS One11, e0147817 (2016). PubMedPubMed Central Google Scholar
Sato, N. et al. Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome. PLoS One7, e42450 (2012). CASPubMedPubMed Central Google Scholar
Monsbakken, K. W., Vandvik, P. O. & Farup, P. G. Perceived food intolerance in subjects with irritable bowel syndrome–etiology, prevalence and consequences. Eur. J. Clin. Nutr.60, 667–672 (2006). CASPubMed Google Scholar
Buscail, C. et al. Western dietary pattern is associated with irritable bowel syndrome in the french nutrinet cohort. Nutrients9, 986 (2017). PubMed Central Google Scholar
Eswaran, S. Low FODMAP in 2017: lessons learned from clinical trials and mechanistic studies. Neurogastroenterol. Motil.29, e13055 (2017). Google Scholar
Hill, P., Muir, J. G. & Gibson, P. R. Controversies and recent developments of the low-FODMAP diet. Gastroenterol. Hepatol.13, 36–45 (2017). Google Scholar
Catassi, C. et al. The overlapping area of non-celiac gluten sensitivity (NCGS) and wheat-sensitive irritable bowel syndrome (IBS): an update. Nutrients9, 1268 (2017). PubMed Central Google Scholar
Dionne, J. et al. A systematic review and meta-analysis evaluating the efficacy of a gluten-free diet and a low FODMAPs diet in treating symptoms of irritable bowel syndrome. Am. J. Gastroenterol.113, 1290–1300 (2018). CASPubMed Google Scholar
Zhou, Q. et al. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut68, 996–1002 (2019). CASPubMed Google Scholar
Parker, T. J. et al. Irritable bowel syndrome: is the search for lactose intolerance justified? Eur. J. Gastroenterol. Hepatol.13, 219–225 (2001). CASPubMed Google Scholar
Fritscher-Ravens, A. et al. Many patients with irritable bowel syndrome have atypical food allergies not associated with immunoglobulin E. Gastroenterology157, 109–118.e5 (2019). PubMed Google Scholar
Chong, P. P. et al. The microbiome and irritable bowel syndrome-a review on the pathophysiology, current research and future therapy. Front. Microbiol.10, 1136 (2019). PubMedPubMed Central Google Scholar
Kassinen, A. et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology133, 24–33 (2007). CASPubMed Google Scholar
Parthasarathy, G. et al. Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation. Gastroenterology150, 367–379.e1 (2016). PubMed Google Scholar
Tap, J. et al. Identification of an Intestinal microbiota signature associated with severity of irritable bowel syndrome. Gastroenterology152, 111–123.e8 (2017). PubMed Google Scholar
Quigley, E. M. M. Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nat. Rev. Gastroenterol. Hepatol.14, 315–320 (2017). PubMed Google Scholar
Halmos, E. P. et al. Diets that differ in their FODMAP content alter the colonic luminal microenvironment. Gut64, 93–100 (2015). CASPubMed Google Scholar
Pimentel, M. et al. Antibiotic treatment of constipation-predominant irritable bowel syndrome. Dig. Dis. Sci.59, 1278–1285 (2014). CASPubMed Google Scholar
Ianiro, G. et al. Systematic review with meta-analysis: efficacy of faecal microbiota transplantation for the treatment of irritable bowel syndrome. Aliment. Pharmacol. Ther.50, 240–248 (2019). PubMed Google Scholar
El-Salhy, M., Hatlebakk, J. G., Gilja, O. H., Brathen Kristoffersen, A. & Hausken, T. Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study. Guthttps://doi.org/10.1136/gutjnl-2019-319630 (2019). ArticlePubMed Google Scholar
Ford, A. C. et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am. J. Gastroenterol.109, 1547–1561 (2014). PubMed Google Scholar
Ford, A. C., Harris, L. A., Lacy, B. E., Quigley, E. M. M. & Moayyedi, P. Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome. Aliment. Pharmacol. Ther.48, 1044–1060 (2018). PubMed Google Scholar
Deschasaux, M. et al. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nat. Med.24, 1526–1531 (2018). CASPubMed Google Scholar
Mueller, S. et al. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl. Environ. Microbiol.72, 1027–1033 (2006). CASPubMedPubMed Central Google Scholar
Spiller, R. & Garsed, K. Postinfectious irritable bowel syndrome. Gastroenterology136, 1979–1988 (2009). PubMed Google Scholar
Card, T. et al. Post-infectious IBS: defining its clinical features and prognosis using an internet-based survey. United European Gastroenterol. J.6, 1245–1253 (2018). PubMedPubMed Central Google Scholar
Neal, K. R., Hebden, J. & Spiller, R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. BMJ314, 779–782 (1997). CASPubMedPubMed Central Google Scholar
Thabane, M., Kottachchi, D. T. & Marshall, J. K. Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome. Aliment. Pharmacol. Ther.26, 535–544 (2007). CASPubMed Google Scholar
Wadhwa, A. et al. High risk of post-infectious irritable bowel syndrome in patients with Clostridium difficile infection. Aliment. Pharmacol. Ther.44, 576–582 (2016). CASPubMedPubMed Central Google Scholar
Ghoshal, U. C. & Rahman, M. M. Post-infection irritable bowel syndrome in the tropical and subtropical regions: Vibrio cholerae is a new cause of this well-known condition. Indian J. Gastroenterol.38, 87–94 (2019). PubMed Google Scholar
Neal, K. R., Barker, L. & Spiller, R. C. Prognosis in post-infective irritable bowel syndrome: a six year follow up study. Gut51, 410–413 (2002). CASPubMedPubMed Central Google Scholar
