Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human (original) (raw)

Cancer Gene Therapy volume 15, pages 225–230 (2008)Cite this article

Abstract

This paper highlights our experience of the transfer of hydrodynamic gene therapy (HGT) from the large animal, the pig, into clinical practice. The modification of balloon catheters and the development of a minimally invasive technique to allow selective isolation of liver segments for HGT in the large animal and human are described. Finally, our preliminary results from a phase I clinical study of HGT for thrombopoietin (TPO) in cirrhotic patients with thrombocytopenia are discussed. Based on these provisional data, minimally invasive selective HGT of liver segments appears to be technically safe, but further work is required to optimize the efficiency of gene transfer in order to achieve clinical benefit.

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Acknowledgements

This work was generously supported by the Pedersen Family Charitable Foundation and InvivoGen Inc.

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Authors and Affiliations

  1. Faculty of Medicine, Imperial College London, London, UK
    S E Khorsandi, P Bachellier, J C Weber, S Helmy, L Jiao, J Nicholls, A J Davies, N Levicar, S Jensen & N Habib
  2. Foundation Transplantation, Strasbourg, Hôspital Hautpierre, Strasbourg, France
    P Bachellier, J C Weber, M Greget & D Jaeck
  3. Larissa University School of Medicine, Larissa, Greece
    D Zacharoulis & C Rountas
  4. Faculty of Medicine, Cairo University, Cairo, Egypt
    S Helmy, A Helmy, M Al-Waracky & H Salama

Authors

  1. S E Khorsandi
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  2. P Bachellier
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  3. J C Weber
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  4. M Greget
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  5. D Jaeck
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  6. D Zacharoulis
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  7. C Rountas
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  8. S Helmy
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  9. A Helmy
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  10. M Al-Waracky
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  11. H Salama
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  12. L Jiao
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  13. J Nicholls
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  14. A J Davies
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  15. N Levicar
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  16. S Jensen
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  17. N Habib
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Correspondence toN Habib.

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Khorsandi, S., Bachellier, P., Weber, J. et al. Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human.Cancer Gene Ther 15, 225–230 (2008). https://doi.org/10.1038/sj.cgt.7701119

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