Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence (original) (raw)
- Original Research Article
- Published: 04 August 1998
- P Gorwood2,
- N Griffon3,
- M-C Bourdel1,
- F Sautel3,
- P Sokoloff3,
- J-C Schwartz3,
- J Ades2,
- H Lôo1 &
- …
- M-F Poirier1
Molecular Psychiatry volume 3, pages 333–336 (1998)Cite this article
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Abstract
Anatomical, pharmacological and human post-mortem studies suggest the dopamine D3 receptor (DRD3) gene as a candidate for drug dependence. We thus performed an association study of the Bal I polymorphism at the DRD3 gene, including 54 opiate addicts and 70 controls. Opiate addicts had a higher sensation-seeking score (on the Zückerman scale) than controls (P = 0.001), particularly a subgroup (70%) who had a distinctly higher score, exceeding 24. There were no marked differences in genotypes between patients as a whole and controls. However, patients with a sensation-seeking score above 24 were more frequently homozygotes for both alleles than patients with a sensation-seeking score under 24 (P = 0.038) or controls (P = 0.034). Although obtained in a sample of limited size, these results suggest that the DRD3 gene may have a role in drug dependence susceptibility in individuals with high sensation-seeking scores. This hypothesis is consistent with the role of DRD3 in mediating responses to drugs of abuse in animals and the association of homozygosity at the Bal I polymorphism with drug abuse in schizophrenic patients (see companion article by Krebs et al).
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Authors and Affiliations
- Service Hospitalo-Universitaire de Santé Mentale et Thérapeutique, Université René Descartes, Hôpital Sainte-Anne, Paris, France
E Duaux, M-C Bourdel, H Lôo & M-F Poirier - Service de Psychiatrie d'Adultes, Hôpital Louis Mourier, Colombes, France
P Gorwood & J Ades - Unité de Neurobiologie et Pharmacologie Moléculaire (U109), Centre Paul Broca de l'INSERM, Paris, France
N Griffon, F Sautel, P Sokoloff & J-C Schwartz
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Duaux, E., Gorwood, P., Griffon, N. et al. Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence.Mol Psychiatry 3, 333–336 (1998). https://doi.org/10.1038/sj.mp.4000409
- Received: 23 October 1997
- Revised: 17 February 1998
- Accepted: 18 March 1998
- Published: 04 August 1998
- Issue Date: 01 July 1998
- DOI: https://doi.org/10.1038/sj.mp.4000409