Synthetic alternatives to Matrigel (original) (raw)
References
Orkin, R. W. et al. A murine tumor producing a matrix of basement membrane. J. Exp. Med.145, 204–220 (1977). CAS Google Scholar
LeBleu, V. S., Macdonald, B. & Kalluri, R. Structure and function of basement membranes. Exp. Biol. Med.232, 1121–1129 (2007). CAS Google Scholar
Kubota, Y., Kleinman, H. K., Martin, G. R. & Lawley, T. J. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J. Cell Biol.107, 1589–1598 (1988). CAS Google Scholar
Kleinman, H. K. et al. Basement membrane complexes with biological activity. Biochemistry25, 312–318 (1986). This paper investigates the protein composition and biological activity of the basement-membrane extract from EHS mouse chondrosarcomas; this extract was later developed and commercialized as Matrigel. CAS Google Scholar
Kleinman, H. K. & Martin, G. R. Matrigel: basement membrane matrix with biological activity. Semin. Cancer Biol.15, 378–386 (2005). CAS Google Scholar
Hughes, C. S., Postovit, L. M. & Lajoie, G. A. Matrigel: a complex protein mixture required for optimal growth of cell culture. Proteomics10, 1886–1890 (2010). A full proteomic analysis of Matrigel and GFR Matrigel, reporting their complex, ill-defined and variable composition. CAS Google Scholar
Timpl, R. et al. Laminin — a glycoprotein from basement membranes. J. Biol. Chem.254, 9933–9937 (1979). CAS Google Scholar
Terranova, V. P., Aumailley, M., Sultan, L. H., Martin, G. R. & Kleinman, H. K. Regulation of cell attachment and cell number by fibronectin and laminin. J. Cell. Physiol.127, 473–479 (1986). CAS Google Scholar
Miyazaki, T. et al. Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Biochem. Biophys. Res. Commun.375, 27–32 (2008). CAS Google Scholar
Ponce, M. L. et al. Identification of endothelial cell binding sites on the laminin γ1 chain. Circ. Res.84, 688–694 (1999). CAS Google Scholar
Wang, K., Ji, L. & Hua, Z. Functional peptides from laminin-1 improve the cell adhesion capacity of recombinant mussel adhesive protein. Protein Pept. Lett.24, 348–352 (2017). Google Scholar
Heaton, M. B. & Swanson, D. J. The influence of laminin on the initial differentiation of cultured neural tube neurons. J. Neurosci. Res.19, 212–218 (1988). CAS Google Scholar
Farrukh, A. et al. Bifunctional hydrogels containing the laminin motif IKVAV promote neurogenesis. Stem Cell Rep.9, 1432–1440 (2017). CAS Google Scholar
Ali, S., Saik, J. E., Gould, D. J., Dickinson, M. E. & West, J. L. Immobilization of cell-adhesive laminin peptides in degradable PEGDA hydrogels influences endothelial cell tubulogenesis. BioResearch Open Access2, 241–249 (2013). CAS Google Scholar
Engbring, J. A. & Kleinman, H. K. The basement membrane matrix in malignancy. J. Pathol.200, 465–470 (2003). CAS Google Scholar
Kikkawa, Y. et al. Laminin-111-derived peptides and cancer. Cell Adh. Migr.7, 150–159 (2013). Google Scholar
Vukicevic, S. et al. Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp. Cell Res.202, 1–8 (1992). This study identifies multiple active growth factors in Matrigel and suggests caution when interpreting cellular activity when cultured on Matrigel. CAS Google Scholar
Talbot, N. C. & Caperna, T. J. Proteome array identification of bioactive soluble proteins/peptides in Matrigel: relevance to stem cell responses. Cytotechnology67, 873–883 (2015). CAS Google Scholar
Gillette, K. M., Forbes, K. & Sehgal, I. Detection of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinase-2, urokinase and plasminogen activator inhibitor-1 within Matrigel and growth factor-reduced Matrigel basement membrane. Tumori89, 421–425 (2003). CAS Google Scholar
Xu, C. et al. Feeder-free growth of undifferentiated human embryonic stem cells. Nat. Biotechnol.19, 971–974 (2001). CAS Google Scholar
Qian, L. & Saltzman, W. M. Improving the expansion and neuronal differentiation of mesenchymal stem cells through culture surface modification. Biomaterials25, 1331–1337 (2004). CAS Google Scholar
