E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7 (original) (raw)

• Short Report
• Published: 16 May 2005
• Anne Graham1,
• Xuijie Zhao1,
• Rebecca Fisher1,
• Baidehi Maiti2,
• Gustavo Leone2 &
• …
• Nicholas B La Thangue1

Oncogene volume 24, pages 5000–5004 (2005)Cite this article

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Abstract

E2F is a family of transcription factors implicated in cell cycle control. To understand the role of E2F in controlling cell cycle progression, it is necessary to clarify the breadth of the E2F family. To date, seven E2F subunits have been identified. We report here the characterization of a new E2F subunit, E2F-8, which resembles the organization of E2F-7 in the presence of two separate DNA-binding domains, the integrity of which is required for E2F-8 to bind to DNA. Furthermore, like E2F-7, we find that E2F-8 can repress transcription and delay cell cycle progression. The similarities between E2F-7 and E2F-8 define a new subgroup of the E2F family, and further imply that E2F-7 and E2F-8 may act through overlapping mechanisms in mediating cell cycle control.

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Acknowledgements

We thank Marie Caldwell for help in preparing this paper, and the MRC, CRUK and EU for supporting our research.

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Authors and Affiliations

1. Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
   Nicola Logan, Anne Graham, Xuijie Zhao, Rebecca Fisher & Nicholas B La Thangue
2. Department of Molecular Virology, Human Cancer Genetics Program, Immunology and Medical Genetics, The Ohio State University, Columbus, 43210, OH, USA
   Baidehi Maiti & Gustavo Leone

Authors

1. Nicola Logan
2. Anne Graham
3. Xuijie Zhao
4. Rebecca Fisher
5. Baidehi Maiti
6. Gustavo Leone
7. Nicholas B La Thangue

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Correspondence toNicholas B La Thangue.

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Logan, N., Graham, A., Zhao, X. et al. E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.Oncogene 24, 5000–5004 (2005). https://doi.org/10.1038/sj.onc.1208703

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• Received: 03 February 2005
• Revised: 10 March 2005
• Accepted: 15 March 2005
• Published: 16 May 2005
• Issue date: 21 July 2005
• DOI: https://doi.org/10.1038/sj.onc.1208703

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