High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus (original) (raw)
Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J . Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus. Science 2001; 294: 1540–1543. ArticleCAS Google Scholar
Kim T, Kanayama Y, Negoro N, Okamura M, Takeda T, Inoue T . Serum levels of interferons in patients with systemic lupus erythematosus. Clin Exp Immunol 1987; 70: 562–569. CASPubMedPubMed Central Google Scholar
Kirou KA, Lee C, George S, Louca K, Peterson MG, Crow MK . Activation of the interferon-α pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. Arthritis Rheum 2005; 52: 1491–1503. ArticleCAS Google Scholar
Ronnblom LE, Alm GV, Oberg KE . Possible induction of systemic lupus erythematosus by interferon-α treatment in a patient with a malignant carcinoid tumour. J Intern Med 1990; 227: 207–210. ArticleCAS Google Scholar
Niewold TB, Swedler WI . Systemic lupus erythematosus arising during interferon-α therapy for cryoglobulinemic vasculitis associated with hepatitis C. Clin Rheumatol 2005; 24: 178–181. Article Google Scholar
Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003; 197: 711–723. ArticleCAS Google Scholar
Kirou KA, Lee C, George S, Louca K, Papagiannis IG, Peterson MG et al. Coordinate overexpression of interferon-_α_-induced genes in systemic lupus erythematosus. Arthritis Rheum 2004; 50: 3958–3967. ArticleCAS Google Scholar
Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003; 100: 2610–2615. ArticleCAS Google Scholar
Tsao BP, Grossman JM, Riemekasten G, Strong N, Kalsi J, Wallace DJ et al. Familiality and co-occurrence of clinical features of systemic lupus erythematosus. Arthritis Rheum 2002; 46: 2678–2685. Article Google Scholar
Scofield RH, Bruner GR, Harley JB, Namjou B . Autoimmune thyroid disease is associated with a diagnosis of secondary Sjogren's syndrome in familial systemic lupus. Ann Rheum Dis 2007; 66: 410–413. Article Google Scholar
Ioannou Y, Isenberg DA . Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy. Arthritis Rheum 2000; 43: 1431–1442. ArticleCAS Google Scholar
Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G et al. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 2005; 76: 528–537. ArticleCAS Google Scholar
Graham RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006; 38: 550–555. ArticleCAS Google Scholar
Hua J, Kirou K, Lee C, Crow MK . Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies. Arthritis Rheum 2006; 54: 1906–1916. ArticleCAS Google Scholar
Jabs WJ, Hennig C, Zawatzky R, Kirchner H . Failure to detect antiviral activity in serum and plasma of healthy individuals displaying high activity in ELISA for IFN-α and IFN-beta. J Interferon Cytokine Res 1999; 19: 463–469. ArticleCAS Google Scholar
Risch N . Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990; 46: 222–228. CASPubMedPubMed Central Google Scholar
Rybicki BA, Elston RC . The relationship between the sibling recurrence-risk ratio and genotype relative risk. Am J Hum Genet 2000; 66: 593–604. ArticleCAS Google Scholar
Lovgren T, Eloranta ML, Bave U, Alm GV, Ronnblom L . Induction of interferon-α production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. Arthritis Rheum 2004; 50: 1861–1872. Article Google Scholar
Ramos PS, Kelly JA, Gray-McGuire C, Bruner GR, Leiran AN, Meyer CM et al. Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus. Genes Immun 2006; 7: 417–432. ArticleCAS Google Scholar
Bengtsson AA, Sturfelt G, Truedsson L, Blomberg J, Alm G, Vallin H et al. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 2000; 9: 664–671. ArticleCAS Google Scholar
Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003; 349: 1526–1533. ArticleCAS Google Scholar
Bave U, Nordmark G, Lovgren T, Ronnelid J, Cajander S, Eloranta ML et al. Activation of the type I interferon system in primary Sjogren's syndrome: a possible etiopathogenic mechanism. Arthritis Rheum 2005; 52: 1185–1195. ArticleCAS Google Scholar
Lovgren T, Eloranta ML, Kastner B, Wahren-Herlenius M, Alm GV, Ronnblom L . Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjogren's syndrome autoantigen-associated RNA. Arthritis Rheum 2006; 54: 1917–1927. Article Google Scholar
Consortium. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 2005; 437: 69–87. Article Google Scholar
Wang ET, Kodama G, Baldi P, Moyzis RK . Global landscape of recent inferred Darwinian selection for Homo sapiens. Proc Natl Acad Sci USA 2006; 103: 135–140. ArticleCAS Google Scholar
Taniguchi T, Takaoka A . A weak signal for strong responses: interferon-α/beta revisited. Nat Rev Mol Cell Biol 2001; 2: 378–386. ArticleCAS Google Scholar
Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci USA 2003; 100: 1896–1901. ArticleCAS Google Scholar
Graham RR, Kyogoku C, Sigurdsson S, Vlasova IA, Davies LR, Baechler EC et al. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci USA 2007; 104: 6758–6763. ArticleCAS Google Scholar
Kozyrev SV, Lewen S, Reddy PM, Pons-Estel B, Witte T, Junker P et al. Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus. Arthritis Rheum 2007; 56: 1234–1241. ArticleCAS Google Scholar
von Wussow P, Jakschies D, Hartung K, Deicher H . Presence of interferon and anti-interferon in patients with systemic lupus erythematosus. Rheumatol Int 1988; 8: 225–230. ArticleCAS Google Scholar
Griffiths AJF, Gelbart WM, Miller JH, Lewontin RC . Modern Genetic Analysis, 7th edn. WH Freeman Publishers: New York, NY, 1999. Google Scholar
Olson JM, Witte JS, Elston RC . Association within twin pairs for a dichotomous trait. Genet Epidemiol 1996; 13: 489–499. ArticleCAS Google Scholar