Bone marrow transplantation for therapy-induced acute myeloid leukemia in children with previous lymphoid malignancies (original) (raw)

Acute leukaemia

Bone Marrow Transplantation volume 24, pages 735–739 (1999)Cite this article

Abstract

Twenty-one children who developed therapy-related acute myeloid leukemia after treatment for acute lymphoblastic leukemia received allogeneic bone marrow transplants between January 1990 and June 1997. All had previously received epipodophyllotoxin-containing regimens and 11 had cytogenetic abnormalities involving 11q23. Induction chemotherapy was given to 13 patients and eight patients went directly to BMT. Eleven received marrow from matched siblings, eight from matched unrelated donors and two from haploidentical family members. Conditioning regimens included cyclophosphamide (CY), cytarabine, and total body irradiation. Four patients are alive disease-free between 1118 and 1825 days post-BMT resulting in a 3-year DFS of 19%. Ten patients relapsed at a median of 150 days (range 30–664 days) post-BMT and all eventually died of disease. Seven patients died of regimen-related toxicity. The outlook for patients with therapy-related AML/MDS remains poor and more effective therapy is needed.

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Author notes

  1. GA Hale
    Present address: Division of Blood and Marrow Transplantation, University of Kentucky, 800 Rose Street, Lexington, 40536, KY, USA

Authors and Affiliations

  1. Division of Bone Marrow Transplantation, St Jude Children’s Research Hospital, Memphis, TN, USA
    GA Hale, HE Heslop, LC Bowman, RA Rochester, MK Brenner & RA Krance
  2. Department of Pediatrics, University of Tennessee College of Medicine, Memphis, TN, USA
    HE Heslop, LC Bowman, C-H Pui, MK Brenner & RA Krance
  3. Division of Leukemia, Department of Hematology/Oncology, St Jude Children’s Research Hospital, Memphis, TN, USA
    C-H Pui
  4. Center for Cell and Gene Therapy, Baylor College of Medicine, 1102 Bates St, Suite 1140, Houston, 77030, TX, USA
    HE Heslop, MK Brenner & RA Krance

Authors

  1. GA Hale
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  2. HE Heslop
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  3. LC Bowman
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  4. RA Rochester
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  5. C-H Pui
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  6. MK Brenner
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  7. RA Krance
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Hale, G., Heslop, H., Bowman, L. et al. Bone marrow transplantation for therapy-induced acute myeloid leukemia in children with previous lymphoid malignancies.Bone Marrow Transplant 24, 735–739 (1999). https://doi.org/10.1038/sj.bmt.1701962

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