PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers (original) (raw)

• Original Paper
• Published: 03 August 1998
• Donald J Tindall2,
• Harry Drabkin4,
• Robert Gemmill4,
• Wilbur Franklin5,
• Ping Yang3,
• Kenji Sugio6,
• David I Smith1 &
• …
• Wanguo Liu1

Oncogene volume 17, pages 475–479 (1998)Cite this article

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Abstract

A putative tumor suppressor, PTEN/MMAC1 gene at 10q23 was recently identified and found to be mutated in many different human tumors. To determine the role of the PTEN/MMAC1 gene in lung cancer, we screened 34 small cell lung cancer (SCLC) cell lines, 10 SCLC tumors, 13 non-small cell lung cancer (NSCLC) cell lines and 10 NSCLC tumors using Denaturing HPLC (DHPLC) and direct sequencing methods. In SCLC, six (18%) of the cell lines and one of the primary tumor samples (10%) showed alterations of the PTEN/MMAC1 gene including point mutations, small fragment deletions, and homozygous deletions. All of the point mutations and small fragment deletions were observed in hemizygously deleted cell lines. In contrast to SCLC, none of the NSCLC tumors or cell lines had mutations in the PTEN/MMAC1 gene. These data indicate that PTEN/MMAC1 mutations contribute to the pathogenesis and neoplastic evolution in SCLC but not in NSCLC.

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Authors and Affiliations

1. Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN, USA
   Akira Yokomizo, David I Smith & Wanguo Liu
2. Department of Urology Research, Mayo Foundation, Rochester, MN, USA
   Akira Yokomizo & Donald J Tindall
3. Health Sciences Research, Mayo Foundation, Rochester, MN, USA
   Ping Yang
4. Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, CO, USA
   Harry Drabkin & Robert Gemmill
5. Department of Pathology, University of Colorado Health Sciences Center, Denver, CO, USA
   Wilbur Franklin
6. Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, 812-82, Japan
   Kenji Sugio

Authors

1. Akira Yokomizo
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2. Donald J Tindall
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3. Harry Drabkin
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4. Robert Gemmill
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5. Wilbur Franklin
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6. Ping Yang
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7. Kenji Sugio
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8. David I Smith
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9. Wanguo Liu
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Yokomizo, A., Tindall, D., Drabkin, H. et al. PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.Oncogene 17, 475–479 (1998). https://doi.org/10.1038/sj.onc.1201956

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• Received: 02 December 1997
• Revised: 09 March 1998
• Accepted: 09 March 1998
• Published: 03 August 1998
• Issue Date: 30 July 1998
• DOI: https://doi.org/10.1038/sj.onc.1201956

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