Schwille-Kiuntke, J. et al. Postinfectious irritable bowel syndrome: follow-up of a patient cohort of confirmed cases of bacterial infection with Salmonella or Campylobacter. Neurogastroenterol. Motil.23, e479–e488 (2011). CASPubMed Google Scholar
Rodriguez, L. A. & Ruigomez, A. Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study. BMJ318, 565–566 (1999). CASPubMedPubMed Central Google Scholar
Zanini, B. et al. Incidence of post-infectious irritable bowel syndrome and functional intestinal disorders following a water-borne viral gastroenteritis outbreak. Am. J. Gastroenterol.107, 891–899 (2012). PubMed Google Scholar
Marshall, J. K., Thabane, M., Borgaonkar, M. R. & James, C. Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen. Clin. Gastroenterol. Hepatol.5, 457–460 (2007). PubMed Google Scholar
Hanevik, K. et al. Irritable bowel syndrome and chronic fatigue 6 years after giardia infection: a controlled prospective cohort study. Clin. Infect. Dis.59, 1394–1400 (2014). CASPubMedPubMed Central Google Scholar
Wensaas, K. A. et al. Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. Gut61, 214–219 (2012). PubMed Google Scholar
Svendsen, A. T., Bytzer, P. & Engsbro, A. L. Systematic review with meta-analyses: does the pathogen matter in post-infectious irritable bowel syndrome? Scand. J. Gastroenterol.54, 546–562 (2019). CASPubMed Google Scholar
Klem, F. et al. Prevalence, risk factors, and outcomes of irritable bowel syndrome after infectious enteritis: a systematic review and meta-analysis. Gastroenterology152, 1042–1054.e1 (2017). PubMed Google Scholar
Rahman, M. M. et al. Long-term gastrointestinal consequences are frequent following sporadic acute infectious diarrhea in a tropical country: a prospective cohort study. Am. J. Gastroenterol.113, 1363–1375 (2018). CASPubMed Google Scholar
Parida, P. K. et al. A prospective study on incidence, risk factors, and validation of a risk score for post-infection irritable bowel syndrome in coastal eastern India. Indian J. Gastroenterol.38, 134–142 (2019). PubMed Google Scholar
Youn, Y. H. et al. Long-term clinical course of post-infectious irritable bowel syndrome after shigellosis: a 10-year follow-up study. J. Neurogastroenterol. Motil.22, 490–496 (2016). PubMedPubMed Central Google Scholar
Center for Disease Control and Prevention. Foodborne illness and germs (CDC, 2019).
GBD Diarrhoeal Diseases Collaborators. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect. Dis.17, 909–948 (2017). Google Scholar
Zamani, M., Alizadeh-Tabari, S. & Zamani, V. Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther.50, 132–143 (2019). PubMed Google Scholar
Van Oudenhove, L. et al. Biopsychosocial aspects of functional gastrointestinal disorders: how central and environmental processes contribute to the development and expression of functional gastrointestinal disorders. Gastroenterology150, 1355–1367.e2 (2016). Google Scholar
Koloski, N. A. et al. The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut61, 1284–1290 (2012). CASPubMed Google Scholar
Quigley, E. M. M. The gut-brain axis and the microbiome: clues to pathophysiology and opportunities for novel management strategies in irritable bowel syndrome (IBS). J. Clin. Med.7, 6 (2018). PubMed Central Google Scholar
Koloski, N. A., Jones, M. & Talley, N. J. Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. Aliment. Pharmacol. Ther.44, 592–600 (2016). CASPubMed Google Scholar
World Health Organization. Mental disorders affect one in four people (WHO, 2019).
Baxter, A. J. et al. Challenging the myth of an “epidemic” of common mental disorders: trends in the global prevalence of anxiety and depression between 1990 and 2010. Depress. Anxiety31, 506–516 (2014). PubMed Google Scholar
Steel, Z. et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980-2013. Int. J. Epidemiol.43, 476–493 (2014). PubMedPubMed Central Google Scholar
Baxter, A. J., Scott, K. M., Vos, T. & Whiteford, H. A. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol. Med.43, 897–910 (2013). CASPubMed Google Scholar
Khoury, C. K. et al. Increasing homogeneity in global food supplies and the implications for food security. Proc. Natl Acad. Sci. USA111, 4001–4006 (2014). CASPubMedPubMed Central Google Scholar
Davies, S. C. Annual report of the Chief Medical Officer 2015, on the state of the public’s health, baby boomers: fit for the future (Department of Health and Social Care, 2016).
Black, C. J. & Ford, A. C. Rational investigations in irritable bowel syndrome. Frontline Gastroenterol.11, 140–147 (2019). PubMedPubMed Central Google Scholar
Lacy, B. E., Ford, A. C. & Talley, N. J. Quality of care and the irritable bowel syndrome: is now the time to set standards? Am. J. Gastroenterol.113, 167–169 (2018). PubMed Google Scholar
Chang, L. et al. Functional bowel disorders: a roadmap to guide the next generation of research. Gastroenterology154, 723–735 (2018). PubMed Google Scholar
International Confederation of Dietetic Associations. Dieticians around the world: their education and their work (ICDA, 2008).
Choudhry, F. R., Mani, V., Ming, L. C. & Khan, T. M. Beliefs and perception about mental health issues: a meta-synthesis. Neuropsychiatr. Dis. Treat.12, 2807–2818 (2016). PubMedPubMed Central Google Scholar
Beck, A., Nadkarni, A., Calam, R., Naeem, F. & Husain, N. Increasing access to cognitive behaviour therapy in low and middle income countries: a strategic framework. Asian J. Psychiatr.22, 190–195 (2016). PubMed Google Scholar