- Browner WS, Pressman AR, Nevitt MC, Cauley JA and Cummings SR (1993) Association between low bone density and stroke in elderly women. The study of osteoporotic fractures. Stroke 24: 940–946
Article CAS PubMed Google Scholar
- Von der Recke P, Hansen MA and Hassager C (1999) The association between low bone mass at the menopause and cardiovascular mortality. Am. J. Med. 106: 273–278
Article CAS PubMed Google Scholar
- Kado DM, Browner WS, Blackwell T, Gore R and Cummings SR (2000) Rate of bone loss is associated with mortality in older women: a prospective study. J. Bone Miner. Res. 15: 1974–1980
Article CAS PubMed Google Scholar
- Boukhris R and Becker KL (1972) Calcification of the aorta and osteoporosis. A roentgenographic study. JAMA. 219: 1307–1311
Article CAS PubMed Google Scholar
- Frye MA, Melton Lj, Bryant SC, Fitzpatrick LA, Wahner HW, Schwartz RS and Riggs BL (1992) Osteoporosis and calcification of the aorta. Bone Miner. 19: 185–194
Article CAS PubMed Google Scholar
- Vogt MT, San Valentin R, Rorrest KY, Nevitt MC and Cauley JA (1997) Bone mineral density and aortic calcification: the study of osteoporotic fractures. J. Am. Geriatr. Soc. 45: 140–145
Article CAS PubMed Google Scholar
- Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C and Chomka EV (1998) Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif. Tissue Int. 62: 209–213
Article CAS PubMed Google Scholar
- Broulik PD and Kapitola J (1993) Interrelations between body weight, cigarette smoking and spine mineral density in osteoporotic Czech women. Endocr. Regul. 27: 57–60
CAS PubMed Google Scholar
- Uyama O, Yoshimoto Y, Uamamoto Y and Kawai A (1997) Bone change and carotid atherosclerosis in postmenopausal women. Stroke 28: 1730–1732
Article CAS PubMed Google Scholar
- Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sow H, Chen Q and Chihara K (2002) Plasma lipids and osteoporosis in postmenopausal women. Endocrine J. 49: 211–217
Article CAS Google Scholar
- Steinberg D, Carew TE, Fielding C, Fogelman AM, Mahley RW, Sniderman AD and Zilversmit DB (1989) Lipoproteins and the pathogenesis of atherosclerosis. Circulation 80: 719–723
Article CAS PubMed Google Scholar
- Witztum JL and Steinberg D (1991) Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88: 1785–1792
Article CAS PubMed Central PubMed Google Scholar
- Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M and Demer LL (1999) Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J. Bone Miner. Res. 14: 2067–2078
Article CAS PubMed Google Scholar
- Diascro Jr DD, Vogel RL, Johnson TE, Witherup KM, Pitzenberger SM, Rutledge SJ, Prescott DJ, Rodan GA and Schmidt A (1998) High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells. J Bone Miner. Res. 13: 96–106
Article CAS PubMed Google Scholar
- Parhami F and Demer LL (1997) Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids? Curr. Opin. Lipidol. 8: 312–314
Article CAS PubMed Google Scholar
- Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W and Demer LL (2001) Atherogenic high-fat diet reduces bone mineralization in mice. J. Bone Miner. Res. 16: 182–188
Article CAS PubMed Google Scholar
- Sato T, Morita I and Murota S (1998) Involvement of cholesterol in osteoclast-like cell formation via cellular fusion. Bone 23: 135–140
Article CAS PubMed Google Scholar
- Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA and Rodan G (2000) Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch. Biochem. Biophys. 373: 231–241
Article CAS PubMed Google Scholar
- Kilsdonk EP, Yancey PG, Stoudt GW, Bangerter FW, Johnson WJ, Phillips MC and Rothblat GH (1995) Cellular cholesterol efflux mediated by cyclodextrins. J. Biol. Chem. 270: 17250–17256
Article CAS PubMed Google Scholar
- Reszka AA, Halasy-Nagy JM, Masarachia PJ and Rodan GA (1999) Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. J. Biol. Chem. 274: 34967–34973
Article CAS PubMed Google Scholar
- Ito M, Amizuka N, Nakajami T and Ozana H (2001) Bisphosphonate acts on osteoclasts independent of ruffled borders in osteosclerotic (ocloc) mice. Bone 28: 609–616
Article CAS PubMed Google Scholar
- Ha H, Kwak HB, Lee SK, Na DS, Rudd CE, Lee ZH and Kim HH (2003) Membrane rafts play a crucial role in receptor activator of nuclear factor kappaB signaling and osteoclast function. J. Biol. Chem. 278: 18573–18580
Article CAS PubMed Google Scholar
- Glantschnig H, Fisher JE, Wesolowski G, Rodan GA and Reszka AA (2003) M-CSF, TNF_α_ and RANK-ligand promote osteoclast survival by signaling through mTOR/S6 kinase. Cell Death Diff. 10: 1165–1177