Lee, S.-W. et al. Optimization of Matrigel-based culture for expansion of neural stem cells. Anim. Cell Syst.19, 175–180 (2015). CAS Google Scholar
Laflamme, M. A. et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat. Biotechnol.25, 1015–1024 (2007). CAS Google Scholar
Ponce, M. L. Tube formation: an in vitro Matrigel angiogenesis assay. Methods Mol. Biol.467, 183–188 (2009). CAS Google Scholar
Ponce, M. L. In vitro Matrigel angiogenesis assays. Methods Mol. Med.46, 205–209 (2001). CAS Google Scholar
Mondrinos, M. J. et al. Engineering three-dimensional pulmonary tissue constructs. Tissue Eng.12, 717–728 (2006). CAS Google Scholar
Li, Z. & Guan, J. Hydrogels for cardiac tissue engineering. Polymers3, 740–761 (2011). CAS Google Scholar
Lancaster, M. A. & Knoblich, J. A. Organogenesis in a dish: modeling development and disease using organoid technologies. Science345, 1247125 (2014). Google Scholar
Lancaster, M. A. et al. Cerebral organoids model human brain development and microcephaly. Nature501, 373–379 (2013). CAS Google Scholar
Benton, G., Kleinman, H. K., George, J. & Arnaoutova, I. Multiple uses of basement membrane-like matrix (BME/Matrigel) in vitro and in vivo with cancer cells. Int. J. Cancer128, 1751–1757 (2011). CAS Google Scholar
Cruz-Acuña, R. & García, A. J. Synthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions. Matrix Biol.57–58, 324–333 (2017). Google Scholar
Polykandriotis, E., Arkudas, A., Horch, R. E., Kneser, U. & Mitchell, G. To Matrigel or not to Matrigel. Am. J. Pathol.172, 1441–1442 (2008). Google Scholar
Kohen, N. T., Little, L. E. & Healy, K. E. Characterization of Matrigel interfaces during defined human embryonic stem cell culture. Biointerphases4, 69–79 (2009). Google Scholar
Soofi, S. S., Last, J. A., Liliensiek, S. J., Nealey, P. F. & Murphy, C. J. The elastic modulus of Matrigel as determined by atomic force microscopy. J. Struct. Biol.167, 216–219 (2009). CAS Google Scholar
Dirami, G. et al. Identification of transferrin and inhibin-like proteins in Matrigel. In Vitro Cell. Dev. Biol. Anim.31, 409–411 (1995). CAS Google Scholar
Hansen, K. C. et al. An in-solution ultrasonication-assisted digestion method for improved extracellular matrix proteome coverage. Mol. Cell. Proteom.8, 1648–1657 (2009). CAS Google Scholar
Zaman, M. H. et al. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc. Natl Acad. Sci. USA103, 10889–10894 (2006). CAS Google Scholar
Semler, E. J., Ranucci, C. S. & Moghe, P. V. Mechanochemical manipulation of hepatocyte aggregation can selectively induce or repress liver-specific function. Biotechnol. Bioeng.69, 359–369 (2000). CAS Google Scholar
Kane, K. I. W. et al. Determination of the rheological properties of Matrigel for optimum seeding conditions in microfluidic cell cultures. AIP Adv.8, 125332 (2018). Google Scholar
Alcaraz, J. et al. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J.27, 2829–2838 (2008). CAS Google Scholar
Reed, J., Walczak, W. J., Petzold, O. N. & Gimzewski, J. K. In situ mechanical interferometry of Matrigel films. Langmuir25, 36–39 (2009). CAS Google Scholar
Peterson, N. C. From bench to cageside: risk assessment for rodent pathogen contamination of cells and biologics. ILAR J.49, 310–315 (2008). CAS Google Scholar
Liu, H. et al. Removal of lactate dehydrogenase-elevating virus from human-in-mouse breast tumor xenografts by cell-sorting. J. Virol. Methods173, 266–270 (2011). CAS Google Scholar
Ammann, C. G., Messer, R. J., Peterson, K. E. & Hasenkrug, K. J. Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNα responses by plasmacytoid dendritic cells. PLoS One4, e6105 (2009). Google Scholar
Riley, V. et al. The LDH virus: an interfering biological contaminant. Science200, 124–126 (1978). CAS Google Scholar
Caliari, S. R. & Burdick, J. A. A practical guide to hydrogels for cell culture. Nat. Methods13, 405–414 (2016). CAS Google Scholar
