The CD7− subset of CD4+ memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15) (original) (raw)

References

  1. Reinhold U, Abken H . 1997 CD4+CD7− T cells: a separate subpopulation of memory T cells? J. Clin. Immunol. 17: 265–271
    Article CAS Google Scholar
  2. Ginaldi L, De Martinis M, Modesti M, Loreto F, Corsi MP, Quaglino D . 2000 Immunophenotypical changes of T lymphocytes in the elderly Gerontology 46: 242–248
    Article CAS Google Scholar
  3. Kukel S, Reinhold U, Oltermann I, Kreysel HW . 1994 Progressive increase of CD7− T cells in human lymphocytes with ageing Clin. Exp. Immunol. 98: 163–168
    Article CAS Google Scholar
  4. Moll M, Reinhold U, Kukel S, Abken H, Müller R, Oltermann I, Kreysel HW . 1994 CD7-negative helper T cells accumulate in inflammatory skin lesions J. Invest. Dermatol. 102: 328–332
    Article CAS Google Scholar
  5. Lazarovits AI, White MJ, Karsh J . 1992 CD7− T cells in rheumatoid arthritis Arthritis Rheum. 35: 615–624
    Article CAS Google Scholar
  6. Schmidt D, Goronzy JJ, Weyand CM . 1996 CD4+ CD7− CD28− T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity J. Clin. Invest. 97: 2027–2037
    Article CAS Google Scholar
  7. Barrou B, Legac E, Blanc C, Bitker MO, Luciani J, Chatelain C, Debré P, Autran B . 1995 Expansion of CD4+CD7− T helper cells with a Th0-Th2 function in kidney transplant recipients Transplant. Proc. 27: 1676–1677
    CAS PubMed Google Scholar
  8. Liu L, Abken H, Pföhler C, Rappl G, Tilgen W, Reinhold U . 2000 Accumulation of CD4+CD7− T cells in inflammatory skin lesions: evidence for preferential adhesion to vascular endothelial cells Clin. Exp. Immunol. 121: 94–99
    Article CAS Google Scholar
  9. Rappl G, Kapsokefalou A, Heuser C, Rößler M, Ugurel S, Tilgen W, Reinhold U, Abken H . 2000 Dermal fibroblasts sustain proliferation of activated T cells via membrane-bound IL-15 upon long-term stimulation with TNF-α J. Invest. Dermatol. in press
  10. Tsudo M, Kitamura F, Miyasaka M . 1989 Characterization of the interleukin 2 receptor β chain using three distinct monoclonal antibodies Proc. Natl. Acad. Sci. USA 86: 1982 –1986
    Article Google Scholar
  11. Tinhofer I, Marschitz I, Henn T, Egle A, Greil R . 2000 Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma Blood 95: 610–618
    CAS PubMed Google Scholar
  12. Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Shapiro DN, Morris SW, Park LS, Cosman D . 1995 Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL-15Rα and IL-2Rα genes J. Biol. Chem. 270: 29862–29869
    Article CAS Google Scholar
  13. Rückert R, Asadullah K, Seifert M, Budagian VM, Arnold R, Trombotto C, Paus R, Bulfone-Paus S . 2000 Inhibition of keratinocyte apoptosis by IL-15: A new parameter in the pathogenesis of psoriasis J. Immunol. 165: 2240–2250
    Article Google Scholar
  14. Musso T, Calosso L, Zucca M, Millesimo M, Ravarino D, Giovarelli M, Malavasi F, Ponzi AN, Paus R, Bulfone-Paus S . 1999 Human monocytes constitutively express membrane-bound, biologically active, and IFN-γ upregulated interleukin-15 Blood 93: 3531–3539
    CAS PubMed Google Scholar
  15. Waldmann TA, Tagaya Y . 1999 The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens Ann. Rev. Immunol. 17: 19–49
    Article CAS Google Scholar
  16. Aggarwal S, Gupta S . 1998 Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax J. Immunol. 160: 1627–1637
    CAS PubMed Google Scholar
  17. Lorenz HM, Grünke M, Hieronymus T, Herrmann M, Kühnel A, Manger B, Kalden JR . 1997 In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases Arthritis Rheum. 40: 306–317
    Article CAS Google Scholar
  18. Uehara T, Miyawaki T, Ohta K, Tamaru Y, Yokoi T, Nakamura S, Taniguchi N . 1992 Apoptotic cell death of primed CD45R0+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis Blood 80: 452–458
    CAS PubMed Google Scholar