Article CAS Google Scholar
- Glantschnig H, Varga F and Klaushofer K (1996) The cellular protooncogenes c-fos and egr-1 are regulated by prostacyclin in rodent osteoblasts and fibroblasts. Endocrinology 137: 4536–4541
Article CAS PubMed Google Scholar
- Inoki K, Li Y, Zhu T, Wu J and Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4: 648–657
Article CAS PubMed Google Scholar
- Fogelman AM, Seager J, Edwards PA and Popjak G (1977) Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes. J. Biol. Chem. 252: 644–651
CAS PubMed Google Scholar
- Osborne TF, Gil G, Goldstein JL and Brown MS (1988) Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element. J. Biol. Chem. 263: 3380–3387
CAS PubMed Google Scholar
- Field FJ, Shreves T, Fujiwara D, Murthy S, Albright E and Mathur SN (1991) Regulation of gene expression and synthesis and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by micellar cholesterolin CaCo-2 cells. J. Lipid Res. 32: 1811–1821
CAS PubMed Google Scholar
- Bist A, Fielding PE and Fielding CJ (1997) Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol. Proc. Natl. Acad. Sci. USA 94: 10693–10698
Article CAS PubMed Central PubMed Google Scholar
- Uittenbogaard A and Smart EJ (2000) Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae. J. Biol. Chem. 275: 25595–25599
Article CAS PubMed Google Scholar
- Fujimoto T, Kogo H, Nomura R and Une T (2000) Isoforms of caveolin-1 and caveolar structure. J. Cell Sci. 113 (Part 19) 3509–3517
CAS PubMed Google Scholar
- Christian AE, Haynes MP, Phillips MC and Rothblat GH (1997) Use of cyclodextrins for manipulating cellular cholesterol content. J. Lipid Res. 38: 2264–2272
CAS PubMed Google Scholar
- Parhami F, Garfinkel A and Demer LL (2000) Role of lipids in osteoporosis. Arterioscler. Thromb. Vasc. Biol. 20: 2346–2348
Article CAS PubMed Google Scholar
- Demer LL (2002) Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids. Int. J. Epidemiol. 31: 737–741
Article PubMed Google Scholar
- Burnett JR and Vasikaran SD (2002) Cardiovascular disease and osteoporosis: is there a link between lipids and bone? Ann. Clin. Biochem. 39 (Part 3): 203–210
Article CAS PubMed Google Scholar
- Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA and Demer LL (1997) Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler. Thromb. Vasc. Biol. 17: 680–687
Article CAS PubMed Google Scholar
- Tintut Y, Saedi B, Saini T, Ariax-Magaloona, Parhami F and Demer LL (2002) Hyperlipidemia enhanced osteoclastic potential of bone-marrow preosteoclasts. J. Bone Miner. Res. 17 (Suppl 1): M261
Google Scholar
- Luegmayr E, Rodan GA and Reszka AA (2002) Lipoproteins/exogenous cholesterol regulate osteoclast formation and survival. J. Bone Miner. Res. 17 (Suppl 1): F241
Google Scholar
- Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M and Gutierrez G (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286: 1946–1949
Article CAS PubMed Google Scholar
- Johnston Jr CC, Bjarnason NH, Cohen FJ, Shah A, Lindsay R, Mitlak BH, Huster W, Draper MW, Harper KD, Heath 3rd H, Gennari C, Christiansen C, Arnaud CD and Delmas PD (2000) Long-term effects of raloxifene on bone mineral density, bone turnover, and serum lipid levels in early postmenopausal women: three-year data from 2 double-blind, randomized, placebo-controlled trials. Arch. Intern. Med. 160: 3444–3450
Article CAS PubMed Google Scholar
- Rogers MJ (2000) Statins: lower lipids and better bones? Nat. Med. 6: 21–23
Article CAS PubMed Google Scholar
- Toledano JE and Partridge NC (2000) Statins: not just for cholesterol? Trends Endocrinol. Metab. 11: 255–256
Article CAS PubMed Google Scholar
- Ferber D (2000) Osteoporosis: cholesterol drugs show promise as bone builders. Science 288: 2297–2298
Article CAS PubMed Google Scholar
- Ylitalo R (2000) Bisphosphonates and atherosclerosis. Gen. Pharmacol. 35: 287–296
Article CAS PubMed Google Scholar
- Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M and Demer LL (2002) 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J. Biol. Chem. 277: 14221–14226
Article CAS PubMed Google Scholar
- Rothblat GH, de la Llera-Moya M, Atger V, Kellner-Weibel G, Williams DL and Phillips MC (1999) Cell cholesterol efflux: integration of old and new observations provides new insights. J. Lipid Res. 40: 781–796
CAS PubMed Google Scholar
- Suc I, Escargueil-Blanc I, Troly M, Salvayre R and Negre-Salvayre A (1997) HDL and ApoA prevent cell death of endothelial cells induced by oxidized LDL. Arterioscler. Thromb. Vasc. Biol. 17: 2158–2166