Li, X., Sun, Q., Li, Q., Kawazoe, N. & Chen, G. Functional hydrogels with tunable structures and properties for tissue engineering applications. Front. Chem.6, 499 (2018). CAS Google Scholar
Fischer, R. S., Myers, K. A., Gardel, M. L. & Waterman, C. M. Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior. Nat. Protoc.7, 2056–2066 (2012). CAS Google Scholar
Tse, J. R. & Engler, A. J. Preparation of hydrogel substrates with tunable mechanical properties. Curr. Protoc. Cell Biol.47, 10.16.1–10.16.16 (2010). Google Scholar
Pelham, R. J. Jr. & Wang, Y.-l. Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc. Natl Acad. Sci. USA94, 13661–13665 (1997). CAS Google Scholar
Zustiak, S. P. & Leach, J. B. Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical properties. Biomacromolecules11, 1348–1357 (2010). CAS Google Scholar
Krsko, P. & Libera, M. Biointeractive hydrogels. Mater. Today8, 36–44 (2005). CAS Google Scholar
Zhu, J. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials31, 4639–4656 (2010). CAS Google Scholar
Lin, C.-C. & Anseth, K. S. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm. Res.26, 631–643 (2009). CAS Google Scholar
Tibbitt, M. W. & Anseth, K. S. Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol. Bioeng.103, 655–663 (2009). CAS Google Scholar
Fairbanks, B. D. et al. A versatile synthetic extracellular matrix mimic via thiol-norbornene photopolymerization. Adv. Mater.21, 5005–5010 (2009). CAS Google Scholar
Bryant, S. & Anseth, K. in Scaffolding in Tissue Engineering (eds Ma, P. X. & Elisseeff, J.) 71–90 (CRC, 2005).
Nguyen, K. T. & West, J. L. Photopolymerizable hydrogels for tissue engineering applications. Biomaterials23, 4307–4314 (2002). CAS Google Scholar
Nair, D. P. et al. The thiol-Michael addition click reaction: a powerful and widely used tool in materials chemistry. Chem. Mater.26, 724–744 (2014). CAS Google Scholar
Schense, J. C. & Hubbell, J. A. Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjug. Chem.10, 75–81 (1999). CAS Google Scholar
Ehrbar, M. et al. Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions. Biomacromolecules8, 3000–3007 (2007). CAS Google Scholar
Bryant, S. J., Chowdhury, T. T., Lee, D. A., Bader, D. L. & Anseth, K. S. Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann. Biomed. Eng.32, 407–417 (2004). Google Scholar
Roberts, J. J. & Bryant, S. J. Comparison of photopolymerizable thiol-ene PEG and acrylate-based PEG hydrogels for cartilage development. Biomaterials34, 9969–9979 (2013). CAS Google Scholar
Burdick, J. A. & Anseth, K. S. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials23, 4315–4323 (2002). CAS Google Scholar
Kharkar, P. M., Rehmann, M. S., Skeens, K. M., Maverakis, E. & Kloxin, A. M. Thiol–ene click hydrogels for therapeutic delivery. ACS Biomater. Sci. Eng.2, 165–179 (2016). CAS Google Scholar
Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science282, 1145–1147 (1998). CAS Google Scholar
Avior, Y., Sagi, I. & Benvenisty, N. Pluripotent stem cells in disease modelling and drug discovery. Nat. Rev. Mol. Cell Biol.17, 170–182 (2016). CAS Google Scholar
Singh, V. K., Kalsan, M., Kumar, N., Saini, A. & Chandra, R. Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery. Front. Cell Dev. Biol.3, 2 (2015). Google Scholar
Shi, Y., Inoue, H., Wu, J. C. & Yamanaka, S. Induced pluripotent stem cell technology: a decade of progress. Nat. Rev. Drug. Discov.16, 115–130 (2017). CAS Google Scholar
Ortiz-Vitali, J. L. & Darabi, R. iPSCs as a platform for disease modeling, drug screening, and personalized therapy in muscular dystrophies. Cells8, 20 (2019). CAS Google Scholar
Hovatta, O. Derivation of human embryonic stem cell lines, towards clinical quality. Reprod. Fertil. Dev.18, 823–828 (2006). Google Scholar
Qian, X., Villa-Diaz, L. G., Kumar, R., Lahann, J. & Krebsbach, P. H. Enhancement of the propagation of human embryonic stem cells by modifications in the gel architecture of PMEDSAH polymer coatings. Biomaterials35, 9581–9590 (2014). CAS Google Scholar
