PTEN mutations in gliomas and glioneuronal tumors (original) (raw)

Oncogene volume 16, pages 2259–2264 (1998)Cite this article

Abstract

Cytogenetic and loss of heterozygosity studies have suggested the presence of at least one tumor suppressor gene on chromosome 10 involved in the formation of high grade gliomas. Recently, the PTEN gene, also termed MMAC1 or TEP1, on chromosomal band 10q23 has been identified. Initial studies revealed mutations of PTEN in limited series of glioma cell lines and glioblastomas. In order to systematically evaluate the involvement of PTEN in gliomas, we have analysed the entire PTEN coding sequence by SSCP and direct sequencing in a series of 331 gliomas and glioneuronal tumors. PTEN mutations were detected in 20/142 glioblastomas, 1/7 giant cell glioblastomas, 1/2 gliosarcomas, 1/30 pilocytic astrocytomas and 2/22 oligodendrogliomas. No PTEN mutations were detected in 52 astrocytomas, 37 oligoastrocytomas, three subependymal giant cell astrocytomas, four pleomorphic xanthoastrocytomas, 15 ependymomas, 16 gangliogliomas and one dysembryoplastic neuroepithelial tumor. In addition, all tumors were examined for the presence of homozygous deletions of the PTEN gene; these were detected in 7 glioblastomas that did not have PTEN mutations. Therefore, PTEN mutations occur in approximately 20% of glioblastomas but are rare in lower grade gliomas. These findings confirm that PTEN is one of the chromosome 10 tumor suppressor genes involved in the development of glioblastomas.

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Authors and Affiliations

  1. Department of Neuropathology, University of Bonn Medical Center, Bonn, D-53105, Germany
    Eva-Maria Duerr, Britta Rollbrocker, Yutaka Hayashi, Nils Peters, Birgit Meyer-Puttlitz, Otmar D Wiestler & Andreas von Deimling
  2. C.S. Kubik Laboratory for Neuropathology and Molecular Neuro-Oncology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA
    David N Louis
  3. Department of Neurosurgery, University of Bonn Medical Center, D-53105
    Johannes Schramm
  4. Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, New York, 10032, NY
    Ramon Parsons
  5. Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Charis Eng

Authors

  1. Eva-Maria Duerr
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  2. Britta Rollbrocker
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  3. Yutaka Hayashi
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  4. Nils Peters
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  5. Birgit Meyer-Puttlitz
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  6. David N Louis
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  7. Johannes Schramm
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  8. Otmar D Wiestler
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  9. Ramon Parsons
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  10. Charis Eng
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  11. Andreas von Deimling
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Duerr, EM., Rollbrocker, B., Hayashi, Y. et al. PTEN mutations in gliomas and glioneuronal tumors.Oncogene 16, 2259–2264 (1998). https://doi.org/10.1038/sj.onc.1201756

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