  19. Akbar AN, Borthwick N, Salmon M, Gombert W, Bofill M, Shamsadeen N, Pilling D, Pett S, Grundy JE, Janossy G . 1993 The significance of low bcl-2 expression by CD45R0 T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory J. Exp. Med. 178: 427–438
    Article CAS Google Scholar
  20. Naora H, Gougeon ML . 1999 Interleukin-15 is a potent survival factor in the prevention of spontaneous but not CD95-induced apoptosis in CD4 and CD8 T lymphocytes of HIV-infected individuals. Correlation with its ability to increase Bcl-2 expression Cell Death Differ. 10: 1002–1011
    Article Google Scholar
  21. Mugnaini EN, Haaheim LL, Sannes M, Brinchmann JE . 1999 In vivo expansion coincident with excessive in vitro cell death within the memory subset of CD8+ T cells in HIV type 1 infection AIDS Res. Hum. Retroviruses 15: 265–272
    Article CAS Google Scholar
  22. Hebib NC, Deas O, Rouleau M, Durrbach A, Charpentier B, Beaujean F, Vernant JP, Senik A . 1999 Peripheral blood T cells generated after allogeneic bone marrow transplantation: lower levels of bcl-2 protein and enhanced sensitivity to spontaneous and CD95-mediated apoptosis in vitro. Abrogation of the apoptotic phenotype coincides with the recovery of normal naive/primed T-cell profiles Blood 94: 1803–1813
    CAS PubMed Google Scholar
  23. Maurice MM, van der Voort EA, Leow A, Levarht N, Breedveld FC, Verweij CL . 1998 CD28 co-stimulation is intact and contributes to prolonged ex vivo survival of hyporesponsive synovial fluid T cells in rheumatoid arthritis Eur. J. Immunol. 28: 1554–1562
    Article CAS Google Scholar
  24. Salmon M, Scheel-Toellner D, Huissoon AP, Pilling D, Shamsadeen N, Hyde H, D'Angeac AD, Bacon PA, Emery P, Akbar AN . 1997 Inhibition of T cell apoptosis in the rheumatoid synovium J. Clin. Invest. 99: 439–446
    Article CAS Google Scholar
  25. Akbar AN, Lord JM, Salmon M . 2000 IFN-α and IFN-β: a link between immune memory and chronic inflammation Immunol. Today 21: 337–342
    Article CAS Google Scholar
  26. Akbar AN, Borthwick NJ, Wickremasinghe RG, Panayoitidis P, Pilling D, Bofill M, Krajewski S, Reed JC, Salmon M . 1996 Interleukin-2 receptor common γ-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression Eur. J. Immunol. 26: 294–299
    Article CAS Google Scholar
  27. Reinhold U, Abken H, Kukel S, Moll M, Müller R, Oltermann I, Kreysel HW . 1993 CD7− T cells respresent a subset of normal human blood lymphocytes J. Immunol. 150: 2081–2089
    CAS PubMed Google Scholar
  28. Grundstrom S, Dohlsten M, Sundstedt A . 2000 IL-2 unresponsiveness in anergic CD4+ T cells is due to defective signaling through the common γ-chain of the IL-2 receptor J. Immunol. 164: 1175–1184
    Article CAS Google Scholar
  29. Dooms H, Van Belle T, Desmedt M, Rottiers P, Grooten J . 2000 Interleukin-15 redirects the outcome of a tolerizing stimulus from apoptosis to anergy Blood 96: 1006–1012
    CAS PubMed Google Scholar
  30. Bulfone-Paus S, Ungureanu D, Pohl T, Lindner G, Paus R, Rückert R, Krause H, Kunzendorf U . 1997 Interleukin-15 protects from lethal apoptosis in vivo Nature Med. 3: 1124–1128
    Article CAS Google Scholar
  31. Dooms H, Desmedt M, Vancaeneghem S, Rottiers P, Goossens V, Fiers W, Grooten J . 1998 Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen J. Immunol. 161: 2141–2150
    CAS PubMed Google Scholar
  32. Chu CL, Chen SS, Wu TS, Kuo SC, Liao NS . 1999 Differential effects of IL-2 and IL-15 on the death and survival of activated TCR gamma delta+ intestinal intraepithelial lymphocytes J. Immunol. 162: 1896–1903
    CAS PubMed Google Scholar
  33. Dobbeling U, Dummer R, Laine E, Potoczna N, Qin JZ, Burg G . 1998 Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells Blood 92: 252–258
    CAS Google Scholar
  34. Bulfone-Paus S, Bulanova E, Pohl T, Budagian V, Durkop H, Rückert R, Kunzendorf U, Paus R, Krause H . 1999 Death deflected: IL-15 inhibits TNF-alpha- mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain FASEB J. 13: 1575–1585
