Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma (original) (raw)

• Original Paper
• Published: 23 January 1997
• Adel K El-Naggar2,
• Kenneth Hurr2,
• Huai Lin1,3,
• WK Alfred Yung1,3 &
• …
• Peter A Steck1,3

Oncogene volume 14, pages 369–373 (1997)Cite this article

• 381 Accesses
• 66 Citations
• 3 Altmetric
• Metrics details

Abstract

Genomic deletions involving chromosome 4 have recently been implicated in several human cancers. To identify and characterize genetic events associated with the development of head and neck squamous cell carinoma (HNSCC), a fine mapping of allelic losses associated with chromosome 4 was performed on DNA isolated from 27 matched primary tumor specimens and normal tissues. Loss of heterozygosity (LOH) of at least one chromosome 4 polymorphic allele was seen in the majority of tumors (92%). Allelic deletions were confined to short arm loci in four tumors and to the long arm loci in 12 tumors, suggesting the presence of two regions of common deletion. One region of frequent deletion was centered at D4S405 on 4p and included the loci D4S1546 to D4S428 in ∼41% of the tumors. The common region of deletion on 4q was more complex and extended from D4S1571 to D4S1573. Frequent genetic alterations were observed within this region (4q25) and one marker, D4S407, exhibited a high frequency of LOH (>75%). These results indicate that alterations of chromosome 4 regions are associated with HNSCC tumorigenesis and further localizes the regions that may harbor tumor suppressor genes.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 50 print issues and online access

$259.00 per year

only $5.18 per issue

Buy this article

• Purchase on SpringerLink
• Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

Similar content being viewed by others

Author information

Authors and Affiliations

1. Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA
   Mark A Pershouse, Huai Lin, WK Alfred Yung & Peter A Steck
2. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA
   Adel K El-Naggar & Kenneth Hurr
3. Department of The Brain Tumour Centre, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA
   Mark A Pershouse, Huai Lin, WK Alfred Yung & Peter A Steck

Authors

1. Mark A Pershouse
   You can also search for this author inPubMed Google Scholar
2. Adel K El-Naggar
   You can also search for this author inPubMed Google Scholar
3. Kenneth Hurr
   You can also search for this author inPubMed Google Scholar
4. Huai Lin
   You can also search for this author inPubMed Google Scholar
5. WK Alfred Yung
   You can also search for this author inPubMed Google Scholar
6. Peter A Steck
   You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Pershouse, M., El-Naggar, A., Hurr, K. et al. Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma.Oncogene 14, 369–373 (1997). https://doi.org/10.1038/sj.onc.1200836

Download citation

• Received: 28 June 1996
• Revised: 17 September 1996
• Accepted: 17 September 1996
• Issue Date: 23 January 1997
• DOI: https://doi.org/10.1038/sj.onc.1200836

Keywords

This article is cited by