Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling (original) (raw)

• Alexandre C, Lecourtois M, Vincent J . (1999). Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development 126: 5689–5698.
  CAS Google Scholar
• Allenspach EJ, Maillard I, Aster JC, Pear WS . (2002). Notch signaling in cancer. Cancer Biol Ther 1: 466–476.
  Article Google Scholar
• Amundson SA, Myers TG, Fornace Jr AJ . (1998). Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 17: 3287–3299.
  Article Google Scholar
• Baonza A, Freeman M . (2001). Notch signalling and the initiation of neural development in the Drosophila eye. Development 128: 3889–3898.
  CAS Google Scholar
• Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U et al. (2003). Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol 163: 723–728.
  Article CAS Google Scholar
• Borzillo GV, Lippa B . (2005). The Hedgehog signaling pathway as a target for anticancer drug discovery. Curr Top Med Chem 5: 147–157.
  Article CAS Google Scholar
• Chakraborty PK, Ghosh A, Chowdhury JR . (1984). Ceruloplasmin in human malignancies. Acta Med Okayama 38: 315–320.
  CAS Google Scholar
• Chen JK, Taipale J, Cooper MK, Beachy PA . (2002). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16: 2743–2748.
  Article CAS Google Scholar
• Dakubo GD, Mazerolle CJ, Wallace VA . (2006). Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice. J Neurooncol 79: 221–227.
  Article CAS Google Scholar
• Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R et al. (2004). Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function. J Biol Chem 279: 30771–30780.
  Article CAS Google Scholar
• Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C et al. (2005). Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 6: 314–322.
  Article CAS Google Scholar
• Eichberger T, Sander V, Schnidar H, Regl G, Kasper M, Schmid C et al. (2006). Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes. Genomics 87: 616–632.
  Article CAS Google Scholar
• Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD et al. (1991). TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649–661.
  Article CAS Google Scholar
• Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D et al. (2004). Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res 64: 7787–7793.
  Article CAS Google Scholar
• Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H et al. (2002). Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol 1: 1–10.
  Article Google Scholar
• Fu W, Baker NE . (2003). Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development. Development 130: 5229–5239.
  Article CAS Google Scholar
• Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C . (2002). A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep 3: 688–694.
  Article CAS Google Scholar
• Goodrich LV, Scott MP . (1998). Hedgehog and patched in neural development and disease. Neuron 21: 1243–1257.
  Article CAS Google Scholar
• Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A et al. (1996). Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85: 841–851.
  Article CAS Google Scholar
• Hallahan AR, Pritchard JI, Hansen S, Benson M, Stoeck J, Hatton BA et al. (2004). The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res 64: 7794–7800.
  Article CAS Google Scholar
• Hansson EM, Lendahl U, Chapman G . (2004). Notch signaling in development and disease. Semin Cancer Biol 14: 320–328.
  Article CAS Google Scholar
• Hays R, Buchanan KT, Neff C, Orenic TV . (1999). Patterning of Drosophila leg sensory organs through combinatorial signaling by hedgehog, decapentaplegic and wingless. Development 126: 2891–2899.
  CAS Google Scholar
• Hegde P, Qi R, Abernathy K, Gay C, Dharap S, Gaspard R et al. (2000). A concise guide to cDNA microarray analysis. Biotechniques 29: 548–550, 552–554, 556 passim.
  Article CAS Google Scholar
• Hirata H, Yoshiura S, Ohtsuka T, Bessho Y, Harada T, Yoshikawa K et al. (2002). Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 298: 840–843.
  Article CAS Google Scholar
• Ingram WJ, Wicking CA, Grimmond SM, Forrest AR, Wainwright BJ . (2002). Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells. Oncogene 21: 8196–8205.
  Article CAS Google Scholar
• Iso T, Kedes L, Hamamori Y . (2003). HES and HERP families: multiple effectors of the Notch signalling pathway. J Cell Physiol 194: 237–255.
  Article CAS Google Scholar
• Iso T, Sartorelli V, Chung G, Shichinohe T, Kedes L, Hamamori Y . (2001). HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol 21: 6071–6079.
  Article CAS Google Scholar
• Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A . (1995). Signalling downstream of activated mammalian Notch. Nature 377: 355–358.
  Article CAS Google Scholar
• Jia J, Jiang J . (2006). Decoding the Hedgehog signal in animal development. Cell Mol Life Sci 63: 1249–1265.
  Article CAS Google Scholar
• Johansson FK, Goransson H, Westermark B . (2005). Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice. Oncogene 24: 3896–3905.
  Article CAS Google Scholar
• Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM et al. (1996). Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272: 1668–1671.
  Article CAS Google Scholar
• Kageyama R, Ohtsuka T, Hatakeyama J, Ohsawa R . (2005). Roles of bHLH genes in neural stem cell differentiation. Exp Cell Res 306: 343–348.
  Article CAS Google Scholar
• Kappler R, Bauer R, Calzada-Wack J, Rosemann M, Hemmerlein B, Hahn H . (2004a). Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcoma. Oncogene 23: 8785–8795.