Nandivada, H. et al. Fabrication of synthetic polymer coatings and their use in feeder-free culture of human embryonic stem cells. Nat. Protoc.6, 1037–1043 (2011). CAS Google Scholar
Villa-Diaz, L. G. et al. Synthetic polymer coatings for long-term growth of human embryonic stem cells. Nat. Biotechnol.28, 581–583 (2010). Along with reference 74, this was one of the first studies to develop a fully synthetic, chemically defined scaffold for long-term hESC culture and to directly compare the performance with that of Matrigel. CAS Google Scholar
Brafman, D. A. et al. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials31, 9135–9144 (2010). CAS Google Scholar
Meng, Y. et al. Characterization of integrin engagement during defined human embryonic stem cell culture. FASEB J.24, 1056–1065 (2009). Google Scholar
Rowland, T. J. et al. Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin. Stem Cell Dev.19, 1231–1240 (2010). CAS Google Scholar
Mondal, G., Barui, S. & Chaudhuri, A. The relationship between the cyclic-RGDfK ligand and αvβ3 integrin receptor. Biomaterials34, 6249–6260 (2013). CAS Google Scholar
Lambshead, J. W. et al. Long-term maintenance of human pluripotent stem cells on cRGDfK-presenting synthetic surfaces. Sci. Rep.8, 701 (2018). Google Scholar
Nguyen, E. H. et al. Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nat. Biomed. Eng.1, 0096 (2017). This study uses a high-throughput screening method of synthetic scaffolds to determine a synthetic alternative to Matrigel, finding that matrix-induced effects caused by the biological function of Matrigel can affect toxicity screenings. CAS Google Scholar
Hayman, E. G., Pierschbacher, M. D., Suzuki, S. & Ruoslahti, E. Vitronectin — a major cell attachment-promoting protein in fetal bovine serum. Exp. Cell Res.160, 245–258 (1985). CAS Google Scholar
Melkoumian, Z. et al. Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells. Nat. Biotechnol.28, 606–610 (2010). An early report on tethering synthetic peptides to synthetic scaffolds that provides a direct comparison with Matrigel. CAS Google Scholar
Deng, Y. et al. Long-term self-renewal of human pluripotent stem cells on peptide-decorated poly(OEGMA-co-HEMA) brushes under fully defined conditions. Acta Biomater.9, 8840–8850 (2013). CAS Google Scholar
Higuchi, A. et al. Long-term xeno-free culture of human pluripotent stem cells on hydrogels with optimal elasticity. Sci. Rep.5, 18136 (2015). CAS Google Scholar
Jin, S., Yao, H., Weber, J. L., Melkoumian, Z. K. & Ye, K. A synthetic, xeno-free peptide surface for expansion and directed differentiation of human induced pluripotent stem cells. PLoS One7, e50880 (2012). CAS Google Scholar
Yasuda, S. et al. Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells. Nat. Biomed. Eng.2, 173–182 (2018). CAS Google Scholar
Farach-Carson, M. C. & Carson, D. D. Perlecan — a multifunctional extracellular proteoglycan scaffold. Glycobiology17, 897–905 (2007). CAS Google Scholar
Furue, M. K. et al. Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. Proc. Natl Acad. Sci. USA105, 13409–13414 (2008). CAS Google Scholar
Spivak-Kroizman, T. et al. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell79, 1015–1024 (1994). CAS Google Scholar
Vlodavsky, I., Miao, H. Q., Medalion, B., Danagher, P. & Ron, D. Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor. Cancer Metastasis Rev.15, 177–186 (1996). CAS Google Scholar
Chang, C.-W. et al. Engineering cell–material interfaces for long-term expansion of human pluripotent stem cells. Biomaterials34, 912–921 (2013). CAS Google Scholar
Klim, J. R., Li, L., Wrighton, P. J., Piekarczyk, M. S. & Kiessling, L. L. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat. Methods7, 989–994 (2010). CAS Google Scholar
Musah, S. et al. Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. ACS Nano6, 10168–10177 (2012). CAS Google Scholar
