Unsuccessful CTL transfusion in a case of post-BMT Epstein–Barr virus-associated lymphoproliferative disorder (EBV-LPD) (original) (raw)

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• Published: 01 August 1997

Bone Marrow Transplantation volume 20, pages 337–340 (1997)Cite this article

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Abstract

A patient with AML (FAB M4Eo) developed EBV-LPD 1.5 months after allogeneic BMT from his one locus-mismatched mother, the diagnosis being confirmed on day +82. Attempts to eradicate the monoclonally proliferating LPD using chemotherapy (VP16/dexa- methasone) followed by two doses of EBV-specific CTL and one dose of unstimulated donor leukocytes were not successful. We assume delay of infusions (day +100, +107) and insufficient CTL cell doses (total 9.2 × 106) may have been responsible for the poor outcome in this case.

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Authors and Affiliations

1. Division of Pediatrics, Children’s Research Hospital, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyo-ku, Kyoto, Japan
   S Imashuku, S Hibi & S Todo
2. Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyo-ku, Kyoto, Japan
   T Goto, T Matsumura, S Hibi & S Todo
3. Division of Pediatrics, Kyoto City Hospital, Kyoto, Japan
   S Imashuku, M Naya, M Yamori & M Hojo

Authors

1. S Imashuku
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2. T Goto
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3. T Matsumura
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4. M Naya
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5. M Yamori
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6. M Hojo
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7. S Hibi
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8. S Todo
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Cite this article

Imashuku, S., Goto, T., Matsumura, T. et al. Unsuccessful CTL transfusion in a case of post-BMT Epstein–Barr virus-associated lymphoproliferative disorder (EBV-LPD).Bone Marrow Transplant 20, 337–340 (1997). https://doi.org/10.1038/sj.bmt.1700883

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• Received: 13 December 1996
• Accepted: 19 April 1997
• Issue Date: 01 August 1997
• DOI: https://doi.org/10.1038/sj.bmt.1700883

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