Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis (original) (raw)

• Ando K, Takei N, Matsumoto H, Iyo M, Isoda H, Mori N (2002). Neural damage in the lenticular nucleus linked with tardive dyskinesia in schizophrenia: a preliminary study using proton magnetic resonance spectroscopy. Schizophr Res 57: 273–279.
  Article PubMed Google Scholar
• Ariza M, Junque C, Mataro M, Poca MA, Bargallo N, Olondo M et al (2004). Neuropsychological correlates of basal ganglia and medial temporal lobe NAA/Cho reductions in traumatic brain injury. Arch Neurol 61: 541–544.
  Article PubMed Google Scholar
• Auer DP, Wilke M, Grabner A, Heidenreich JO, Bronisch T, Wetter TC (2001). Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation. Schizophr Res 52: 87–99.
  Article CAS PubMed Google Scholar
• Barker PB (2001). _N_-acetyl aspartate—a neuronal maker? Ann Neurol 49: 423–424.
  Article CAS PubMed Google Scholar
• Bartha R, Al-Semaan YM, Williamson PC, Drost DJ, Malla AK, Carr TJ et al (1999). A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients. Biol Psychiat 45: 1403–1411.
  Article CAS PubMed Google Scholar
• Bartha R, Williamson PC, Drost DJ, Malla A, Carr TJ, Cortese L et al (1997). Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy. Arch Gen Psychiat 54: 959–965.
  Article CAS PubMed Google Scholar
• Bernasconi A, Bernasconi N, Natsume J, Antel SB, Andermann F, Arnold DL (2003). Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy. Brain 126: 2447–2454.
  Article CAS PubMed Google Scholar
• Bertolino A, Callicott JH, Elman I, Mattay VS, Tedeschi G, Frank JA et al (1998b). Regionally specific neuronal pathology in untreated patients with schizophrenia: a proton magnetic resonance spectroscopic imaging study. Biol Psychiat 43: 641–648.
  Article CAS PubMed Google Scholar
• Bertolino A, Callicott JH, Mattay VS, Weidenhammer KM, Rakow R, Egan MF et al (2001). The effect of treatment with antipsychotic drugs on brain _N_-acetylaspartate measures in patients with schizophrenia. Biol Psychiat 49: 39–46.
  Article CAS PubMed Google Scholar
• Bertolino A, Callicott JH, Nawroz S, Mattay VS, Duyn JH, Tedeschi G et al (1998c). Reproducibility of proton magnetic resonance spectroscopic imaging in patients with schizophrenia. Neuropsychopharmacology 18: 1–9.
  Article CAS PubMed Google Scholar
• Bertolino A, Esposito G, Callicott JH, Mattay VS, Van Horn JD, Frank JA et al (2000). Specific relationship between prefrontal neuronal _N_-acetylaspartate and activation of the working memory cortical network in schizophrenia. Am J Psychiat 157: 26–33.
  Article CAS PubMed Google Scholar
• Bertolino A, Kumra S, Callicott JH, Mattay VS, Lestz RM, Jacobsen L et al (1998a). Common pattern of cortical pathology of childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging. Am J Psychiatr 155: 1376–1383.
  Article CAS PubMed Google Scholar
• Bertolino A, Nawroz S, Mattay VS, Barnett AS, Duyn JH, Moonen CTW et al (1996). Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am J Psychiat 153: 1554–1563.
  Article CAS PubMed Google Scholar
• Bertolino A, Sciota D, Brudaglio F, Altamura M, Blasi G, Bellomo A et al (2003). Working memeory deficits and levels of _N_-acetylaspartate in patients with schizophreniform disorder. Am J Psychiatr 160: 483–489.
  Article PubMed Google Scholar
• Bertolino A, Weinberger DR (1999). Proton magnetic resonance spectroscopy in schizophrenia. Eur J Radiol 30: 132–141.
  Article CAS PubMed Google Scholar
• Birken DL, Oldendorf WH (1989). _N_-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 13: 23–31.
  Article CAS PubMed Google Scholar
• Block W, Bayer TA, Tepest R, Traber F, Rietschel M, Muller DJ et al (2000). Decreased frontal lobe ratio of _N_-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study. Neurosci Lett 289: 147–151.
  Article CAS PubMed Google Scholar
• Braus DF, Ende G, Weber-Fahr W, Demirakca T, Henn FA (2001). Favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics: an MRSI study. Pharmacopsychiatry 34: 251–253.
