The OMgp gene, a second growth suppressor within the NF1 gene (original) (raw)
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- Published: 01 April 1998
Oncogene volume 16, pages 1525–1531 (1998)Cite this article
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Abstract
The Oligodendrocyte-Myelin glycoprotein gene (OMgp) is placed within an intron of the NF1 gene. Neurofibromin, the product of NF1, acts as a RasGAP and suppresses growth; inactivating mutations in NF1 lead to neurofibromatosis type 1. We report that OMgp also has growth suppressive effects and downregulates mitogenic signaling pathways closely related to those influenced by neurofibromin. Overexpression of OMgp alters mitogenic signaling in NIH3T3 fibroblasts. Cells overexpressing OMgp grow more slowly in serum compared to controls and show a partial G1 block upon cell cycle analysis. PDGF is the primary mitogen for fibroblasts in serum. Overexpression of OMgp alters PDGF signaling in fibroblasts which results in a block of mitogenic signaling. PDGF induced activation of c-Src is blocked, as is the induction of c-Myc and c-Fos, while tyrosine phosphorylation of the PDGFβ receptor, PLCγ1 and induction of c-Jun are intact. Although a number of genes embedded within other genes have been described, the biological significance of this arrangement remains unknown. We demonstrate here that structurally unrelated products of two such genes may exercise closely related functions. Our data also raise the possibility of a role for OMgp in disorders of cell proliferation such as NF1.
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Authors and Affiliations
- Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, 02115, Massachusetts, USA
Amyn A Habib, Jeffrey R Gulcher, Thorbergur Högnason & Leiya Zheng - DeCode Genetics, Lyngháls 1, 110 Reykjavík, Iceland
Kári Stefánsson
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- Amyn A Habib
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Habib, A., Gulcher, J., Högnason, T. et al. The OMgp gene, a second growth suppressor within the NF1 gene.Oncogene 16, 1525–1531 (1998). https://doi.org/10.1038/sj.onc.1201683
- Received: 15 August 1997
- Revised: 28 October 1997
- Accepted: 29 October 1997
- Published: 01 April 1998
- Issue Date: 26 March 1998
- DOI: https://doi.org/10.1038/sj.onc.1201683