Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia (original) (raw)

Leukemia volume 19, pages 2009–2010 (2005)Cite this article

TO THE EDITOR

MicroRNAs (miRs) are small endogenous RNAs that have important biological functions (see for review, Bartel1 and Ambros2). The miRs are 17–25 bp, generated from longer noncoding RNAs in step-wise processes. First, primary miRs are transcribed from genomic DNA and then truncated to produce ∼70 bp of RNAs, called precursor miRs in the nucleus. Second, the precursor miRs are further cut to become mature miRs in the cytoplasm. Although the detailed mechanism remains unclear, the miRs can function as translation repressors through binding to 3′ untranslation regions of target messenger RNAs. Since many miRs highly conserve nucleotide alignments between distantly related species, it has been suggested that the small RNAs have fundamental biological roles. Accumulated results have proven that miRs participate in diverse biological processes. Examples include developmental timing, cellular asymmetry, cell growth, apoptosis and hematopoiesis.1, 2 In addition to the biological roles of miRs, a number of miRs have been found to associate with chromosome amplification, deletion and translocation sites seen in B-cell malignancies, suggesting involvements of miRs in the tumorigenesis.3, 4 In fact, a very recent report has demonstrated that an miRNA polycistron (miR-17-19b) on chromosome 13 band q31–32 can act as oncogenes.5

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References

  1. Bartel DP . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281–297.
    Article CAS Google Scholar
  2. Ambros V . The functions of animal microRNAs. Nature 2004; 431: 350–355.
    Article CAS Google Scholar
  3. Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, Kira S et al. Identification and characterization of a novel gene, C13orf25, as a target for 13q31–q32 amplification in malignant lymphoma. Cancer Res 2004; 64: 3087–3095.
    Article CAS Google Scholar
  4. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T . Identification of tissue-specific microRNAs from mouse. Curr Biol 2002; 12: 735–739.
    Article CAS Google Scholar
  5. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S et al. A microRNA polycistron as a potential human oncogene. Nature 2005; 435: 828–833.
    Article CAS Google Scholar
  6. Kuppers R, Dalla-Favera R . Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 2001; 20: 5580–5594.
    Article CAS Google Scholar
  7. Sonoki T, Iwanaga E, Mitsuya H, Asou N . Ovarian relapse seven years after bone marrow transplantation for B-cell acute lymphoblastic leukemia: an unusual Krukenberg tumor. Am J Hematol, 2005; 80: 75–76.
    Article Google Scholar
  8. Willis TG, Jadayel DM, Coignet LJ, Abdul-Rauf M, Treleaven JG, Catovsky D et al. Rapid molecular cloning of rearrangements of the IGHJ locus using long-distance inverse polymerase chain reaction. Blood 1997; 90: 2456–2464.
    CAS PubMed Google Scholar

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Acknowledgements

This work was supported in part by Grants-in-aid for Scientific Research from the Japanese Ministry of Education, Culture, Sport, Science and Technology and Grants-in-Aid for Cancer Research from the Japanese Ministry of Health, Labor and Welfare. TS was supported by Miyajima Academic Foundation, Yatsushiro, Japan. We thank Professor Martin JS Dyer (Leicester University, UK) for critical reading of this manuscript.

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Authors and Affiliations

  1. Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan
    T Sonoki, E Iwanaga, H Mitsuya & N Asou
  2. Department of Hematology and Oncology, Wakayama Medical University, Wakayama, Japan
    T Sonoki

Authors

  1. T Sonoki
  2. E Iwanaga
  3. H Mitsuya
  4. N Asou

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Correspondence toN Asou.

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Sonoki, T., Iwanaga, E., Mitsuya, H. et al. Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia.Leukemia 19, 2009–2010 (2005). https://doi.org/10.1038/sj.leu.2403938

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