Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study (original) (raw)

References

  1. Marti A, Marcos A, Martinez JA . Obesity and immune function relationships. Review. Obes Rev 2001; 2: 131–140.
    Article CAS Google Scholar
  2. Chandra RK, Kutty KM . Immunocompetence in obesity. Acta Paediatr Scand 1980; 69: 25–30.
    Article CAS Google Scholar
  3. Must A, Strauss RS . Risks and consequences of childhood and adolescent obesity. Int J Obes Relat Metab Disord 1999; 23 (Suppl 2): S2–S11.
    Article Google Scholar
  4. Moreno LA, Pineda I, Rodríguez G, Fleta J, Sarría A, Bueno M . Waist circumference for the screening of the metabolic syndrome in children. Acta Paediatr 2002; 91: 1307–1312.
    Article CAS Google Scholar
  5. Sonnenberg GE, Krakower GR, Kissebah AH . A novel pathway to the manifestations of metabolic syndrome. Obes Res 2004; 12: 180–186.
    Article CAS Google Scholar
  6. Lesauskaite V, Tanganelli P, Bianciardi G, Simoes C, Toti P, Weber G . World Health Organization (WHO) and the World Heart Federation (WHF) Pathobiological Determinants of Atherosclerosis in Youth (PBDAY) Study. Histomorphometric investigation of the aorta and coronary arteries in young people from different geographical locations. Nutr Metab Cardiovasc Dis 1999; 9: 266–276.
    CAS PubMed Google Scholar
  7. McGill Jr HC, McMahan CA, Zieske AW, Sloop GD, Walcott JV, Troxclair DA, Malcom GT, Tracy RE, Oalmann MC, Strong JP . Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb Vasc Biol 2000; 20: 1998–2004.
    Article Google Scholar
  8. McGill Jr HC, McMahan CA, Herderick EE, Malcom GT, Tracy RE, Strong JP . Origin of atherosclerosis in childhood and adolescence. Review. Am J Clin Nutr 2000; 72 (Suppl): S1307–S1315.
    Google Scholar
  9. Millonig G, Malcom GT, Wick G . Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Atherosclerosis 2002; 160: 441–448.
    Article CAS Google Scholar
  10. González-Gross M, Castillo MJ, Moreno L, Nova E, González-Lamuño D, Pérez-Llamas F, Gutiérrez A, Garaulet M, Joyanes M, Leyva A, Marcos A, and Grupo AVENA. Alimentación y Valoración del Estado Nutricional de los Adolescentes Españoles (AVENA project). Risk evaluation and intervention proposals. I. Methodological description of the study. Nutr Hosp 2003; 18: 15–28.
    PubMed Google Scholar
  11. Moreno LA, Joyanes M, Mesana MI, González-Gross M, Gil CM, Sarría A, Gutiérrez A, Garaulet M, Pérez-Prieto R, Bueno M, Marcos A, for the AVENA Study Group. Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition 2003; 19: 481–486.
    Article Google Scholar
  12. Cole TJ, Bellizzi MC, Flegal M, Dietz WH . Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2002; 320: 1–6.
    Article Google Scholar
  13. Tanner JM, Whitehouse RH . Clinical longitudinal standards for height, weight, height velocity and stages of puberty. Arch Dis Child 1976; 51: 170–179.
    Article CAS Google Scholar
  14. Moreno LA, Tomás C, González-Gross M, Bueno G, Pérez-González JM, Bueno M . Micro-environmental and socio-demographic determinants of childhood obesity. Int J Obes Relat Metab Disord 2004; 28 (Suppl): S16–S20.
    Article Google Scholar
  15. Wu DM, Chu NF, Shen MH, Chang JB . Plasma C-reactive protein levels and their relationship to anthropometric and lipid characteristics among children. J Clin Epidemiol 2003; 56: 94–100.
    Article Google Scholar
  16. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB . Low-grade systemic inflammation in overweight children. Pediatrics 2001; 107: E13 1–6.
    Article CAS Google Scholar
  17. Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, Miller GJ, Strachan DP . C-reactive protein concentration in children: relationship to adiposity and other cardiovascular disease risk factors. Atherosclerosis 2000; 49: 139–150.
    Article Google Scholar
  18. Ford ES, Galuska DA, Gillespie C, Will JC, Giles WH, Dietz WH . C-reactive protein and body mass index in children: findings from the Third National Health and Nutrition Examination Survey, 1988–1994. J Pediatr 2001; 138: 486–492.
    Article CAS Google Scholar
  19. Ford ES . Body mass index, diabetes, and C-reactive protein among US adults. Diabetes Care 1999; 22: 1971–1977.
    Article CAS Google Scholar
  20. Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, Cioffi M, D'Andrea F, Molinari AM, Giugliano D . Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002; 105: 804–809.
    Article CAS Google Scholar
  21. Marfella R, Esposito K, Siniscalchi M, Cacciapuoti F, Giugliano F, Labriola D, Ciotola M, Di Palo C, Misso L, Giugliano D . Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women. Diabetes Care 2004; 27: 47–52.
    Article CAS Google Scholar
  22. Dixon D, Goldberg R, Schneiderman N, Delamater A . Gender differences in TNF-alpha levels among obese vs nonobese Latino children. Eur J Clin Nutr 2004; 58: 696–699.
    Article CAS Google Scholar
  23. Jarvisalo MJ, Harmoinen A, Hakanen M, Paakkunainen U, Viikari J, Hartiala J, Lehtimaki T, Simell O, Raitakari OT . Elevated serum C-reactive protein levels and early arterial changes in healthy children. Atheroscler Thromb Vasc Biol 2002; 22: 1323–1328.
    Article CAS Google Scholar