  Article CAS PubMed Google Scholar
• Braus DF, Ende G, Weber-Fahre W, Demirakca T, Tost H, Henn FA (2002). Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia. Eur Neuropsychopharm 12: 145–152.
  Article CAS Google Scholar
• Brooks WM, Hodde-Vargas J, Vargas LA, Yeo RA, Ford CC, Hendren RL (1998). Frontal lobe of children with schizophrenia spectrum disorders: a proton magnetic resonance spectroscopy study. Biol Psychiatr 43: 263–269.
  Article CAS Google Scholar
• Buckley PF, Moore C, Long H, Larkin C, Thompson P, Mulvany F et al (1994). 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates. Biol Psychiatr 36: 792–800.
  Article CAS Google Scholar
• Bustillo JR, Lauriello J, Rowland LM, Jung RE, Petropoulos H, Hart BL et al (2001). Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophrenia. Psychiatr Res Neuroimaging 107: 135–149.
  Article CAS Google Scholar
• Bustillo JR, Lauriello J, Rowland LM, Thomson LM, Petropoulos H, Hammond R et al (2002a). Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposure. Schizophr Res 58: 313–321.
  Article PubMed Google Scholar
• Bustillo JR, Rowland LM, Lauriello J, Petropoulos H, Hammond R, Hart B et al (2002b). High choline concentrations in the caudate nucleus in antipsychotic-naïve patients with schizophrenia. Am J Psychiatr 159: 130–133.
  Article PubMed Google Scholar
• Callicott JH, Bertolino A, Egan MF, Mattay VS, Langheim FJP, Weinberger DR (2000). Selective relationship between prefrontal _N_-acetylaspartate measures and negative symptoms in schizophrenia. Am J Psychiatr 157: 1646–1651.
  Article CAS PubMed Google Scholar
• Callicott JH, Egan MF, Bertolino A, Mattay VS, Langheim FJP, Frank JA et al (1998). Hippocampal _N_-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype. Biol Psychiatr 44: 941–950.
  Article CAS Google Scholar
• Cecil KM, DelBello MP, Sellars MC, Strakowski SM (2003). Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorder. J Child Adolesc Psychopharmacol 13: 545–555.
  Article PubMed Google Scholar
• Cecil KM, Lenkinski RE, Gur RE, Gur RC (1999). Proton magnetic resonance spectroscopy in the frontal and temporal lobes of neuroleptic naïve patients with schizophrenia. Neuropsychopharmacology 20: 131–140.
  Article CAS PubMed Google Scholar
• Choe BY, Kim K-T, Suh TS, Lee C, Paik IH, Bahk YW et al (1994). 1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-naïve, chronic schizophrenia. Acad Radiol 1: 211–216.
  Article CAS PubMed Google Scholar
• Choe BY, Suh TS, Shinn KS, Lee CW, Lee C, Paik IH (1996). Observation of metabolic changes in chronic schizophrenia after neuroleptic treatment by in vivo hydrogen magnetic resonance spectroscopy. Invest Radiol 31: 345–352.
  Article CAS PubMed Google Scholar
• de Stefano N, Matthews PM, Arnold DL (1995). Reversible decreases in _N_-acetylaspartate after acute brain injury. Mag Reson Med 34: 721–727.
  Article CAS Google Scholar
• Deicken RF, Eliaz Y, Feiwell R, Schuff N (2001b). Increased thalamic _N_-acetylaspartate in male patients with familial bipolar I disorder. Psychiatr Res Neuroimag 106: 35–45.
  Article CAS Google Scholar
• Deicken RF, Feiwell R, Schuff N, Soher B (2001a). Evidence for altered cerebellar vermis neuronal integrity in schizophrenia. Psychiatr Res Neuroimagig 107: 125–134.
  Article CAS Google Scholar
• Deicken RF, Johnson C, Eliaz Y, Schuff N (2000). Reduced concentrations of thalamic _N_-acetylaspartate in male patients with schizophrenia. Am J Psychiatr 157: 644–647.
  Article CAS PubMed Google Scholar
• Deicken RF, Pegues M, Amend D (1999). Reduced hippocampal _N_-acetylaspartate without volume loss in schizophrenia. Schizophr Res 37: 217–223.