Gerecht, S. et al. Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc. Natl Acad. Sci. USA104, 11298–11303 (2007). CAS Google Scholar
Lei, Y. & Schaffer, D. V. A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation. Proc. Natl Acad. Sci. USA110, E5039–E5048 (2013). CAS Google Scholar
Ovadia, E. M., Colby, D. W. & Kloxin, A. M. Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells. Biomater. Sci.6, 1358–1370 (2018). CAS Google Scholar
Murphy, W. L., McDevitt, T. C. & Engler, A. J. Materials as stem cell regulators. Nat. Mater.13, 547–557 (2014). CAS Google Scholar
Folkman, J. & Moscona, A. Role of cell shape in growth control. Nature273, 345–349 (1978). CAS Google Scholar
Caiazzo, M. et al. Defined three-dimensional microenvironments boost induction of pluripotency. Nat. Mater.15, 344–352 (2016). CAS Google Scholar
Khalil, A. S., Xie, A. W. & Murphy, W. L. Context clues: the importance of stem cell–material interactions. ACS Chem. Biol.9, 45–56 (2014). CAS Google Scholar
Eve, D. J. The continued promise of stem cell therapy in regenerative medicine. Med. Sci. Monit.17, RA292–RA305 (2011). Google Scholar
Helmy, K. Y., Patel, S. A., Silverio, K., Pliner, L. & Rameshwar, P. Stem cells and regenerative medicine: accomplishments to date and future promise. Ther. Deliv.1, 693–705 (2010). Google Scholar
Hoffman, T., Khademhosseini, A. & Langer, R. Chasing the paradigm: clinical translation of 25 years of tissue engineering. Tissue Eng. Part A25, 679–687 (2019). Google Scholar
Hwang, N. S., Varghese, S. & Elisseeff, J. Controlled differentiation of stem cells. Adv. Drug Deliv. Rev.60, 199–214 (2008). CAS Google Scholar
Burdick, J. A. & Vunjak-Novakovic, G. Engineered microenvironments for controlled stem cell differentiation. Tissue Eng. Part A15, 205–219 (2009). CAS Google Scholar
Lutolf, M. P., Gilbert, P. M. & Blau, H. M. Designing materials to direct stem-cell fate. Nature462, 433–441 (2009). CAS Google Scholar
Uriel, S. et al. Extraction and assembly of tissue-derived gels for cell culture and tissue engineering. Tissue Eng. Part C15, 309–321 (2009). CAS Google Scholar
Enemchukwu, N. O. et al. Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis. J. Cell Biol.212, 113–124 (2016). CAS Google Scholar
Le, N. N. T., Zorn, S., Schmitt, S. K., Gopalan, P. & Murphy, W. L. Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior. Acta Biomater.34, 93–103 (2016). CAS Google Scholar
Koepsel, J. T., Brown, P. T., Loveland, S. G., Li, W.-J. & Murphy, W. L. Combinatorial screening of chemically defined human mesenchymal stem cell culture substrates. J. Mater. Chem.22, 19474–19481 (2012). CAS Google Scholar
Koutsopoulos, S. & Zhang, S. Long-term three-dimensional neural tissue cultures in functionalized self-assembling peptide hydrogels, Matrigel and Collagen I. Acta Biomater.9, 5162–5169 (2013). CAS Google Scholar
Zhang, J. et al. A genome-wide analysis of human pluripotent stem cell-derived endothelial cells in 2D or 3D culture. Stem Cell Rep.8, 907–918 (2017). CAS Google Scholar
Farhat, W. et al. Hydrogels for advanced stem cell therapies: a biomimetic materials approach for enhancing natural tissue function. IEEE Rev. Biomed. Eng.12, 333–351 (2019). Google Scholar
Tsou, Y.-H., Khoneisser, J., Huang, P.-C. & Xu, X. Hydrogel as a bioactive material to regulate stem cell fate. Bioact. Mater.1, 39–55 (2016). Google Scholar
Donnelly, H., Salmeron-Sanchez, M. & Dalby, M. J. Designing stem cell niches for differentiation and self-renewal. J. R. Soc. Interface15, 20180388 (2018). Google Scholar
Vining, K. H. & Mooney, D. J. Mechanical forces direct stem cell behaviour in development and regeneration. Nat. Rev. Mol. Cell Biol.18, 728–742 (2017). CAS Google Scholar
Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell126, 677–689 (2006). CAS Google Scholar
Slater, K., Partridge, J. & Nandivada, H. Tuning the elastic moduli of Corning Matrigel and collagen I 3D matrices by varying the protein concentration (Corning, 2018).