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Acknowledgements

This study was supported by the Spanish Ministry of Health (FIS 00/0015) and grants by Panrico, SA, Madaus, SA and Procter & Gamble, SA, España. We gratefully acknowledge all participating adolescents, and their parents and teachers for their collaboration. We also acknowledge Ms Laura Barrios for her statistically support.

Author information

Author notes

  1. For details, see Appendix A1.

Authors and Affiliations

  1. Department of Metabolism and Nutrition, Immunonutrition Research Group, Consejo Superior de Investigaciones Científicas, Madrid, Spain
    J Wärnberg & A Marcos
  2. Escuela Universitaria de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Spain
    L A Moreno & M I Mesana

Authors

  1. J Wärnberg
  2. L A Moreno
  3. M I Mesana
  4. A Marcos

Consortia

the AVENA group

Corresponding author

Correspondence toA Marcos.

Appendix A1. AVENA Sudy Group

Appendix A1. AVENA Sudy Group

**Coordinador:**A Marcos, Madrid.

**Main Investigators:**MJ Castillo, Granada.A Marcos, Madrid.S Zamora, Murcia.M García Fuentes, Santander.M Bueno, Zaragoza, Spain.

Granada: MJ Castillo, MD Cano, R Sola (Biochemistry); A Gutiérrez, JL Mesa, J Ruiz (Physical fitness); M Delgado, P Tercedor, P Chillón (Physical activity), M Martín, F Carreño, F Ortega, GV Rodríguez, R Castillo, F Arellano (C_ollaborators_). Universidad de Granada, E-18071 Granada.

Madrid: A Marcos, M González-Gross, J Wärnberg, S Medina, F Sánchez Muniz, E Nova, A Montero, B de la Rosa, S Gómez, S Samartín, J Romeo, R Álvarez, (Coordination, immunology) A Álvarez (Cytometric analysis) L Barrios (Statistical analysis) A Leyva, B Payá (Psychological assessment). L Martínez, E Ramos, R Ortiz, A Urzanqui (Collaborators). Instituto de Nutrición y Bromatología, Consejo Superior de Investigaciones Científicas (CSIC), E-28040 Madrid.

Murcia: S Zamora, M Garaulet, F Pérez-Llamas, JC Baraza, JF Marín, F Pérez de Heredia, MA Fernández, C González, R García, C Torralba, E Donat, E Morales, MD García, JA Martínez, JJ Hernández, A Asensio, FJ Plaza, MJ López (Diet analysis). Dpto. Fisiología, Universidad de Murcia, E-30100 Murcia.

Santander: M García Fuentes, D González-Lamuño, P de Rufino, R Pérez-Prieto, D Fernández, T Amigo (Genetic study). Dpto. Pediatría, Universidad de Cantabria, E-19003 Santander.

Z aragoza: M Bueno, L Moreno, A Sarriá, J Fleta, G Rodríguez, CM Gil, MI Mesana, JA Casajús, Vicente Blay, María Guadalupe Blay (Anthropometric assessment). Escuela Universitaria de Ciencias de la Salud, Universidad de Zaragoza, E-50009 Zaragoza.

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Wärnberg, J., Moreno, L., Mesana, M. et al. Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study.Int J Obes 28 (Suppl 3), S59–S63 (2004). https://doi.org/10.1038/sj.ijo.0802809

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