The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11) (original) (raw)

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• Published: 17 December 1998

Oncogene volume 17, pages 3199–3202 (1998)Cite this article

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Abstract

The ectopic expression of LMO1 or LMO2 in T cell acute leukaemias resulting from chromosomal translocations t(11;14)(p15;q11) or t(11;14)(p13;q11) respectively in a causal factor in tumorigenesis. LMO1 has been found as a heterodimer with a 46 Kd protein in a T cell line derived from a childhood T-acute leukaemia. This 46 Kd protein is the LIM-binding protein LDB1/NLI. The latter is a phosphoprotein and binds to LMO1 in its phosphorylated state and essentially all the LMO1 and LDB1 protein in the T cell line is part of the complex. Therefore, the LMO1-LDB1 interaction is likely to be involved in tumorigenesis after LMO1 is ectopically expressed following chromosomal translocation in T cells prior to development of acute leukaemias.

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Authors and Affiliations

1. Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
   V Valge-Archer, A Forster & T H Rabbitts
2. Cambridge Antibody Technology, The Science Park, Melbourn, SG8 6JJ, Royston
   V Valge-Archer

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1. V Valge-Archer
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2. A Forster
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3. T H Rabbitts
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Valge-Archer, V., Forster, A. & Rabbitts, T. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11).Oncogene 17, 3199–3202 (1998). https://doi.org/10.1038/sj.onc.1202353

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• Received: 25 June 1998
• Accepted: 07 August 1998
• Published: 17 December 1998
• Issue Date: 17 December 1998
• DOI: https://doi.org/10.1038/sj.onc.1202353

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