  Article CAS PubMed Google Scholar
• Deicken RF, Zhou L, Corwin F, Vinogradov S, Weiner MW (1997b). Decreased left frontal lobe _N_-acetylaspartate in schizophrenia. Am J Psychiatr 154: 688–690.
  Article CAS PubMed Google Scholar
• Deicken RF, Zhou L, Schuff N, Fein G, Weiner MW (1998). Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy. Biol Psychiatr 43: 483–488.
  Article CAS Google Scholar
• Deicken RF, Zhou L, Schuff N, Weiner MW (1997a). Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia. Schizophr Res 27: 65–71.
  Article CAS PubMed Google Scholar
• Delamillieure P, Constans JM, Fernandez J, Brazo P, Benali K, Courtheoux P et al (2002). Proton magnetic resonance spectroscopy (1H MRS) in schizophrenia: investigation of the right and left hippocampus, thalamus, and prefrontal cortex. Schizophr Bull 28: 329–339.
  Article PubMed Google Scholar
• Delamillieure P, Fernandez J, Constans JM, Brazo P, Benali K, Abadie P et al (2000). Proton magnetic resonance spectroscopy of the medial prefrontal cortex in patients with deficit schizophrenia: preliminary report. Am J Psychiatr 157: 641–643.
  Article CAS PubMed Google Scholar
• Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD (2002). Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain 125: 2332–2341.
  Article PubMed Google Scholar
• Dowling C, Bollen AW, Noworolski SM, McDermott MW, Barbaro NM, Day MR et al (2001). Preoperative proton MR spectroscopic imaging of brain tumors and correlation with histopathologic analysis of resection specimens. Am J Neuroradiol 22: 604–612.
  CAS PubMed PubMed Central Google Scholar
• Eluri R, Paul C, Roemer R, Boyko O (1998). Single-voxel proton magnetic resonance spectroscopy of the pons and cerebellum in patients with schizophrenia: a preliminary study. Psychiatr Res Neuroimaging 84: 17–26.
  Article CAS Google Scholar
• Ende G, Braus DF, Walter S, Henn FA (2001). Lower concentration of thalamic _N_-acetylaspartate in patients with schizophrenia: a replication study. Am J Psychiatr 158: 1314–1316.
  Article CAS PubMed Google Scholar
• Ende G, Braus DF, Walter S, Weber-Fahr W, Henn FA (2003). Multiregional 1H-MRSI of the hippocampus, thalamus, and basal ganglia in schizophrenia. Eur Arch Psychiatry Clin Neurosci 253: 9–15.
  Article PubMed Google Scholar
• Ende G, Braus DF, Wlater S, Weber-Fahr W, Soher B, Maudsley AA et al (2000). Effects of age, medication, and illness duration on the _N_-acetyl aspartate signal of the anterior cingulate region in schizophrenia. Schizophr Res 41: 389–395.
  Article CAS PubMed Google Scholar
• Fannon D, Simmons A, Tennakoon L, O'Ceallaigh S, Sumich A, Doku V et al (2003). Selective deficit of hippocampal _N_-acetylaspartate in antipsychotic-naïve patients with schizophrenia. Biol Psychiatr 54: 587–598.
  Article CAS Google Scholar
• Fujimoto T, Nakano T, Takano T, Takeuchi K, Yamada K, Fukuzako T et al (1996). Proton magnetic resonance spectroscopy of basal ganglia in chronic schizophrenia. Biol Psychiatr 40: 14–18.
  Article CAS Google Scholar
• Fukuzako H, Kodama S, Fukuzako T, Yamada K, Doi W, Sato D et al (1999). Subtype-associated metabolite differences in the temporal lobe in schizophrenia detected by proton magnetic resonance spectroscopy. Psychiatr Res Neuroimaging 92: 45–56.
  Article CAS Google Scholar
• Fukuzako H, Takeuchi K, Hokazono Y, Fukuzako T, Yamada K, Hashiguchi T et al (1995). Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report. Psychiatr Res Neuroimaging 61: 193–200.
  Article CAS Google Scholar
• Fukuzako H (2000). Heritability heightens brain metabolite differences in schizophrenia. J Neuropsychiatry Clin Neurosci 12: 95–97.
  Article CAS PubMed Google Scholar
• Gadea M, Martinez-Bisbal MC, Marti-Bonmati L, Espert R, Casanova R, Coret F et al (2004). Spectroscopic axonal damage to the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclerosis. Brain 127: 89–98.
