Identification of several genes differentially expressed during progression of chronic myelogenous leukemia (original) (raw)

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• Published: 30 April 1998

Chronic Myeloid Leukemia

Leukemia volume 12, pages 326–332 (1998)Cite this article

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Abstract

The Bcr-Abl fusion protein plays a crucial role in the initiation and maintenance of chronic myelogenous leukemia (CML). However, additional events are necessary for the transition from the chronic phase to the terminal phase of the disease. To identify genes involved in the disease progression, we constructed a subtractive library from enriched K562 cell mRNA. We obtained 1084 cDNA clones. After a specific hybridization of these clones with a cDNA probe from either chronic phase or K562 cells, 43 clones which present a differential hybridization level have been selected. Among them, several clones corresponded to ribosomal protein genes showing an increased transcription level during the blast crisis. We observed variations in the expression of a cellular adhesion molecule, a laminin-binding protein. An increased transcription level of the MAZ gene has been shown in the terminal phase of the disease. This gene encodes a protein that regulates the transcription of myc.

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Authors and Affiliations

1. Laboratoire de Génétique Cellulaire et Moléculaire, CHU de Poitiers, BP 577, Poitiers Cedex, 86021, France
   L Dahéron, S Salmeron, S Patri, J-C Chomel & A Kitzis
2. Department of Microbiology, Thomas Jefferson University, Philadelphia, PA, USA
   L Dahéron
3. Laboratoire d’Hématologie, CHU de Poitiers, BP 577, Poitiers Cedex, 86021, France
   A Brizard
4. Département d’Hématologie et Oncologie Médicale, CHU de Poitiers, BP 577, Poitiers Cedex, 86021, France
   F Guilhot

Authors

1. L Dahéron
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2. S Salmeron
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3. S Patri
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4. A Brizard
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5. F Guilhot
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6. J-C Chomel
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7. A Kitzis
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Dahéron, L., Salmeron, S., Patri, S. et al. Identification of several genes differentially expressed during progression of chronic myelogenous leukemia.Leukemia 12, 326–332 (1998). https://doi.org/10.1038/sj.leu.2400923

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• Received: 07 October 1996
• Accepted: 31 October 1997
• Published: 30 April 1998
• Issue Date: 01 March 1998
• DOI: https://doi.org/10.1038/sj.leu.2400923

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