Gobaa, S. et al. Artificial niche microarrays for probing single stem cell fate in high throughput. Nat. Methods8, 949–955 (2011). CAS Google Scholar
Rape, A. D., Zibinsky, M., Murthy, N. & Kumar, S. A synthetic hydrogel for the high-throughput study of cell–ECM interactions. Nat. Commun.6, 8129 (2015). Google Scholar
Nemir, S. & West, J. L. Synthetic materials in the study of cell response to substrate rigidity. Ann. Biomed. Eng.38, 2–20 (2010). Google Scholar
Sill, T. J. & von Recum, H. A. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials29, 1989–2006 (2008). CAS Google Scholar
Xu, C., Inai, R., Kotaki, M. & Ramakrishna, S. Electrospun nanofiber fabrication as synthetic extracellular matrix and its potential for vascular tissue engineering. Tissue Eng.10, 1160–1168 (2004). CAS Google Scholar
Rashidi, H., Yang, J. & M. Shakesheff, K. Surface engineering of synthetic polymer materials for tissue engineering and regenerative medicine applications. Biomater. Sci.2, 1318–1331 (2014). CAS Google Scholar
Yim, E. K. F., Pang, S. W. & Leong, K. W. Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Exp. Cell Res.313, 1820–1829 (2007). CAS Google Scholar
Zhu, W. et al. 3D printing of functional biomaterials for tissue engineering. Curr. Opin. Biotechnol.40, 103–112 (2016). CAS Google Scholar
Yamazoe, T. et al. A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells. J. Cell Sci.126, 5391–5399 (2013). CAS Google Scholar
Franzin, C. et al. Single-cell PCR analysis of murine embryonic stem cells cultured on different substrates highlights heterogeneous expression of stem cell markers. Biol. Cell105, 549–560 (2013). CAS Google Scholar
Highet, A. R., Zhang, V. J., Heinemann, G. K. & Roberts, C. T. Use of Matrigel in culture affects cell phenotype and gene expression in the first trimester trophoblast cell line HTR8/SVneo. Placenta33, 586–588 (2012). CAS Google Scholar
Sampaziotis, F. et al. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat. Protoc.12, 814–827 (2017). CAS Google Scholar
Ranga, A. et al. Neural tube morphogenesis in synthetic 3D microenvironments. Proc. Natl Acad. Sci. USA113, E6831–E6839 (2016). CAS Google Scholar
Schneider, M. C. et al. Local heterogeneities improve matrix connectivity in degradable and photoclickable poly(ethylene glycol) hydrogels for applications in tissue engineering. ACS Biomater. Sci. Eng.3, 2480–2492 (2017). CAS Google Scholar
Chu, S. et al. Understanding the spatiotemporal degradation behavior of aggrecanase-sensitive poly(ethylene glycol) hydrogels for use in cartilage tissue engineering. Tissue Eng. Part A23, 795–810 (2017). CAS Google Scholar
Dolo, V. et al. Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer cells in vivo and in vitro. Clin. Exp. Metastasis17, 131–140 (1999). CAS Google Scholar
Balduyck, M. et al. Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro. Clin. Exp. Metastasis18, 171–178 (2000). CAS Google Scholar
Wong, A. P., Cortez, S. L. & Baricos, W. H. Role of plasmin and gelatinase in extracellular matrix degradation by cultured rat mesangial cells. Am. J. Physiol.263, F1112–F1118 (1992). CAS Google Scholar
Wolf, M. Influence of matrigel on biodistribution studies in cancer research. Pharmazie63, 43–48 (2008). CAS Google Scholar
Shen, D., Wen, R., Tuo, J., Bojanowski, C. M. & Chan, C.-C. Exacerbation of retinal degeneration and choroidal neovascularization induced by subretinal injection of Matrigel in CCL2/MCP-1-deficient mice. Ophthalmic Res.38, 71–73 (2006). CAS Google Scholar
Kano, M. R. et al. VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. J. Cell Sci.118, 3759–3768 (2005). CAS Google Scholar
Lee, J. H. Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering. Biomater. Res.22, 27 (2018). Google Scholar
Yu, L. & Ding, J. Injectable hydrogels as unique biomedical materials. Chem. Soc. Rev.37, 1473–1481 (2008). CAS Google Scholar
Kretlow, J. D., Klouda, L. & Mikos, A. G. Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv. Drug Deliv. Rev.59, 263–273 (2007). CAS Google Scholar