Article CAS PubMed Google Scholar
- Sugano M, Tsuchida K and Makino N (2000) High-density lipoproteins protect endothelial cells from tumor necrosis factor-alpha-induced apoptosis. Biochem. Biophys. Res. Commun. 272: 872–876
Article CAS PubMed Google Scholar
- Nofer JR, Levkau B, Wolinska I, Junker R, Fobker M, von Eckardstein A, Seedorf U and Assmann G (2001) Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. J. Biol. Chem. 276: 34480–34485
Article CAS PubMed Google Scholar
- Matsunaga T, Iguchi K, Nakajima T, Koyama I, Miyazaki T, Inoue I, Kawai S, Katayama S, Hirano K, Hokari S and Komoda T (2001) Glycated high-density lipoprotein induces apoptosis of endothelial cells via a mitochondrial dysfunction. Biochem. Biophys. Res. Commun. 287: 714–720
Article CAS PubMed Google Scholar
- Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE and Herz J (1993) Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92: 883–893
Article CAS PubMed Central PubMed Google Scholar
- Parhami F, Watson AD, Dominguez A, Beamer WG, Hama S, Navab M, Drake TA and Wand X (2001) Parallel development of vascular calcification and osteoporosis in hyperlipidemic mice: evidence for the role of lipid oxidation products. J. Bone Miner. Res. 16 (Suppl 1): 1144
Google Scholar
- Ohtani Y, Irie T, Uekama K, Fukunaga K and Pitha J (1989) Differential effects of alpha-, beta- and gamma-cyclodextrins on human erythrocytes. Eur. J. Biochem. 186: 17–22
Article CAS PubMed Google Scholar
- Irie T, Fukunaga K and Pitha J (1992) Hydroxypropylcyclodextrins in parenteral use. I: Lipid dissolution and effects on lipid transfers in vitro. J. Pharm. Sci. 81: 521–523
Article CAS PubMed Google Scholar
- Greenberg-Ofrath N, Terespolosky Y, Kahane I and Bar R (1993) Cyclodextrins as carriers of cholesterol and fatty acids in cultivation of mycoplasmas. Appl. Environ. Microbiol. 59: 547–551
CAS PubMed PubMed Central Google Scholar
- Klein U, Gimpl G and Fahrenholz F (1995) Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor. Biochemistry 34: 13784–13793
Article CAS PubMed Google Scholar
- Gimpl G, Burger K and Fahrenholz F (1997) Cholesterol as modulator of receptor function. Biochemistry 36: 10959–10974
Article CAS PubMed Google Scholar
- Green JM, Zhelesnyak A, Chung J, Lindberg FP, Sarfati M, Frazier WA and Brown EJ (1999) Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins. J. Cell Biol. 146: 673–682
Article CAS PubMed Central PubMed Google Scholar
- Gupta AK and Rudney H (1991) Plasma membrane sphingomyelin and the regulation of HMG-CoA reductase activity and cholesterol biosynthesis in cell cultures. J. Lipid Res. 32: 125–136
CAS PubMed Google Scholar
- Muir LV, Born E, Mathur SN and Field FJ (1996) Lysophosphatidylcholine increases 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene expression in CaCo-2 cells. Gastroenterology 110: 1068–1076
Article CAS PubMed Google Scholar
- Nordskog BK, Reagan Jr JW and St Clair RW (1999) Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux. J. Lipid Res. 40: 1806–1817
CAS PubMed Google Scholar
- Field FJ, Born E, Murthy S and Mathur SN (2001) Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells. J. Lipid Res. 42: 1687–1698
CAS PubMed Google Scholar
- Fielding CJ and Fielding PE (2001) Caveolae and intracellular trafficking of cholesterol. Adv. Drug Deliv. Rev. 49: 251–264
Article CAS PubMed Google Scholar
- Fuller K, Owens JM, Jagger CJ, Wilson A, Moss R and Chambers TJ (1993) Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts. J. Exp. Med. 178: 1733–1744
Article CAS PubMed Google Scholar
- Boyle WJ, Simonet WS and Lacey DL (2003) Osteoclast differentiation and activation. Nature 423: 337–342
Article CAS PubMed Google Scholar
- Wesolowski G, Duong LT, Lakkakorpi PT, Nagy RM, Tezuka K, Tanaka H, Rodan GA and Rodan SB (1995) Isolation and characterization of highly enriched, prefusion mouse osteoclastic cells. Exp. Cell Res. 219: 679–686
Article CAS PubMed Google Scholar
- Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA and Reszka AA (1999) Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc. Natl. Acad. Sci. USA 96: 133–138
Article CAS PubMed Central PubMed Google Scholar
- Halasy-Nagy JM, Rodan GA and Reszka AA (2001) Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis. Bone 29: 553–559
Article CAS PubMed Google Scholar
- Reszka AA, Halasy-Nagy J and Rodan GA (2001) Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. Mol. Pharmacol. 59: 193–202
Article CAS PubMed Google Scholar