  Article PubMed Google Scholar
• Galanaud D, Chinot O, Nicoli F, Confort-Gouny S, Le Fur Y, Barrie-Attarian M et al (2003). Use of proton magnetic resonance spectroscopy of the brain to differentiate gliomatosis cerebri from low-grade glioma. J Neurosurg 98: 269–276.
  Article PubMed Google Scholar
• Gimenez M, Junque C, perez M, Vendrell P, Baeza I, Salamero M et al (2003). Basal ganglia _N_-acetylaspartate correlates with the performance in the procedural task ‘Tower of Hanoi’ of neuroleptic-naïve schizophrenic patients. Neurosci Lett 347: 97–100.
  Article CAS PubMed Google Scholar
• Guerrini L, Lolli F, Ginestroni A, Belli G, Della Nave RD, Tessa C et al (2004). Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study. Brain 127: 1785–1795.
  Article CAS PubMed Google Scholar
• Hagino H, Suzuki M, Mori K, Nohara S, Yamashita I, Takahashi T et al (2002). Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia: a preliminary report. Psychaitr Clin Neurosci 56: 499–507.
  Article Google Scholar
• Heimberg C, Komoroski RA, Lawson WB, Cardwell D, Karson CN (1998). Regional proton magnetic resonance spectroscopy in schizophrenia and exploration of the drug effect. Psychiatr Res Neuroimaging 83: 105–115.
  Article CAS Google Scholar
• Kalra S, Cashman NR, Genge A, Arnold DL (1998). Recovery of _N_-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 9: 1757–1761.
  Article CAS PubMed Google Scholar
• Kegeles L, Humaran TJ, Mann JJ (1998). In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopy. Biol Psychiatr 44: 382–398.
  Article CAS Google Scholar
• Kegeles LS, Shungu DC, Anjilvel S, Chan S, Ellis SP, Xanthopoulos E et al (2000). Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies. Psychiatr Res Neuroimaging 98: 163–175.
  Article CAS Google Scholar
• Komoroski RA, Kotrla KJ, Lemen L, Lindquist D, Diaz P, Foundas A (2004). Brain metabolite concentration ratios in vivo: multisite reproducibility by single-voxel 1H MR spectroscopy. Mag Reson Imaging 22: 721–725.
  Article CAS Google Scholar
• Lim KO, Adalsteinsson E, Spielman D, Sullivan EV, Rosenbloom MJ, Pfefferbaum A (1998). Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia. Arch Gen Psychiatr 55: 346–352.
  Article CAS PubMed Google Scholar
• Lyoo IK, Renshaw PF (2002). Magnetic resonance spectroscopy: current and future applications in psychiatric research. Biol Psychiatr 51: 195–207.
  Article Google Scholar
• Maier M, Ron MA, Barker GJ, Tofts PS (1995). Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia. Psychol Med 25: 1201–1209.
  Article CAS PubMed Google Scholar
• Maier M, Ron MA (1996). Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study. Schizophr Res 22: 5–17.
  Article CAS PubMed Google Scholar
• Martin E, Capone A, Schneider J, Hennig J, Thiel T (2001). Absence of _N_-acetylaspartate in the human brain: impact on neurospectroscopy? Ann Neurol 49: 518–521.
  Article CAS PubMed Google Scholar
• Mascalchi M, Belli G, Guerrini L, Nistri M, Del Sappia I, Vallari N (2002). Proton MR spectroscopy of Wernicke encephalopathy. Am J Neuroradiol 23: 1803–1806.
  PubMed PubMed Central Google Scholar
• Matalon R, Michals K, Kaul R (1995). Canavan disease: from spongy degeneration to molecular analysis. J Pediatr 127: 511–517.
  Article CAS PubMed Google Scholar
• Meyerhoff DJ, MacKay S, Bachman L, Poole N, Dillon WP, Weiner MW et al (1993). Reduced brain _N_-acetyl-aspartate suggests neuronal loss in cognitively impaired human immuno-deficiency virus-seropositive individuals: _in vivo_1H magnetic resonance spectroscopic imaging. Neurology 43: 509–515.
  Article CAS PubMed Google Scholar
• Miller SP, McQuillen PS, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM et al (2004). Preoperative brain injury in newborns with transposition of the great arteries. Ann Thorac Surg 77: 1698–1706.