Pascual-Garrido, C. et al. Current and novel injectable hydrogels to treat focal chondral lesions: properties and applicability. J. Orthop. Res.36, 64–75 (2018). CAS Google Scholar
Kharkar, P. M., Kiick, K. L. & Kloxin, A. M. Designing degradable hydrogels for orthogonal control of cell microenvironments. Chem. Soc. Rev.42, 7335–7372 (2013). CAS Google Scholar
Han, W. M. et al. Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma. Sci. Adv.4, eaar4008 (2018). CAS Google Scholar
Fernandes, S., Kuklok, S., McGonigle, J., Reinecke, H. & Murry, C. E. Synthetic matrices to serve as niches for muscle cell transplantation. Cells Tissues Organs195, 48–59 (2012). CAS Google Scholar
Nagahama, K. et al. Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering. Biomater. Sci.6, 550–561 (2018). CAS Google Scholar
Clevers, H. Modeling development and disease with organoids. Cell165, 1586–1597 (2016). CAS Google Scholar
Camp, J. G. et al. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc. Natl Acad. Sci. USA112, 15672–15677 (2015). CAS Google Scholar
Murrow, L. M., Weber, R. J. & Gartner, Z. J. Dissecting the stem cell niche with organoid models: an engineering-based approach. Development144, 998–1007 (2017). CAS Google Scholar
Astashkina, A. I., Mann, B. K., Prestwich, G. D. & Grainger, D. W. A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays. Biomaterials33, 4700–4711 (2012). CAS Google Scholar
Takebe, T. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature499, 481–484 (2013). CAS Google Scholar
Eiraku, M. et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature472, 51–56 (2011). CAS Google Scholar
Dye, B. R. et al. In vitro generation of human pluripotent stem cell derived lung organoids. eLife4, e05098 (2015). Google Scholar
Cruz-Acuña, R. et al. Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat. Cell Biol.19, 1326–1335 (2017). The authors present a protocol to generate human intestinal and lung organoids using a fully synthetic, chemically defined PEG hydrogel scaffold. Google Scholar
Chua, C. W. et al. Single luminal epithelial progenitors can generate prostate organoids in culture. Nat. Cell Biol.16, 951–961 (2014). CAS Google Scholar
Ardalani, H. et al. 3-D culture and endothelial cells improve maturity of human pluripotent stem cell-derived hepatocytes. Acta Biomater.95, 371–381 (2019). CAS Google Scholar
Ramachandran, S. D. et al. In vitro generation of functional liver organoid-like structures using adult human cells. PLoS One10, e0139345 (2015). Google Scholar
Spence, J. R. et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature470, 105–109 (2011). Google Scholar
Cruz-Acuña, R. et al. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat. Protoc.13, 2102 (2018). Google Scholar
Gjorevski, N. et al. Designer matrices for intestinal stem cell and organoid culture. Nature539, 560–564 (2016). CAS Google Scholar
Gjorevski, N. & Lutolf, M. P. Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture. Nat. Protoc.12, 2263–2274 (2017). CAS Google Scholar
Fatehullah, A., Tan, S. H. & Barker, N. Organoids as an in vitro model of human development and disease. Nat. Cell Biol.18, 246–254 (2016). Google Scholar
Bray, L. J. et al. A three-dimensional ex vivo tri-culture model mimics cell-cell interactions between acute myeloid leukemia and the vascular niche. Haematologica102, 1215–1226 (2017). CAS Google Scholar
Papadimitriou, C. et al. 3D culture method for Alzheimer’s disease modeling reveals interleukin-4 rescues Aβ42-induced loss of human neural stem cell plasticity. Dev. Cell46, 85–101.e8 (2018). CAS Google Scholar
Nowak, M., Freudenberg, U., Tsurkan, M. V., Werner, C. & Levental, K. R. Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro. Biomaterials112, 20–30 (2017). CAS Google Scholar
Weber, H. M., Tsurkan, M. V., Magno, V., Freudenberg, U. & Werner, C. Heparin-based hydrogels induce human renal tubulogenesis in vitro. Acta Biomater.57, 59–69 (2017). CAS Google Scholar
Livingston, M. K. et al. Evaluation of PEG-based hydrogel influence on estrogen-receptor-driven responses in MCF7 breast cancer cells. ACS Biomater. Sci. Eng.5, 6089–6098 (2019). CAS Google Scholar
