Pol η is required for DNA replication during nucleotide deprivation by hydroxyurea (original) (raw)
Arnaudeau C, Lundin C, Helleday T . (2001). DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J Mol Biol307: 1235–1245. ArticleCAS Google Scholar
Arnaudeau C, Tenorio Miranda E, Jenssen D, Helleday T . (2000). Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells. Mutat Res461: 221–228. ArticleCAS Google Scholar
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N et al. (2006). Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature444: 633–637. ArticleCAS Google Scholar
Broughton BC, Cordonnier A, Kleijer WJ, Jaspers NG, Fawcett H, Raams A et al. (2002). Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc Natl Acad Sci U S A.99: 815–820. ArticleCAS Google Scholar
Burgers PM, Koonin EV, Bruford E, Blanco L, Burtis KC, Christman MF et al. (2001). Eukaryotic DNA polymerases: proposal for a revised nomenclature. J. Biological Chemistry276: 43487–43490. ArticleCAS Google Scholar
Carter GL, Thompson DP, Cory JG . (1989). Mechanisms of drug resistance to inhibitors directed at the individual subunits of ribonucleotide reductase. Cancer Commun1: 13–20. ArticleCAS Google Scholar
Cleaver JE, Afzal V, Feeney L, McDowell M, Sadinski W, Volpe JPG et al. (1999). Increased UV sensitivity and chromosomal instability related to p53 function in the xeroderma pigmentosum variant. Cancer Res59: 1102–1108. CASPubMed Google Scholar
Cleaver JE, Bartholomew J, Char S, Crowley E, Feeney L, Limoli CL . (2002). Polymerase η and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S-phase checkpoint arrest after UV irradiation. DNA Repair3: 1–17. Google Scholar
Cordeiro-stone M, Makhov AM, Zaritskaya LS, Griffith JD . (1999). Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand. J Mol Biol289: 1207–1218. ArticleCAS Google Scholar
Cordonnier AM, Lehmann AR, Fuchs RP . (1999). Impaired translesion synthesis in xeroderma pigmentosum variant extracts. Mol Cell Biol19: 2206–2211. ArticleCAS Google Scholar
Feijoo C, Hall-Jackson C, Wu R, Jenkins D, Leitch J, Gilbert DM et al. (2001). Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S-phase checkpoint monitoring replication origin firing. J Cell Biol154: 913–923. ArticleCAS Google Scholar
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA et al. (2003). Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA-double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem278: 20303–20312. ArticleCAS Google Scholar
Godov VG, Jarosz DF, Walker FL, Simmons LA, Walker GC . (2006). Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression. EMBO J25: 868–879. Article Google Scholar
Halicka HD, Huang X, Traganos F, King MA, Dai W, Darzynkiewicz Z . (2005). Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis. Cell Cycle4: 339–345. ArticleCAS Google Scholar
Hammond EM, Green SL, Giaccia AJ . (2003). Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutat Res532: 205–213. ArticleCAS Google Scholar
Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W et al. (2006). Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol8: 339–347. CAS Google Scholar
Hurta RA, Wright JA . (1990). Amplification of the genes for both components of ribonucleotide reductase in hydroxyurea resistant mammalian cells. Biochem Biophys Res Commun28: 258–264. Article Google Scholar
Johnson RE, Kondratick CM, Prakash S, Prakash L . (1999). hRAD30 mutations in the variant form of xeroderma pigmentosum. Science264: 263–265. Article Google Scholar
Kannouche P, Broughton BC, Volker M, Hanaoka F, Mullenders LH, Lehmann AR . (2001). Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells. Genes Dev15: 158–172. ArticleCAS Google Scholar
Kurose A, Tanaka T, Huang X, Traganos F, Dai W, Darzynkiewicz Z . (2006a). Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis. Cytometry A69: 212–221. Article Google Scholar
Kurose A, Tanaka T, Huang X, Traganos F, Darzynkiewicz Z . (2006b). Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage. Cell Prolif39: 231–240. ArticleCAS Google Scholar
Limoli CL, Giedzinski E, Bonner WM, Cleaver JE . (2002a). UV-induced replication arrest in the xeroderma pigmentosum variant leads to double strand breaks, _γ_-H2Ax formation, and Mre11 relocalization. Proc Natl Acad Sci USA99: 233–238. ArticleCAS Google Scholar
Limoli CL, Giedzinski E, Cleaver JE . (2005). Alternative recombination pathways in UV-irradiated XP Variant cells. Oncogene24: 3708–3714. ArticleCAS Google Scholar
Limoli CL, Giedzinski E, Morgan WF, Cleaver JE . (2000). Polymerase η deficiency in the XP variant uncovers an overlap between the S-phase checkpoint and double strand break repair. Proc Nat Acad Sci USA97: 7939–7946. ArticleCAS Google Scholar
Limoli CL, Laposa R, Cleaver JE . (2002b). DNA Replication arrest in XP Variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor Wortmannin. Mutat Res510: 121–129. ArticleCAS Google Scholar
Lowndes NF, Toh GW-L . (2005). DNA repair: the importance of phosphorylating histone H2AX. Curr Biol15: R99–R102. ArticleCAS Google Scholar
Lu C, Zhu F, Cho YY, Tang F, Zykova T, Ma WY et al. (2006). Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell23: 121–132. ArticleCAS Google Scholar
Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE . (2006). H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double strand breaks. Proc Natl Acad Sci USA103: 9891–9896. ArticleCAS Google Scholar
Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokol M, Yuasa M et al. (1999). The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η. Nature399: 700–704. ArticleCAS Google Scholar
Mukherjee B, Kessinger C, Kobayashi J, Chen BP, Chen DJ, Chatterjee A et al. (2006). DNA-PK phosphorylates H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair5: 575–590. ArticleCAS Google Scholar
O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA . (2003). A splicing mutation affecting expression of ataxia-telangiectasis and Rad 3-related protein (ATR) results in Seckel syndrome. Nat Genet33: 497–501. ArticleCAS Google Scholar
Ogi T, Kannouche P, Lehmann AR . (2005). Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci. 118 (Partt 1): 129–136.
Rappold I, Iwabuchi K, Date T, Chen J . (2001). Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol153: 613–620. ArticleCAS Google Scholar
Robison JG, Elliott J, Dixon K, Oakley GG . (2004). Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks. J Biol Chem279: 34802–34810. ArticleCAS Google Scholar
Saintigny Y, Delacote F, Vares G, Petitot F, Lambert S, Averbeck D et al. (2001). Characterization of homologous recombination induced by replication inhibition in mammalian cells. EMBO J20: 3861–3870. ArticleCAS Google Scholar
Thakur M, Wernick M, Collins C, Limoli C, Crowley E, Cleaver JE . (2001). DNA polymerase η undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination. Genes Chromosomes Cancer32: 222–235. ArticleCAS Google Scholar
Ward IM, Chen J . (2001). Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem276: 47759–47762. ArticleCAS Google Scholar
Washington MT, Johnson RE, Prakash L, Prakash S . (2003). The mechanism of nucleotide incorporation by human polymerase eta differs from that of the yeast enzyme. Mol Cell Biol23: 8316–8322. ArticleCAS Google Scholar
Zhao H, Piwnica-Worms H . (2001). ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol21: 4129–4139. ArticleCAS Google Scholar