  Article PubMed Google Scholar
• Moore CM, Bonello CM, Sherwood AR, Cohen BM, Renshaw PF, Yurgulen-Todd DA (2002). Mesial temporal lobe Cho to Cr(PRc) ratio asymmetry in chronic schizophrenics. Schizophr Res 57: 35–42.
  Article PubMed Google Scholar
• Mullins PG, Rowland L, Bustillo J, Bedrick EJ, Lauriello J, Brooks WM (2003). Reproducibility of 1H-MRS measurements in schizophrenic patients. Mag Reson Med 50: 704–707.
  Article CAS Google Scholar
• Murphy DG, Critchley HD, Schmitz N, McAlonan G, Van Amelsvoort T, Robertson D et al (2002). Asperger syndrome: a proton magnetic resonance spectroscopy study of brain. Arch Gen Psychiatr 59: 885–891.
  Article CAS PubMed Google Scholar
• Nasrallah HA, Skinner TE, Schmalbrock P, Robitaille PM (1994). Proton magnetic resonance spectroscopy (1H MRS) of the hippocampal formation in schizophrenia: a pilot study. Br J Psychiatr 165: 481–485.
  Article CAS Google Scholar
• Ohara K, Isoda H, Suzuki Y, Takehara Y, Ochiai M, Takeda H et al (2000). Proton magnetic resonance spectroscopy of lenticular nuclei in simple schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatr 24: 507–519.
  Article CAS Google Scholar
• Omori M, Murata T, Kimura H, Koshimoto Y, Kado H, Ishimori Y et al (2000). Thalamic abnormalities in patients with schizophrenia revealed by proton magnetic resonance spectroscopy. Psychiatr Res Neuroimaging 98: 155–162.
  Article CAS Google Scholar
• Omori M, Pearce J, Komoroski RA, Griffin ST, Mrak RE, Husain MM et al (1997). _In vitro_1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia. Biol Psychiatr 42: 359–366.
  Article CAS Google Scholar
• O'Neill J, Levitt J, Caplan R, Asarnow R, McCracken JT, Toga AW et al (2004). 1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia. Neuroimage 21: 1781–1789.
  Article PubMed Google Scholar
• Pavlakis SG, Kingsley PB, Harper R, Buckwald S, Spinazzola R, Frank Y et al (1999). Correlation of basal ganglia magnetic resonance spectroscopy with Apgar score in perinatal asphyxia. Arch Neurol 56: 1476–1481.
  Article CAS PubMed Google Scholar
• Renshaw PF, Yurgelun-Todd DA, Tohen M, Gruber S, Cohen BM (1995). Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis. Am J Psychiatr 152: 444–446.
  Article CAS PubMed Google Scholar
• Richards TL (1991). Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy. Am J Roentgenol 157: 1073–1078.
  Article CAS Google Scholar
• Sanchez-Pernaute R, Garcia-Segura JM, del Barrio AA, Viano J, de Yebenes JG (1999). Clinical correlation of striatal 1H MRS changes in Huntington's disease. Neurology 53: 806–812.
  Article CAS PubMed Google Scholar
• Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D et al (2003). Different patterns of _N_-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology 61: 358–364.
  Article CAS PubMed Google Scholar
• Sharma R, Venkatasubramanian PN, Barany M, Davis JM (1992). Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients. Schizophr Res 8: 43–49.
  Article CAS PubMed Google Scholar
• Shenton ME, Dickey CC, Frumin M, McCarley RW (2001). A review of MRI findings in schizophrenia. Schizophr Res 49: 1–52.
  Article CAS PubMed PubMed Central Google Scholar
• Shimizu H, Shirane R, Fujiwara S, Takahashi A, Yoshimoto T (1997). Proton magnetic resonance spectroscopy in children with moya–moya disease. Clin Neurol Neurosurg 99: S64–S67.
  Article PubMed Google Scholar
• Shioiri T, Hamakawa H, Kato T, Murashita J, Fujii K, Inubushi T et al (1996). Proton magnetic resonance spectroscopy of the basal ganglia in patients with schizophrenia: a preliminary report. Schizophr Res 22: 19–26.
  Article CAS PubMed Google Scholar
• Sigmundsson T, Maier M, Toone BK, Williams SCR, Simmons A, Greenwood K et al (2003). Frontal lobe _N_-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study. Schizophr Res 64: 63–71.