Edmondson, R., Adcock, A. F. & Yang, L. Influence of matrices on 3D-cultured prostate cancer cells’ drug response and expression of drug-action associated proteins. PLoS One11, e0158116 (2016). Google Scholar
Collier, J. H. & Segura, T. Evolving the use of peptides as biomaterials components. Biomaterials32, 4198–4204 (2011). CAS Google Scholar
Hosoyama, K., Lazurko, C., Muñoz, M., McTiernan, C. D. & Alarcon, E. I. Peptide-based functional biomaterials for soft-tissue repair. Front. Bioeng. Biotechnol.7, 205 (2019). Google Scholar
Xie, A. W. & Murphy, W. L. Engineered biomaterials to mitigate growth factor cost in cell biomanufacturing. Curr. Opin. Biomed. Eng.10, 1–10 (2019). Google Scholar
Heidariyan, Z. et al. Efficient and cost-effective generation of hepatocyte-like cells through microparticle-mediated delivery of growth factors in a 3D culture of human pluripotent stem cells. Biomaterials159, 174–188 (2018). CAS Google Scholar
Bratt-Leal, A. M., Nguyen, A. H., Hammersmith, K. A., Singh, A. & McDevitt, T. C. A microparticle approach to morphogen delivery within pluripotent stem cell aggregates. Biomaterials34, 7227–7235 (2013). CAS Google Scholar
Alberti, K. et al. Functional immobilization of signaling proteins enables control of stem cell fate. Nat. Methods5, 645–650 (2008). CAS Google Scholar
Platt, M. O. et al. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. J. Cell. Physiol.221, 306–317 (2009). CAS Google Scholar
Yu, X. et al. Nanostructured mineral coatings stabilize proteins for therapeutic delivery. Adv. Mater.29, 1701255 (2017). Google Scholar
Khalil, A. S., Xie, A. W., Johnson, H. J. & Murphy, W. L. Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. Biomaterials248, 120007 (2020). CAS Google Scholar
Belair, D. G., Le, N. N. & Murphy, W. L. Design of growth factor sequestering biomaterials. Chem. Commun.50, 15651–15668 (2014). CAS Google Scholar
Belair, D. G. & Murphy, W. L. Specific VEGF sequestering to biomaterials: influence of serum stability. Acta Biomater.9, 8823–8831 (2013). CAS Google Scholar
Yan, H. J. et al. Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation. Biomaterials161, 190–202 (2018). CAS Google Scholar
Jha, A. K. et al. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials47, 1–12 (2015). CAS Google Scholar
Chen, K. G., Mallon, B. S., McKay, R. D. G. & Robey, P. G. Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell14, 13–26 (2014). CAS Google Scholar
Julavijitphong, S. et al. A xeno-free culture method that enhances Wharton’s jelly mesenchymal stromal cell culture efficiency over traditional animal serum-supplemented cultures. Cytotherapy16, 683–691 (2014). CAS Google Scholar
Thirumala, S., Goebel, W. S. & Woods, E. J. Manufacturing and banking of mesenchymal stem cells. Expert Opin. Biol. Ther.13, 673–691 (2013). CAS Google Scholar
Halme, D. G. & Kessler, D. A. FDA regulation of stem-cell-based therapies. N. Engl. J. Med.355, 1730–1735 (2006). CAS Google Scholar
Xiao, J., Yang, D., Li, Q., Tian, W. & Guo, W. The establishment of a chemically defined serum-free culture system for human dental pulp stem cells. Stem Cell Res. Ther.9, 191 (2018). CAS Google Scholar
Hirata, T. M. et al. Expression of multiple stem cell markers in dental pulp cells cultured in serum-free media. J. Endod.36, 1139–1144 (2010). Google Scholar
Chen, G. et al. Chemically defined conditions for human iPSC derivation and culture. Nat. Methods8, 424–429 (2011). CAS Google Scholar
Beers, J. et al. A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture. Sci. Rep.5, 11319 (2015). CAS Google Scholar
Xie, A. W. et al. Controlled self-assembly of stem cell aggregates instructs pluripotency and lineage bias. Sci. Rep.7, 14070 (2017). Google Scholar
Leong, M. F. et al. Electrospun polystyrene scaffolds as a synthetic substrate for xeno-free expansion and differentiation of human induced pluripotent stem cells. Acta Biomater.46, 266–277 (2016). CAS Google Scholar