Cell cycle targets of Ras/Raf signalling (original) (raw)
- Review Article
- Published: 22 September 1998
Review Article
Oncogene volume 17, pages 1457–1462 (1998)Cite this article
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Abstract
The regulation of cell proliferation in multicellular organisms is a complex process, which is primarily regu-lated by external growth factors provided by surrounding cells. Once induced to proliferate, the passage through the mitotic cell cycle is directed by the components of the so called cell cycle machinery. Over the last years research on growth factor signal-transduction and the components of the cell cycle system has lead to a detailed knowledge of the mechanisms by which growth factors transmit their signals and of the relationship between the components of the cell cycle machinery. The remaining question how the growth factor mediated signal-transduction cascades couple with the cell cycle regulators has recently been a focus of interest.
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Authors and Affiliations
- Institut für medizinische Strahlenkunde und Zellforschung University of Würzburg (USZ), Versbacher Str. 5, Würzburg, 97078, Germany
Eugen Kerkhoff & Ulf R Rapp
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- Eugen Kerkhoff
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Cite this article
Kerkhoff, E., Rapp, U. Cell cycle targets of Ras/Raf signalling.Oncogene 17, 1457–1462 (1998). https://doi.org/10.1038/sj.onc.1202185
- Published: 22 September 1998
- Issue Date: 17 September 1998
- DOI: https://doi.org/10.1038/sj.onc.1202185