  Article PubMed Google Scholar
• Spaniel F, Hajek T, Tintera J, Harantova P, Dezortova M, Hajek M (2003). Differences in fMRI and MRS in a monozygotic twin pair discordant for schizophrenia (case report). Acta Psychiatr Scand 107: 155–158.
  Article CAS PubMed Google Scholar
• Stanley JA, Williamson PC, Drost DJ, Rylett RJ, Carr TJ, Malla A et al (1996). An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients. Schizophr Bull 22: 597–609.
  Article CAS PubMed Google Scholar
• Steel RM, Bastin ME, McConell S, Marshall I, Cunningham-Owens DG, Lawrie SM et al (2001). Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls. Psychiatr Res Neuroimaging 106: 161–170.
  Article CAS Google Scholar
• Steen RG, Ogg RJ (2005). Abnormally high levels of brain _N_-acetylaspartate in children with sickle cell disease. Am J Neuroradiol 26: 463–468.
  PubMed PubMed Central Google Scholar
• Takanashi J, Inoue K, Tomita M, Kurihara A, Morita F, Ikehira H et al (2002). Brain _N_-acety-laspartate is elevated in Pelizaeus–Merzbacher disease with PLP1 duplication. Neurology 58: 237–241.
  Article CAS PubMed Google Scholar
• Tartaglia MC, Narayanan S, Francis SJ, Santos AC, De Stefano N, Lapierre Y et al (2004). The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Arch Neurol 61: 201–207.
  Article PubMed Google Scholar
• Taylor JS, Ogg RJ, Langston JW (1998). Proton MR spectroscopy of pediatric brain tumors. Neuroimag Clin N Am 8: 753–779.
  CAS Google Scholar
• Theberge J, Al-Semaan Y, Williamson PC, Menon RS, Neufeld RW, Rajakumar N et al (2003). Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy controls measured with 4.0 T proton MRS. Am J Psychiatr 160: 2231–2233.
  Article PubMed Google Scholar
• Theberge J, Bartha R, Drost DJ, Menon RS, Malla A, Takhar J et al (2002). Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers. Am J Psychiatr 159: 1944–1946.
  Article PubMed Google Scholar
• Thomas MA, Ke Y, Levitt J, Caplan R, Curran J, Asarnow R et al (1998). Preliminary study of frontal lobe 1H MR spectroscopy in childhood-onset schizophrenia. J Magn Reson Imag 8: 841–846.
  Article CAS Google Scholar
• Tibbo P, Hanstock CC, Asghar S, Silverstone P, Allen PS (2000). Proton magnetic resonance spectroscopy (1H-MRS) of the cerebellum in men with schizophrenia. J Psychiaty Neurosci 25: 509–512.
  CAS Google Scholar
• Valenzuela MJ, Sachdev P (2001). Magnetic resonance spectroscopy in AD. Neurology 56: 592–598.
  Article CAS PubMed Google Scholar
• Vermathen P, Laxer KD, Schuff N, Matson GB, Weiner MW (2003). Evidence of neuronal injury outside the medial temporal lobe in temporal lobe epilepsy: _N_-acetylaspartate concentration reductions detected with multisection proton MR spectroscopic imaging-initial experience. Radiology 226: 195–202.
  Article PubMed Google Scholar
• Vuori K, Kankaanranta L, Hakkinen AM, Gaily E, Valanne L, Granstrom ML et al (2004). Low-grade gliomas and focal cortical developmental malformations: differentiation with proton MR spectroscopy. Radiology 230: 703–708.
  Article PubMed Google Scholar
• Weber-Fahr W, Ende G, Braus DF, Bachert P, Soher BJ, Henn FA et al (2002). A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia. Neuroimage 16: 49–60.
  Article CAS PubMed Google Scholar
• Yamasue H, Fukui T, Fukuda R, Yamada H, Yamasaki S, Kuroki N et al (2002). 1H-MR spectroscopy and gray matter volume of the anterior cingulate cortex in schizophrenia. Neuroreport 13: 2133–2137.
  Article CAS PubMed Google Scholar
• Yurgelun-Todd DA, Renshaw PF, Gruber SA, Waternaux C, Cohen BM (1996). Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls. Schizophr Res 19: 55–59.
  Article CAS PubMed Google Scholar
• Zimmerman RA, Wang ZJ (1997). The value of proton MR spectroscopy in pediatric metabolic brain disease. Am J Neuroradiol 18: 1872–1879.
  CAS PubMed PubMed Central Google Scholar