Testosterone therapy in women: a review (original) (raw)
Laumann EO, Paik A, Rosen RC . Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999; 281: 537–544. ArticleCAS Google Scholar
Basson R et al. Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 2000; 163: 888–893. ArticleCAS Google Scholar
Basson R . Female sexual response: the role of drugs in the management of sexual dysfunction. Obstet Gynecol 2001; 98: 350–353. CASPubMed Google Scholar
Basson R et al. Definitions of women's sexual dysfunction reconsidered: advocating expansion and revision. J Psychosom Obstet Gynecol 2003; 24: 221–229. ArticleCAS Google Scholar
Ogawa S et al. Survival of reproductive behaviors in estrogen receptor beta gene-deficient male and female mice. Proc Natl Acad Sci USA 1999; 96: 12887–12892. ArticleCAS Google Scholar
Cone RD, Low MJ, Elmquist JK, Cameron JL . Neuroendocrinology. In: Larsen PR, Kroneneberg HM, Melmed S, Polonsky KS (eds). Williams Textbook of Endocrinology. Elsevier: New York, 2003 p 134. Google Scholar
Bixo M, Backstrom T, Winblad B, Andersson A . Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 1995; 55: 297–303. ArticleCAS Google Scholar
Davis SR, Tran J . Testosterone influences libido and well being in women. Trends Endocrinol Metab 2001; 12: 33–37. ArticleCAS Google Scholar
Perksy H et al. Plasma testosterone levels and the sexual behavior of couples. Arch Sex Behav 1978; 7: 157–173. Article Google Scholar
Morris NM, Udry JR, Khan-Dawood F, Dawood MY . Marital sexual frequency and midcycle female testosterone. Arch Sex Behav 1987; 16: 27–37. ArticleCAS Google Scholar
Van Goozen SHM et al. Psychoendocrinological assessment of the menstrual cycle: the relationship between hormones, sexuality, and mood. Arch Sex Behav 1997; 26: 359–382. ArticleCAS Google Scholar
Tuiten A et al. Discrepancies between genital responses and subjective sexual function during testosterone substitution in women with hypothalamic amenorrhea. Psychosom Med 1996; 58: 234–241. ArticleCAS Google Scholar
Nathorst-Boos J, von Schoultz B . Psychological reactions and sexual life after hysterectomy with and without oophorectomy. Gynecol Obstet Invest 1992; 34: 97–101. ArticleCAS Google Scholar
Berman JR et al. Correlation of androgen receptors, aromatase, and 5-alpha reductase in the human vagina with menopausal status. Fertil Steril 2003; 79: 925–931. Article Google Scholar
Hodgins MB, Spike RC, Mackie RM, MacLean AB . An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina. Br J Obstet Gynaecol 1998; 105: 216–222. ArticleCAS Google Scholar
Clayton AH . Sexual function and dysfunction in women. Psychiat Clin N Am 2003; 26: 673–682. Article Google Scholar
Zumoff B, Strain GW, Miller LK, Rosner W . Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab 1995; 80: 1429–1430. CASPubMed Google Scholar
Lasley BL et al. The relationship of circulating DHEA, testosterone, and estradiol to stages of the menopausal transition and ethnicity. J Clin Endocrinol Metab 2002; 87: 3760–3767. ArticleCAS Google Scholar
Burger HG et al. A prospective longitudinal study of serum testosterone, DHEA-S, and SHBG levels through the menopause transition. J Clin Endocrinol Metab 2000; 85: 2832–2838. CASPubMed Google Scholar
Judd HL, Lucas WE, Yen SC . Effects of oophorectomy on circulating testosterone and androsteinedione levels in patients with endometrial cancer. Am J Obstet Gynecol 1974; 118: 793–798. ArticleCAS Google Scholar
Hughes CL, Wall LL, Creasman WT . Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause. Gynecol Oncol 1991; 40: 42–45. Article Google Scholar
Laughlin GA, Barrett-Conner E, Kritz-Silverstein D, Von Muhlen D . Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000; 85: 645–651. CASPubMed Google Scholar
Simon JA . Estrogen replacement therapy and the endogenous androgen milieu. Fertil Steril 2002; 77: s77–s82. Article Google Scholar
Vehkavaara S et al. Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation 2000; 102: 2687–2693. ArticleCAS Google Scholar
Braunstein GD . Androgen insufficiency in women: a summary of critical issues. Fertil Steril 2002; 77: S94–S99. Article Google Scholar
Bachmann G et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril 2002; 77: 660–665. Article Google Scholar
Miller KK et al. Measurement of free testosterone in normal women and women with androgen deficiency: a comparison of methods. J Clin Endocrinol Metab 2004; 89: 525–533. ArticleCAS Google Scholar
Sarrel P, Dobay B, Wiita B . Estrogen and estrogen–androgen therapy in postmenopausal women with dissatisfied with estrogen-only therapy. J Reprod Med 1998; 43: 847–856. CASPubMed Google Scholar
Greenblatt RB et al. Evaluation of an androgen, estrogen, estrogen–androgen combination, and a placebo in the treatment of menopause. J Clin Endocrinol Metab 1950; 10: 1547–1558. ArticleCAS Google Scholar
Simon JA et al. Transdermal testosterone patch improves sexual activity and desire in sexual activity and desire in surgically menopausal women. Obstet Gynecol 2004; 103 (s): 64s. Google Scholar
