Cytolytic P2X purinoceptors (original) (raw)

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• Published: 07 April 1998
• Paola Chiozzi1,
• Simonetta Falzoni1,
• Davide Ferrari1,
• Juana M Sanz1,
• Vishwanath Venketaraman1 &
• …
• Olavio R Baricordi2,3

Cell Death & Differentiation volume 5, pages 191–199 (1998)Cite this article

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Abstract

Anedoctal evidence accumulated over almost 20 years has shown that many different cell types are killed by sustained exposure to high concentrations of extracellular ATP. The plasma membrane receptors involved have been pharmacologically characterized and cloned during the last 3 years, and named purinergic P2X. P2X receptors share an intriguing structural relatedness with Caenorhabditis elegans degenerins and mammalian amiloride-sensitive Na channels (ENaCs). Depending on the ATP dose, length of stimulation and receptor subtype, P2X receptor stimulation may cause necrosis or apoptosis. The intracellular pathways activated are poorly known, but the perturbation in intracellular ion homeostasis clearly plays a major role. ICE proteases (caspases) are also triggered, nonetheless their activation is not requested for ATP-dependent cell death. The physiological meaning of P2X receptor-dependent cytotoxicity is not understood, but an involvement in immune-mediated reactions is postulated.

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Authors and Affiliations

1. Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
   Francesco Di Virgilio, Paola Chiozzi, Simonetta Falzoni, Davide Ferrari, Juana M Sanz & Vishwanath Venketaraman
2. Center of Biotechnology, University of Ferrara, Italy
   Francesco Di Virgilio & Olavio R Baricordi
3. Department of Experimental and Diagnostic Medicine, Section of Medical Genetics, University of Ferrara, Italy
   Olavio R Baricordi

Authors

1. Francesco Di Virgilio
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2. Paola Chiozzi
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3. Simonetta Falzoni
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4. Davide Ferrari
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5. Juana M Sanz
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6. Vishwanath Venketaraman
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7. Olavio R Baricordi
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Correspondence toFrancesco Di Virgilio.

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Edited by M. Piacentini

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Virgilio, F., Chiozzi, P., Falzoni, S. et al. Cytolytic P2X purinoceptors.Cell Death Differ 5, 191–199 (1998). https://doi.org/10.1038/sj.cdd.4400341

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• Received: 08 September 1997
• Accepted: 22 October 1997
• Published: 07 April 1998
• Issue Date: 01 March 1998
• DOI: https://doi.org/10.1038/sj.cdd.4400341

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