  Article CAS Google Scholar
• Kappler R, Hess I, Schlegel J, Hahn H . (2004b). Transcriptional up-regulation of Gadd45a in Patched-associated medulloblastoma. Int J Oncol 25: 113–120.
  CAS Google Scholar
• Kato M, Seki N, Sugano S, Hashimoto K, Masuho Y, Muramatsu M et al. (2001). Identification of sonic hedgehog-responsive genes using cDNA microarray. Biochem Biophys Res Commun 289: 472–478.
  Article CAS Google Scholar
• Kinto N, Iwamoto M, Enomoto-Iwamoto M, Noji S, Ohuchi H, Yoshioka H et al. (1997). Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. FEBS Lett 404: 319–323.
  Article CAS Google Scholar
• Kunapuli SP, Singh H, Singh P, Kumar A . (1987). Ceruloplasmin gene expression in human cancer cells. Life Sci 40: 2225–2228.
  Article CAS Google Scholar
• Kwon C, Hays R, Fetting J, Orenic TV . (2004). Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc. Development 131: 2681–2692.
  Article CAS Google Scholar
• Li X, Gu W, Mohan S, Baylink DJ . (2002). DNA microarrays: their use and misuse. Microcirculation 9: 13–22.
  Article CAS Google Scholar
• Lowndes SA, Harris AL . (2004). Copper chelation as an antiangiogenic therapy. Oncol Res 14: 529–539.
  Article CAS Google Scholar
• Martinez Arias A, Zecchini V, Brennan K . (2002). CSL-independent Notch signalling: a checkpoint in cell fate decisions during development? Curr Opin Genet Dev 12: 524–533.
  Article Google Scholar
• McGlinn E, van Bueren KL, Fiorenza S, Mo R, Poh AM, Forrest A et al. (2005). Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev 122: 1218–1233.
  Article CAS Google Scholar
• Minoguchi S, Taniguchi Y, Kato H, Okazaki T, Strobl LJ, Zimber-Strobl U et al. (1997). RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol 17: 2679–2687.
  Article CAS Google Scholar
• Mumm JS, Kopan R . (2000). Notch signaling: from the outside in. Dev Biol 228: 151–165.
  Article CAS Google Scholar
• Murata K, Hattori M, Hirai N, Shinozuka Y, Hirata H, Kageyama R et al. (2005). Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol 25: 4262–4271.
  Article CAS Google Scholar
• Nakagawa Y, Kaneko T, Ogura T, Suzuki T, Torii M, Kaibuchi K et al. (1996). Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells. Development 122: 2449–2464.
  CAS Google Scholar
• Nakamura T, Aikawa T, Iwamoto-Enomoto M, Iwamoto M, Higuchi Y, Pacifici M et al. (1997). Induction of osteogenic differentiation by hedgehog proteins. Biochem Biophys Res Commun 237: 465–469.
  Article CAS Google Scholar
• Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM et al. (2003). Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci USA 100: 7331–7336.
  Article CAS Google Scholar
• Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT et al. (2005). Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development 132: 2425–2439.
  Article CAS Google Scholar
• Pathi S, Pagan-Westphal S, Baker DP, Garber EA, Rayhorn P, Bumcrot D et al. (2001). Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev 106: 107–117.
  Article CAS Google Scholar
• Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J et al. (1997). Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 57: 2085–2088.
  CAS Google Scholar
• Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME et al. (2002). Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415: 436–442.
  Article CAS Google Scholar
• Reznikoff CA, Brankow DW, Heidelberger C . (1973). Establishment and characterization of a cloned line of C3 H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res 33: 3231–3238.
  CAS Google Scholar
• Senra Varela A, Lopez Saez JJ, Quintela Senra D . (1997). Serum ceruloplasmin as a diagnostic marker of cancer. Cancer Lett 121: 139–145.
  Article CAS Google Scholar
• Shawber C, Nofziger D, Hsieh JJ, Lindsell C, Bogler O, Hayward D et al. (1996). Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 122: 3765–3773.
  CAS Google Scholar
• Solecki DJ, Liu XL, Tomoda T, Fang Y, Hatten ME . (2001). Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation. Neuron 31: 557–568.
  Article CAS Google Scholar
• van den Boom J, Wolter M, Kuick R, Misek DE, Youkilis AS, Wechsler DS et al. (2003). Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Pathol 163: 1033–1043.
  Article CAS Google Scholar
• Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC et al. (2003). Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 23: 655–664.
  Article CAS Google Scholar
• Woodward WA, Chen MS, Behbod F, Rosen JM . (2005). On mammary stem cells. J Cell Sci 118: 3585–3594.
  Article CAS Google Scholar
• Yokota N, Mainprize TG, Taylor MD, Kohata T, Loreto M, Ueda S et al. (2004). Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 23: 3444–3453.
  Article CAS Google Scholar
• Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA et al. (2002). Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 277: 5548–5555.
  Article CAS Google Scholar
• Zhao Q, Kho A, Kenney AM, Yuk Di DI, Kohane I, Rowitch DH . (2002). Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci USA 99: 5704–5709.
  Article CAS Google Scholar