Goldsmith CL et al. Esterified estrogens and methyltestosterone: effects on sexual interest and hormone profiles. Obstet Gynecol 2004; 103 (suppl): 63S. Google Scholar
Goldstat R et al. Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Menopause 2003; 10: 390–398. Article Google Scholar
Braunstein GD et al. Testosterone patch for the treatment of low sexual desire in surgically menopausal women. Abstr Menopause 2003; 10: 587. Google Scholar
Lobo RA et al. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive desire disorder. Fertil Steril 2003; 79: 1341–1352. Article Google Scholar
Davis S et al. Efficacy and safety of testosterone patches for the treatment of low sexual desire in surgically menopausal women. Fertil Steril 2003; 30s: 76. Article Google Scholar
Floter A, Nathorst-Boos K, Carlstrom K, Schoultz B . Addition of testosterone to estrogen replacement in oophorectomized women: effects on sexuality and well-being. Climacteric 2002; 5: 357–365. ArticleCAS Google Scholar
Shifren JL et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. New England Journal of Medicine 2000; 343: 682–688. ArticleCAS Google Scholar
Davis SR, McCloud P, Strauss BJG, Burger H . Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995; 21: 227–236. ArticleCAS Google Scholar
Myers LS et al. Effects of estrogen, androgen, and progestin on sexual psychophysiology and behavior in postmenopausal women. J Clin Endocrinol Metab 1990; 70: 1124–1131. ArticleCAS Google Scholar
Burger H, Hailes J, Nelson J, Menelaus M . Effects of combined implants of estradiol and testosterone on libido in postmenopausal women. Br Med J 1987; 294: 936–937. ArticleCAS Google Scholar
Sherwin BB, Gelfand MM . Role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987; 49: 397–409. ArticleCAS Google Scholar
Sherwin BB, Gelfand M, Brender W . Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985; 47: 339–351. ArticleCAS Google Scholar
Sherwin BB, Gelfand MM . Differential symptom response to parental estrogen and/or androgen administration in the surgical menopause. Am J Obstet Gynecol 1985; 151: 153–160. ArticleCAS Google Scholar
Burger H et al. The management of persistent menopausal symptoms with oestradiol–testosterone implants: clinical, lipid and hormonal results. Maturitas 1984; 6: 351–358. ArticleCAS Google Scholar
Dow MG, Hart DM . Hormonal treatments of sexually unresponsiveness in postmenopausal women: a comparative study. Br J Obstet Gynecol 1983; 90: 361–366. ArticleCAS Google Scholar
Geist SH . Androgen therapy in gynecology. JAMA 1940; 117: 2207–2213. Article Google Scholar
Braunstein GD, Cameron DR . Postmenopausal androgen therapy. Female Patient 2004; 29: 1. Google Scholar
Barrett-Connor E et al. A two-year, double blind comparison of estrogen–androgen and conjugated estrogens in surgical menopausal women. Effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 1999; 44: 1012–1020. CASPubMed Google Scholar
Raisz LG et al. Comparison of effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 1996; 81: 37–43. CASPubMed Google Scholar
Basaria S, Dobs AS . Safety and adverse effects of androgens: how to counsel patients. Mayo Clinic Proc 2004; 79: S25–S32. CAS Google Scholar
Worboys S et al. Evidence that parenteral testosterone therapy may improve endothelium-dependent and -independent vasodilation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 2001; 86: 158–161. ArticleCAS Google Scholar
Key T, Appleby P, Barnes I, Reeves G . Endogenous hormones and breast cancer collaborative group. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002; 94: 606–616. ArticleCAS Google Scholar
Labrie F et al. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursors DHEA. Endocr Rev 2003; 24: 152–182. ArticleCAS Google Scholar
Somboonporn W, Davis SR . Testosterone effects on breast: implications for testosterone therapy for women. Endocr Rev 2004; 25: 374–388. ArticleCAS Google Scholar
Dimitrakakis C et al. A physiological role for testosterone in limiting estrogenic stimulation of the breast. Menopause 2003; 10: 292–298. Article Google Scholar
Dimitrakakis C, Jones RA, Liu A, Bondy CA . Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy. Menopause 2004; 11: 531–535. Article Google Scholar
Tuckerman EM, Okon MA, Li TC, Laird SM . Do androgens have a direct inhibitory effect on endometrial function? An in vitro study. Fertil Steril 2000; 74: 771–779. ArticleCAS Google Scholar
Miller N, Bedard YC, Cooter NB, Shaul DL . Histological changes in the genital tract in transsexual women following androgen therapy. Histopathology 1986; 10: 661–669. ArticleCAS Google Scholar
Alexander JL et al. The effects of postmenopausal hormone therapies on female sexual functioning: a review of double-blind, randomized controlled trials. Menopause 2004; 11: 740–765. Article Google Scholar
Cameron DR, Braunstein GD . Androgen replacement therapy in women. Fertil Steril 2004; 82: 273–289. ArticleCAS Google Scholar