    Article CAS Google Scholar
  35. Perola O, Ripatti A, Pelkonen J . 2000 T-lymphocyte subpopulations do not express identical combinations of interleukin-2 receptor chains in the early phase of their activation and proliferation Scand. J. Immunol. 52: 123–130
    Article CAS Google Scholar
  36. Chae DW, Nosaka Y, Strom TB, Maslinski W . 1996 Distribution of IL-15 receptor α-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression J. Immunol. 157: 2813–2819
    CAS PubMed Google Scholar
  37. Naora H, Gougeon ML . 1999 Activation, survival and apoptosis of CD45RO+ and CD45RO− T cells of human immunodeficiency virus-infected individuals: effects of interleukin-15 and comparison with interleukin-2 Immunology 97: 181–187
    Article CAS Google Scholar
  38. Carson W, Caligiuri MA . 1998 Interleukin-15 as a potential regulator of the innate immune response Braz. J. Med. Biol. Res. 31: 1–9
    Article CAS Google Scholar
  39. Zhang X, Sun S, Hwang I, Tough DF, Sprent J . 1998 Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15 Immunity 8: 591–599
    Article CAS Google Scholar
  40. Kumaki S, Armitage R, Ahdieh M, Park L, Cosman D . 1996 Interleukin-15 up-regulates interleukin-2 receptor α chain but downregulates its own high-affinity binding sites on human T and B cells Eur. J. Immunol. 26: 1235–1239
    Article CAS Google Scholar
  41. Agrawal S, Marquet J, Delfau-Larue MH, Copie-Bergman C, Jouault H, Reyes F, Bensussan A, Farcet JP . 1998 CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs J. Clin. Invest. 102: 1715–1723
    Article CAS Google Scholar
  42. Legac E, Autran B, Merle-Beral H, Katlama C, Debré P . 1992 CD4+CD7−CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection Blood 79: 1746–1753
    CAS PubMed Google Scholar
  43. Chang KH, Kim JM, Kim HY, Song YG, Choi YH, Park YS, Cho JH, Hong SK . 2000 Spontaneous programmed cell death of peripheral blood mononuclear cells from HIV-infected persons is decreased with interleukin-15 Yonsei Med. J. 41: 112–118
    Article CAS Google Scholar
  44. Inagaki-Ohara K, Nishimura H, Mitani A, Yoshikai Y . 1997 Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice Eur. J. Immunol. 27: 2885–2891
    Article CAS Google Scholar
  45. Tsujino S, Di Santo JP, Takaoka A, McKernan TL, Noguchi S, Taya C, Yonekawa H, Saito T, Taniguchi T, Fujii H . 2000 Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function Proc. Natl. Acad. Sci. USA 97: 10514–10519
    Article CAS Google Scholar
  46. Yu CR, Young HA, Ortaldo JR . 1998 Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells J. Leukoc. Biol. 64: 245–258
    Article CAS Google Scholar
  47. Nielsen M, Kaestel CG, Eriksen KW, Woetmann A, Stokkedal T, Kaltoft K, Geisler C, Ropke C, Odum N . 1999 Inhibition of constitutively activated STAT3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells Leukemia 13: 735–738
    Article CAS Google Scholar
  48. Gombert W, Borthwick NJ, Wallace DL, Hyde H, Bofill M, Pilling D, Beverley PC, Janossy G, Salmon M, Akbar AN . 1996 Fibroblasts prevent apoptosis of IL-2- deprived T cells without inducing proliferation: a selective effect on Bcl-xL expression Immunology 89: 397–404
    Article CAS Google Scholar
  49. Barker JN . 1995 Adhesion molecules in cutaneous inflammation Ciba Found. Symp. 189: 91–106
    CAS PubMed Google Scholar
  50. Reinhold U, Liu L, Sesterhenn J, Schnautz S, Abken H . 1996 The CD7− T cell subset represents the majority of IL-5-secreting cells within CD4+CD45RA− T cells Clin. Exp. Immunol. 106: 555–559
    Article CAS Google Scholar
  51. Yagi H, Tokura Y, Matsushita K, Hanaoka K, Furukawa F, Takigawa M . 1997 Wells' syndrome: a pathogenic role for circulating CD4+CD7− T cells expressing interleukin-5 mRNA Br. J. Dermatol. 136: 918–923
    Article CAS Google Scholar

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