Src family kinases, key regulators of signal transduction (original) (raw)

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• Published: 18 October 2004

Oncogene volume 23, pages 7906–7909 (2004)Cite this article

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Abstract

The Src family of protein tyrosine kinases (SFKs) plays key roles in regulating signal transduction by a diverse set of cell surface receptors in the context of a variety of cellular environments. SFKs have evolved many ingenious molecular strategies to couple receptors with the cytoplasmic signaling machinery. The contributions to this issue of ONCOGENE describe how this machinery regulates fundamental cellular processes, including cell growth, differentiation, cell shape, migration and survival, and specialized cell signals. The pleotropic functions of Src and Src family members underscore the importance of these kinases and explain why many of the members of this family have been identified as cellular oncogenes. In this volume, we have attempted to provide the reader with an overview of the current understanding of the function of Src family kinases in the regulation of selected cellular signaling pathways.

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Authors and Affiliations

1. Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, 22908-0734, VA, USA
   Sarah J Parsons & J Thomas Parsons

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1. Sarah J Parsons
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2. J Thomas Parsons
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Correspondence toSarah J Parsons or J Thomas Parsons.

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Parsons, S., Parsons, J. Src family kinases, key regulators of signal transduction.Oncogene 23, 7906–7909 (2004). https://doi.org/10.1038/sj.onc.1208160

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• Published: 18 October 2004
• Issue Date: 18 October 2004
• DOI: https://doi.org/10.1038/sj.onc.1208160

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